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Human Placental Mesenchymal Stem Cells Relieve Primary Sclerosing Cholangitis via Upregulation of TGR5 in Mdr2−/−Mice and Human Intrahepatic Cholangiocyte Organoid Models

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Bile acids and their receptors in hepatic immunity

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Primary Sclerosing Cholangitis-Associated Cholangiocarcinoma: From Pathogenesis to Diagnostic and Surveillance Strategies

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Microbial Players in Primary Sclerosing Cholangitis: Current Evidence and Concepts

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Secondary bile acids as immune and metabolic mediators

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Bile Acids-Based Therapies for Primary Sclerosing Cholangitis: Current Landscape and Future Developments

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A novel lipid metabolism gene signature for clear cell renal cell carcinoma using integrated bioinformatics analysis

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Folic acid supplementation prevents high body fat-induced bone loss through TGR5 signaling pathways

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Macrophages in cholangiopathies

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Liver GPBAR1 Associates With Immune Dysfunction in Primary Sclerosing Cholangitis and Its Activation Attenuates Cholestasis in Abcb4−/− Mice

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Gut–Liver Axis, Microbiota, Bile Acids, and Immune Response in Pathogenesis of Primary Sclerosing Cholangitis: An Overview

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Current Therapeutics in Primary Sclerosing Cholangitis

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Antagonistic effects of the cytotoxic molecules granzyme B and TRAIL in the immunopathogenesis of sclerosing cholangitis

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Biological functions and pharmacological behaviors of bile acids in metabolic diseases

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Bile acids and coronavirus disease 2019

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The role of bile acid-activated receptor TGR5 in inflammation and liver diseases

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Bryodulcosigenin a natural cucurbitane-type triterpenoid attenuates dextran sulfate sodium (DSS)-induced colitis in mice

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Targeting bile salt homeostasis in biliary diseases

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The many facets of bile acids in the physiology and pathophysiology of the human liver

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Mucosal immunity in primary sclerosing cholangitis: from the bowel to bile ducts and back again

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Targeting the gut microbiota-bile acid axis: Therapeutic strategies for cholestatic liver disease and metabolic dysfunction-associated steatotic liver disease

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Molecular Mechanisms of Fibrosis in Cholestatic Liver Diseases and Regenerative Medicine-Based Therapies

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TGR5 signalling in heart and brain injuries: focus on metabolic and ischaemic mechanisms

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Immunobiology of bile and cholangiocytes

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IgG4-Related Cholangitis

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PPARα agonist ameliorates cholestatic liver injury by regulating hepatic macrophage homeostasis

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Bile acid receptor Tgr5 prevents macrophage hyperinflammation during bacterial sepsis through metabolic and epigenetic silencing

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Bile acid receptors and renal regulation of water homeostasis

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Aberrant basement membrane production by HSCs in MASLD is attenuated by the bile acid analog INT-767

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Advances in Biliary Disease Organoid Research: From Model Construction to Clinical Applications

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Primary sclerosing cholangitis and the path to translation

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A novel model to study mechanisms of cholestasis in human cholangiocytes reveals a role for the SIPR2 pathway

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Hepatobiliary organoid research: the progress and applications

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A Closer Look into Autoimmune Liver Diseases

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Ferroptosis as a potential therapeutic target for obesity-related metabolic diseases

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Activation of TGR5 Increases Urine Concentration by Inducing AQP2 and AQP3 Expression in Renal Medullary Collecting Ducts

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The functions and applications of organoids in rheumatic immune diseases

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Total astragalus saponins attenuate primary sclerosing cholangitis in mice by upregulation of TGR5

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Bile as a liquid biopsy matrix: potential applications and limitations

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An update on novel pharmacological agents for primary sclerosing cholangitis

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A comprehensive 26‐color immunophenotyping panel to study the role of the gut‐liver axis in chronic liver diseases

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MDSCs in Chronic Liver Disease: Updates and Future Challenges

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Deletion of Tgm2 suppresses BMP ‐mediated hepatocyte‐to‐cholangiocyte metaplasia in ductular reaction

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Innovative construction and application of bile duct organoids: Unraveling the complexity of bile duct diseases and potential therapeutic strategies

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Human Vascularized Bile Duct-on-a Chip: A multi-cellular micro-physiological system for studying Primary Sclerosing CholangitisPreprint

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Distinct metabolomic and lipidomic profiles in serum samples of patients with primary sclerosing cholangitis

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Targeting of a Bile Acid Receptor, Takeda G Protein Receptor 5 [TGR5], by a Novel First-in-Class Competitive Antagonist, SBI-364, Diminishes Hepatic and Renal Cystogenesis in Polycystic Liver and Kidney Disease

Masyuk, T. V., Masyuk, A. I., Trussoni, C. E., Pisarello, M. J. L., Ardecky, R., Pinkerton, A. B., Sergienko, E., Olson, S. H., Zou, J., Reddy, S., et al. (2025) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.4c00701 · Cited by 3 · see citing works

Microbial Modulation of the Gut–Liver Axis in Autoimmune Liver Diseases

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Distinct phenotype of primary sclerosing cholangitis-associated inflammatory bowel disease

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Bile Acids: A Bridge Linking Gut Microbiota and NAFLD

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Increased expression of TNFRSF14 and LIGHT in biliary epithelial cells of patients with primary sclerosing cholangitis

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The utilisation of biliary organoids for biomedical applications

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Protocol for fabricating a vascularized bile duct-on-a-chip

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Bile acid species as hepatic T lymphocyte response modulators – when bile acids interfere with tumor growth

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Adverse events of ursodeoxycholic acid: a real-world pharmacovigilance study using FAERS (2004–2023)

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Microbiota in cholestatic diseases: crosstalk among bile composition, the biliary microbiome, and host immunity

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PGC1α deficiency reverses cholestasis-induced liver injury via attenuating hepatic inflammation and promoting bile duct remodeling

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A bidirectional two-sample Mendelian randomization using the gut microbiota to reveal potential therapeutic targets for primary sclerosing cholangitis

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Primary Cilia in Hepatic Biliary Hyperplasia: Implications for Liver Diseases

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Harnessing organoid technology to model autoimmune pathways in rheumatological and inflammatory disorders

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Single-cell and spatial transcriptomics reveals the human liver immunological landscape and myeloid dysfunction in PSCPreprint

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The bile acid receptor TGR5 and cholestasis

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Cholecystectomy Is Linked to Worse Clinical Outcomes in Primary Sclerosing Cholangitis

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Primary Sclerosing Cholangitis: Diagnosis, Management, and Clinical Challenges

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Primary sclerosing cholangitis

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Unraveling the Converging Roles of ASC-Dependent Inflammasomes, Interleukin-1 Superfamily Members, Serum Amyloid A, and Non-Sterile Inflammation in Disease Pathology and Fibrosis in Inflammatory Bowel Disease and Primary Sclerosing Cholangitis

Losa, M., Schwarzfischer, M., Emmenegger, M., Spalinger, M. R., Rogler, G., & Scharl, M. M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26168042 · Cited by 2 · see citing works

Early Deregulation of Cholangiocyte NR0B2 During Primary Sclerosing Cholangitis

Desterke, C., Chung, C., Pan, D. Z., Trauner, M. A., Samuel, D., Azoulay, D., & Féray, C. (2022) · Gastro Hep Advances · doi:10.1016/j.gastha.2022.07.023 · Cited by 1 · see citing works

Diagnostic workup of suspected hereditary cholestasis in adults: a case report

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Musashi2 binds TGFβR1 regulates mastitis via TGFβ/Smad signaling pathway in dairy cowsPreprint

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TGR5 (Gpbar-1) expression is downregulated in biliary epithelial cells in livers of PSC patients and in Abcb4-/- mice

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Biliary TGR5 expression is reduced in the course sclerosing cholangitis in humans and mice

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The TGR5 protein amount is reduced in patients with primary sclerosing cholangitis (PSC)

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TGR5: Pathogenetic Role and/or Therapeutic Target in Fibrosing Cholangitis?

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Mutational Characterization of the Bile Acid Receptor TGR5 in Primary Sclerosing Cholangitis

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