Testa, Giuseppe

The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing

De Santa, F., Totaro, M. G., Prosperini, E., Notarbartolo, S., Testa, G., & Natoli, G. (2007) · Cell

Epigenetics and DNA MethylationGenomics and Chromatin Dynamics

Cited by 965

From cohorts to molecules: adverse impacts of endocrine disrupting mixtures

Caporale, N., Leemans, M., Birgersson, L., Germain, P.-L., Cheroni, C., Borbély, G., Engdahl, E., Lindh, C., Bressan, R. B., Cavallo, F., et al. (2022) · Science

Effects and risks of endocrine disrupting chemicalsToxic Organic Pollutants Impact

Cited by 368

Multi-omic measurements of heterogeneity in HeLa cells across laboratories

Liu, Y., Mi, Y., Mueller, T., Kreibich, S., Williams, E. G., Van Drogen, A., Borel, C., Frank, M., Germain, P.-L., Bludau, I., et al. (2019) · Nature Biotechnology

Advanced Proteomics Techniques and ApplicationsViral Infectious Diseases and Gene Expression in Insects

Cited by 338

YY1 haploinsufficiency causes an intellectual disability syndrome featuring transcriptional and chromatin dysfunction

Gabriele, M., Vulto-van Silfhout, A. T., Germain, P.-L., Vitriolo, A., Kumar, R., Douglas, E., Haan, E., Kosaki, K., Takenouchi, T., Rauch, A., et al. (2017) · The American Journal of Human Genetics

Genetics and Neurodevelopmental DisordersGenomics and Rare Diseases

Cited by 163

Systematic proteome and proteostasis profiling in human trisomy 21 fibroblast cells

Liu, Y., Borel, C., Li, L., Müller, T., Williams, E. G., Germain, P.-L., Buljan, M., Sajic, T., Boersema, P. J., Shao, W., et al. (2017) · Nature Communications

Down syndrome and intellectual disability researchAdvanced Proteomics Techniques and Applications

Cited by 141

7q11.23 dosage-dependent dysregulation in human pluripotent stem cells affects transcriptional programs in disease-relevant lineages

Adamo, A., Atashpaz, S., Germain, P.-L., Zanella, M., D'Agostino, G., Albertin, V., Chenoweth, J., Micale, L., Fusco, C., Unger, C., et al. (2015) · Nature Genetics

Williams Syndrome ResearchPluripotent Stem Cells Research

Cited by 129

The chromatin basis of neurodevelopmental disorders: Rethinking dysfunction along the molecular and temporal axes

Gabriele, M., Lopez Tobon, A., D'Agostino, G., & Testa, G. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry

Genetics and Neurodevelopmental DisordersAutism Spectrum Disorder Research

Cited by 103

Dosage analysis of the 7q11.23 Williams region identifies BAZ1B as a major human gene patterning the modern human face and underlying self-domestication

Zanella, M., Vitriolo, A., Andirko, A., Martins, P. T., Sturm, S., O’Rourke, T., Laugsch, M., Malerba, N., Skaros, A., Trattaro, S., et al. (2019) · Science Advances

Williams Syndrome ResearchCraniofacial Disorders and Treatments

Cited by 101

Taming Human Genetic Variability: Transcriptomic Meta-Analysis Guides the Experimental Design and Interpretation of iPSC-Based Disease Modeling

Germain, P.-L., & Testa, G. (2017) · Stem Cell Reports

Pluripotent Stem Cells ResearchSingle-cell and spatial transcriptomics

Cited by 94

Polycomb proteins control proliferation and transformation independently of cell cycle checkpoints by regulating DNA replication

Piunti, A., Rossi, A., Cerutti, A., Albert, M., Jammula, S., Scelfo, A., Cedrone, L., Fragola, G., Olsson, L., Koseki, H., et al. (2014) · Nature Communications

Epigenetics and DNA MethylationCancer-related Molecular Pathways

Cited by 93

DNA Damage in Mammalian Neural Stem Cells Leads to Astrocytic Differentiation Mediated by BMP2 Signaling through JAK-STAT

Schneider, L., Pellegatta, S., Favaro, R., Pisati, F., Roncaglia, P., Testa, G., Nicolis, S. K., Finocchiaro, G., & d’Adda di Fagagna, F. (2013) · Stem Cell Reports

Neurogenesis and neuroplasticity mechanismsGlioma Diagnosis and Treatment

Cited by 92

CHD8 haploinsufficiency links autism to transient alterations in excitatory and inhibitory trajectories

Villa, C. E., Cheroni, C., Dotter, C. P., López-Tóbon, A., Oliveira, B., Sacco, R., Yahya, A. Ç., Morandell, J., Gabriele, M., Tavakoli, M. R., et al. (2022) · Cell Reports

Genetics and Neurodevelopmental DisordersAutism Spectrum Disorder Research

Cited by 92

Single cell-derived spheroids capture the self-renewing subpopulations of metastatic ovarian cancer

Velletri, T., Villa, C. E., Cilli, D., Barzaghi, B., Lo Riso, P., Lupia, M., Luongo, R., López-Tobón, A., De Simone, M., Bonnal, R. J. P., et al. (2022) · Cell Death & Differentiation

Ovarian cancer diagnosis and treatmentCancer Cells and Metastasis

Cited by 48

Novel in vitro Experimental Approaches to Study Myelination and Remyelination in the Central Nervous System

Marangon, D., Caporale, N., Boccazzi, M., Abbracchio, M. P., Testa, G., & Lecca, D. (2021) · Frontiers in Cellular Neuroscience

Neurogenesis and neuroplasticity mechanismsMultiple Sclerosis Research Studies

Cited by 34

The sociability spectrum: evidence from reciprocal genetic copy number variations

López-Tobón, A., Trattaro, S., & Testa, G. (2020) · Molecular Autism

Genetics and Neurodevelopmental DisordersGenomic variations and chromosomal abnormalities

Cited by 20