Weir, Gordon C.

Induced pluripotent stem cells generated without viral integration

Stadtfeld, M., Nagaya, M., Utikal, J., Weir, G., & Hochedlinger, K. (2008) · Science

Pluripotent Stem Cells ResearchCRISPR and Genetic Engineering

Cited by 1,683

Five stages of evolving beta-cell dysfunction during progression to diabetes

Weir, G. C., & Bonner-Weir, S. (2004) · Diabetes

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 1,126

Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates

Veiseh, O., Doloff, J. C., Ma, M., Vegas, A. J., Tam, H. H., Bader, A. R., Li, J., Langan, E., Wyckoff, J., Loo, W. S., et al. (2015) · Nature Materials

Tissue Engineering and Regenerative MedicinePancreatic function and diabetes

Cited by 897

Long-term glycemic control using polymer-encapsulated human stem cell–derived beta cells in immune-competent mice

Vegas, A. J., Veiseh, O., Gürtler, M., Millman, J. R., Pagliuca, F. W., Bader, A. R., Doloff, J. C., Li, J., Chen, M., Olejnik, K., et al. (2016) · Nature Medicine

Pancreatic function and diabetesTissue Engineering and Regenerative Medicine

Cited by 710

Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates

Vegas, A. J., Veiseh, O., Doloff, J. C., Ma, M., Tam, H. H., Bratlie, K., Li, J., Bader, A. R., Langan, E., Olejnik, K., et al. (2016) · Nature Biotechnology

Hydrogels: synthesis, properties, applicationsPolymer Surface Interaction Studies

Cited by 551

Acceleration of β Cell Aging Determines Diabetes and Senolysis Improves Disease Outcomes

Aguayo-Mazzucato, C., Andle, J., Lee, T. B., Midha, A., Talemal, L., Chipashvili, V., Hollister-Lock, J., van Deursen, J., Weir, G., & Bonner-Weir, S. (2019) · Cell Metabolism

Pancreatic function and diabetesTelomeres, Telomerase, and Senescence

Cited by 469

Beta-cell adaptation and decompensation during the progression of diabetes

Weir, G. C., Laybutt, D. R., Kaneto, H., Bonner-Weir, S., & Sharma, A. (2001) · Diabetes

Pancreatic function and diabetesDiabetes Treatment and Management

Cited by 462

β-Cell Failure in Type 2 Diabetes: Postulated Mechanisms and Prospects for Prevention and Treatment

Halban, P. A., Polonsky, K. S., Bowden, D. W., Hawkins, M. A., Ling, C., Mather, K. J., Powers, A. C., Rhodes, C. J., Sussel, L., & Weir, G. C. (2014) · Diabetes Care

Pancreatic function and diabetesDiabetes Treatment and Management

Cited by 460

The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients

Marchetti, P., Bugliani, M., Lupi, R., Marselli, L., Masini, M., Boggi, U., Filipponi, F., Weir, G. C., Eizirik, D. L., & Cnop, M. (2007) · Diabetologia

Endoplasmic Reticulum Stress and DiseasePancreatic function and diabetes

Cited by 413

Alginate encapsulation as long-term immune protection of allogeneic pancreatic islet cells transplanted into the omental bursa of macaques

Bochenek, M. A., Veiseh, O., Vegas, A. J., McGarrigle, J. J., Qi, M., Marchese, E., Omami, M., Doloff, J. C., Mendoza-Elias, J., Nourmohammadzadeh, M., et al. (2018) · Nature Biomedical Engineering

Pancreatic function and diabetesTissue Engineering and Regenerative Medicine

Cited by 367

Responses of Neonatal Rat Islets to Streptozotocin: Limited B-Cell Regeneration and Hyperglycemia

Bonner-Weir, S., Trent, D. F., Honey, R. N., & Weir, G. C. (1981) · Diabetes

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 324

Gene Expression Profiles of Beta-Cell Enriched Tissue Obtained by Laser Capture Microdissection from Subjects with Type 2 Diabetes

Marselli, L., Thorne, J., Dahiya, S., Sgroi, D. C., Sharma, A., Bonner-Weir, S., Marchetti, P., & Weir, G. C. (2010) · PLoS ONE

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 313

Islet β cell mass in diabetes and how it relates to function, birth, and death

Weir, G. C., & Bonner‐Weir, S. (2013) · Annals of the New York Academy of Sciences

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 296

Islet amyloid formation associated with hyperglycemia in transgenic mice with pancreatic beta cell expression of human islet amyloid polypeptide.

Verchere, C. B., D'Alessio, D. A., Palmiter, R. D., Weir, G. C., Bonner-Weir, S., Baskin, D. G., & Kahn, S. E. (1996) · Proceedings of the National Academy of Sciences

Pancreatic function and diabetesAlzheimer's disease research and treatments

Cited by 278

β Cell Aging Markers Have Heterogeneous Distribution and Are Induced by Insulin Resistance

Aguayo-Mazzucato, C., van Haaren, M., Mruk, M., Lee, T. B., Crawford, C., Hollister-Lock, J., Sullivan, B. A., Johnson, J. W., Ebrahimi, A., Dreyfuss, J. M., et al. (2017) · Cell Metabolism

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 198

Long-term implant fibrosis prevention in rodents and non-human primates using crystallized drug formulations

Farah, S., Doloff, J. C., Müller, P., Sadraei, A., Han, H. J., Olafson, K., Vyas, K., Tam, H. H., Hollister-Lock, J., Kowalski, P. S., et al. (2019) · Nature Materials

Advanced Drug Delivery SystemsTissue Engineering and Regenerative Medicine

Cited by 181

Adrenergic Modulation of Pancreatic A, B, and D Cells

Samols, E., & Weir, G. C. (1979) · Journal of Clinical Investigation

Pancreatic function and diabetesReceptor Mechanisms and Signaling

Cited by 176

Overexpression of c-Myc in β-Cells of Transgenic Mice Causes Proliferation and Apoptosis, Downregulation of Insulin Gene Expression, and Diabetes

Laybutt, D. R., Weir, G. C., Kaneto, H., Lebet, J., Palmiter, R. D., Sharma, A., & Bonner-Weir, S. (2002) · Diabetes

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 144

Suppression of β Cell Energy Metabolism and Insulin Release by PGC-1α

Yoon, J. C., Xu, G., Deeney, J. T., Yang, S.-N., Rhee, J., Puigserver, P., Levens, A. R., Yang, R., Zhang, C.-Y., Lowell, B. B., et al. (2003) · Developmental Cell

Pancreatic function and diabetesMetabolism, Diabetes, and Cancer

Cited by 143

Enhanced function of immuno-isolated islets in diabetes therapy by co-encapsulation with an anti-inflammatory drug

Dang, T. T., Thai, A. V., Cohen, J., Slosberg, J. E., Siniakowicz, K., Doloff, J. C., Ma, M., Hollister-Lock, J., Tang, K. M., Gu, Z., et al. (2013) · Biomaterials

Pancreatic function and diabetesTissue Engineering and Regenerative Medicine

Cited by 125

GLP-1/exendin-4 facilitates β-cell neogenesis in rat and human pancreatic ducts

Xu, G., Kaneto, H., Lopez-Avalos, M. D., Weir, G. C., & Bonner-Weir, S. (2006) · Diabetes Research and Clinical Practice

Pancreatic function and diabetesDiabetes Treatment and Management

Cited by 115

Reanalysis of study of pancreatic effects of incretin therapy: methodological deficiencies

Bonner‐Weir, S., In't Veld, P. A., & Weir, G. C. (2014) · Diabetes, Obesity and Metabolism

Diabetes Treatment and ManagementPancreatic and Hepatic Oncology Research

Cited by 54