Cited by 551Hydrogels: synthesis, properties, applicationsPolymer Surface Interaction StudiesTissue Engineering and Regenerative Medicine

Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates

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Vegas, Arturo J, Veiseh, Omid, Doloff, Joshua C, Ma, Minglin, Tam, Hok Hei, Bratlie, Kaitlin, Li, Jie, Bader, Andrew R +27 more·2016·Nature Biotechnology

Abstract

The foreign body response is an immune-mediated reaction that can lead to the failure of implanted medical devices and discomfort for the recipient. There is a critical need for biomaterials that overcome this key challenge in the development of medical devices. Here we use a combinatorial approach for covalent chemical modification to generate a large library of variants of one of the most widely used hydrogel biomaterials, alginate. We evaluated the materials in vivo and identified three triazole-containing analogs that substantially reduce foreign body reactions in both rodents and, for at least 6 months, in non-human primates. The distribution of the triazole modification creates a unique hydrogel surface that inhibits recognition by macrophages and fibrous deposition. In addition to the utility of the compounds reported here, our approach may enable the discovery of other materials that mitigate the foreign body response.

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  • A combinatorial biomaterial screen identified three different triazole-containing covalent modifications to alginate that significantly reduced the foreign body response in both rodents and non-human primates.

    “For example, a combinatorial biomaterial screen identified three different triazole-containing covalent modifications to alginate that significantly reduced the foreign body response in both rodents and non-human primates.”

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Research works printed but not linked: 4

  1. [7]Wick G The immunology of fbrosis Annu. Rev. Immunol 2013 31 107 135 23516981
  2. [8]Wynn TA Ramalingam TR Mechanisms of fbrosis: therapeutic translation for fbrotic disease Nat. Med 2012 18 1028 1040 22772564 PMC3405917
  3. [26]King A Sandler S Andersson A The effect of host factors and capsule composition on the cellular overgrowth on implanted alginate capsules J. Biomed. Mater. Res 2001 57 374 383 11523032
  4. [32]Haller J Visualization of pulmonary infammation using noninvasive fuorescence molecular imaging J. Appl. Physiol 2008 104 795 802 18202169

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Authors
Vegas, A. J., Veiseh, O., Doloff, J. C., Ma, M., Tam, H. H., Bratlie, K., Li, J., Bader, A. R., Langan, E., Olejnik, K., Fenton, P., Kang, J. W., Hollister-Locke, J., Bochenek, M. A., Chiu, A., Siebert, S., Tang, K., Jhunjhunwala, S., Aresta-Dasilva, S., Dholakia, N., Thakrar, R., Vietti, T., Chen, M., Cohen, J., Siniakowicz, K., Qi, M., McGarrigle, J., Graham, A. C., Lyle, S., Harlan, D. M., Greiner, D. L., Oberholzer, J., Weir, G. C., Langer, R., & Anderson, D. G.
Affiliations
  • Boston Children's Hospital (US)
  • Koch Institute for Integrative Cancer Research At MIT (US)
  • Massachusetts Institute of Technology (US)
  • University of Illinois Chicago (US)
  • Joslin Diabetes Center (US)
  • Harvard University (US)
  • University of Massachusetts Chan Medical School (US)
Corresponding author
Anderson, Daniel G
Venue
Nature Biotechnology
Published
2016-01-25
Volume
34
Issue
3
Pages
345-352
ISSN
  • 0733-222X (ISSN-L)
  • 1087-0156
  • 1546-1696
OpenAlex
W2260141621
Cited by
551
References
57
Citations by year
2026: 41 · 2025: 42 · 2024: 58 · 2023: 56 · 2022: 54 · 2021: 71 · 2020: 61 · 2019: 50 · 2018: 55 · 2017: 32 · 2016: 31
FWCI
27.32
Type
journal article
Language
en
Update notices
erratum (2016-06-09)
Open access
Locations
  • Nature Biotechnology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • Iowa State University Digital Repository (Iowa State University) (submittedVersion)
  • DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion)
Funders
  • U.S. Department of Defense (P30-CA14051, W81XWH, W81XWH1310215, W81XWH-13)
  • Leona M. and Harry B. Helmsley Charitable Trust
  • Harvard University
  • Joslin Diabetes Center (P30DK036836)
  • Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology (P30-CA14051)
  • Diabetes Research and Wellness Foundation
  • Skolkovo Institute of Science and Technology
  • National Institutes of Health (4r37eb000244-34, W81XWH, CA151884, EB-000244)
  • Diabetes Research Center (P30 DK 036836)
  • National Cancer Institute (U54CA151884, CA14051, CA151884, P30CA014051, P30-CA-14051)
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01DK091526, R01DK093909, P30DK036836)
  • National Institute of Biomedical Imaging and Bioengineering (EB-000244, R01EB000244, R37-EB000244, P41EB015871, EB 000351, R01EB000351)
  • National Institute of Dental and Craniofacial Research (DE013023, R01DE013023)
  • Congressionally Directed Medical Research Programs
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Keywords
foreign body reaction, alginate hydrogel, combinatorial libraries, biomaterials, biomedical implants, macrophage recognition, non-human primates, biocompatibility
MeSH terms
Animals, Biocompatible Materials, Foreign Bodies, Foreign-Body Reaction, Humans, Macrophages, Primates, Prostheses and Implants, Hydrogels

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