Brites, Dora

Microglia states and nomenclature: A field at its crossroads

Paolicelli, R. C., Sierra, A., Stevens, B., Tremblay, M.-E., Aguzzi, A., Ajami, B., Amit, I., Audinat, E., Bechmann, I., Bennett, M., et al. (2022) · Neuron

Neuroinflammation and Neurodegeneration MechanismsNeurogenesis and neuroplasticity mechanisms

Cited by 1,973

Neuroinflammation and Depression: Microglia Activation, Extracellular Microvesicles and microRNA Dysregulation

Brites, D., & Fernandes, A. (2015) · Frontiers in Cellular Neuroscience

Neuroinflammation and Neurodegeneration MechanismsTryptophan and brain disorders

Cited by 599

Polyphenols journey through blood-brain barrier towards neuronal protection

Figueira, I., Garcia, G., Pimpão, R. C., Terrasso, A. P., Costa, I., Almeida, A. F., Tavares, L., Pais, T. F., Pinto, P., Ventura, M. R., et al. (2017) · Scientific Reports

Phytochemicals and Antioxidant ActivitiesBarrier Structure and Function Studies

Cited by 290

Microglia change from a reactive to an age-like phenotype with the time in culture

Caldeira, C., Oliveira, A. F., Cunha, C., Vaz, A. R., Falcão, A. S., Fernandes, A., & Brites, D. (2014) · Frontiers in Cellular Neuroscience

Neuroinflammation and Neurodegeneration MechanismsNeurological Disease Mechanisms and Treatments

Cited by 156

Exploring New Inflammatory Biomarkers and Pathways during LPS-Induced M1 Polarization

Cunha, C., Gomes, C., Vaz, A. R., & Brites, D. (2016) · Mediators of Inflammation

Neuroinflammation and Neurodegeneration MechanismsInflammasome and immune disorders

Cited by 153

Exosomes from NSC-34 Cells Transfected with hSOD1-G93A Are Enriched in miR-124 and Drive Alterations in Microglia Phenotype

Pinto, S., Cunha, C., Barbosa, M., Vaz, A. R., & Brites, D. (2017) · Frontiers in Neuroscience

Extracellular vesicles in diseaseAmyotrophic Lateral Sclerosis Research

Cited by 135

Key Aging-Associated Alterations in Primary Microglia Response to Beta-Amyloid Stimulation

Caldeira, C., Cunha, C., Vaz, A. R., Falcão, A. S., Barateiro, A., Seixas, E., Fernandes, A., & Brites, D. (2017) · Frontiers in Aging Neuroscience

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 117

Systemic inflammation in early neonatal mice induces transient and lasting neurodegenerative effects

Cardoso, F. L., Herz, J., Fernandes, A., Rocha, J., Sepodes, B., Brito, M. A., McGavern, D. B., & Brites, D. (2015) · Journal of Neuroinflammation

Neuroinflammation and Neurodegeneration MechanismsNeonatal and fetal brain pathology

Cited by 103

Human iPSC-Derived Hippocampal Spheroids: An Innovative Tool for Stratifying Alzheimer Disease Patient-Specific Cellular Phenotypes and Developing Therapies

Pomeshchik, Y., Klementieva, O., Gil, J., Martinsson, I., Hansen, M. G., de Vries, T., Sancho-Balsells, A., Russ, K., Savchenko, E., Collin, A., et al. (2020) · Stem Cell Reports

Alzheimer's disease research and treatmentsPluripotent Stem Cells Research

Cited by 95

Secretome from SH-SY5Y APPSwe cells trigger time-dependent CHME3 microglia activation phenotypes, ultimately leading to miR-21 exosome shuttling

Fernandes, A., Ribeiro, A. R., Monteiro, M., Garcia, G., Vaz, A. R., & Brites, D. (2018) · Biochimie

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 93

Cortical neurotoxic astrocytes with early ALS pathology and miR-146a deficit replicate gliosis markers of symptomatic SOD1G93A mouse model

Gomes, C., Cunha, C., Nascimento, F., Ribeiro, J. A., Vaz, A. R., & Brites, D. (2019) · Molecular Neurobiology

Amyotrophic Lateral Sclerosis ResearchNeuroinflammation and Neurodegeneration Mechanisms

Cited by 79

Phenotypic Effects of Wild-Type and Mutant SOD1 Expression in N9 Murine Microglia at Steady State, Inflammatory and Immunomodulatory Conditions

Vaz, A. R., Pinto, S., Ezequiel, C., Cunha, C., Carvalho, L. A., Moreira, R., & Brites, D. (2019) · Frontiers in Cellular Neuroscience

Neuroinflammation and Neurodegeneration MechanismsAmyotrophic Lateral Sclerosis Research

Cited by 55

Emerging Role of miR-21-5p in Neuron–Glia Dysregulation and Exosome Transfer Using Multiple Models of Alzheimer’s Disease

Garcia, G., Pinto, S., Ferreira, S., Lopes, D., Serrador, M. J., Fernandes, A., Vaz, A. R., Mendonça, A. D., Edenhofer, F., Malm, T., et al. (2022) · Cells

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 55

Challenges in the Development of Drug Delivery Systems Based on Small Extracellular Vesicles for Therapy of Brain Diseases

Loch-Neckel, G., Matos, A. T., Vaz, A. R., & Brites, D. (2022) · Frontiers in Pharmacology

Extracellular vesicles in diseaseNanoparticle-Based Drug Delivery

Cited by 46

Neuronal Dynamics and miRNA Signaling Differ between SH-SY5Y APPSwe and PSEN1 Mutant iPSC-Derived AD Models upon Modulation with miR-124 Mimic and Inhibitor

Garcia, G., Pinto, S., Cunha, M., Fernandes, A., Koistinaho, J., & Brites, D. (2021) · Cells

Alzheimer's disease research and treatmentsMicroRNA in disease regulation

Cited by 39

Protective Signature of IFNγ-Stimulated Microglia Relies on miR-124-3p Regulation From the Secretome Released by Mutant APP Swedish Neuronal Cells

Garcia, G., Fernandes, A., Stein, F., & Brites, D. (2022) · Frontiers in Pharmacology

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 32

Intrathecal Injection of the Secretome from ALS Motor Neurons Regulated for miR-124 Expression Prevents Disease Outcomes in SOD1-G93A Mice

Barbosa, M., Santos, M., de Sousa, N., Duarte-Silva, S., Vaz, A. R., Salgado, A. J., & Brites, D. (2022) · Biomedicines

Amyotrophic Lateral Sclerosis ResearchNeurogenetic and Muscular Disorders Research

Cited by 14