Lashuel, Hilal A.

The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration

Mahul-Mellier, A.-L., Burtscher, J., Maharjan, N., Weerens, L., Croisier, M., Kuttler, F., Leleu, M., Knott, G. W., & Lashuel, H. A. (2020) · Proceedings of the National Academy of Sciences

Parkinson's Disease Mechanisms and TreatmentsAlzheimer's disease research and treatments

Cited by 710

The Ratio of Monomeric to Aggregated Forms of Aβ40 and Aβ42 Is an Important Determinant of Amyloid-β Aggregation, Fibrillogenesis, and Toxicity

Jan, A., Gokce, O., Luthi-Carter, R., & Lashuel, H. A. (2008) · Journal of Biological Chemistry

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 291

Resolving molecule-specific information in dynamic lipid membrane processes with multi-resonant infrared metasurfaces

Rodrigo, D., Tittl, A., Ait-Bouziad, N., John-Herpin, A., Limaj, O., Kelly, C., Yoo, D., Wittenberg, N. J., Oh, S.-H., Lashuel, H. A., et al. (2018) · Nature Communications

Metamaterials and Metasurfaces ApplicationsSpectroscopy Techniques in Biomedical and Chemical Research

Cited by 269

Quaternary Structure, Protein Dynamics, and Synaptic Function of SAP97 Controlled by L27 Domain Interactions

Nakagawa, T., Futai, K., Lashuel, H. A., Lo, I., Okamoto, K., Walz, T., Hayashi, Y., & Sheng, M. (2004) · Neuron

Neuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental Disorders

Cited by 250

Activation of the STING-Dependent Type I Interferon Response Reduces Microglial Reactivity and Neuroinflammation

Mathur, V., Burai, R., Vest, R. T., Bonanno, L. N., Lehallier, B., Zardeneta, M. E., Mistry, K. N., Do, D., Marsh, S. E., Abud, E. M., et al. (2017) · Neuron

interferon and immune responsesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 175

Oxidative and nitrative alpha‐synuclein modifications and proteostatic stress: implications for disease mechanisms and interventions in synucleinopathies

Schildknecht, S., Gerding, H. R., Karreman, C., Drescher, M., Lashuel, H. A., Outeiro, T. F., Di Monte, D. A., & Leist, M. (2013) · Journal of Neurochemistry

Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and Signaling

Cited by 148

Nanoplasmonic mid-infrared biosensor for in vitro protein secondary structure detection

Etezadi, D., Warner IV, J. B., Ruggeri, F. S., Dietler, G., Lashuel, H. A., & Altug, H. (2017) · Light: Science & Applications

Plasmonic and Surface Plasmon ResearchGold and Silver Nanoparticles Synthesis and Applications

Cited by 137

Nuclear and cytoplasmic huntingtin inclusions exhibit distinct biochemical composition, interactome and ultrastructural properties

Riguet, N., Mahul-Mellier, A.-L., Maharjan, N., Burtscher, J., Croisier, M., Knott, G., Hastings, J., Patin, A., Reiterer, V., Farhan, H., et al. (2021) · Nature Communications

Genetic Neurodegenerative DiseasesPrion Diseases and Protein Misfolding

Cited by 118

O-GlcNAc forces an α-synuclein amyloid strain with notably diminished seeding and pathology

Balana, A. T., Mahul-Mellier, A.-L., Nguyen, B. A., Horvath, M., Javed, A., Hard, E. R., Jasiqi, Y., Singh, P., Afrin, S., Pedretti, R., et al. (2024) · Nature Chemical Biology

Parkinson's Disease Mechanisms and TreatmentsAlzheimer's disease research and treatments

Cited by 84

Mouse α-synuclein fibrils are structurally and functionally distinct from human fibrils associated with Lewy body diseases

Sokratian, A., Zhou, Y., Tatli, M., Burbidge, K. J., Xu, E., Viverette, E., Donzelli, S., Duda, A. M., Yuan, Y., Li, H., et al. (2024) · Science Advances

Parkinson's Disease Mechanisms and TreatmentsAlzheimer's disease research and treatments

Cited by 32

Post-fibrillization nitration of alpha-synuclein abolishes its seeding activity and pathology formation in primary neurons and in vivo

Donzelli, S., OSullivan, S. A., Mahul-Mellier, A.-L., Ulusoy, A., Fusco, G., Kumar, S. T., Chiki, A., Burtscher, J., Boussouf, M. L. D., Rostami, I., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory)

Parkinson's Disease Mechanisms and TreatmentsAlzheimer's disease research and treatments

Cited by 13