CSF-1R inhibition alters macrophage polarization and blocks glioma progression
Open accessAbstract
Glioblastoma multiforme (GBM) comprises several molecular subtypes, including proneural GBM. Most therapeutic approaches targeting glioma cells have failed. An alternative strategy is to target cells in the glioma microenvironment, such as tumor-associated macrophages and microglia (TAMs). Macrophages depend on colony stimulating factor-1 (CSF-1) for differentiation and survival. We used an inhibitor of the CSF-1 receptor (CSF-1R) to target TAMs in a mouse proneural GBM model, which significantly increased survival and regressed established tumors. CSF-1R blockade additionally slowed intracranial growth of patient-derived glioma xenografts. Surprisingly, TAMs were not depleted in treated mice. Instead, glioma-secreted factors, including granulocyte-macrophage CSF (GM-CSF) and interferon-γ (IFN-γ), facilitated TAM survival in the context of CSF-1R inhibition. Expression of alternatively activated M2 markers decreased in surviving TAMs, which is consistent with impaired tumor-promoting functions. These gene signatures were associated with enhanced survival in patients with proneural GBM. Our results identify TAMs as a promising therapeutic target for proneural gliomas and establish the translational potential of CSF-1R inhibition for GBM.
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Inhibition of CSF-1R leads to a phenotypic shift in microglia from anti-inflammatory/homeostatic to primed/activated.
“Inhibition of CSF-1R has been shown to lead to a phenotypic shift in microglia from anti-inflammatory/homeostatic to primed/activated [43].”
From Loss of homeostatic microglial phenotype in CSF1R-related Leukoencephalopathy (2020) · cites this paper as [43]
The Results section, “CSF-1R inhibition reduces M2 macrophage polarization in treated gliomas” (page not specified), reports reduced M2-associated gene expression in glioma-associated macrophages and similar results in microglia cell lines. It does not establish a shift of microglia from a homeostatic state to a primed or activated state; the same section says M1 activation genes were generally not upregulated. (LLM, conf=0.88)
Experimental — accuracy not yet measuredThe inflammatory phenotype observed in HDLS has been reported in other studies investigating consequences of loss of CSF-1 signaling.
“In addition, the inflammatory phenotype we observe in HDLS has been reported in other studies investigating consequences of loss of CSF-1 signaling [16, 43].”
From Loss of homeostatic microglial phenotype in CSF1R-related Leukoencephalopathy (2020) · cites this paper as [43]
The Results section on macrophage polarization reports that CSF-1R inhibition reduced M2-associated markers in treated gliomas, with IL-1β as an exception among M1-associated genes. It does not report an HDLS-like inflammatory phenotype; the same passage says other M1 genes were not correspondingly upregulated. Page numbers are unavailable in our copy. (LLM, conf=0.84)
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- Authors
- Pyonteck, S. M., Akkari, L., Schuhmacher, A. J., Bowman, R. L., Sevenich, L., Quail, D. F., Olson, O. C., Quick, M. L., Huse, J. T., Teijeiro, V., Setty, M., Leslie, C. S., Oei, Y., Pedraza, A., Zhang, J., Brennan, C. W., Sutton, J. C., Holland, E. C., Daniel, D., & Joyce, J. A.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- Corresponding author
- Joyce, Johanna A
- ORCID
- Venue
- Nature Medicine
- Published
- 2013-09-22
- Volume
- 19
- Issue
- 10
- Pages
- 1264-1272
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- PMC
- PMC3840724
- OpenAlex
- W1980485314
- Cited by
- 2,463
- References
- 72
- Citations by year
- 2026: 169 · 2025: 205 · 2024: 226 · 2023: 268 · 2022: 243 · 2021: 278 · 2020: 211 · 2019: 183 · 2018: 160 · 2017: 142 · 2016: 142 · 2015: 117 · 2014: 98 · 2013: 8 · 2012: 1
- FWCI
- 67.34
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (F31CA167863, F31CA171384, U54CA126518, U54CA148967, CA148967, CA 126518)
- National Institute of General Medical Sciences (T32GM008539)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Health Sciences › Medicine › Genetics › Glioma Diagnosis and Treatment
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- CSF1R inhibition, colony-stimulating factor 1 receptor, tumor-associated macrophages, macrophage polarization, proneural glioblastoma, glioma microenvironment, M2 macrophages, GM-CSF, interferon-gamma, macrophage survival, patient-derived xenografts, prognostic gene signature, glioma treatment
- MeSH terms
- Animals, Brain Neoplasms, Glioblastoma, Macrophages, Signal Transduction, Receptor, Macrophage Colony-Stimulating Factor, Disease Progression, Mice
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Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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