Origin and functions of tissue macrophages

Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity

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Macrophage activation and polarization: nomenclature and experimental guidelines

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Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

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Macrophage biology in development, homeostasis and disease

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Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

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The Classical Complement Cascade Mediates CNS Synapse Elimination

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Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis

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<i>TREM2</i> Variants in Alzheimer's Disease

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Analysis of Fractalkine Receptor CX₃CR1 Function by Targeted Deletion and Green Fluorescent Protein Reporter Gene Insertion

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Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor

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A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

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Hematopoiesis: An Evolving Paradigm for Stem Cell Biology

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Tissue-Resident Macrophages Self-Maintain Locally throughout Adult Life with Minimal Contribution from Circulating Monocytes

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The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions

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Identification of splenic reservoir monocytes and their deployment to inflammatory sites

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Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation

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Tissue-resident macrophages

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Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis

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Monitoring of Blood Vessels and Tissues by a Population of Monocytes with Patrolling Behavior

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Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages

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Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2

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Local self-renewal can sustain CNS microglia maintenance and function throughout adult life

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Resting Microglia Directly Monitor the Functional State of Synapses <i>In Vivo</i> and Determine the Fate of Ischemic Terminals

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THE ORIGIN AND KINETICS OF MONONUCLEAR PHAGOCYTES

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Microglial interactions with synapses are modulated by visual experience

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Embryonic and Adult-Derived Resident Cardiac Macrophages Are Maintained through Distinct Mechanisms at Steady State and during Inflammation

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Programmed cell senescence during mammalian embryonic development

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Local macrophage proliferation, rather than recruitment from the blood, is a signature of Th2 inflammation

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Alveolar macrophages: plasticity in a tissue-specific context

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Alveolar macrophages develop from fetal monocytes that differentiate into long-lived cells in the first week of life via GM-CSF

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Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior

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Senescence is a developmental mechanism that contributes to embryonic growth and patterning

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Targeted disruption of the mouse colony-stimulating factor 1 receptor gene results in osteopetrosis, mononuclear phagocyte deficiency, increased primitive progenitor cell frequencies, and reproductive defects

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Microglia development and function

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Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction

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Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities

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Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool

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A Clonogenic Bone Marrow Progenitor Specific for Macrophages and Dendritic Cells

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Local proliferation dominates lesional macrophage accumulation in atherosclerosis

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Total absence of colony-stimulating factor 1 in the macrophage-deficient osteopetrotic (op/op) mouse.

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IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia

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Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta

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Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease

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Tissue-specific signals control reversible program of localization and functional polarization of macrophages

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Involvement of Granulocyte-Macrophage Colony-Stimulating Factor in Pulmonary Homeostasis

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The Evolution of Adaptive Immune Systems

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Macrophages are required for adult salamander limb regeneration

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Macrophages are required for neonatal heart regeneration

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Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac–derived macrophages

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Origins and functional specialization of macrophages and of conventional and monocyte-derived dendritic cells in mouse skin

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Hepatic recruitment of the inflammatory Gr1+ monocyte subset upon liver injury promotes hepatic fibrosis

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Layer V cortical neurons require microglial support for survival during postnatal development

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Nr4a1-Dependent Ly6Clow Monocytes Monitor Endothelial Cells and Orchestrate Their Disposal

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Minimal differentiation of classical monocytes as they survey steady state tissues and transport antigen to lymph nodes

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Microglia Promote the Death of Developing Purkinje Cells

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Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease

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Comparison of gene expression profiles between human and mouse monocyte subsets

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A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation

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Origin of monocytes and macrophages in a committed progenitor

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The transcription factor NR4A1 (Nur77) controls bone marrow differentiation and the survival of Ly6C- monocytes

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Local Proliferation of Macrophages Contributes to Obesity-Associated Adipose Tissue Inflammation

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Ly-6C high Monocytes Depend on Nr4a1 to Balance Both Inflammatory and Reparative Phases in the Infarcted Myocardium

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Macrophage depletion impairs wound healing and increases left ventricular remodeling after myocardial injury in mice

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Osteopetrosis in mice lacking haematopoietic transcription factor PU.1

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Beyond stem cells: self-renewal of differentiated macrophages

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Genetic programs expressed in resting and IL-4 alternatively activated mouse and human macrophages: similarities and differences

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Role for Spi-C in the development of red pulp macrophages and splenic iron homeostasis

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Cell tracing shows the contribution of the yolk sac to adult haematopoiesis

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Microglia: actively surveying and shaping neuronal circuit structure and function

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Heme-mediated SPI-C induction promotes monocyte differentiation into iron-recycling macrophages

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WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature

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Metchnikoff and the phagocytosis theory

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IL-4 directly signals tissue-resident macrophages to proliferate beyond homeostatic levels controlled by CSF-1

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The Transcription Factor Gata6 Links Tissue Macrophage Phenotype and Proliferative Renewal

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Selective Impairment of TLR-Mediated Innate Immunity in Human Newborns: Neonatal Blood Plasma Reduces Monocyte TNF-α Induction by Bacterial Lipopeptides, Lipopolysaccharide, and Imiquimod, but Preserves the Response to R-848

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Absence of the Chemokine Receptor CCR2 Protects Against Cerebral Ischemia/Reperfusion Injury in Mice

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Distinct and Non-Redundant Roles of Microglia and Myeloid Subsets in Mouse Models of Alzheimer's Disease

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Developmental Neuronal Death in Hippocampus Requires the Microglial CD11b Integrin and DAP12 Immunoreceptor

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Nanoparticles in tumor microenvironment remodeling and cancer immunotherapy

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Macrophages in cardiovascular diseases: molecular mechanisms and therapeutic targets

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Tumor-associated macrophages: potential therapeutic strategies and future prospects in cancer

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Immune modulation of some autoimmune diseases: the critical role of macrophages and neutrophils in the innate and adaptive immunity

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Macrophages: An Inflammatory Link Between Angiogenesis and Lymphangiogenesis

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Perivascular macrophages mediate the neurovascular and cognitive dysfunction associated with hypertension

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Beyond a neurotransmitter: The role of serotonin in inflammation and immunity

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The Role of Macrophages in Staphylococcus aureus Infection

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Dealing with danger in the CNS: the response of the immune system to injury

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Skeletal muscle regeneration is modulated by inflammation

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Tissue‐resident macrophages: then and now

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Primitive Embryonic Macrophages are Required for Coronary Development and Maturation

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Nanoparticles and innate immunity: new perspectives on host defence

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THP-1 cells as a model for human monocytes

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Non-classical tissue monocytes and two functionally distinct populations of interstitial macrophages populate the mouse lung

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Molecular and epigenetic basis of macrophage polarized activation

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Reciprocal regulation of mesenchymal stem cells and immune responses

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Macrophage Polarity and Disease Control

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Extracellular vesicle activities regulating macrophage- and tissue-mediated injury and repair responses

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The pancreas anatomy conditions the origin and properties of resident macrophages

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Alveolar Macrophages

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Macrophage cell membrane-based nanoparticles: a new promising biomimetic platform for targeted delivery and treatment

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Single-cell analysis of fate-mapped macrophages reveals heterogeneity, including stem-like properties, during atherosclerosis progression and regression

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Macrophage reaction against biomaterials in the mouse model–phenotypes, functions and markers

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Yolk sac macrophage progenitors traffic to the embryo during defined stages of development

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When Immune Cells Turn Bad—Tumor-Associated Microglia/Macrophages in Glioma

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Macrophages: The Road Less Traveled, Changing Anticancer Therapy

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The Role of Decidual Macrophages During Normal and Pathological Pregnancy

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Targeting of the pulmonary capillary vascular niche promotes lung alveolar repair and ameliorates fibrosis

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The Role of Monocytes and Macrophages in Acute and Acute-on-Chronic Liver Failure

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Mitochondria as central hub of the immune system

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TNF Counterbalances the Emergence of M2 Tumor Macrophages

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Effects of Mesenchymal Stem Cell-Derived Exosomes on Autoimmune Diseases

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The Mononuclear Phagocyte System: The Relationship between Monocytes and Macrophages

Hume, D. A., Irvine, K. M., & Pridans, C. (2018) · Trends in Immunology · doi:10.1016/j.it.2018.11.007 · Cited by 262 · see citing works

From the Cradle to the Grave: The Role of Macrophages in Erythropoiesis and Erythrophagocytosis

Klei, T. R. L., Meinderts, S. M., van den Berg, T. K., & van Bruggen, R. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00073 · Cited by 262 · see citing works

Innate cell communication kick-starts pathogen-specific immunity

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Dual Effect of Immune Cells within Tumour Microenvironment: Pro- and Anti-Tumour Effects and Their Triggers

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Delivery strategies to control inflammatory response: Modulating M1–M2 polarization in tissue engineering applications

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Transcriptome analysis highlights the conserved difference between embryonic and postnatal-derived alveolar macrophages

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Cross-Talk Between Alveolar Macrophages and Lung Epithelial Cells is Essential to Maintain Lung Homeostasis

Bissonnette, É. Y., Lauzon‐Joset, J., Debley, J. S., & Ziegler, S. F. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.583042 · Cited by 253 · see citing works

Aging and cancer: The role of macrophages and neutrophils

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Two to Tango: Dialog between Immunity and Stem Cells in Health and Disease

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Ontogeny and Polarization of Macrophages in Inflammation: Blood Monocytes Versus Tissue Macrophages

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Tumor-associated fibrosis as a regulator of tumor immunity and response to immunotherapy

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Development and Functional Differentiation of Tissue-Resident Versus Monocyte-Derived Macrophages in Inflammatory Reactions

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The origins and homeostasis of monocytes and tissue‐resident macrophages in physiological situation

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Origins and diversity of macrophages in health and disease

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Monocytes and macrophages: developmental pathways and tissue homeostasis

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Origin, development, and homeostasis of tissue‐resident macrophages

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