Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism
Open accessAbstract
Metabolic support for T cell functions: For immunological T cells, responding to infections is energetically demanding. T cells rewire their metabolism so that they rely more heavily on aerobic glycolysis. This helps them to support important effector functions such as secreting the cytokine interferon γ (IFNγ). Peng et al. now provide insight into how aerobic glycolysis promotes T cell effector function. Activated T cells express the aerobic glycolysis–supporting enzyme lactate dehydrogenase A (LDHA), allowing these cells to maintain high amounts of acetyl–coenzyme A, which in turn promotes histone acetylation and transcription of cytokines such as IFNγ. Engineered mice whose T cells lacked LDHA were protected from IFNγ-dependent pathologies that often characterize autoinflammatory diseases. Science , this issue p. 481
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The glycolytic metabolic pathway promotes IFN-γ expression and T cell effector function.
“It is known that the glycolytic metabolic pathway promotes IFN-γ expression and T cell effector function20,24–27.”
From Microbial short-chain fatty acids modulate CD8+ T cell responses and improve adoptive immunotherapy for cancer (2021) · cites this paper as [25]
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“, 2015) and epigenetic state (Peng et al., 2016) in activated T cells.”
Background
- Authors
- Peng, M., Yin, N., Chhangawala, S., Xu, K., Leslie, C. S., & Li, M. O.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- Corresponding author
- Peng, Min
- Yin, Na
- Li, Ming O.
- Venue
- Science
- Published
- 2016-10-28
- Volume
- 354
- Issue
- 6311
- Pages
- 481-484
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC5539971
- OpenAlex
- W2523989131
- Cited by
- 787
- References
- 38
- Citations by year
- 2026: 54 · 2025: 93 · 2024: 86 · 2023: 86 · 2022: 93 · 2021: 107 · 2020: 91 · 2019: 53 · 2018: 58 · 2017: 57 · 2016: 7 · 2014: 1
- FWCI
- 24.31
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Ludwig Center for Cancer Immunology
- Functional Genomics Initiative
- Howard Hughes Medical Institute
- Memorial Sloan Kettering Cancer Center (P30 CA008748)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- aerobic glycolysis, Warburg effect, Th1 cells, LDHA, interferon-gamma, acetyl-CoA, histone acetylation, epigenetic regulation, effector T cell differentiation, regulatory T cells, autoinflammatory disease, T cell metabolism
- MeSH terms
- Lactate Dehydrogenase 5, Acetylation, Aerobiosis, Animals, Cell Differentiation, Glycolysis, Interferon-gamma, Isoenzymes, L-Lactate Dehydrogenase, Lymphocyte Activation, Mice, Transgenic, Gene Expression, Th1 Cells, 3' Untranslated Regions, Epigenesis, Genetic, T-Lymphocytes, Regulatory, Mice
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