Xu, Jian

Human Fetal Hemoglobin Expression Is Regulated by the Developmental Stage-Specific Repressor BCL11A

Sankaran, V. G., Menne, T. F., Xu, J., Akie, T. E., Lettre, G., Van Handel, B., Mikkola, H. K. A., Hirschhorn, J. N., Cantor, A. B., & Orkin, S. H. (2008) · Science

Hemoglobinopathies and Related DisordersHemoglobin structure and function

Cited by 919

An Erythroid Enhancer of BCL11A Subject to Genetic Variation Determines Fetal Hemoglobin Level

Bauer, D. E., Kamran, S. C., Lessard, S., Xu, J., Fujiwara, Y., Lin, C., Shao, Z., Canver, M. C., Smith, E. C., Pinello, L., et al. (2013) · Science

Hemoglobinopathies and Related DisordersGenomics and Chromatin Dynamics

Cited by 653

Direct promoter repression by BCL11A controls the fetal to adult hemoglobin switch

Liu, N., Hargreaves, V. V., Zhu, Q., Kurland, J. V., Hong, J., Kim, W., Sher, F., Macias-Trevino, C., Rogers, J. M., Kurita, R., et al. (2018) · Cell

Hemoglobinopathies and Related DisordersHemoglobin structure and function

Cited by 478

Developmental and species-divergent globin switching are driven by BCL11A

Sankaran, V. G., Xu, J., Ragoczy, T., Ippolito, G. C., Walkley, C. R., Maika, S. D., Fujiwara, Y., Ito, M., Groudine, M., Bender, M. A., et al. (2009) · Nature

Hemoglobinopathies and Related DisordersHemoglobin structure and function

Cited by 379

Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin

Masuda, T., Wang, X., Maeda, M., Canver, M. C., Sher, F., Funnell, A. P. W., Fisher, C., Suciu, M., Martyn, G. E., Norton, L. J., et al. (2016) · Science

Hemoglobinopathies and Related DisordersHemoglobin structure and function

Cited by 373

Transcriptional silencing of γ-globin by BCL11A involves long-range interactions and cooperation with SOX6

Xu, J., Sankaran, V. G., Ni, M., Menne, T. F., Puram, R. V., Kim, W., & Orkin, S. H. (2010) · Genes & Development

Hemoglobinopathies and Related DisordersGenomics and Chromatin Dynamics

Cited by 361

Correction of Sickle Cell Disease in Adult Mice by Interference with Fetal Hemoglobin Silencing

Xu, J., Peng, C., Sankaran, V. G., Shao, Z., Esrick, E. B., Chong, B. G., Ippolito, G. C., Fujiwara, Y., Ebert, B. L., Tucker, P. W., et al. (2011) · Science

Hemoglobinopathies and Related DisordersHemoglobin structure and function

Cited by 326

CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells

Kim, J., Hu, Z., Cai, L., Li, K., Choi, E., Faubert, B., Bezwada, D., Rodriguez-Canales, J., Villalobos, P., Lin, Y.-F., et al. (2017) · Nature

Biochemical and Molecular ResearchCancer, Hypoxia, and Metabolism

Cited by 325

Dissecting super-enhancer hierarchy based on chromatin interactions

Huang, J., Li, K., Cai, W., Liu, X., Zhang, Y., Orkin, S. H., Xu, J., & Yuan, G.-C. (2018) · Nature Communications

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 241

Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A

Xu, J., Bauer, D. E., Kerenyi, M. A., Vo, T. D., Hou, S., Hsu, Y.-J., Yao, H., Trowbridge, J. J., Mandel, G., & Orkin, S. H. (2013) · Proceedings of the National Academy of Sciences

Hemoglobinopathies and Related DisordersHemoglobin structure and function

Cited by 233

Loss of EZH2 Reprograms BCAA Metabolism to Drive Leukemic Transformation

Gu, Z., Liu, Y., Cai, F., Patrick, M., Zmajkovic, J., Cao, H., Zhang, Y., Tasdogan, A., Chen, M., Qi, L., et al. (2019) · Cancer Discovery

Acute Myeloid Leukemia ResearchEpigenetics and DNA Methylation

Cited by 173

Suppression of the SWI/SNF Component Arid1a Promotes Mammalian Regeneration

Sun, X., Chuang, J.-C., Kanchwala, M., Wu, L., Celen, C., Li, L., Liang, H., Zhang, S., Maples, T., Nguyen, L. H., et al. (2016) · Cell Stem Cell

Liver physiology and pathologyChromatin Remodeling and Cancer

Cited by 161

Epigenetic characterization of hematopoietic stem cell differentiation using miniChIP and bisulfite sequencing analysis

Attema, J. L., Papathanasiou, P., Forsberg, E. C., Xu, J., Smale, S. T., & Weissman, I. L. (2007) · Proceedings of the National Academy of Sciences

Epigenetics and DNA MethylationHematopoietic Stem Cell Transplantation

Cited by 134

Blocking LAIR1 signaling in immune cells inhibits tumor development

Xie, J., Gui, X., Deng, M., Chen, H., Chen, Y., Liu, X., Ku, Z., Tan, L., Huang, R., He, Y., et al. (2022) · Frontiers in Immunology

Cancer Immunotherapy and BiomarkersImmune Cell Function and Interaction

Cited by 36

Synthetic ZFTA fusions pinpoint disordered protein domain acquisition as a mechanism of brain tumorigenesis

Arabzade, A., Shirnekhi, H. K., Varadharajan, S., Ippagunta, S. M., Phillips, A. H., Laboe, N., Baggett, D. W., Wahiduzzaman, Jo, M., Zheng, T., et al. (2025) · Nature Cell Biology

Genomics and Chromatin DynamicsGlioma Diagnosis and Treatment

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