Marek, Martin

Structural Basis for the Inhibition of Histone Deacetylase 8 (HDAC8), a Key Epigenetic Player in the Blood Fluke Schistosoma mansoni

Marek, M., Kannan, S., Hauser, A.-T., Moraes Mourão, M., Caby, S., Cura, V., Stolfa, D. A., Schmidtkunz, K., Lancelot, J., Andrade, L., et al. (2013) · PLoS Pathogens

Histone Deacetylase Inhibitors ResearchParasites and Host Interactions

Cited by 173

Structure-Based Design and Synthesis of Novel Inhibitors Targeting HDAC8 from Schistosoma mansoni for the Treatment of Schistosomiasis

Heimburg, T., Chakrabarti, A., Lancelot, J., Marek, M., Melesina, J., Hauser, A.-T., Shaik, T. B., Duclaud, S., Robaa, D., Erdmann, F., et al. (2016) · Journal of Medicinal Chemistry

Histone Deacetylase Inhibitors ResearchParasites and Host Interactions

Cited by 124

Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants

Marek, M., Shaik, T. B., Heimburg, T., Chakrabarti, A., Lancelot, J., Ramos-Morales, E., Da Veiga, C., Kalinin, D., Melesina, J., Robaa, D., et al. (2018) · Journal of Medicinal Chemistry

Histone Deacetylase Inhibitors ResearchEnzyme function and inhibition

Cited by 122

Synthesis and Biological Investigation of Phenothiazine-Based Benzhydroxamic Acids as Selective Histone Deacetylase 6 Inhibitors

Vögerl, K., Ong, N., Senger, J., Herp, D., Schmidtkunz, K., Marek, M., Müller, M., Bartel, K., Shaik, T. B., Porter, N. J., et al. (2019) · Journal of Medicinal Chemistry

Histone Deacetylase Inhibitors ResearchPhenothiazines and Benzothiazines Synthesis and Activities

Cited by 104

Molecular Basis for the Antiparasitic Activity of a Mercaptoacetamide Derivative That Inhibits Histone Deacetylase 8 (HDAC8) from the Human Pathogen Schistosoma mansoni

Stolfa, D. A., Marek, M., Lancelot, J., Hauser, A.-T., Walter, A., Leproult, E., Melesina, J., Rumpf, T., Wurtz, J.-M., Cavarelli, J., et al. (2014) · Journal of Molecular Biology

Histone Deacetylase Inhibitors ResearchParasites and Host Interactions

Cited by 75

A Novel Class of Schistosoma mansoni Histone Deacetylase 8 (HDAC8) Inhibitors Identified by Structure-Based Virtual Screening and In Vitro Testing

Simoben, C., Robaa, D., Chakrabarti, A., Schmidtkunz, K., Marek, M., Lancelot, J., Kannan, S., Melesina, J., Shaik, T., Pierce, R., et al. (2018) · Molecules

Histone Deacetylase Inhibitors ResearchComputational Drug Discovery Methods

Cited by 44

Domino-like effect of C112R mutation on ApoE4 aggregation and its reduction by Alzheimer’s Disease drug candidate

Nemergut, M., Marques, S. M., Uhrik, L., Vanova, T., Nezvedova, M., Gadara, D. C., Jha, D., Tulis, J., Novakova, V., Planas-Iglesias, J., et al. (2023) · Molecular Neurodegeneration

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 30

Synthesis, Crystallization Studies, and in vitro Characterization of Cinnamic Acid Derivatives as Sm HDAC8 Inhibitors for the Treatment of Schistosomiasis

Bayer, T., Chakrabarti, A., Lancelot, J., Shaik, T. B., Hausmann, K., Melesina, J., Schmidtkunz, K., Marek, M., Erdmann, F., Schmidt, M., et al. (2018) · ChemMedChem

Histone Deacetylase Inhibitors ResearchParasites and Host Interactions

Cited by 23

Engineering Dehalogenase Enzymes using Variational Autoencoder-Generated Latent Spaces and Microfluidics

Kohout, P., Vasina, M., Majerova, M., Novakova, V., Damborsky, J., Bednar, D., Marek, M., Prokop, Z., & Mazurenko, S. (2024) · JACS Au

Enzyme Catalysis and ImmobilizationProtein Structure and Dynamics

Cited by 14

Insights into the bioluminescence systems of three sea pens (Cnidaria: Anthozoa): from de novo transcriptome analyses to biochemical assays

Duchatelet, L., Galeazzo, G. A., Coubris, C., Bridoux, L., Rezsohazy, R., Melo, M. R. S., Marek, M., Amaral, D. T., Dupont, S., Garbuglio de Oliveira, A., et al. (2025) · Open Biology

bioluminescence and chemiluminescence researchMarine Invertebrate Physiology and Ecology

Cited by 6