Komander, David

The ubiquitin code

Komander, D., & Rape, M. (2012) · Annual Review of Biochemistry

Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors

Cited by 3,679

The nuts and bolts of AGC protein kinases

Pearce, L. R., Komander, D., & Alessi, D. R. (2010) · Nature Reviews Molecular Cell Biology

Protein Kinase Regulation and GTPase SignalingPI3K/AKT/mTOR signaling in cancer

Cited by 1,294

The emerging complexity of protein ubiquitination

Komander, D. (2009) · Biochemical Society Transactions

Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors

Cited by 821

Molecular basis of USP7 inhibition by selective small-molecule inhibitors.

Turnbull, A. P., Ioannidis, S., Krajewski, W. W., Pinto-Fernandez, A., Heride, C., Martin, A. C. L., Tonkin, L. M., Townsend, E. C., Buker, S. M., Lancia, D. R., et al. (2017) · Nature

Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors

Cited by 463

The deubiquitinase OTULIN is an essential negative regulator of inflammation and autoimmunity

Damgaard, R. B., Walker, J. A., Marco-Casanova, P., Morgan, N. V., Titheradge, H. L., Elliott, P. R., McHale, D., Maher, E. R., McKenzie, A. N. J., & Komander, D. (2016) · Cell

NF-κB Signaling PathwaysUbiquitin and proteasome pathways

Cited by 348

LC3C, Bound Selectively by a Noncanonical LIR Motif in NDP52, Is Required for Antibacterial Autophagy

von Muhlinen, N., Akutsu, M., Ravenhill, B. J., Foeglein, Á., Bloor, S., Rutherford, T. J., Freund, S. M. V., Komander, D., & Randow, F. (2012) · Molecular Cell

Autophagy in Disease and TherapyUbiquitin and proteasome pathways

Cited by 332

Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network

Markson, G., Kiel, C., Hyde, R., Brown, S., Charalabous, P., Bremm, A., Semple, J., Woodsmith, J., Duley, S., Salehi-Ashtiani, K., et al. (2009) · Genome Research

Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors

Cited by 157

Structure of human PINK1 at a mitochondrial TOM-VDAC array

Callegari, S., Kirk, N. S., Gan, Z. Y., Dite, T., Cobbold, S. A., Leis, A., Dagley, L. F., Glukhova, A., & Komander, D. (2025) · Science

Mitochondrial Function and PathologyParkinson's Disease Mechanisms and Treatments

Cited by 75

PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCF FBXL4

Nguyen-Dien, G. T., Townsend, B., Kulkarni, P., Kozul, K.-L., Ooi, S. S., Eldershaw, D., Weeratunga, S., Liu, M., Jones, M. J., Millard, S. S., et al. (2024) · EMBO Reports

Autophagy in Disease and TherapyUbiquitin and proteasome pathways

Cited by 30

PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCFFBXL4

Nguyen-Dien, G. T., Townsend, B., Kulkarni, P. G., Kozul, K.-L., Ooi, S. S., Eldershaw, D. N., Weeratunga, S., Liu, M., Jones, M. J., Millard, S. S., et al. (2024) · EMBO Reports

Autophagy in Disease and TherapyUbiquitin and proteasome pathways

Cited by 30

Interaction of PINK1 with nucleotides and kinetin

Gan, Z. Y., Callegari, S., Nguyen, T. N., Kirk, N. S., Leis, A., Lazarou, M., Dewson, G., & Komander, D. (2024) · Science Advances

Parkinson's Disease Mechanisms and TreatmentsAutophagy in Disease and Therapy

Cited by 14

Major histocompatibility class II in murine antigen presenting cells is modified with a branched K63 and K11-linked ubiquitin chain

Liu, H., Francis, L., Dagley, L. F., Cobbold, S. A., Webb, A. I., Komander, D., Villadangos, J. A., & Mintern, J. D. (2025) · Scientific Reports

Ubiquitin and proteasome pathwaysImmunotherapy and Immune Responses

Cited by 2

Major histocompatibility class II in murine antigen presenting cells is modified with a branched K63 and K11-linked ubiquitin chain

Liu, H., Francis, L., Dagley, L. F., Cobbold, S. A., Webb, A. I., Komander, D., Villadangos, J. A., & Mintern, J. D. (2025) · Scientific Reports

Ubiquitin and proteasome pathwaysImmunotherapy and Immune Responses

Cited by 2