Adrenergic Modulation of Pancreatic A, B, and D Cells
Open accessAbstract
The effects of adrenergic substances on pancreatic insular secretions were studied in a completely isolated canine pancreas with exclusion of the duodenum from the perfusion circuit. To ensure adequate blockade, blockers were infused before agonists. A dose range of beta-receptor blockade was tested, and putative alpha-adrenergic effects were confirmed by combined alpha- and beta-adrenergic receptor blockade.beta-Adrenergic agonism (2 ng/ml isoproterenol) induced a mean integrated increase of 79+/-20% in somatostatin secretion, whereas glucagon and insulin secretion were increased by 185+/-45 and 495+/-146%, respectively. The stimulations of D, A, and B cells were abolished by propranolol.alpha-Adrenergic agonism (10 ng/ml epinephrine) after beta-adrenergic blockade) moderately decreased somatostatin (-37+/-7%) secretion, moderately increased glucagon (91+/-19%), and markedly decreased insulin (-85+/-3%) release. Similar effects on D-, A-, and B-cell secretion were induced with 2 ng/ml epinephrine or 10 ng/ml norepinephrine after beta-adrenergic blockade. The alpha-adrenergic effects on the D and A cell were abolished by either phentolamine or by phenoxybenzamine. This study showed that there are indeed alpha-adrenergic receptors on A cells and that the secretion of glucagon, a "stress" hormone, was stimulated either by alpha- or beta-adrenergic receptor agonism. D-cell secretion, like that of the B cell, was inhibited by alpha-adrenergic agonism and was stimulated by beta-adrenergic agonism. However, beta-adrenergic-induced changes in D-cell secretion were smaller in magnitude than those of B-cell secretion.
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Epinephrine increases glucagon secretion and inhibits insulin secretion via adrenergic receptors.
“Epinephrine increases glucagon secretion and inhibits insulin secretion via adrenergic receptors (23).”
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Cites
Coated Charcoal Immunoassay of Insulin
Herbert, V. D., Lau, K., Gottlieb, C. W., & Bleicher, S. J. (1965) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-25-10-1375 · Cited by 2,969 · see citing works
Furchgott, R. F. (1972) · Springer eBooks · doi:10.1007/978-3-642-65249-3_9 · Cited by 814 · see citing works
Neural control of the endocrine pancreas.
Woods, S. C., & Porte, D. (1974) · Physiological Reviews · doi:10.1152/physrev.1974.54.3.596 · Cited by 646 · see citing works
GROWTH-HORMONE RELEASE-INHIBITING HORMONE IN GASTROINTESTINAL AND PANCREATIC D CELLS
Polak, J., Grimelius, L., Pearse, A. G. E., et al. (1975) · The Lancet · doi:10.1016/s0140-6736(75)92198-4 · Cited by 525 · see citing works
Somatostatin in Hypothalamus, Extrahypothalamic Brain, and Peripheral Tissues of the Rat*
Patel, Y., & Reichlin, S. (1978) · Endocrinology · doi:10.1210/endo-102-2-523 · Cited by 473 · see citing works
THE PHARMACOLOGICAL DIFFERENTIATION OF ADRENERGIC RECEPTORS*
Furchgott, R. F. (1967) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1967.tb41229.x · Cited by 378 · see citing works
Regulation of Pancreatic Insulin and Glucagon Secretion
Gerich, J. E., Charles, M. A., & Grodsky, G. M. (1976) · Annual Review of Physiology · doi:10.1146/annurev.ph.38.030176.002033 · Cited by 332 · see citing works
Glucagon: Role in the Hyperglycemia of Diabetes Mellitus
Dobbs, R., Sakurai, H., Sasaki, H., Faloona, G., Valverde, I., Baetens, D., Orci, L., & Unger, R. (1975) · Science · doi:10.1126/science.1089999 · Cited by 229 · see citing works
Iversen, J. (1973) · Journal of Clinical Investigation · doi:10.1172/jci107395 · Cited by 207 · see citing works
Williams, L. T., Mullikin, D., & Lefkowitz, R. J. (1976) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32922-8 · Cited by 190 · see citing works
Iversen, J., & Miles, D. W. (1971) · Diabetes · doi:10.2337/diab.20.1.1 · Cited by 180 · see citing works
Adrenergic Modulation of Pancreatic Glucagon Secretion in Man
Gerich, J. E., Langlois, M., Noacco, C., Schneider, V. B., & Forsham, P. H. (1974) · Journal of Clinical Investigation · doi:10.1172/jci107692 · Cited by 144 · see citing works
Langer, S. Z., & TRENDELENBURG, U. (1969) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)28259-3 · Cited by 134 · see citing works
Pagliara, A. S., Stillings, S. N., Hover, B., Martin, D. M., & Matschinsky, F. M. (1974) · Journal of Clinical Investigation · doi:10.1172/jci107822 · Cited by 115 · see citing works
The Effect of Adrenergic Blockade on the Glucagon Responses to Starvation and Hypoglycemia in Man
Walter, R. M., Dudl, R. J., Palmer, J. P., & Ensinck, J. W. (1974) · Journal of Clinical Investigation · doi:10.1172/jci107864 · Cited by 106 · see citing works
Pharmacological characteristics of adrenergic receptors.
Rf, F. (1970) · PubMed · Cited by 78 · see citing works
The Effect of Adrenergic Blockade on Exercise-Induced Hyperglucagonemia*
Harvey, W., Faloona, G. R., & Unger, R. H. (1974) · Endocrinology · doi:10.1210/endo-94-5-1254 · Cited by 75 · see citing works
UPTAKE OF PROPRANOLOL BY ISOLATED GUINEA-PIG ATRIA
Potter, L. T., & Sweetland, C. B. (1967) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)27529-2 · Cited by 72 · see citing works
High concentration of somatostatin immunoreactivity in chicken pancreas
Weir, G. C., Goltsos, P. C., Steinberg, E. P., et al. (1976) · Diabetologia · doi:10.1007/bf00428977 · Cited by 67 · see citing works
Self-citationSamols, E., Weir, G. C., Ramseur, R., et al. (1978) · Metabolism · doi:10.1016/0026-0495(78)90046-x · Cited by 65 · see citing works
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Flagged first, then by citations
Research works printed but not linked: 2
- [7]7. Gerich, J. E., J. H. Karam, and P. H. Forsham. 1972. Reciprocal adrenergic control of pancreatic alpha-and beta-cell function in man. Diabetes; 21: 332-333. (Abstr.)
- [27]27. Samols, E., J. Tyler, and V. Marks. 1972. Glucagon-insulin interrelationships. In Glucagon. Molecular Physiology, Clinical and Therapeutic Implications. P. J. Lefebvre and R. H. Unger, editors. Pergamon Press Ltd., Oxford. 1st edition. 9: 151-173.
Cited by
Sorted by citations
Hepatic fuel metabolism during muscular work: role and regulation
Wasserman, D. H., & Cherrington, A. D. (1991) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1991.260.6.e811 · Cited by 137 · see citing works
Exercise effects on postprandial glucose metabolism in type 1 diabetes: a triple-tracer approach
Mallad, A., Hinshaw, L., Schiavon, M., Dalla Man, C., Dadlani, V., Basu, R., Lingineni, R., Cobelli, C., Johnson, M. L., Carter, R., et al. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00014.2015 · Cited by 94 · see citing works
Glucoregulation During Exercise: The Role of the Neuroendocrine System
Coker, R. H., & Kjaer, M. (2005) · Sports Medicine · doi:10.2165/00007256-200535070-00003 · Cited by 60 · see citing works
Green-Golan, L., Yates, C., Drinkard, B., VanRyzin, C., Eisenhofer, G., Weise, M., & Merke, D. P. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-0493 · Cited by 50 · see citing works
Goto, Y., Carpenter, R. G., Berelowitz, M., & Frohman, L. A. (1980) · Metabolism · doi:10.1016/0026-0495(80)90044-x · Cited by 37 · see citing works
Gandasi, N. R., Gao, R., Kothegala, L., Pearce, A., Santos, C., Acreman, S., Basco, D., Benrick, A., Chibalina, M. V., Clark, A., et al. (2024) · Diabetologia · doi:10.1007/s00125-023-06060-w · Cited by 31 · see citing works
- Authors
- Samols, E., & Weir, G. C.
- Affiliations
- United States Department of Veterans Affairs (US)
- ORCID
- Weir, Gordon C.
- Venue
- Journal of Clinical Investigation
- Published
- 1979-02-01
- Volume
- 63
- Issue
- 2
- Pages
- 230-238
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC371944
- OpenAlex
- W1645430512
- Semantic Scholar
- b8151c495c151ddeef8cbd1e774033d640a027f6
- Cited by
- 176
- References
- 20
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 1 · 2021: 2 · 2019: 1 · 2018: 1 · 2015: 2 · 2014: 2 · 2013: 2 · 2012: 3
- FWCI
- 26.29
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (AM 20349)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- adrenergic modulation, pancreatic islets, alpha-adrenergic receptors, beta-adrenergic receptors, A cells, B cells, D cells, somatostatin, glucagon secretion, insulin secretion, epinephrine, norepinephrine, isoproterenol, propranolol, phentolamine, phenoxybenzamine, stress hormones
- MeSH terms
- Insulin Secretion, Adrenergic alpha-Agonists, Adrenergic alpha-Antagonists, Adrenergic beta-Agonists, Adrenergic beta-Antagonists, Animals, Dogs, Glucagon, Insulin, Male, Pancreas, Receptors, Adrenergic, Receptors, Adrenergic, alpha, Receptors, Adrenergic, beta, Somatostatin
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