Lein, Ed S.

Signature morphoelectric properties of diverse GABAergic interneurons in the human neocortex

Lee, B. R., Dalley, R., Miller, J. A., Chartrand, T., Close, J., Mann, R., Mukora, A., Ng, L., Alfiler, L., Baker, K., et al. (2023) · Science

Neuroscience and Neuropharmacology ResearchSingle-cell and spatial transcriptomics

Cited by 125

Cortical fast-spiking parvalbumin interneurons enwrapped in the perineuronal net express the metallopeptidases Adamts8, Adamts15 and Neprilysin

Rossier, J., Bernard, A., Cabungcal, J.-H., Perrenoud, Q., Savoye, A., Gallopin, T., Hawrylycz, M., Cuénod, M., Do, K., Urban, A., et al. (2015) · Molecular Psychiatry

Neuroscience and Neuropharmacology ResearchProtease and Inhibitor Mechanisms

Cited by 101

Evolution and development of the mammalian cerebral cortex

Molnár, Z., Kaas, J. H., de Carlos, J. A., Hevner, R. F., Lein, E., & Němec, P. (2014) · Brain Behavior and Evolution

Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene Regulation

Cited by 93

Transcriptomic Perspectives on Neocortical Structure, Development, Evolution, and Disease

Lein, E. S., Belgard, T. G., Hawrylycz, M., & Molnár, Z. (2017) · Annual Review of Neuroscience

Single-cell and spatial transcriptomicsNeurogenesis and neuroplasticity mechanisms

Cited by 92

Morphoelectric and transcriptomic divergence of the layer 1 interneuron repertoire in human versus mouse neocortex

Chartrand, T., Dalley, R., Close, J., Goriounova, N. A., Lee, B. R., Mann, R., Miller, J. A., Molnar, G., Mukora, A., Alfiler, L., et al. (2023) · Science

Neuroscience and Neuropharmacology ResearchNeural dynamics and brain function

Cited by 88

Distinct Transcriptomic Cell Types and Neural Circuits of the Subiculum and Prosubiculum along the Dorsal-Ventral Axis

Ding, S.-L., Yao, Z., Hirokawa, K. E., Nguyen, T. N., Graybuck, L. T., Fong, O., Bohn, P., Ngo, K., Smith, K. A., Koch, C., et al. (2020) · Cell Reports

Memory and Neural MechanismsSingle-cell and spatial transcriptomics

Cited by 82

Biallelic mutations in human DCC cause developmental split-brain syndrome

Jamuar, S. S., Schmitz-Abe, K., D'Gama, A. M., Drottar, M., Chan, W.-M., Peeva, M., Servattalab, S., Lam, A.-T. N., Delgado, M. R., Clegg, N. J., et al. (2017) · Nature Genetics

Fetal and Pediatric Neurological DisordersAxon Guidance and Neuronal Signaling

Cited by 81

Cell type discovery and representation in the era of high-content single cell phenotyping

Bakken, T., Cowell, L., Aevermann, B. D., Novotny, M., Hodge, R., Miller, J. A., Lee, A., Chang, I., McCorrison, J., Pulendran, B., et al. (2017) · BMC Bioinformatics

Single-cell and spatial transcriptomicsBiomedical Text Mining and Ontologies

Cited by 55

Improving reliability and absolute quantification of human brain microarray data by filtering and scaling probes using RNA-Seq

Miller, J. A., Menon, V., Goldy, J., Kaykas, A., Lee, C.-K., Smith, K. A., Shen, E. H., Phillips, J. W., Lein, E. S., & Hawrylycz, M. J. (2014) · BMC Genomics

Gene expression and cancer classificationGenomics and Phylogenetic Studies

Cited by 48

SEA-AD is a multimodal cellular atlas and resource for Alzheimer’s disease

Hawrylycz, M., Kaplan, E. S., Travaglini, K. J., Gabitto, M. I., Miller, J. A., Ng, L., Close, J. L., Hodge, R. D., Long, B., Mollenkopf, T., et al. (2024) · Nature Aging

Alzheimer's disease research and treatmentsSingle-cell and spatial transcriptomics

Cited by 47

Divergent and nonuniform gene expression patterns in mouse brain

Morris, J. A., Royall, J. J., Bertagnolli, D., Boe, A. F., Burnell, J. J., Byrnes, E. J., Copeland, C., Desta, T., Fischer, S. R., Goldy, J., et al. (2010) · Proceedings of the National Academy of Sciences

Pharmacogenetics and Drug MetabolismGenetic Mapping and Diversity in Plants and Animals

Cited by 36

A community-based transcriptomics classification and nomenclature of neocortical cell types

Yuste, R., Hawrylycz, M., Aalling, N., Aguilar-Valles, A., Arendt, D., Armañanzas, R., Ascoli, G. A., Bielza, C., Bokharaie, V., Bergmann, T. B., et al. (2020) · Nature Neuroscience

Single-cell and spatial transcriptomicsCell Image Analysis Techniques

Cited by 32

Shifting the paradigm: new approaches for characterizing and classifying neurons

Bernard, A., Sorensen, S. A., & Lein, E. S. (2009) · Current Opinion in Neurobiology

Neuroscience and Neuropharmacology ResearchSingle-cell and spatial transcriptomics

Cited by 26

Somatic cancer driver mutations are enriched and associated with inflammatory states in Alzheimer’s disease microglia

Huang, A. Y., Zhou, Z., Talukdar, M., Miller, M. B., Chhouk, B., Enyenihi, L., Rosen, I., Stronge, E., Zhao, B., Kim, D., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory)

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 16

Somatic cancer variants enriched in Alzheimer’s disease microglia-like cells drive inflammatory and proliferative states

Huang, A. Y., Zhou, Z., Talukdar, M., Enyenihi, L., Miller, M. B., Chhouk, B., Rosen, I., Zheng, M., Zhou, M., Yang, A., et al. (2026) · Cell

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 15