Nakayama, Keiichi I.

Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders

Johmura, Y., Yamanaka, T., Omori, S., Wang, T.-W., Sugiura, Y., Matsumoto, M., Suzuki, N., Kumamoto, S., Yamaguchi, K., Hatakeyama, S., et al. (2021) · Science

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 440

Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence

Lin, H.-K., Chen, Z., Wang, G., Nardella, C., Lee, S.-W., Chan, C.-H., Yang, W.-L., Wang, J., Egia, A., Nakayama, K. I., et al. (2010) · Nature

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 400

Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene

Mao, J.-H., Perez-losada, J., Wu, D., DelRosario, R., Tsunematsu, R., Nakayama, K. I., Brown, K., Bryson, S., & Balmain, A. (2004) · Nature

Cancer-related Molecular PathwaysUbiquitin and proteasome pathways

Cited by 390

Artificial intelligence in oncology

Shimizu, H., & Nakayama, K. I. (2020) · Cancer Science

AI in cancer detectionArtificial Intelligence in Healthcare and Education

Cited by 388

CHD8 haploinsufficiency results in autistic-like phenotypes in mice

Katayama, Y., Nishiyama, M., Shoji, H., Ohkawa, Y., Kawamura, A., Sato, T., Suyama, M., Takumi, T., Miyakawa, T., & Nakayama, K. I. (2016) · Nature

Genetics and Neurodevelopmental DisordersAutism Spectrum Disorder Research

Cited by 353

Slowly dividing neural progenitors are an embryonic origin of adult neural stem cells

Furutachi, S., Miya, H., Watanabe, T., Kawai, H., Yamasaki, N., Harada, Y., Imayoshi, I., Nelson, M., Nakayama, K. I., Hirabayashi, Y., et al. (2015) · Nature Neuroscience

Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene Regulation

Cited by 329

Blue light-induced autophosphorylation of phototropin is a primary step for signaling

Inoue, S.-I., Kinoshita, T., Matsumoto, M., Nakayama, K. I., Doi, M., & Shimazaki, K.-I. (2008) · Proceedings of the National Academy of Sciences

Light effects on plantsPlant Molecular Biology Research

Cited by 269

Deletion of Cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice

Uchida, T., Nakamura, T., Hashimoto, N., Matsuda, T., Kotani, K., Sakaue, H., Kido, Y., Hayashi, Y., Nakayama, K. I., White, M. F., et al. (2005) · Nature Medicine

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 218

Deciphering the transcriptional complex critical for RhoA gene expression and cancer metastasis

Chan, C.-H., Lee, S.-W., Li, C.-F., Wang, J., Yang, W.-L., Wu, C.-Y., Wu, J., Nakayama, K. I., Kang, H.-Y., Huang, H.-Y., et al. (2010) · Nature Cell Biology

Protein Kinase Regulation and GTPase SignalingUbiquitin and proteasome pathways

Cited by 209

KDM7 is a dual demethylase for histone H3 Lys 9 and Lys 27 and functions in brain development

Tsukada, Y.-I., Ishitani, T., & Nakayama, K. I. (2010) · Genes & Development

Epigenetics and DNA MethylationGenomics and Chromatin Dynamics

Cited by 158

Combined Mutation of Apc, Kras , and Tgfbr2 Effectively Drives Metastasis of Intestinal Cancer

Sakai, E., Nakayama, M., Oshima, H., Kouyama, Y., Niida, A., Fujii, S., Ochiai, A., Nakayama, K. I., Mimori, K., Suzuki, Y., et al. (2018) · Cancer Research

Cancer Cells and MetastasisColorectal Cancer Treatments and Studies

Cited by 133

Transcription factor PU.1 represses and activates gene expression in early T cells by redirecting partner transcription factor binding

Hosokawa, H., Ungerbäck, J., Wang, X., Matsumoto, M., Nakayama, K. I., Cohen, S. M., Tanaka, T., & Rothenberg, E. V. (2018) · Immunity

Genomics and Chromatin DynamicsT-cell and B-cell Immunology

Cited by 116

ZFP36L1 and ZFP36L2 control LDLR mRNA stability via the ERK–RSK pathway

Adachi, S., Homoto, M., Tanaka, R., Hioki, Y., Murakami, H., Suga, H., Matsumoto, M., Nakayama, K. I., Hatta, T., Iemura, S.-I., et al. (2014) · Nucleic Acids Research

RNA Research and SplicingCholesterol and Lipid Metabolism

Cited by 109

Structural basis for the assembly of the Ragulator-Rag GTPase complex

Yonehara, R., Nada, S., Nakai, T., Nakai, M., Kitamura, A., Ogawa, A., Nakatsumi, H., Nakayama, K. I., Li, S., Standley, D. M., et al. (2017) · Nature Communications

PI3K/AKT/mTOR signaling in cancerAutophagy in Disease and Therapy

Cited by 75

Targeted Destruction of c-Myc by an Engineered Ubiquitin Ligase Suppresses Cell Transformation and Tumor Formation

Hatakeyama, S., Watanabe, M., Fujii, Y., & Nakayama, K. I. (2005) · Cancer Research

Ubiquitin and proteasome pathwaysCancer-related Molecular Pathways

Cited by 67

Identification and characterization of a neuron-specific isoform of protrudin

Ohnishi, T., Shirane, M., Hashimoto, Y., Saita, S., & Nakayama, K. I. (2014) · Genes to Cells

Cellular transport and secretionAxon Guidance and Neuronal Signaling

Cited by 33

LIGHTHOUSE illuminates therapeutics for a variety of diseases including COVID-19

Shimizu, H., Kodama, M., Matsumoto, M., Orba, Y., Sasaki, M., Sato, A., Sawa, H., & Nakayama, K. I. (2021) · iScience

Computational Drug Discovery MethodsBioinformatics and Genomic Networks

Cited by 9