Hara, Eiji

Biallelic Mutations in p16INK4a Confer Resistance to Ras- and Ets-Induced Senescence in Human Diploid Fibroblasts

Huot, T. J., Rowe, J., Harland, M., Drayton, S., Brookes, S., Gooptu, C., Purkis, P., Fried, M., Bataille, V., Hara, E., et al. (2002) · Molecular and Cellular Biology

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 107

Cellular senescence in white matter microglia is induced during ageing in mice and exacerbates the neuroinflammatory phenotype

Matsudaira, T., Nakano, S., Konishi, Y., Kawamoto, S., Uemura, K., Kondo, T., Sakurai, K., Ozawa, T., Hikida, T., Komine, O., et al. (2023) · Communications Biology

Neuroinflammation and Neurodegeneration MechanismsTelomeres, Telomerase, and Senescence

Cited by 98

Bacterial induction of B cell senescence promotes age-related changes in the gut microbiota

Kawamoto, S., Uemura, K., Hori, N., Takayasu, L., Konishi, Y., Katoh, K., Matsumoto, T., Suzuki, M., Sakai, Y., Matsudaira, T., et al. (2023) · Nature Cell Biology

Gut microbiota and healthGenetics, Aging, and Longevity in Model Organisms

Cited by 91

SARS-CoV-2 infection triggers paracrine senescence and leads to a sustained senescence-associated inflammatory response

Tsuji, S., Minami, S., Hashimoto, R., Konishi, Y., Suzuki, T., Kondo, T., Sasai, M., Torii, S., Ono, C., Shichinohe, S., et al. (2022) · Nature Aging

Telomeres, Telomerase, and SenescenceCOVID-19 Clinical Research Studies

Cited by 84

Crosstalk between the Rb pathway and AKT signaling forms a quiescence-senescence switch.

Imai, Y., Takahashi, A., Hanyu, A., Hori, S., Sato, S., Naka, K., Hirao, A., Ohtani, N., & Hara, E. (2014) · Cell Reports

FOXO transcription factor regulationTelomeres, Telomerase, and Senescence

Cited by 84

Pericentromeric noncoding RNA changes DNA binding of CTCF and inflammatory gene expression in senescence and cancer

Miyata, K., Imai, Y., Hori, S., Nishio, M., Loo, T. M., Okada, R., Yang, L., Nakadai, T., Maruyama, R., Fujii, R., et al. (2021) · Proceedings of the National Academy of Sciences

Telomeres, Telomerase, and SenescenceGenomics and Chromatin Dynamics

Cited by 74

Visualizing the dynamics of p21 Waf1/Cip1 cyclin-dependent kinase inhibitor expression in living animals

Ohtani, N., Imamura, Y., Yamakoshi, K., Hirota, F., Nakayama, R., Kubo, Y., Ishimaru, N., Takahashi, A., Hirao, A., Shimizu, T., et al. (2007) · Proceedings of the National Academy of Sciences

Cancer-related Molecular PathwaysCircadian rhythm and melatonin

Cited by 73

p16Ink4a and p21Cip1/Waf1 promote tumour growth by enhancing myeloid-derived suppressor cells chemotaxis

Okuma, A., Hanyu, A., Watanabe, S., & Hara, E. (2017) · Nature Communications

Immune cells in cancerChemokine receptors and signaling

Cited by 69

Cellular senescence: a double‐edged sword in the fight against cancer

Ohtani, N., Takahashi, A., Mann, D. J., & Hara, E. (2012) · Experimental Dermatology

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 57

RNaseH2A downregulation drives inflammatory gene expression via genomic DNA fragmentation in senescent and cancer cells

Sugawara, S., Okada, R., Loo, T. M., Tanaka, H., Miyata, K., Chiba, M., Kawasaki, H., Katoh, K., Kaji, S., Maezawa, Y., et al. (2022) · Communications Biology

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 23

Comparative analysis of senolytic drugs reveals mitochondrial determinants of efficacy and resistance

Wakita, M., Ito, K., Fujii, K., Sakamoto, D., Mikawa, T., Sugawara, S., Zhou, X., Park, J. H., Miyagawa, H., Motooka, D., et al. (2026) · Nature Aging

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 9