Epelman, Slava

Origin and functions of tissue macrophages

Epelman, S., Lavine, K. J., & Randolph, G. J. (2014) · Immunity

Immune cells in cancerPhagocytosis and Immune Regulation

Cited by 1,585

Embryonic and Adult-Derived Resident Cardiac Macrophages Are Maintained through Distinct Mechanisms at Steady State and during Inflammation

Epelman, S., Lavine, K. J., Beaudin, A. E., Sojka, D. K., Carrero, J. A., Calderon, B., Brija, T., Gautier, E. L., Ivanov, S., Satpathy, A. T., et al. (2014) · Immunity

Cardiac Fibrosis and RemodelingAtherosclerosis and Cardiovascular Diseases

Cited by 1,494

Origin, fate and dynamics of macrophages at central nervous system interfaces

Goldmann, T., Wieghofer, P., Jordão, M. J. C., Prutek, F., Hagemeyer, N., Frenzel, K., Amann, L., Staszewski, O., Kierdorf, K., Krueger, M., et al. (2016) · Nature Immunology

Neuroinflammation and Neurodegeneration MechanismsNeurogenesis and neuroplasticity mechanisms

Cited by 1,209

Self-Renewing Resident Cardiac Macrophages Limit Adverse Remodeling Following Myocardial Infarction

Dick, S. A., Macklin, J. A., Nejat, S., Momen, A., Clemente-Casares, X., Althagafi, M. G., Chen, J., Kantores, C., Hosseinzadeh, S., Aronoff, L., et al. (2019) · Nature Immunology

Cardiac Fibrosis and RemodelingAtherosclerosis and Cardiovascular Diseases

Cited by 883

Distinct macrophage lineages contribute to disparate patterns of cardiac recovery and remodeling in the neonatal and adult heart

Lavine, K. J., Epelman, S., Uchida, K., Weber, K. J., Nichols, C. G., Schilling, J. D., Ornitz, D. M., Randolph, G. J., & Mann, D. L. (2014) · Proceedings of the National Academy of Sciences

Cardiac Fibrosis and RemodelingCongenital heart defects research

Cited by 818

Tissue Resident CCR2− and CCR2+ Cardiac Macrophages Differentially Orchestrate Monocyte Recruitment and Fate Specification Following Myocardial Injury

Bajpai, G., Bredemeyer, A., Li, W., Zaitsev, K., Koenig, A. L., Lokshina, I., Mohan, J., Ivey, B., Hsiao, H.-M., Weinheimer, C., et al. (2019) · Circulation Research

Cardiac Fibrosis and RemodelingAtherosclerosis and Cardiovascular Diseases

Cited by 751

The human heart contains distinct macrophage subsets with divergent origins and functions

Bajpai, G., Schneider, C., Wong, N., Bredemeyer, A., Hulsmans, M., Nahrendorf, M., Epelman, S., Kreisel, D., Liu, Y., Itoh, A., et al. (2018) · Nature Medicine

Cardiac Fibrosis and RemodelingAtherosclerosis and Cardiovascular Diseases

Cited by 712

Three tissue resident macrophage subsets coexist across organs with conserved origins and life cycles

Dick, S. A., Wong, A., Hamidzada, H., Nejat, S., Nechanitzky, R., Vohra, S., Mueller, B., Zaman, R., Kantores, C., Aronoff, L., et al. (2022) · Science Immunology

Immune cells in cancerSingle-cell and spatial transcriptomics

Cited by 538

Self-renewing resident arterial macrophages arise from embryonic CX3CR1+ precursors and circulating monocytes immediately after birth

Ensan, S., Li, A., Besla, R., Degousee, N., Cosme, J., Roufaiel, M., Shikatani, E. A., El-Maklizi, M., Williams, J. W., Robins, L., et al. (2016) · Nature Immunology

Atherosclerosis and Cardiovascular DiseasesImmune cells in cancer

Cited by 372

Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis

Sergin, I., Evans, T. D., Zhang, X., Bhattacharya, S., Stokes, C. J., Song, E., Ali, S., Dehestani, B., Holloway, K. B., Micevych, P. S., et al. (2017) · Nature Communications

Autophagy in Disease and TherapyAtherosclerosis and Cardiovascular Diseases

Cited by 351

The pancreas anatomy conditions the origin and properties of resident macrophages

Calderon, B., Carrero, J. A., Ferris, S. T., Sojka, D. K., Moore, L., Epelman, S., Murphy, K. M., Yokoyama, W. M., Randolph, G. J., & Unanue, E. R. (2015) · Journal of Experimental Medicine

Immune cells in cancerPancreatic function and diabetes

Cited by 321

The Macrophage in Cardiac Homeostasis and Disease

Lavine, K. J., Pinto, A. R., Epelman, S., Kopecky, B. J., Clemente-Casares, X., Godwin, J., Rosenthal, N., & Kovacic, J. C. (2018) · Journal of the American College of Cardiology

Cardiac Fibrosis and RemodelingAtherosclerosis and Cardiovascular Diseases

Cited by 234

Effect of Convalescent Plasma on Organ Support–Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial

Writing Committee for the REMAP-CAP Investigators, Abdelhady, H., Abdelrazik, M., Abdi, Z., Abdo, D., Abdulle, A., Abel, L., Abouzeenni, S., Abrahamson, G., Abusamra, Y., et al. (2021) · JAMA

COVID-19 Clinical Research StudiesSARS-CoV-2 and COVID-19 Research

Cited by 212

High-protein diets increase cardiovascular risk by activating macrophage mTOR to suppress mitophagy

Zhang, X., Sergin, I., Evans, T. D., Jeong, S.-J., Rodriguez-Velez, A., Kapoor, D., Chen, S., Song, E., Holloway, K. B., Crowley, J. R., et al. (2020) · Nature Metabolism

Atherosclerosis and Cardiovascular DiseasesAutophagy in Disease and Therapy

Cited by 191

Peripheral monocyte-derived cells counter amyloid plaque pathogenesis in a mouse model of Alzheimer’s disease

Yan, P., Kim, K.-W., Xiao, Q., Ma, X., Czerniewski, L. R., Liu, H., Rawnsley, D. R., Yan, Y., Randolph, G. J., Epelman, S., et al. (2022) · Journal of Clinical Investigation

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 95

Exploring cardiac macrophage heterogeneity in the healthy and diseased myocardium

Zaman, R., Hamidzada, H., & Epelman, S. (2021) · Current Opinion in Immunology

Cardiac Fibrosis and RemodelingAtherosclerosis and Cardiovascular Diseases

Cited by 65

Intravenous Vitamin C for Patients Hospitalized With COVID-19: Two Harmonized Randomized Clinical Trials

The LOVIT-COVID Investigators, O. B. O. T. C. C. C. T. G., Florescu, S., Stanciu, D., Zaharia, M., Kosa, A., Codreanu, D., Fareed, K., Kidwai, A., Kaye, C., Coutts, A., et al. (2023) · JAMA

Vitamin C and Antioxidants ResearchCOVID-19 Clinical Research Studies

Cited by 55