Ahituv, Nadav

In vivo enhancer analysis of human conserved non-coding sequences

Pennacchio, L. A., Ahituv, N., Moses, A. M., Prabhakar, S., Nobrega, M. A., Shoukry, M., Minovitsky, S., Dubchak, I., Holt, A., Lewis, K. D., et al. (2006) · Nature

Genomics and Chromatin DynamicsDevelopmental Biology and Gene Regulation

Cited by 1,165

A Genome-wide Framework for Mapping Gene Regulation via Cellular Genetic Screens

Gasperini, M., Hill, A. J., McFaline-Figueroa, J. L., Martin, B., Kim, S., Zhang, M. D., Jackson, D., Leith, A., Schreiber, J., Noble, W. S., et al. (2019) · Cell

Genomics and Chromatin DynamicsCRISPR and Genetic Engineering

Cited by 613

Massively parallel functional dissection of mammalian enhancers in vivo

Patwardhan, R. P., Hiatt, J. B., Witten, D. M., Kim, M. J., Smith, R. P., May, D., Lee, C., Andrie, J. M., Lee, S.-I., Cooper, G. M., et al. (2012) · Nature Biotechnology

Genomics and Chromatin DynamicsCRISPR and Genetic Engineering

Cited by 536

Variant interpretation: functional assays to the rescue

Starita, L. M., Ahituv, N., Dunham, M. J., Kitzman, J. O., Roth, F. P., Seelig, G., Shendure, J., & Fowler, D. M. (2017) · The American Journal of Human Genetics

Genomics and Rare DiseasesGenetic Associations and Epidemiology

Cited by 381

A systematic comparison reveals substantial differences in chromosomal versus episomal encoding of enhancer activity

Inoue, F., Kircher, M., Martin, B., Cooper, G. M., Witten, D. M., McManus, M. T., Ahituv, N., & Shendure, J. (2017) · Genome Research

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 331

CRISPR-mediated activation of a promoter or enhancer rescues obesity caused by haploinsufficiency

Matharu, N., Rattanasopha, S., Tamura, S., Maliskova, L., Wang, Y., Bernard, A., Hardin, A., Eckalbar, W. L., Vaisse, C., & Ahituv, N. (2019) · Science

CRISPR and Genetic EngineeringRegulation of Appetite and Obesity

Cited by 323

Genome-wide de novo risk score implicates promoter variation in autism spectrum disorder

An, J.-Y., Lin, K., Zhu, L., Werling, D. M., Dong, S., Brand, H., Wang, H. Z., Zhao, X., Schwartz, G. B., Collins, R. L., et al. (2018) · Science

Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental Disorders

Cited by 316

Decoding enhancers using massively parallel reporter assays

Inoue, F., & Ahituv, N. (2015) · Genomics

Genomics and Chromatin DynamicsGenetic Associations and Epidemiology

Cited by 272

Massively parallel decoding of mammalian regulatory sequences supports a flexible organizational model

Smith, R. P., Taher, L., Patwardhan, R. P., Kim, M. J., Inoue, F., Shendure, J., Ovcharenko, I., & Ahituv, N. (2013) · Nature Genetics

Genomics and Chromatin DynamicsGene Regulatory Network Analysis

Cited by 239

Saturation mutagenesis of twenty disease-associated regulatory elements at single base-pair resolution

Kircher, M., Xiong, C., Martin, B., Schubach, M., Inoue, F., Bell, R. J. A., Costello, J. F., Shendure, J., & Ahituv, N. (2019) · Nature Communications

Genomics and Chromatin DynamicsGenetic Associations and Epidemiology

Cited by 234

A systematic evaluation of the design and context dependencies of massively parallel reporter assays

Klein, J. C., Agarwal, V., Inoue, F., Keith, A., Martin, B., Kircher, M., Ahituv, N., & Shendure, J. (2020) · Nature Methods

Genomics and Chromatin DynamicsCRISPR and Genetic Engineering

Cited by 226

Enhancer Interaction Networks as a Means for Singular Olfactory Receptor Expression

Markenscoff-Papadimitriou, E., Allen, W. E., Colquitt, B. M., Goh, T., Murphy, K. K., Monahan, K., Mosley, C. P., Ahituv, N., & Lomvardas, S. (2014) · Cell

Genomics and Chromatin DynamicsOlfactory and Sensory Function Studies

Cited by 214

Function and Regulation of AUTS2, a Gene Implicated in Autism and Human Evolution

Oksenberg, N., Stevison, L., Wall, J. D., & Ahituv, N. (2013) · PLoS Genetics

Genetics and Neurodevelopmental DisordersAutism Spectrum Disorder Research

Cited by 167

Massively parallel characterization of transcriptional regulatory elements

Agarwal, V., Inoue, F., Schubach, M., Penzar, D., Martin, B. K., Dash, P. M., Keukeleire, P., Zhang, Z., Sohota, A., Zhao, J., et al. (2025) · Nature

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 146

Use antibiotics in cell culture with caution: genome-wide identification of antibiotic-induced changes in gene expression and regulation

Ryu, A. H., Eckalbar, W. L., Kreimer, A., Yosef, N., & Ahituv, N. (2017) · Scientific Reports

Genomics and Chromatin DynamicsBacterial Genetics and Biotechnology

Cited by 139

Use Antibiotics in Cell Culture with Caution: Genome-wide Identification of Antibiotic-Induced Changes in Gene Expression and Regulation

Ryu, A. H., Eckalbar, W. L., Kreimer, A., Yosef, N., & Ahituv, N. (2017) · Scientific Reports

Genomics and Chromatin DynamicsBacterial Genetics and Biotechnology

Cited by 139

Three-dimensional genome rewiring in loci with human accelerated regions

Keough, K. C., Whalen, S., Inoue, F., Przytycki, P. F., Fair, T., Deng, C., Steyert, M., Ryu, H., Lindblad-Toh, K., Karlsson, E., et al. (2023) · Science

Genomics and Chromatin DynamicsChromosomal and Genetic Variations

Cited by 113

Transcription factor binding site orientation and order are major drivers of gene regulatory activity

Georgakopoulos-Soares, I., Deng, C., Agarwal, V., Chan, C. S. Y., Zhao, J., Inoue, F., & Ahituv, N. (2023) · Nature Communications

Genomics and Chromatin DynamicsGene Regulatory Network Analysis

Cited by 82

Prenatal β-catenin/Brn2/Tbr2 transcriptional cascade regulates adult social and stereotypic behaviors

Belinson, H., Nakatani, J., Babineau, B. A., Birnbaum, R. Y., Ellegood, J., Bershteyn, M., McEvilly, R. J., Long, J. M., Willert, K., Klein, O. D., et al. (2016) · Molecular Psychiatry

Genetics and Neurodevelopmental DisordersNeurogenesis and neuroplasticity mechanisms

Cited by 79

The cis-regulatory effects of modern human-specific variants

Weiss, C. V., Harshman, L., Inoue, F., Fraser, H. B., Petrov, D. A., Ahituv, N., & Gokhman, D. (2021) · eLife

Genomics and Chromatin DynamicsPleistocene-Era Hominins and Archaeology

Cited by 70

TAD evolutionary and functional characterization reveals diversity in mammalian TAD boundary properties and function

Okhovat, M., VanCampen, J., Nevonen, K. A., Harshman, L., Li, W., Layman, C. E., Ward, S., Herrera, J., Wells, J., Sheng, R. R., et al. (2023) · Nature Communications

Genomics and Chromatin DynamicsChromosomal and Genetic Variations

Cited by 68

Bat accelerated regions identify a bat forelimb specific enhancer in the HoxD locus

Booker, B. M., Friedrich, T., Mason, M. K., VanderMeer, J. E., Zhao, J., Eckalbar, W. L., Logan, M., Illing, N., Pollard, K. S., & Ahituv, N. (2016) · PLOS Genetics

Developmental Biology and Gene RegulationGenomics and Chromatin Dynamics

Cited by 66

Functional characterization of tissue-specific enhancers in the DLX5/6 locus

Birnbaum, R. Y., Everman, D. B., Murphy, K. K., Gurrieri, F., Schwartz, C. E., & Ahituv, N. (2012) · Human Molecular Genetics

Genomics and Chromatin DynamicsDevelopmental Biology and Gene Regulation

Cited by 63

Single cell epigenomic atlas of the developing human brain and organoids

Ziffra, R. S., Kim, C. N., Wilfert, A., Turner, T. N., Haeussler, M., Casella, A. M., Przytycki, P. F., Kreimer, A., Pollard, K. S., Ament, S. A., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory)

Single-cell and spatial transcriptomicsGenomics and Chromatin Dynamics

Cited by 33