Distinct Transcriptomic Cell Types and Neural Circuits of the Subiculum and Prosubiculum along the Dorsal-Ventral Axis
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Abstract
Subicular regions play important roles in spatial processing and many cognitive functions, and these are mainly attributed to the subiculum (Sub) rather than the prosubiculum (PS). Using single-cell RNA sequencing, we identify 27 transcriptomic cell types residing in sub-domains of the Sub and PS. Based on in situ expression of reliable transcriptomic markers, the precise boundaries of the Sub and PS are consistently defined along the dorsoventral axis. Using these borders to evaluate Cre-line specificity and tracer injections, we find bona fide Sub projections topographically to structures important for spatial processing and navigation. In contrast, the PS sends its outputs to widespread brain regions crucial for motivation, emotion, reward, stress, anxiety, and fear. The Sub and PS, respectively, dominate dorsal and ventral subicular regions and receive different afferents. These results reveal two molecularly and anatomically distinct circuits centered in the Sub and PS, respectively, providing a consistent explanation for historical data and a clearer foundation for future studies.
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The L2/3 RHP subclass contains two supertypes assigned to the superficial layers of ProS (L2/3 IT ProS Dcn Cbln4) and HATA (IT HATA Id4, also extending to ventral ENT) regions.
“The L2/3 RHP subclass contains two supertypes assigned to the superficial layers of ProS (L2/3 IT ProS Dcn Cbln4, Fig. 4I–J) and HATA (IT HATA Id4, also extending to ventral ENT) regions (Ding et al., 2020).”
From A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation (2021) · cites this paper as Ding et al., 2020
ProS contains cell types similar to either SUB or CA1, as in previous study.
“suggesting ProS contains cell types similar to either SUB or CA1, as in our previous study (Ding et al., 2020)”
From A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation (2021) · cites this paper as Ding et al., 2020
This predicted isocortex-like circuit organization is highly consistent with currently known interareal connections of HPF, providing validation to the transcriptomic cell type framework.
“This prediction is highly consistent with the currently known interareal connections of HPF, providing a level of validation to the transcriptomic cell type framework”
From A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation (2021) · cites this paper as Ding et al., 2020
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- Authors
- Ding, S.-L., Yao, Z., Hirokawa, K. E., Nguyen, T. N., Graybuck, L. T., Fong, O., Bohn, P., Ngo, K., Smith, K. A., Koch, C., Phillips, J. W., Lein, E. S., Harris, J. A., Tasic, B., & Zeng, H.
- Affiliations
- Allen Institute for Brain Science (US)
- Corresponding author
- Ding, Song-Lin
- ORCID
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2020-05
- Volume
- 31
- Issue
- 7
- Pages
- 107648
- ISSN
- 2211-1247 (ISSN-L)
- PMC
- PMC7394561
- OpenAlex
- W3027926441
- Cited by
- 82
- References
- 96
- Citations by year
- 2026: 12 · 2025: 19 · 2024: 10 · 2023: 11 · 2022: 11 · 2021: 14 · 2020: 5
- FWCI
- 5.51
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cell Reports (publishedVersion, cc-by-nc-nd)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institute of Mental Health
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Single-cell and spatial transcriptomics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- subiculum, dorsal-ventral axis, single-cell transcriptomics, cell types, neural circuits, spatial processing, navigation, afferent projections, tracer injection
- MeSH terms
- Animals, Hippocampus, Neural Pathways, Transcriptome
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