Dummer, Reinhard

Phase Ib study of MIW815 (ADU-S100) in combination with spartalizumab (PDR001) in patients (pts) with advanced/metastatic solid tumors or lymphomas.

Meric-Bernstam, F., Sandhu, S. K., Hamid, O., Spreafico, A., Kasper, S., Dummer, R., Shimizu, T., Steeghs, N., Lewis, N., Talluto, C. C., et al. (2019) · Journal of Clinical Oncology

Cancer Immunotherapy and Biomarkersinterferon and immune responses

Cited by 190

A Fatty Acid Oxidation-dependent Metabolic Shift Regulates the Adaptation of BRAF -mutated Melanoma to MAPK Inhibitors

Aloia, A., Müllhaupt, D., Chabbert, C. D., Eberhart, T., Flückiger-Mangual, S., Vukolic, A., Eichhoff, O., Irmisch, A., Alexander, L. T., Scibona, E., et al. (2019) · Clinical Cancer Research

Melanoma and MAPK PathwaysCancer, Lipids, and Metabolism

Cited by 130

Antagonistic Cross-Regulation between Sox9 and Sox10 Controls an Anti-tumorigenic Program in Melanoma

Shakhova, O., Cheng, P., Mishra, P. J., Zingg, D., Schaefer, S. M., Debbache, J., Häusel, J., Matter, C., Guo, T., Davis, S., et al. (2015) · PLOS Genetics

Melanoma and MAPK PathwaysCutaneous Melanoma Detection and Management

Cited by 111

Hedgehog pathway inhibitors promote adaptive immune responses in basal cell carcinoma

Otsuka, A., Dreier, J., Cheng, P. F., Nägeli, M., Lehmann, H., Felderer, L., Frew, I. J., Matsushita, S., Levesque, M. P., & Dummer, R. (2015) · Clinical Cancer Research

Hedgehog Signaling Pathway StudiesNonmelanoma Skin Cancer Studies

Cited by 106

Methylation-dependent SOX9 expression mediates invasion in human melanoma cells and is a negative prognostic factor in advanced melanoma

Cheng, P. F., Shakhova, O., Widmer, D. S., Eichhoff, O. M., Zingg, D., Frommel, S. C., Belloni, B., Raaijmakers, M. I., Goldinger, S. M., Santoro, R., et al. (2015) · Genome Biology

Epigenetics and DNA MethylationMelanoma and MAPK Pathways

Cited by 100

MEK inhibitor-associated retinopathy (MEKAR) in metastatic melanoma: Long-term ophthalmic effects

Urner-Bloch, U., Urner, M., Jaberg-Bentele, N., Frauchiger, A. L., Dummer, R., & Goldinger, S. M. (2016) · European Journal of Cancer

Drug-Induced Ocular ToxicityOcular Oncology and Treatments

Cited by 82

The low affinity neurotrophin receptor CD271 regulates phenotype switching in melanoma

Restivo, G., Diener, J., Cheng, P. F., Kiowski, G., Bonalli, M., Biedermann, T., Reichmann, E., Levesque, M. P., Dummer, R., & Sommer, L. (2017) · Nature Communications

Melanoma and MAPK PathwaysCutaneous Melanoma Detection and Management

Cited by 82

Hedgehog signaling in basal cell carcinoma

Otsuka, A., Levesque, M. P., Dummer, R., & Kabashima, K. (2015) · Journal of Dermatological Science

Hedgehog Signaling Pathway StudiesNonmelanoma Skin Cancer Studies

Cited by 72

Yin Yang 1 Orchestrates a Metabolic Program Required for Both Neural Crest Development and Melanoma Formation

Varum, S., Baggiolini, A., Zurkirchen, L., Atak, Z. K., Cantù, C., Marzorati, E., Bossart, R., Wouters, J., Häusel, J., Tuncer, E., et al. (2019) · Cell Stem Cell

Developmental Biology and Gene RegulationMelanoma and MAPK Pathways

Cited by 65

Senescent fibroblast-derived Chemerin promotes squamous cell carcinoma migration

Farsam, V., Basu, A., Gatzka, M., Treiber, N., Schneider, L. A., Mulaw, M. A., Lucas, T., Kochanek, S., Dummer, R., Levesque, M. P., et al. (2016) · Oncotarget

Nonmelanoma Skin Cancer StudiesSkin Protection and Aging

Cited by 59

Epigenetic control of melanoma cell invasiveness by the stem cell factor SALL4

Diener, J., Baggiolini, A., Pernebrink, M., Dalcher, D., Lerra, L., Cheng, P. F., Varum, S., Häusel, J., Stierli, S., Treier, M., et al. (2021) · Nature Communications

Melanoma and MAPK PathwaysEpigenetics and DNA Methylation

Cited by 34

Activation of CD8(+) T cells contributes to antitumor effects of CDK4/6 inhibitors plus MEK inhibitors

Teh, J. L. F., Erkes, D. A., Cheng, P. F., Tiago, M., Wilski, N. A., Field, C. O., Chervoneva, I., Levesque, M. P., Xu, X., Dummer, R., et al. (2020) · Cancer Immunology Research

Melanoma and MAPK PathwaysCancer Immunotherapy and Biomarkers

Cited by 22

ADAMTSL5 Is upregulated in melanoma tissues in patients with idiopathic psoriasis vulgaris induced by nivolumab

Nonomura, Y., Otsuka, A., Ohtsuka, M., Yamamoto, T., Dummer, R., & Kabashima, K. (2017) · Journal of the European Academy of Dermatology and Venereology

Cancer Immunotherapy and BiomarkersPsoriasis: Treatment and Pathogenesis

Cited by 19

HLA-A*26 is correlated with response to nivolumab in Japanese melanoma patients

Ishida, Y., Otsuka, A., Tanaka, H., Levesque, M. P., Dummer, R., & Kabashima, K. (2017) · Journal of Investigative Dermatology

Cancer Immunotherapy and BiomarkersCutaneous Melanoma Detection and Management

Cited by 13