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Cited by 212COVID-19 Clinical Research StudiesSARS-CoV-2 and COVID-19 ResearchRespiratory Support and Mechanisms

Effect of Convalescent Plasma on Organ Support–Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial

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Writing Committee for the REMAP-CAP Investigators, Abdelhady, Hesham, Abdelrazik, Marwa, Abdi, Zakee, Abdo, David, Abdulle, Amina, Abel, Lynn, Abouzeenni, Shrefee +2437 more·2021·JAMA
DOI 10.1001/jama.2021.18178PMC PMC8491132
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Abstract

IMPORTANCE: The evidence for benefit of convalescent plasma for critically ill patients with COVID-19 is inconclusive. OBJECTIVE: To determine whether convalescent plasma would improve outcomes for critically ill adults with COVID-19. DESIGN, SETTING, AND PARTICIPANTS: The ongoing Randomized, Embedded, Multifactorial, Adaptive Platform Trial for Community-Acquired Pneumonia (REMAP-CAP) enrolled and randomized 4763 adults with suspected or confirmed COVID-19 between March 9, 2020, and January 18, 2021, within at least 1 domain; 2011 critically ill adults were randomized to open-label interventions in the immunoglobulin domain at 129 sites in 4 countries. Follow-up ended on April 19, 2021. INTERVENTIONS: The immunoglobulin domain randomized participants to receive 2 units of high-titer, ABO-compatible convalescent plasma (total volume of 550 mL ± 150 mL) within 48 hours of randomization (n = 1084) or no convalescent plasma (n = 916). MAIN OUTCOMES AND MEASURES: The primary ordinal end point was organ support-free days (days alive and free of intensive care unit-based organ support) up to day 21 (range, -1 to 21 days; patients who died were assigned -1 day). The primary analysis was an adjusted bayesian cumulative logistic model. Superiority was defined as the posterior probability of an odds ratio (OR) greater than 1 (threshold for trial conclusion of superiority >99%). Futility was defined as the posterior probability of an OR less than 1.2 (threshold for trial conclusion of futility >95%). An OR greater than 1 represented improved survival, more organ support-free days, or both. The prespecified secondary outcomes included in-hospital survival; 28-day survival; 90-day survival; respiratory support-free days; cardiovascular support-free days; progression to invasive mechanical ventilation, extracorporeal mechanical oxygenation, or death; intensive care unit length of stay; hospital length of stay; World Health Organization ordinal scale score at day 14; venous thromboembolic events at 90 days; and serious adverse events. RESULTS: Among the 2011 participants who were randomized (median age, 61 [IQR, 52 to 70] years and 645/1998 [32.3%] women), 1990 (99%) completed the trial. The convalescent plasma intervention was stopped after the prespecified criterion for futility was met. The median number of organ support-free days was 0 (IQR, -1 to 16) in the convalescent plasma group and 3 (IQR, -1 to 16) in the no convalescent plasma group. The in-hospital mortality rate was 37.3% (401/1075) for the convalescent plasma group and 38.4% (347/904) for the no convalescent plasma group and the median number of days alive and free of organ support was 14 (IQR, 3 to 18) and 14 (IQR, 7 to 18), respectively. The median-adjusted OR was 0.97 (95% credible interval, 0.83 to 1.15) and the posterior probability of futility (OR <1.2) was 99.4% for the convalescent plasma group compared with the no convalescent plasma group. The treatment effects were consistent across the primary outcome and the 11 secondary outcomes. Serious adverse events were reported in 3.0% (32/1075) of participants in the convalescent plasma group and in 1.3% (12/905) of participants in the no convalescent plasma group. CONCLUSIONS AND RELEVANCE: Among critically ill adults with confirmed COVID-19, treatment with 2 units of high-titer, ABO-compatible convalescent plasma had a low likelihood of providing improvement in the number of organ support-free days. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT02735707.

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  • Convalescent plasma or recombinant therapeutic S protein-targeted antibodies achieved modest or mixed results in preventing severe COVID-19.

    “Consistent with this view, convalescent plasma or recombinant therapeutic S protein-targeted antibodies achieved modest or mixed results in preventing severe COVID-19 (however, the emergence of SARS-CoV-2 VOC with mutations in the spike protein that may allow the evasion of neutralizing antibodies may further complicate the interpretation of these results) (refs.65,162,167).”

    From COVID-19 and cellular senescence (2023) · cites this paper as [65]

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Writing Committee for the REMAP-CAP Investigators, Abdelhady, H., Abdelrazik, M., Abdi, Z., Abdo, D., Abdulle, A., Abel, L., Abouzeenni, S., Abrahamson, G., Abusamra, Y., Adams, L., Adebambo, O., Ademokun, D., Adhikari, N., Affron, D., Aggarwal, A., Agno, R., Ahmad, H., Ahmad, N., Ahmed, S., Ainscough, K., Ainsworth, J., Airoldi, G., Aitken, L., Ajeneye, F., Akhtar, N., Akinwumiju, O., Al-Bayati, M., Albert, M., Alderman, M., Alegria, A., Alexander, B., Alexander, P. D., Alfonso, J., Ali, H., Ali, S., Allameddine, A., Allan, S., Allard, I., Allen, B., Allen, B., Allen, J., Allen, L., Allen, L., Allibone, S., Ambrosino, R., Amenyah, K., Ammoun, M., Anand, R., Anand, S. P., Andersen, K., Anderson, C., Anderson, K., Anderson, T., Andreae, M., Andrews, S., Andrikopoulos, G., Anjum, A., Anstey, M., Antar, M., Antcliffe, D., Anthony, A., Antoine, P., Anumakonda, V., Apostolides, G., Aravindan, L., Arbane, G., Arbon, E., Archer, S., Aref, N., Arias, A.-M., Armali, C., Armer-Ducker, J., Armstrong, M., Armstrong-Fisher, S., Arnold, J., Arnott, S., Arroyo, A., Arsenault, V., Aryal, D., Asghar, A., Ashby, G., Asher, D., Ashford, B., Ashgar, S., Asif Ali, M., Aspinwall, A., Asquith, A., Atallah, T., Athay-Hunt, R., Attanayaka, U., Atugonza, R., Aube, M., Auclair, M.-C., Austin, K., Austin, P., Awan, S., Bacon, G., Badhesha, H., Bagavathy, K., Baglole, D., Bagnas, C., Bagot, C., Bagshaw, S., Baig, N., Bailey, S., Baillie, K., Bain, W., Baines, S., Baird, A., Baker, C., Baker, E., Bakhtiari, P., Bakthavatsalam, D., Balaie, M., Bali, G., Balkee, S., Ballinger, A., Bamford, A., Bamford, P., Banerjee, M., Banks, L., Bannard-Smith, J., Banning, N., Bansal, B., Banthorpe, R., Barbash, I., Barber, A., Barber, R., Barbosa, M., Barillas, M., Bariola, R., Barker, G., Barnes, N., Barnett, M., Barnett, N., Baron, R., Bart, R., Bartholomew, J., Bartley, S., Barton, D., Barwell, J., Bashyal, A., Basile, K., Bass, F., Bassford, C., Bassi, P., Bassis, B., Bateman, I., Bates, M., Bates, S., Batty, D., Bauchmuller, K., Baughan, P., Baxter, L., Baylem, C., Bayliss, L., Bayne, M., Bays, E., Bazin, R., Beard, G., Beard, K., Beasley, R., Beaudin, L., Beaudoin, J., Beaudoin-Bussières, G., Beddows, S., Bedford, C., Beer, D., Begum, S., Beharry, J., Bei Zhao, X., Belec, N., Bell, G., Bell, G., Bell, J., Bellemare, D., Benettaib, F., Beninato, A., Benlarbi, M., Bennett, A., Bennett, C., Bennett-Mills, C., Benoit, A., Benstead, J., Bentley, D., Berg, L., Bergin, C., Berscheid, C., Best-Lane, J., Bevan, E., Bewley, J., Beyerl, A., Bhagani, S., Bhandal, K., Biddie, S., Biemans, Bignell, K., Bihari, S., Bilodeau, M., Bilton, C., Binney, M. 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H., Lee, M., Lee, S., Lee, S., Lee, W., Lefresne, W., Leguard-White, D., Lehto, P., Lellouche, F., Lenchuk, I., Lesage, L., Leuschner, U., Levett, C., Lewin, A., Lewin, M., Lewis, J., Lewis, L., Lewis, S., Lewis-Prosser, L., Li, A., Li, J., Liao, A., Licanio, K., Lieber, S., Lin, J., Lindergard, G., Linnett, V., Little, C., Liu, T., Liversidge, A., Lizotte, P., Lobato, C., Lobo-Clarke, M., Lock, S., Lockett, T., Lockyer, S., Lofting, T., Logan, M., Lomme, K., Long, M., Lopez Martinez, M., Lopus, A., Lord, S., Lordache, L., Loregnard, K., Lorenzon, C., Lother, S., Loutraris, E., Lovett, H., Loveys, D., Lowe, B., Lowe, C., Lowery, M., Loxley, E., Lucas, R., Lucier, K., Luk, T., Lukasik, B., Lund, H., Lundy, K., Luo, J., Lussier, J., Luyckx, H., Ly, C.-H., Ly, E., Lymn, S., Lynch, C., Lynch, D., Lyon, B., Lyons, E., Macauley, A., MacDonald, K., MacDonald, P., MacDonald, S., MacDonald, T., MacGuigan, C., MacKay, L., MacKenzie, C., MacKenzie, D., Mackey, P., MacLennan, S., MacLeod, S., MacNally, P., MacNeil, N., Madgwick, K., Madiyiko, H., Maggs, T., Maguire, K., Maguire, T., Magwood, S., Maharajh, A., Mailman, J., Main, C., Makanju, E., Makky, A., Makowski, A., Malakouti, S., Male, M., Malley, B., Maloney, C., Maloney, G., Manax, V., Mangindaan, Y., Manguiat, K., Mannion, L., Manoharan, V., Manuel, E., Marange, G., March, L., Marcotte, G., Maria-Osborn, H., Marin, N., Marinakis, D., Marinoff, N., Markgraff, R., Marotti, M., Marrero Hernandez, S., Marriot, C., Marriott, Y., Marroquin, O., Marsden, B. D., Marsden, T., Marsh, E., Marshall, J., Marston, S., Marten, N., Martin, E., Martin, E., Martin, J., Martin, L., Martin, T., Martinez, A., Martins, M., Martins, O., Martins Ferreira, L., Mary-Genetu, R., Mason, L., Massar, B., Masse, C., Masse, M.-H., Massey, N., Mataliotakis, Mathews, C., Mathie, M., Matimba-Mupaya, W., Matsa, R., Matthews, J., Matthews, P., Matthews, S., Matthias, G., Maxwell, G., May, O., Mayak, K., Mayangao, I., Maynard, L., Mayr, F., Mazerall, J., Mbwembwe, M., Mc Goldrick, C., Mc Master, M., Mcaleese, H., McAllery, S., McAuley, J., McCallion, E., McCalmont, M., McCarthy, J., McClintock, D., McCracken, C., McCracken, P., McCreary, E., McCreery, L., McCullagh, I. J., McCulloch, C., McDonald, J., McEldrew, R., McGain, F., McGarry, K., McGarvey, M., McGee, M., McGhee, C., McGivern, H., McGlynn, D., McGuigan, P., McIntyre, L., McKee, M., McKenna, S., McKenna, S., Mckeown, D., Mckie, C., McKilop, S., McLintock, L., McMahon, D. 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H., Mills, S., Miln, R., Milot, C., Minella, A., Mingo Garcia, S., Minhas, A., Minnier, T., Minogue, A., Miranda, L., Mistry, D., Mistry, R., Misztal, B., Mitchard, S., Mitchell, S., Mmadubuko, G., Modi, D., Moghbeli, K., Mohan, M., Moir, R., Molloy, A., Molson, L., Monaghan, H., Monaghan, J., Moody, I., Moore, C., Moore, G., Moore, H., Moore, L., Moore, T., Moore, V., Moorhouse, L., Moreau, M., Moreland, N., Moreno Cuesta, J., Morgan, A., Morgan, J., Morgan, K., Morgan, M., Morgan, R., Morpeth, S., Morris, H., Morris, S., Morrisey, S., Morton, S., Mortuza, R., Mounitsyn, I., Mounsey, L., Moyst, D., Mtuwa, S., Mueller, D., Muir, A., Muir, M., Mukherjee, D., Mukwa, T., Mulder, J., Mulla, S., Mullin, B., Mullings, J., Mullowney, M., Mumford, S., Munt, S., Munu, N., Murdoch, D., Murphy, A., Murphy, E., Murphy, F., Murphy, J., Murphy, P., Murphy, S., Murray, L., Murthy, S., Mushtaq, K., Music, E., Muzengi, N., Mwaura, E., Nabess, J., Naeem, A., Naga, P., Nair, P., Nair Khade, R., Nalumansi Sekiwala, R., Nandani, A., Narayan, S., Natajaran, A., Nayyar, V., Naz, M., Nazarali, S., Neal, M., Netea, M., Netherton, K., Neves, G., Neville, C.-M., Newanji, J., Newman, J., Newman, R., Newman, S., Newman, T., Newsam, C., Ng, C., Nguyen, D., Nicholson, A., Nicholson, G., Nicholson, J., Nijjar, S., Nikitas, N., Nnadi, J., Noble, H., Noel, J., Nolan, J., Nolin, M.-È., Nordstrom, J., Norgrave, J., North, J., Northcote, J., Nortje, J., Nown, A., Noyce, T., Noyon, A., Nwajei Agha, G., Nwankiti, K., Nweje, E., Nygren, O’Connor, A., O’Connor, A., O’Connor, S., O’Halloran, K., O’Kane, S., O’Leary, R., O’Neill, A., O’Reilly, K., Oakley, S., Oborska, A., O'Brien, A., O'Brien, S., O'Connell, M., O'Connell, M., O'Connor, T., Oczkowski, S., O'Dea, R., O'Donnell, R., O'Donnell, V., Odumeru, D., Ogg, B., Ogungbenro, K., O'Kane, C., O'Kell, E., Okundaye, C., Okyne-Turkson, C., Oldham, J., Oliveira, M., Oliver, A., Omer, N., Oncea, L., O'Neill, B., Orath Prabakaran, R., Orchard, C., O'Reilly, J., Orford, N., Oritz-Ruiz de Gordoa, L., Ormrod, D., Orr, K., Orr, L., Osagie, R., Osborne, A., Osborne, D., Osmond, R., Ospina Stella, A., Oueng, K. 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E., Philips, N., Phillips, B., Phillips, D., Phillips, K., Phillips, M., Phillips, P., Phillipson, C., Philpott, K., Phull, M.-K., Pickering, C., Pickford, H., Piercy, C., Piersma, J., Pigeon, C. M., Pillai, S., Pilutti, N., Pinder, J., Pink, J., Pinnell, J., Pitcher, M., Pitts, S., Pletz, M., Ploeg, R., Pogreban, T., Pogson, D., Poles, D., Polgarova, P., Pollock, B., Polson, M., Pomeroy, F., Pooni, J.-S., Popescu, I., Poppitt, E., Porada, C., Porteous, R., Porter, D., Potter, A., Potter, K., Povoa, P., Powel, C., Powell, E., Powell, G., Powter, G., Pramanik, R., Prasad, M., Pratheepkumar, S., Prefontaine, A., Presneill, J., Prévost, J., Prihoda, A., Pring, J., Privatera, L., Prokopiuk, L., Pronyk-Ward, T., Proudfoot, N., Prout, R., Pugh, R., Purandare, L., Purcell, C., Purohit, D., Purvis, S., Putensen, D., Puthucheary, Z., Puxty, K., Qiu, X., Quayle, R., Quinagon, M., Quinn, A., Quinn, K., Quinones-Mateu, M., Quirk, A., Qureshi, H., Rabin, W., Rabusseau, I., Rademaker, E., Rainey, S., Raithatha, A., Ralphs, D., Ramali, M., Ramos, A., Ramos, L., Randall, H., Randall, S., Randell, G., Randhawa, R., Ranton, H., Rao, D., Rao Baikady, R., Rashid, A., Rasko, C., Ratcliff, J., Ratnam, V., Rauniyar, R., Rawlins, S., Ray, M., Raymakers, K., Rayner, B., Reay, M., Rebello, R., Reddy, A., Reddy, Reed, C., Rees, G., Rees, I., Reeve, B., Regan, F., Reid, A., Reilly, R., Reilly, S., Reschreiter, Retzlaff, L., Revill, A., Rewa, O., Reynolds, B., Reynolds, C., Reynolds, J., Reznicek, K., Rhodes, J., Rich, E., Richard, J., Richards, D., Richards, S., Richards-Belle, A., Richardson, C., Richardson, E., Riches, J., Ricketts, D., Ricks, J., Rietveld, I., Rigby, S., Rikkert, L., Rimmer, D., Risbridger, C., Ritchot, M., Ritzema, J., Riverin, P., Roach, M., Robb, M., Roberge, É., Roberts, E., Roberts, L., Roberts, T., Robertson, D., Robertson, D., Robinson, A., Robinson, K., Robinson, M., Robinson, S., Robson, C., Roche, L., Roche, M., Rochwerg, B., Rock, J., Rodden, N., Rodley, C., Rogers, A., Rohde, G., Rojo, R., Romagnuolo, T., Roman, A., Rook, C., Rooney, K., Rosario, M., Rosaroso, L. 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N., Taylor, A., Taylor, B., Taylor, C., Taylor, H., Taylor, M., Tekle, S., Teklehaimanot, S., Templar, H., Templeton, M., Tendler, P., Tervit, A., Tettmar, K., Theander, S., Thellend, S., Thomas, A., Thomas, D., Thomas, E., Thomas, H., Thomas, V., Thomas-Wright, S., Thompson, P., Thompson, T., Thompson, U., Thomson, N., Thorne, W., Thorpe, A., Thrush, J., Thurairatnam, S., Tierney, C., Timms, E. M., Tokessy, M., Tolppa, T., Tomlinson, H., Tong, S., Tony, K., Torrance, S., Tosi, I., Touma, O., Towler, J., Towns, M., Townsend, A., Townsend, C., Tracy, A., Tranter, C., Trapani, T., Trattles, J., Traverse, E., Tremblay, S., Tremblay, T., Treuberg, K., Trevelin, S. C., Trevett, M., Trevett, M., Trim, F., Trimble, T., Trimmer, K., Trueman, A., Truman, N., Tryon, S., Tsakiridou, K., Tsang, H. P., Tsang, J., Tsinaslanidis, G., Tuckley, V., Tuckwell, C., Tully, R. P., Tung, R., Turawa, S., Turco, A., Turek, K., Turki, S., Turner, D., Turner, F., Turner, K., Turner, L., Turner, M., Turner, R., Turner, S., Turner-Bone, I., Turns, M., Turville, S., Udayanga, I., Uddin, R., Udy, A., Unitt, L., Unsworth, A., Uppal, J., Uprichard, J., Uriel, A., Ustianowski, A., Uttley, J., Uyeki, T., Valentine, E., Vamplew, L., van der Poll, T., Van der Riet, C., van Hout, D., van Kimmenade, R., van Beurden, M., Van Deursen, J.-L., Van’t Hoff, W., Vardigans, K., Varghese, S., Vazquez-Grande, G., Veen, A., Veenith, T., Veillette, M., Velcich, T., Veniard, D., Venkatesh, B., Venz, E., Verlander, M., Vertue, M., Verula, J., Viau, C., Victor, S., Viehman, A., Vietri, W., Villeneuve, S., Vimalanathan, S., Vincent, R., Virdee, S., Voutour, L., Vuylsteke, A., Waite, A., Walden, A., Walden, J., Walker, G., Walker, J., Walker, M. T., Walker, R., Walker, S., Wallbank, D., Waller, F., Walsh, J., Walsham, J., Walters, S., Ward, E., Ward, G., Ward, K., Ward, L., Ward, R., Wardle, A., Warnock, M., Warren, L., Washington, C., Watchorn, O., Waters, A., Waterson, S., Watkins, C., Watkins, N., Watpool, I., Watts, A., Waugh, V., Weaver, P., Weber, L., Webert, K., Weerasinghe, T., Weissman, A., Wells, C., Welters, I. D., Wesson, J., Wesson, J., West, A., Westlake, S., Wetherill, B., White, A., White, I., White, K., White, S., Whitehouse, T., Whiteside, V., Whitley, K., Whynot, M., Wibrow, B., Wilby, E., Wilcox, E., Wilcox, L., Wild, H., Wild, L., Wilding, L., Wildman, R., Wiles, D., Wiles, M., Wiley, D., Wilhelmsen, E., Wilkes, C., Wilkinson, D., Wilkinson, H., Wilkinson, H., Willams, F., Williams, A., Williams, A., Williams, A., Williams, G., Williams, H., Williams, J. D., Williams, J., Williams, K., Williams, P., Williams, S., Williams, V., Williamson, D., Williamson, J. D., Willian, B., Willis, J., Willson, J., Wilson, A., Wilson, C., Wilson, M., Wilson, M., Wiltsher, E., Windrum, P., Winter, P., Wise, M., Wisniewski, M. K., Wissett, H., Witherell, K., Woelke, A., Wojcik, P., Wolna, M., Wong, C., Wong, L., Wong, O., Wong, Y. M., Wood, C. A., Wood, H., Wood, H., Wood, K., Wood, T., Woodford, J., Woodford, L., Woodford, U., Woods, D., Woods, J., Woods, L., Wowchuk, S., Woycik, S., Wren, J., Wren, J., Wren, L., Wrey Brown, C., Wright, A., Wright, C., Wright, L., Wright, P., Wright, R., Wu, J., Wyatt, R., Wylie, K., Xavier, K., Xia Le Tai, C., Xiao, H., Yang, Y., Yarad, E., Yates, D., Yealy, D., Yeatman, A., Yedynak, P., Young, I., Young, M., Young, P., Youngstein, T., Yu, H., Yusuff, H., Zaidi, A., Zaki, A., Zaman, M., Zaman, R., Zammit, C., Zarb, L., Zarychanski, R., Zeller, M., Zelman, M., Zimperi, A., Ziortza Fernández de Pinedo Artaraz, D. B., Zouita, L., Zuurbier, W., Zyengi, S., Estcourt, L. J., Turgeon, A. F., McQuilten, Z. K., McVerry, B. J., Al-Beidh, F., Annane, D., Arabi, Y. M., Arnold, D. M., Beane, A., Bégin, P., van Bentum-Puijk, W., Berry, L. R., Bhimani, Z., Birchall, J. E., Bonten, M. J. M., Bradbury, C. A., Brunkhorst, F. M., Buxton, M., Callum, J. L., Chassé, M., Cheng, A. C., Cove, M. E., Daly, J., Derde, L., Detry, M. A., De Jong, M., Evans, A., Fergusson, D. A., Fish, M., Fitzgerald, M., Foley, C., Goossens, H., Gordon, A. C., Gosbell, I. B., Green, C., Haniffa, R., Harvala, H., Higgins, A. M., Hills, T. E., Hoad, V. C., Horvat, C., Huang, D. T., Hudson, C. L., Ichihara, N., Laing, E., Lamikanra, A. A., Lamontagne, F., Lawler, P. R., Linstrum, K., Litton, E., Lorenzi, E., MacLennan, S., Marshall, J., McAuley, D. F., McDyer, J. F., McGlothlin, A., McGuinness, S., Miflin, G., Montgomery, S., Mouncey, P. R., Murthy, S., Nichol, A., Parke, R., Parker, J. C., Priddee, N., Purcell, D. F. J., Reyes, L. F., Richardson, P., Robitaille, N., Rowan, K. M., Rynne, J., Saito, H., Santos, M., Saunders, C. 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Affiliations
  • Writing Committee for the REMAP-CAP Investigators
  • NHS Blood and Transplant (GB)
  • St. Michael's Hospital (CA)
  • Université Laval (CA)
  • Monash Health (AU)
  • University of Pittsburgh (US)
  • Imperial College Healthcare NHS Trust (GB)
  • Université de Versailles Saint-Quentin-en-Yvelines (FR)
  • King Saud bin Abdulaziz University for Health Sciences (SA)
  • McMaster University (CA)
  • Nuffield Department of Clinical Medicine, University of Oxford, Oxford, England
  • Université de Montréal (CA)
  • Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands
  • Berry Consultants, LLC (United States) (US)
  • Welsh Blood Service (GB)
  • Utrecht University (NL)
  • University of Bristol (GB)
  • Jena University Hospital (DE)
  • Global Coalition for Adaptive Research, San Francisco, California
  • Sunnybrook Health Science Centre (CA)
  • The Alfred Hospital (AU)
  • National University of Singapore (SG)
  • Australian Red Cross Lifeblood (AU)
  • Berry Consultants LLC, Austin, Texas
  • Department of Medical Microbiology, University of Amsterdam Medical Center, University of Amsterdam, the Netherlands
  • Ottawa Hospital Research Institute (CA)
  • King's College London (GB)
  • Antwerp University Hospital (BE)
  • Monash University (AU)
  • Mahidol Oxford Tropical Medicine Research Unit (TH)
  • Medical Research Institute of New Zealand (NZ)
  • Children's Hospital of Pittsburgh (US)
  • The University of Tokyo (JP)
  • Université de Sherbrooke (CA)
  • University Health Network (CA)
  • The University of Western Australia (AU)
  • Queen's University Belfast (GB)
  • Auckland City Hospital (NZ)
  • NHS Blood and Transplant, Bristol, England
  • Intensive Care National Audit & Research Centre (GB)
  • University College Dublin (IE)
  • Cardiothoracic and Vascular Intensive Care Unit, Auckland City Hospital, Auckland, New Zealand
  • Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia
  • Scottish National Blood Transfusion Service (GB)
  • The University of Melbourne (AU)
  • Universidad de La Sabana (CO)
  • Héma-Québec (CA)
  • Clinical Trials Unit, Intensive Care National Audit and Research Centre, London, England
  • St. Marianna University School of Medicine (JP)
  • Centre for Experimental Medicine, School of Medicine, Dentistry, and Biomedical Sciences, Queen’s University Belfast, Belfast, Ireland
  • Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands
  • University of Edinburgh (GB)
  • University of California, Los Angeles (US)
  • Addenbrooke's Hospital (GB)
  • St John of God Subiaco Hospital (AU)
Corresponding author
Estcourt, Lise J.
ORCID
Venue
JAMA
Publisher
American Medical Association (AMA)
Published
2021-11-02
Volume
326
Issue
17
Pages
1690
ISSN
  • 0002-9955 (ISSN-L)
  • 0098-7484
DOI
10.1001/jama.2021.18178
PMC
PMC8491132
OpenAlex
W3204742187
Cited by
212
References
25
Citations by year
2026: 9 · 2025: 24 · 2024: 25 · 2023: 48 · 2022: 99 · 2021: 4
FWCI
13.89
Type
journal article
Language
en
Open access
Licence
other-oa
Locations
  • JAMA (publishedVersion, other-oa)
  • PubMed Central (publishedVersion)
  • UWA Profiles and Research Repository (UWA) (publishedVersion, other-oa)
  • PubMed (publishedVersion)
  • Research Portal (King's College London) (publishedVersion, other-oa)
  • Pure Amsterdam UMC (submittedVersion, other-oa)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • HAL (submittedVersion)
  • Intellectum (Universidad de La Sabana) (submittedVersion, cc-by-nc-nd)
  • Research Explorer (The University of Manchester) (submittedVersion, other-oa)
  • Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
  • Research Portal (Queen's University Belfast) (submittedVersion, other-oa)
  • Queen Mary Research Online (Queen Mary University of London) (submittedVersion)
  • Radboud Repository (Radboud University) (submittedVersion)
  • Explore Bristol Research (submittedVersion, other-oa)
  • Spiral (Imperial College London) (submittedVersion)
  • Deakin Research Online (Deakin University)
Funders
  • University of Pittsburgh
  • NHS Blood and Transplant
  • Ottawa Hospital Research Institute
  • Université de Sherbrooke
  • Wellcome Trust (215522)
  • Health Research Board (CTN-2021-010)
  • University Hospitals Bristol NHS Foundation Trust
  • Australian Government
  • Canadian Blood Services
  • National Institute for Health and Care Research (COV19‐RECPLAS, 2016-16-011, COVID-19, CS-2016-16-011, RP-2015-06-018, COVID-19-RECPLAS)
  • Department of Health and Social Care (COVID-19)
  • European Commission (602525, FP7‐HEALTH‐2013‐INNOVATION‐1, FP7-HEALTH-2013INNOVATION, COVID-19, HEALTH-2013)
  • Queen's University Belfast
  • University of Bristol
  • National University of Singapore
  • University College Dublin
  • Monash University
  • Universiteit van Amsterdam
  • Universiteit Utrecht
  • Radboud Universiteit
  • Queen's University
  • University of Toronto
  • Université de Montréal
  • Radboud Universitair Medisch Centrum
  • Universitätsklinikum Jena
  • Sociedade Beneficente Israelita Brasileira Albert Einstein
  • Universidad de La Sabana
  • Minderoo Foundation
  • Western Sydney University
  • Canadian Institutes of Health Research (COVID-19 Rapid Research, 447335, COVID-19, 158584)
  • Medical Research Council (COVID-19)
  • Menzies Centre for Australian Studies, King's College London, University of London
  • National Health and Medical Research Council (602525)
  • NIHR Imperial Biomedical Research Centre
  • Center for Sepsis Control and Care
  • National Heart, Lung, and Blood Institute (T32HL007563)
  • National Institute of General Medical Sciences (K23GM132688, R35GM119519)
  • Children's Hospital of Pittsburgh
  • David Geffen School of Medicine, University of California, Los Angeles
  • Institute of Infection and Immunity
  • FP7 Health (602525)
  • Medical Research Future Fund
Topics
  • Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
  • Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
Keywords
convalescent plasma, COVID-19 pandemic, critically ill patients, ICU length of stay, hospital survival, mechanical ventilation, venous thromboembolism, immunoglobulin therapy, SARS-CoV-2
MeSH terms
ABO Blood-Group System, COVID-19, COVID-19 Serotherapy, Adult, Aged, Female, Humans, Immunization, Passive, Length of Stay, Male, Middle Aged, Respiration, Artificial, Vasoconstrictor Agents, Logistic Models, Critical Illness, Hospital Mortality, Treatment Failure

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