Cortical neurotoxic astrocytes with early ALS pathology and miR-146a deficit replicate gliosis markers of symptomatic SOD1G93A mouse model
Abstract
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by motor neuron (MN) loss. Recent evidences highlight astrocytes as important players in MN death, but the mechanism-based neurotoxicity is still unknown. It is also unclear whether activation of astrocytes in ALS occurs differently in the cerebral cortex and spinal cord. We investigated glial and neuronal alterations in the cortex of SOD1G93A (mSOD1) mice in pre-symptomatic and symptomatic stages. We also characterized astrocytes isolated from the cortex of 7-day-old mSOD1 mice for their aberrancy and MN-induced degenerative effects. In the early stage, we identified a reduction of cell proliferation, NF-kB expression, and of vimentin and micro(miR)-146a expression, suggesting a restrained cortical inflammatory status. However, increased NF-kB expression, cell proliferation, and gene expression of HMGB1, connexin 43 and S100B were distinctive of the symptomatic stage, together with MN loss, downregulated unfold protein response, and decreased expression of synaptic proteins, together with that of miR-125b, miR-21, miR-146a, GFAP, and glutamate transporters. Astrocytes cultured for 13 days in vitro showed comparable NF-kB expression and cell proliferation increase, as well as similar microRNA and gene/protein expression profiles (decreased miR-21, miR-146a, GLT-1 and GFAP, and upregulated HMGB1, S100B and connexin-43), thus sustaining astrocytes as the major contributors of cortical homeostasis deregulation in the symptomatic stage. These reactive astrocytes reduced neurite length and synaptophysin expression in NSC-34/hSOD1WT MN-like cells, and induced mitochondria dysfunction, PSD-95 downregulation, metalloproteinase-9 activation, and late apoptosis in NSC-34/hSOD1G93A cells. Data indicate that astrocytes in mSOD1 mice model acquire early phenotypic aberrancies and highlight downregulated miR-146a as a biomarker and drug target in ALS.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Cortical astrocytes isolated from SOD1G93A mouse model in the early stages of the disease exhibit neuroprotective features, with reduced cell proliferation, low expression of NF-κB and miR-146a, and weakened pro-inflammatory pathways, indicating impaired immune function in ALS patients.
“Gomes et al. (96) found that cortical astrocytes isolated from SOD1G93A mouse model in the early stages of the disease exhibited neuroprotective features, with reduced cell proliferation, low expression of NF-κB and micro(miR)-146a, and weakened pro-inflammatory pathways, indicating impaired immune function in ALS patients.”
From Modulation of the gut–brain axis via the gut microbiota: a new era in treatment of amyotrophic lateral sclerosis (2023) · cites this paper as [96]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Rosen, D. R., Siddique, T., Patterson, D., Figlewicz, D. A., Sapp, P., Hentati, A., Donaldson, D., Goto, J., O'Regan, J. P., Deng, H.-X., et al. (1993) · Nature · doi:10.1038/362059a0 · Cited by 7,062 · see citing works
Taganov, K. D., Boldin, M. P., Chang, K.-J., & Baltimore, D. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605298103 · Cited by 4,317 · see citing works
Motor Neuron Degeneration in Mice that Express a Human Cu,Zn Superoxide Dismutase Mutation
Gurney, M. E., Pu, H., Chiu, A. Y., Dal Canto, M. C., Polchow, C. Y., Alexander, D. D., Caliendo, J., Hentati, A., Kwon, Y. W., Deng, H.-X., et al. (1994) · Science · doi:10.1126/science.8209258 · Cited by 4,143 · see citing works
Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons
Nagai, M., Re, D. B., Nagata, T., Chalazonitis, A., Jessell, T. M., Wichterle, H., & Przedborski, S. (2007) · Nature Neuroscience · doi:10.1038/nn1876 · Cited by 1,220 · see citing works
The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression
B’chir, W., Maurin, A.-C., Carraro, V., Averous, J., Jousse, C., Muranishi, Y., Parry, L., Stepien, G., Fafournoux, P., & Bruhat, A. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt563 · Cited by 1,162 · see citing works
Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis
Yamanaka, K., Chun, S. J., Boillee, S., Fujimori-Tonou, N., Yamashita, H., Gutmann, D. H., Takahashi, R., Misawa, H., & Cleveland, D. W. (2008) · Nature Neuroscience · doi:10.1038/nn2047 · Cited by 1,140 · see citing works
Wild-Type Nonneuronal Cells Extend Survival of SOD1 Mutant Motor Neurons in ALS Mice
Clement, A. M., Nguyen, M. D., Roberts, E. A., Garcia, M. L., Boillée, S., Rule, M., McMahon, A. P., Doucette, W. T., Siwek, D. F., Ferrante, R. J., et al. (2003) · Science · doi:10.1126/science.1086071 · Cited by 1,101 · see citing works
Rosen, D. (1993) · Nature · doi:10.1038/364362c0 · Cited by 922 · see citing works
NF-kappaB Signaling Pathways in Neurological Inflammation: A Mini Review
Shih, R., Wang, C.-Y., & Yang, C. (2015) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2015.00077 · Cited by 912 · see citing works
Astrocytes from familial and sporadic ALS patients are toxic to motor neurons
Haidet-Phillips, A. M., Hester, M. E., Miranda, C. J., Meyer, K., Braun, L., Frakes, A., Song, S., Likhite, S., Murtha, M. J., Foust, K. D., et al. (2011) · Nature Biotechnology · doi:10.1038/nbt.1957 · Cited by 782 · see citing works
Microglia Induce Motor Neuron Death via the Classical NF-κB Pathway in Amyotrophic Lateral Sclerosis
Frakes, A. E., Ferraiuolo, L., Haidet-Phillips, A. M., Schmelzer, L., Braun, L., Miranda, C. J., Ladner, K. J., Bevan, A. K., Foust, K. D., Godbout, J. P., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.01.013 · Cited by 638 · see citing works
Requirement for the Homeobox Gene Hb9 in the Consolidation of Motor Neuron Identity
Arber, S., Han, B., Mendelsohn, M. M., Smith, M., Jessell, T. M., & Sockanathan, S. (1999) · Neuron · doi:10.1016/s0896-6273(01)80026-x · Cited by 607 · see citing works
A role for motoneuron subtype–selective ER stress in disease manifestations of FALS mice
Saxena, S., Cabuy, E., & Caroni, P. (2009) · Nature Neuroscience · doi:10.1038/nn.2297 · Cited by 600 · see citing works
Ma, X., Buscaglia, L. E. B., Barker, J. R., & Li, Y. (2011) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjr007 · Cited by 582 · see citing works
Saxena, S., & Caroni, P. (2011) · Neuron · doi:10.1016/j.neuron.2011.06.031 · Cited by 561 · see citing works
Elusive roles for reactive astrocytes in neurodegenerative diseases
Ben Haim, L., Carrillo-de Sauvage, M.-A., Ceyzériat, K., & Escartin, C. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00278 · Cited by 453 · see citing works
Atomic structure and chemistry of human serum albumin
He, X. M., & Carter, D. C. (1993) · Nature · doi:10.1038/364362b0 · Cited by 415 · see citing works
Kaltschmidt, B., & Kaltschmidt, C. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a001271 · Cited by 392 · see citing works
Kim, H., Raphael, A. R., LaDow, E., McGurk, L., Weber, R. A., Trojanowski, J. Q., Lee, V. M. ‐., Finkbeiner, S. M., Gitler, A. D., & Bonini, N. M. (2013) · Nature Genetics · doi:10.1038/ng.2853 · Cited by 370 · see citing works
Butovsky, O., Jedrychowski, M. P., Cialic, R., Krasemann, S., Murugaiyan, G., Fanek, Z., Greco, D. J., Wu, P. M., Doykan, C. E., Kiner, O., et al. (2015) · Annals of Neurology · doi:10.1002/ana.24304 · Cited by 358 · see citing works
Meyer, K., Ferraiuolo, L., Miranda, C. J., Likhite, S., McElroy, S., Renusch, S., Ditsworth, D., Lagier-Tourenne, C., Smith, R. A., Ravits, J., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1314085111 · Cited by 345 · see citing works
Cardoso, A. L., Guedes, J. R., Pereira de Almeida, L., & Pedroso de Lima, M. C. (2012) · Immunology · doi:10.1111/j.1365-2567.2011.03514.x · Cited by 336 · see citing works
MicroRNA-146a: A Key Regulator of Astrocyte-Mediated Inflammatory Response
Iyer, A., Zurolo, E., Prabowo, A., Fluiter, K., Spliet, W. G. M., van Rijen, P. C., Gorter, J. A., & Aronica, E. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044789 · Cited by 330 · see citing works
Neuronal Matrix Metalloproteinase-9 Is a Determinant of Selective Neurodegeneration
Kaplan, A., Spiller, K. J., Towne, C. L., Kanning, K. C., Choe, G. T., Geber, A. B., Akay, T., Aebischer, P., & Henderson, C. E. (2014) · Neuron · doi:10.1016/j.neuron.2013.12.009 · Cited by 309 · see citing works
Foran, E., & Trotti, D. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2444 · Cited by 300 · see citing works
MicroRNA-125b Promotes Neuronal Differentiation in Human Cells by Repressing Multiple Targets
Le, M. T. N., Xie, H., Zhou, B., Chia, P. H., Rizk, P., Um, M., Udolph, G., Yang, H. H., Lim, B., & Lodish, H. F. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01694-08 · Cited by 288 · see citing works
Oligodendrocyte dysfunction in the pathogenesis of amyotrophic lateral sclerosis
Philips, T., Bento‐Abreu, A., Nonneman, A., Haeck, W., Staats, K. A., Geelen, V., Hersmus, N., Küsters, B., Bosch, L. V. D., Damme, P. V., et al. (2013) · Brain · doi:10.1093/brain/aws339 · Cited by 261 · see citing works
Method for widespread microRNA-155 inhibition prolongs survival in ALS-model mice
Koval, E. D., Shaner, C., Zhang, P., du Maine, X., Fischer, K., Tay, J., Chau, B. N., Wu, G. F., & Miller, T. M. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt261 · Cited by 236 · see citing works
The Role of Immune and Inflammatory Mechanisms in ALS
McCombe, P., & Henderson, R. D. (2011) · Current Molecular Medicine · doi:10.2174/156652411795243450 · Cited by 234 · see citing works
MicroRNA-21 Regulates Astrocytic Response Following Spinal Cord Injury
Bhalala, O. G., Pan, L., Sahni, V., McGuire, T. L., Gruner, K., Tourtellotte, W. G., & Kessler, J. A. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.3860-12.2012 · Cited by 220 · see citing works
Papadeas, S. T., Kraig, S. E., O'Banion, C., Lepore, A. C., & Maragakis, N. J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1103141108 · Cited by 213 · see citing works
Forsberg, K., Andersen, P. M., Marklund, S. L., & Brännström, T. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0805-3 · Cited by 200 · see citing works
Toll-like receptor signaling in amyotrophic lateral sclerosis spinal cord tissue
Casula, M., Iyer, A. M., Spliet, W. G. M., Anink, J. J., Steentjes, K., Sta, M., Troost, D., & Aronica, E. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.02.001 · Cited by 200 · see citing works
Liu, Z., Li, Y., Cui, Y., Roberts, C. J., Lü, M., Wilhelmsson, U., Pekny, M., & Chopp, M. (2014) · Glia · doi:10.1002/glia.22723 · Cited by 200 · see citing works
Wang, Q., Johnson, J. L., Agar, N. Y. R., & Agar, J. N. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060170 · Cited by 198 · see citing works
Wang, J., Xu, G. M., & Borchelt, D. (2002) · Neurobiology of Disease · doi:10.1006/nbdi.2001.0471 · Cited by 196 · see citing works
HMGB1 in Development and Diseases of the Central Nervous System
Fang, P., Schachner, M., & Shen, Y.-Q. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8264-y · Cited by 193 · see citing works
Common molecular signature in SOD1 for both sporadic and familial amyotrophic lateral sclerosis
Gruzman, A., Wood, W. L., Alpert, E., Prasad, M. D., Miller, R. G., Rothstein, J. D., Bowser, R. P., Hamilton, R. L., Wood, T. D., Cleveland, D. W., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705044104 · Cited by 190 · see citing works
MicroRNAs and neurodegeneration: role and impact
Abe, M., & Bonini, N. M. (2013) · Trends in Cell Biology · doi:10.1016/j.tcb.2012.08.013 · Cited by 190 · see citing works
Oligodendrocytes contribute to motor neuron death in ALS via SOD1-dependent mechanism
Ferraiuolo, L., Meyer, K., Sherwood, T. W., Vick, J. S., Likhite, S. B., Frakes, A., Miranda, C. J., Braun, L., Heath, P. R., Pineda, R., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1607496113 · Cited by 189 · see citing works
Díaz‐Amarilla, P., Olivera‐Bravo, S., Trías, E., Cragnolini, A. B., Palma, L. M., Cassina, P., Beckman, J. S., & Barbeito, L. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1110689108 · Cited by 186 · see citing works
SOD1 Function and Its Implications for Amyotrophic Lateral Sclerosis Pathology
Bunton-Stasyshyn, R. K. A., Saccon, R. A., Fratta, P., & Fisher, E. (2014) · The Neuroscientist · doi:10.1177/1073858414561795 · Cited by 180 · see citing works
MicroRNA-146a Inhibits Glioma Development by Targeting Notch1
Mei, J., Bachoo, R. M., & Zhang, C. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.05821-11 · Cited by 170 · see citing works
Rocha, M. C., Pousinha, P. A., Correia, A. M., Sebastião, A. M., & Ribeiro, J. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073846 · Cited by 165 · see citing works
Self-citationIntermediate filaments regulate astrocyte motility
Lepekhin, E. A., Eliasson, C., Berthold, C., Berezin, V., Bock, E., & Pekny, M. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00595.x · Cited by 164 · see citing works
Campos‐Melo, D., Droppelmann, C. A., He, Z., Volkening, K., & Strong, M. J. (2013) · Molecular Brain · doi:10.1186/1756-6606-6-26 · Cited by 160 · see citing works
Parisi, C., Arisi, I., D’Ambrosi, N., Storti, A. E., Brandi, R., D’Onofrio, M., & Volonté, C. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.491 · Cited by 153 · see citing works
Intricate interplay between astrocytes and motor neurons in ALS
Phatnani, H. P., Guarnieri, P., Friedman, B. A., Carrasco, M. A., Muratet, M. A., O’Keeffe, S., Nwakeze, C. L., Pauli, F., Newberry, K. M., Meadows, S. K., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1222361110 · Cited by 146 · see citing works
Strickland, E. R., Hook, M. A., Balaraman, S., Huie, J. R., Grau, J. W., & Miranda, R. C. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.03.063 · Cited by 145 · see citing works
Thomsen, G. M., Gowing, G., Latter, J., Chen, M., Vit, J., Staggenborg, K., Avalos, P., Alkaslasi, M. R., Ferraiuolo, L., Likhite, S. B., et al. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.2037-14.2014 · Cited by 137 · see citing works
Connexin 43 in astrocytes contributes to motor neuron toxicity in amyotrophic lateral sclerosis
Almad, A. A., Doreswamy, A., Gross, S. K., Richard, J., Huo, Y., Haughey, N. J., & Maragakis, N. J. (2016) · Glia · doi:10.1002/glia.22989 · Cited by 137 · see citing works
Astrocytes in mouse models of tauopathies acquire early deficits and lose neurosupportive functions
Sidoryk‐Wȩgrzynowicz, M., Gerber, Y. N., Ries, M., Sastre, M., Tolkovsky, A. M., & Spillantini, M. G. (2017) · Acta Neuropathologica Communications · doi:10.1186/s40478-017-0478-9 · Cited by 137 · see citing works
Luan, Z., Zhang, H., Yang, P., Ma, X., Zhang, C., & Guo, R.-X. (2010) · Immunobiology · doi:10.1016/j.imbio.2009.11.001 · Cited by 132 · see citing works
Selective Proinflammatory Activation of Astrocytes by High-Mobility Group Box 1 Protein Signaling
Pedrazzi, M., Patrone, M., Passalacqua, M., Ranzato, E., Colamassaro, D., Sparatore, B., Pontremoli, S., & Melloni, E. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.12.8525 · Cited by 132 · see citing works
Reactive astrocytes are widespread in the cortical gray matter of amyotrophic lateral sclerosis
Nagy, D., Kato, T., & Kushner, P. D. (1994) · Journal of Neuroscience Research · doi:10.1002/jnr.490380312 · Cited by 131 · see citing works
Savioz, A., Leuba, G., & Vallet, P. G. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2014.09.004 · Cited by 127 · see citing works
Sporadic ALS Astrocytes Induce Neuronal Degeneration In Vivo
Qian, K. X., Huang, H., Peterson, A., Hu, B., Maragakis, N. J., Ming, G., Chen, H., & Zhang, S. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.03.003 · Cited by 123 · see citing works
Tripathi, P., Rodriguez-Muela, N., Klim, J. R., de Boer, A. S., Agrawal, S., Sandoe, J., Lopes, C. S., Ogliari, K. S., Williams, L. A., Shear, M., et al. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.06.008 · Cited by 123 · see citing works
Pasini, S., Corona, C., Liu, J., Greene, L. A., & Shelanski, M. L. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.03.025 · Cited by 116 · see citing works
Pfohl, S. R., Halicek, M. T., & Mitchell, C. S. (2015) · Journal of Neuromuscular Diseases · doi:10.3233/jnd-140068 · Cited by 114 · see citing works
MicroRNA miR124 is required for the expression of homeostatic synaptic plasticity
Hou, Q., Ruan, H., Gilbert, J. P., Wang, G., Ma, Q., Yao, W., & Man, H. (2015) · Nature Communications · doi:10.1038/ncomms10045 · Cited by 103 · see citing works
An enhanced integrated stress response ameliorates mutant SOD1-induced ALS
Wang, L., Popko, B., & Roos, R. P. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt658 · Cited by 101 · see citing works
Matus, S., López, E., Valenzuela, V., Nassif, M., & Hetz, C. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066672 · Cited by 96 · see citing works
Apical dendrite degeneration, a novel cellular pathology for Betz cells in ALS
Genç, B., Jara, J. H., Lagrimas, A. K. B., Pytel, P., Roos, R. P., Mesulam, M. M., Geula, C., Bigio, E. H., & Özdi̇nler, P. H. (2017) · Scientific Reports · doi:10.1038/srep41765 · Cited by 87 · see citing works
Tian, R., Wu, X., Hagemann, T. L., Sosunov, A. A., Messing, A., McKhann, G. M., & Goldman, J. E. (2010) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181d3cb52 · Cited by 86 · see citing works
The neurobiology of amyotrophic lateral sclerosis
Bento‐Abreu, A., Damme, P. V., Bosch, L. V. D., & Robberecht, W. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07260.x · Cited by 85 · see citing works
Cunha, C., Santos, C., Gomes, C., Fernandes, A. M. A., Correia, A. M., Sebastião, A. M., Vaz, A. R., & Brites, D. M. T. O. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0631-2 · Cited by 85 · see citing works
Self-citationZhang, Q., Qing, Y., Yin, C., Zhou, L., Liu, X., Mi, Q., & Zhou, J. (2018) · Arthritis Research & Therapy · doi:10.1186/s13075-018-1546-7 · Cited by 81 · see citing works
Neuromuscular effects of G93A-SOD1 expression in zebrafish
Sakowski, S. A., Lunn, J. S., Busta, A. S., Oh, S. S., Zamora-Berridi, G. J., Palmer, M., Rosenberg, A. A., Philip, S. G., Dowling, J. J., & Feldman, E. L. (2012) · Molecular Neurodegeneration · doi:10.1186/1750-1326-7-44 · Cited by 76 · see citing works
Role of Gap Junction Protein Connexin43 in Astrogliosis Induced by Brain Injury
Theodoric, N., Bechberger, J. F., Naus, C. C. G., & Sin, W. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047311 · Cited by 76 · see citing works
Nikodémová, M., Small, A. L., Smith, S. M. C., Mitchell, G. S., & Watters, J. J. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.11.009 · Cited by 74 · see citing works
Benigni, M., Ricci, C., Jones, A. R., Giannini, F., Al‐Chalabi, A., & Battistini, S. (2016) · NeuroMolecular Medicine · doi:10.1007/s12017-016-8396-8 · Cited by 74 · see citing works
Crosio, C., Valle, C., Casciati, A., Iaccarino, C., & Carrı̀, M. T. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017187 · Cited by 72 · see citing works
Astrocyte-produced miR-146a as a mediator of motor neuron loss in spinal muscular atrophy
Sison, S. L., Patitucci, T. N., Seminary, E. R., Villalón, E., Lorson, C. L., & Ebert, A. D. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx230 · Cited by 71 · see citing works
Yip, P. K., Pizzasegola, C., Gladman, S. J., Biggio, M. L., Marino, M., Jayasinghe, M., Ullah, F., Dyall, S. C., Malaspina, A., Bendotti, C., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061626 · Cited by 69 · see citing works
Kamo, H., HAEBARA, H., Akiguchi, I., Kameyama, M., Kimura, H., & McGeer, P. L. (1987) · Acta Neuropathologica · doi:10.1007/bf00688335 · Cited by 67 · see citing works
Quiroz, J. F. D., Tsai, E. C., Coyle, M. J., Sehm, T., & Echeverri, K. (2014) · Disease Models & Mechanisms · doi:10.1242/dmm.014837 · Cited by 65 · see citing works
Zhou, F., Zhang, C., Guan, Y., Chen, Y., Lü, Q., Jie, L., Gao, H., Du, H., Zhang, H., Liu, Y., et al. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.14229 · Cited by 64 · see citing works
Astrocyte–neuron co-culture on microchips based on the model of SOD mutation to mimic ALS
Kunze, A., Lengacher, S., Dirren, E., Aebischer, P., Magistretti, P. J., & Renaud, P. (2013) · Integrative Biology · doi:10.1039/c3ib40022k · Cited by 61 · see citing works
One Function—Multiple Mechanisms: The Manifold Activities of p53 as a Transcriptional Repressor
Böhlig, L., & Rother, K. (2011) · BioMed Research International · doi:10.1155/2011/464916 · Cited by 58 · see citing works
Vaz, A. R., Cunha, C., Gomes, C., Schmucki, N., Barbosa, M., & Brites, D. M. T. O. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8731-8 · Cited by 57 · see citing works
Self-citationRegulation of the Mammalian Nervous System by MicroRNAs
Zeng, Y. (2008) · Molecular Pharmacology · doi:10.1124/mol.108.052118 · Cited by 53 · see citing works
Coco, D. L., Veglianese, P., Allievi, E., & Bendotti, C. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.10.063 · Cited by 52 · see citing works
Baker, D. J., Blackburn, D. J., Keatinge, M., Sokhi, D. S., Viskaitis, P., Heath, P. R., Ferraiuolo, L., Kirby, J., & Shaw, P. J. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00410 · Cited by 46 · see citing works
MicroRNAs: Newcomers into the ALS Picture
Volonté, C., Apolloni, S., & Parisi, C. (2015) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527314666150116125506 · Cited by 42 · see citing works
Serrano, A., Donno, C., Giannetti, S., Perić, M., Anđjus, P. R., D’Ambrosi, N., & Michetti, F. (2017) · Mediators of Inflammation · doi:10.1155/2017/1626204 · Cited by 39 · see citing works
Nascimento, F., Pousinha, P. A., Correia, A. M., Gomes, R., Sebastião, A. M., & Ribeiro, J. A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104081 · Cited by 36 · see citing works
Self-citationSynaptic Failure: Focus in an Integrative View of ALS
Casas, C., Manzano, R., Vaz, A. R., Osta, R., & Brites, D. M. T. O. (2015) · Brain Plasticity · doi:10.3233/bpl-140001 · Cited by 36 · see citing works
Self-citationAstrocyte reactivity to unconjugated bilirubin requires TNF‐α and IL‐1β receptor signaling pathways
Fernandes, A. M. A., Barateiro, A. P., Falcão, A. S., Silva, S. L., Vaz, A. R., Brito, M. A., Silva, R. F. M., & Brites, D. M. T. O. (2010) · Glia · doi:10.1002/glia.21072 · Cited by 35 · see citing works
Self-citationSignificance of aberrant glial cell phenotypes in pathophysiology of amyotrophic lateral sclerosis
Trías, E., Ibarburu, S., Barreto‐Núñez, R., & Barbeito, L. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.07.052 · Cited by 34 · see citing works
Synaptophysin in spinal anterior horn in aging and ALS: an immunohistological study
Cruz-Sánchez, F. F., Moral, A., Rossi, M. L., Quintó, L., Castejon, C., TOLOSA, E. S., & de Belleroche, J. (1996) · Journal of Neural Transmission · doi:10.1007/bf01271192 · Cited by 29 · see citing works
LI, M., Sun, L., Luo, Y., Xie, C., Pang, Y., & LI, Y. (2014) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2014.1820 · Cited by 26 · see citing works
NF- B in the Nervous SystemPreprint
Kaltschmidt, B., & Kaltschmidt, C. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a001271_erratum · Cited by 25 · see citing works
Yoshii, Y., Otomo, A., Pan, L., Ohtsuka, M., & Hadano, S. (2011) · Neuroscience Research · doi:10.1016/j.neures.2011.03.006 · Cited by 23 · see citing works
The Unfolded Protein Response Induced by Salt Stress in Arabidopsis
Wang, M., Xu, Q., & Yuan, M. (2011) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/b978-0-12-385116-1.00018-2 · Cited by 19 · see citing works
LPS-Primed Release of HMGB-1 from Cortical Astrocytes is Modulated Through PI3K/AKT Pathway
Xie, Z., Xin, G., Xu, Y., Su, Y., & Li, K. (2015) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-015-0223-5 · Cited by 15 · see citing works
Lakatos, A. (2017) · Neural Regeneration Research · doi:10.4103/1673-5374.198977 · Cited by 3 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Going the Extra (Synaptic) Mile: Excitotoxicity as the Road Toward Neurodegenerative Diseases
Armada‐Moreira, A., Gomes, J. I., Pina, C. C., Savchak, O. K., Gonçalves‐Ribeiro, J., Rei, N., Pinto, S., Morais, T. P., Martins, R. S., Ribeiro, F. F., et al. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00090 · Cited by 323 · see citing works
Gasdermin-E mediates mitochondrial damage in axons and neurodegeneration
Neel, D. V., Basu, H., Gunner, G., Bergstresser, M., Giadone, R. M., Chung, H., Miao, R., Chou, V., Brody, E. M., Jiang, X., et al. (2023) · Neuron · doi:10.1016/j.neuron.2023.02.019 · Cited by 139 · see citing works
Fan, W., Liang, C., Ou, M., Zou, T., Sun, F., Zhou, H., & Cui, L. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.00090 · Cited by 109 · see citing works
Zhang, J., Li, P., Zhao, G., He, S., Xu, D., Jiang, W., Peng, Q., Li, Z., Xie, Z., Zhang, H., et al. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-03100-x · Cited by 87 · see citing works
Glial Cells—The Strategic Targets in Amyotrophic Lateral Sclerosis Treatment
Filipi, T., Heřmanová, Z., Turečková, J., Vaňátko, O., & Anděrová, M. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9010261 · Cited by 74 · see citing works
Provenzano, F., Torazza, C., Bonifacino, T., Bonanno, G., & Milanese, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242015430 · Cited by 74 · see citing works
Alarmins and c-Jun N-Terminal Kinase (JNK) Signaling in Neuroinflammation
Anfinogenova, Y., Quinn, M. T., Schepetkin, I. A., & Atochin, D. N. (2020) · Cells · doi:10.3390/cells9112350 · Cited by 67 · see citing works
Michetti, F., Sante, G. D., Clementi, M. E., Sampaolese, B., Casalbore, P., Volonté, C., Spica, V. R., Parnigotto, P. P., Liddo, R. D., Amadio, S., et al. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.04.035 · Cited by 56 · see citing works
Barbosa, M., Gomes, C., Sequeira, C., Gonçalves‐Ribeiro, J., Pina, C. C., Carvalho, L. A. R., Moreira, R., Vaz, S. H., Vaz, A. R., & Brites, D. M. T. O. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.634355 · Cited by 55 · see citing works
Self-citationThe Biogenesis of miRNAs and Their Role in the Development of Amyotrophic Lateral Sclerosis
Liu, J., Zhou, F., Guan, Y., Meng, F., Zhao, Z., Su, Q., Bao, W., Wang, X., Zhao, J., Huo, Z., et al. (2022) · Cells · doi:10.3390/cells11030572 · Cited by 49 · see citing works
Overexpression of miR-124 in Motor Neurons Plays a Key Role in ALS Pathological Processes
Vaz, A. R., Vizinha, D., Morais, H. M. M., Colaço, A. R. A., Loch-Neckel, G., Barbosa, M., & Brites, D. M. T. O. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22116128 · Cited by 45 · see citing works
Self-citationLoch-Neckel, G., Matos, A. T., Vaz, A. R., & Brites, D. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.839790 · Cited by 46 · see citing works
Self-citationZhao, Z., Fu, J., Li, S., & Li, Z. (2019) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-019-09866-x · Cited by 45 · see citing works
Provenzano, F., Nyberg, S., Giunti, D., Torazza, C., Parodi, B., Bonifacino, T., Usai, C., de Rosbo, N. K., Milanese, M., Uccelli, A., et al. (2022) · Cells · doi:10.3390/cells11233923 · Cited by 45 · see citing works
Gomes, C., VanderWall, K. B., Pan, Y., Lu, X., Lavekar, S. S., Huang, K.-C., Fligor, C. M., Harkin, J., Zhang, C., Cummins, T., et al. (2022) · Stem Cell Reports · doi:10.1016/j.stemcr.2022.05.006 · Cited by 39 · see citing works
Self-citationHong, D., Zhang, C., Wu, W., Lu, X., & Zhang, L. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1133546 · Cited by 38 · see citing works
Astrocytes in Neurodegeneration: Inspiration From Genetics
Huang, J., Li, C., & Shang, H. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.882316 · Cited by 37 · see citing works
Aslani, M., Mortazavi‐Jahromi, S. S., & Mirshafiey, A. (2021) · Immunology Letters · doi:10.1016/j.imlet.2021.07.004 · Cited by 36 · see citing works
Gomes, C., Sequeira, C., Barbosa, M., Cunha, C., Vaz, A. R., & Brites, D. M. T. O. (2020) · Experimental Cell Research · doi:10.1016/j.yexcr.2020.112209 · Cited by 36 · see citing works
Self-citationBai, Y., Su, X., Piao, L., Jin, Z., & Jin, R. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.556215 · Cited by 34 · see citing works
Lee, J., Kim, S. W., & Kim, K. (2022) · Cells · doi:10.3390/cells11121902 · Cited by 34 · see citing works
The role of immune-mediated alterations and disorders in ALS disease
Rodrigues Lima-Junior, J., Sulzer, D., Lindestam Arlehamn, C. S., & Sette, A. (2021) · Human Immunology · doi:10.1016/j.humimm.2021.01.017 · Cited by 33 · see citing works
RNA Deregulation in Amyotrophic Lateral Sclerosis: The Noncoding Perspective
Laneve, P., Tollis, P., & Caffarelli, E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910285 · Cited by 32 · see citing works
Gomes, C., Sequeira, C., Likhite, S. B., Dennys, C. N., Kolb, S. J., Shaw, P. J., Vaz, A. R., Kaspar, B. K., Meyer, K., & Brites, D. M. T. O. (2022) · Cells · doi:10.3390/cells11071186 · Cited by 31 · see citing works
Self-citationValori, C. F., Sulmona, C., Brambilla, L., & Rossi, D. (2023) · Cells · doi:10.3390/cells12111450 · Cited by 30 · see citing works
Weng, Y., Chang, Y., & Chern, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043443 · Cited by 29 · see citing works
Biological Significance of microRNA Biomarkers in ALS—Innocent Bystanders or Disease Culprits?
Foggin, S., Mesquita-Ribeiro, R., Dajas‐Bailador, F., & Layfield, R. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00578 · Cited by 29 · see citing works
Zhong, X., Cao, W., Zhao, H., Chen, L., Cao, J., Wei, L., Tang, Y., Zhong, J., Xiao, X., Zu, X., et al. (2020) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2019.11.001 · Cited by 24 · see citing works
The Role of High Mobility Group Box 1 (HMGB1) in Neurodegeneration: A Systematic Review
Shaikh, M. F., Ikram, F. Z., Arulsamy, A., & Retinasamy, T. (2022) · Current Neuropharmacology · doi:10.2174/1570159x20666220114153308 · Cited by 27 · see citing works
Induction of astrocyte reactivity promotes neurodegeneration in human pluripotent stem cell models
Gomes, C., Huang, K.-C., Harkin, J., Baker, A., Hughes, J. M., Pan, Y., Tutrow, K. D., VanderWall, K. B., Lavekar, S. S., Hernandez, M., et al. (2024) · Stem Cell Reports · doi:10.1016/j.stemcr.2024.07.002 · Cited by 26 · see citing works
Self-citationMicroglia Susceptibility to Free Bilirubin Is Age-Dependent
Vaz, A. R., Falcão, A. S., Scarpa, E., Semproni, C., & Brites, D. M. T. O. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.01012 · Cited by 26 · see citing works
Self-citationAli, H. M., Ellakwa, D. E., Elaraby, N. M., Zaher, A., & Amr, K. S. (2022) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.23284 · Cited by 24 · see citing works
Astrocytic MicroRNA in Ageing, Inflammation, and Neurodegenerative Disease
Chu, A. J., & Williams, J. M. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2021.826697 · Cited by 21 · see citing works
Marton, S., Miquel, E., Acosta-Rodríguez, J., Fontenla, S., Libisch, G., & Cassina, P. (2023) · ASN NEURO · doi:10.1177/17590914231197527 · Cited by 22 · see citing works
Why should we care about astrocytes in a motor neuron disease?
Dittlau, K. S., & Bosch, L. V. D. (2023) · Frontiers in Molecular Medicine · doi:10.3389/fmmed.2023.1047540 · Cited by 20 · see citing works
van Zundert, B., & Montecino, M. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232012081 · Cited by 21 · see citing works
Astrocytes in Amyotrophic Lateral Sclerosis
Vaz, S. H., Pinto, S., Sebastião, A. M., & Brites, D. M. T. O. (2021) · Exon Publications eBooks · doi:10.36255/exonpublications.amyotrophiclateralsclerosis.astrocytes.2021 · Cited by 20 · see citing works
Self-citationRavnik‐Glavač, M., Goričar, K., Vogrinc, D., Koritnik, B., Lavrenčič, J. G., Glavač, D., & Dolžan, V. (2022) · Genes · doi:10.3390/genes13050757 · Cited by 18 · see citing works
Peplow, P., & Martinez, B. (2021) · Neural Regeneration Research · doi:10.4103/1673-5374.322431 · Cited by 16 · see citing works
Effects of circadian rhythm disorder on the hippocampus of SHR and WKY rats
Wang, Y., Zhang, Y., Wang, W., Liu, X., Chi, Y., Lei, J., Zhang, B., & Zhang, T. (2019) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2019.107141 · Cited by 16 · see citing works
The Dual Role of Astrocytes in CNS Homeostasis and Dysfunction
Tiwari, A., Rout, S., Deep, P., Sahu, C., & Samal, P. K. (2025) · Neuroglia · doi:10.3390/neuroglia6040038 · Cited by 17 · see citing works
Barbosa, M., Santos, M., de Sousa, N., Duarte-Silva, S., Vaz, A. R., Salgado, A. J., & Brites, D. (2022) · Biomedicines · doi:10.3390/biomedicines10092120 · Cited by 14 · see citing works
Self-citationHistamine Is an Inducer of the Heat Shock Response in SOD1-G93A Models of ALS
Apolloni, S., Caputi, F., Pignataro, A., Amadio, S., Fabbrizio, P., Ammassari‐Teule, M., & Volonté, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20153793 · Cited by 14 · see citing works
Neurodegeneration, demyelination, and astrogliosis in rat spinal cord by chronic lead treatment
Villa‐Cedillo, S. A., Nava-Hernández, M. P., Soto‐Domínguez, A., Hernández‐Ibarra, J. A., Perez‐Trujillo, J. J., & Cárdenas, O. S. (2019) · Cell Biology International · doi:10.1002/cbin.11147 · Cited by 13 · see citing works
miR-146a Regulates Neuroinflammation and Immune Cell Function in Neurodegenerative Diseases
Xiong, J.-R., Yan, Z.-Y., Shi, M., Zhou, G., Zhang, J.-H., Xu, J., Liao, Y., & Tang, H. (2025) · Current Medical Science · doi:10.1007/s11596-025-00080-w · Cited by 14 · see citing works
Zhang, J., Lin, X., Huang, Q., Zhang, F., Huang, Y., Chen, Z., Li, N., & Lin, X. (2025) · Experimental Neurology · doi:10.1016/j.expneurol.2025.115291 · Cited by 12 · see citing works
Bilirubin neurotoxicity: a narrative review on long lasting, insidious, and dangerous effects
Brites, D. M. T. O., & Silva, R. F. M. (2021) · Pediatric Medicine · doi:10.21037/pm-21-37 · Cited by 12 · see citing works
Self-citationCortical glia in SOD1(G93A) mice are subtly affected by ALS-like pathology
Filipi, T., Matusova, Z., Abaffy, P., Vaňátko, O., Turečková, J., Benesova, S., Kubiskova, M., Kirdajová, D., Zahumenský, J., Valihrach, L., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-33608-y · Cited by 11 · see citing works
Differential Modulation of Matrix Metalloproteinases-2 and -7 in LAM/TSC Cells
Ancona, S., Orpianesi, E., Bernardelli, C., Chiaramonte, E., Chiaramonte, R., Terraneo, S., Marco, F. D., & Lesma, E. A. (2021) · Biomedicines · doi:10.3390/biomedicines9121760 · Cited by 10 · see citing works
Zhao, D., Li, Y., Yu, X., Zhu, Y., & Ma, B. (2019) · Medicine · doi:10.1097/md.0000000000017106 · Cited by 10 · see citing works
Lauria, G., Curcio, R., & Tucci, P. (2023) · Biomolecules · doi:10.3390/biom14010047 · Cited by 8 · see citing works
Gento‐Caro, Á., Vilches‐Herrando, E., Portillo, F., González‐Forero, D., & Moreno‐López, B. (2021) · Brain Pathology · doi:10.1111/bpa.13022 · Cited by 7 · see citing works
Glial Cells as Key Mediators in the Pathophysiology of Neurodegenerative Diseases
Bogus, K., Marchesi, N., Campagnoli, L. I. M., Pascale, A., & Pałasz, A. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27020884 · Cited by 7 · see citing works
Rawat, A., Khurana, S., Verma, S., Dhawan, U., Gourie‐Devi, M., Ganguly, N. K., & Taneja, V. (2025) · Scientific Reports · doi:10.1038/s41598-025-04322-8 · Cited by 9 · see citing works
Su, Z., Ren, N., Ling, Z., Sheng, L., Zhou, S., Guo, C., Ke, Z., Xu, T., & Qin, Z. (2021) · Cell Biology International · doi:10.1002/cbin.11679 · Cited by 6 · see citing works
The Neuroepigenetic Landscape of Vertebrate and Invertebrate Models of Neurodegenerative Diseases
Sundaramoorthy, T. H., & Castanho, I. (2022) · Epigenetics Insights · doi:10.1177/25168657221135848 · Cited by 6 · see citing works
Magdy, S., Gamal, M., Samir, N. F., Rashed, L. A., Aboulhoda, B. E., Mohammed, H. S., & Sharawy, N. (2021) · Journal of Cellular Physiology · doi:10.1002/jcp.30387 · Cited by 6 · see citing works
Dogan, E. O., Simonini, S., Bouley, J., Weiss, A., Brown, R. H., & Henninger, N. (2025) · Annals of Neurology · doi:10.1002/ana.27174 · Cited by 4 · see citing works
Lewis, K. N., Craig, G. A., Mason, J., Tomas, D., Cuic, B., Walker, A. K., Gonsalvez, D. G., Turner, B. J., & Barton, S. K. (2025) · Glia · doi:10.1002/glia.70090 · Cited by 3 · see citing works
The role of HMGB1 in central nervous system (CNS) diseases: mechanisms and therapeutic perspectives
Du, O., Wu, Y.-J., Li, M.-Y., & Du, J.-R. (2025) · Cytokine · doi:10.1016/j.cyto.2025.157099 · Cited by 3 · see citing works
MiRNA-Mediated Regulation of S100B: A Review
Dali, A., Basnyat, S., Delancey, R., & Chopra, N. (2025) · NeuroSci · doi:10.3390/neurosci6030075 · Cited by 3 · see citing works
López-Cepeda, L., Castro, J. D., Aristizábal-Pachón, A. F., González‐Giraldo, Y., Pinzón, A. M., Rozo, P. J. P., & González, J. (2022) · Life · doi:10.3390/life12111720 · Cited by 3 · see citing works
ALS-like pathology diminishes swelling of spinal astrocytes in the SOD1 animal model
Filipi, T., Turečková, J., Vaňátko, O., Chmelová, M., Kubiskova, M., Sirotova, N., Matějková, S., Vargová, L., & Anděrová, M. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1472374 · Cited by 2 · see citing works
Role of MicroRNAs in Cancer Drug Resistance
Babu, K. N., & Kilari, S. (2022) · Springer eBooks · doi:10.1007/978-981-16-9186-7_8 · Cited by 2 · see citing works
Hou, X., Jiang, J., & Deng, M. (2025) · Journal of Neurology · doi:10.1007/s00415-025-13028-w · Cited by 2 · see citing works
C9orf72 - derived proline:arginine poly-dipeptides disturb cytoskeletal architecturePreprint
Shiota, T., Nagata, R., Kikuchi, S., Nanaura, H., Matsubayashi, M., Nakanishi, M., Kobashigawa, S., NAGAYAMA, K., Sugie, K., Yamashiro, Y., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.10.14.338566 · Cited by 1 · see citing works
Zhang, J., Li, P., Zhao, G., He, S., Xu, D., Jiang, W., Peng, Q., Li, Z., Xie, Z., Zhang, H., et al. (2022) · Figshare · doi:10.6084/m9.figshare.20430654
Histopathological Changes in The Spinal Cord Tissue of Rats Administered an Experimental Mussel Diet
Ünlü, İ., Özdemır, İ., Tuncer, M. C., & Öztürk, Ş. (2024) · Dicle Medical Journal / Dicle Tip Dergisi · doi:10.5798/dicletip.1552285
Zhang, J., Li, P., Zhao, G., He, S., Xu, D., Jiang, W., Peng, Q., Li, Z., Xie, Z., Zhang, H., et al. (2022) · Figshare · doi:10.6084/m9.figshare.20430666
Zhang, J., Li, P., Zhao, G., He, S., Xu, D., Jiang, W., Peng, Q., Li, Z., Xie, Z., Zhang, H., et al. (2022) · Figshare · doi:10.6084/m9.figshare.20430663
Zhang, J., Li, P., Zhao, G., He, S., Xu, D., Jiang, W., Peng, Q., Li, Z., Xie, Z., Zhang, H., et al. (2022) · Figshare · doi:10.6084/m9.figshare.20430648
Zhang, J., Li, P., Zhao, G., He, S., Xu, D., Jiang, W., Peng, Q., Li, Z., Xie, Z., Zhang, H., et al. (2022) · Figshare · doi:10.6084/m9.figshare.20430675
Zhang, J., Li, P., Zhao, G., He, S., Xu, D., Jiang, W., Peng, Q., Li, Z., Xie, Z., Zhang, H., et al. (2022) · Figshare · doi:10.6084/m9.figshare.20430672
Zhang, J., Li, P., Zhao, G., He, S., Xu, D., Jiang, W., Peng, Q., Li, Z., Xie, Z., Zhang, H., et al. (2022) · Figshare · doi:10.6084/m9.figshare.20430651
Zhang, J., Li, P., Zhao, G., He, S., Xu, D., Jiang, W., Peng, Q., Li, Z., Xie, Z., Zhang, H., et al. (2022) · Figshare · doi:10.6084/m9.figshare.20430660
Zhang, J., Li, P., Zhao, G., He, S., Xu, D., Jiang, W., Peng, Q., Li, Z., Xie, Z., Zhang, H., et al. (2022) · Figshare · doi:10.6084/m9.figshare.20430657
Zhang, J., Li, P., Zhao, G., He, S., Xu, D., Jiang, W., Peng, Q., Li, Z., Xie, Z., Zhang, H., et al. (2022) · Figshare · doi:10.6084/m9.figshare.20430669
HMGB1 functional plasticity in neurodegenerative diseases and its translational implications
Cai, W., Yi, Y., Zeng, R., Yin, Y., Zhao, J., Zhang, J., Fu, G., & Xu, H. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1928641
González‐Garnacho, I., Álvarez, M., Zafra, F., Rodríguez‐Pombo, P., Desviat, L. R., & Richard, E. (2026) · The Journal of Pathology · doi:10.1002/path.70140
- Authors
- Gomes, C., Cunha, C., Nascimento, F., Ribeiro, J. A., Vaz, A. R., & Brites, D.
- Affiliations
- University of Lisbon (PT)
- Corresponding author
- Brites, Dora
- Venue
- Molecular Neurobiology
- Published
- 2018-07-11
- Volume
- 56
- Issue
- 3
- Pages
- 2137-2158
- ISSN
- 0893-7648 (ISSN-L)
- 1559-1182
- OpenAlex
- W2842183226
- Cited by
- 79
- References
- 97
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 3 · 2023: 10 · 2022: 26 · 2021: 14 · 2020: 7 · 2019: 7
- FWCI
- 4.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Molecular Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Fundação para a Ciência e a Tecnologia
- Topics
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- amyotrophic lateral sclerosis, astrocytes, miR-146a, SOD1 G93A mice, motor neuron degeneration, gliosis, NF-kB, HMGB1, S100B, connexin 43, unfolded protein response, microRNA biomarkers, mitochondrial dysfunction, MMP-9, synaptic loss, presymptomatic stage
- MeSH terms
- Neuronal Outgrowth, Superoxide Dismutase-1, Amyotrophic Lateral Sclerosis, Animals, Astrocytes, Cerebral Cortex, Disease Models, Animal, Gliosis, Mice, Transgenic, Motor Neurons, Biomarkers, Matrix Metalloproteinase 9, MicroRNAs, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
