Ellington, Andrew D.

Aptamers as therapeutics

Keefe, A. D., Pai, S., & Ellington, A. (2010) · Nature Reviews Drug Discovery

Advanced biosensing and bioanalysis techniquesRNA Interference and Gene Delivery

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Hachimoji DNA and RNA: A genetic system with eight building blocks.

Hoshika, S., Leal, N. A., Kim, M.-J., Kim, M.-S., Karalkar, N. B., Kim, H.-J., Bates, A. M., Watkins, N. E., SantaLucia, H. A., Meyer, A. J., et al. (2019) · Science

DNA and Nucleic Acid ChemistryRNA and protein synthesis mechanisms

Cited by 494

Modern metabolism as a palimpsest of the RNA world

Benner, S. A., Ellington, A. D., & Tauer, A. (1989) · Proceedings of the National Academy of Sciences

Origins and Evolution of LifeRNA and protein synthesis mechanisms

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Synthetic DNA Synthesis and Assembly: Putting the Synthetic in Synthetic Biology

Hughes, R. A., & Ellington, A. D. (2017) · Cold Spring Harbor Perspectives in Biology

DNA and Nucleic Acid ChemistryCRISPR and Genetic Engineering

Cited by 411

High-throughput sequencing of the paired human immunoglobulin heavy and light chain repertoire

DeKosky, B. J., Ippolito, G. C., Deschner, R. P., Lavinder, J. J., Wine, Y., Rawlings, B. M., Varadarajan, N., Giesecke, C., Dörner, T., Andrews, S. F., et al. (2013) · Nature Biotechnology

T-cell and B-cell ImmunologyMonoclonal and Polyclonal Antibodies Research

Cited by 410

Monoclonal antibodies isolated without screening by analyzing the variable-gene repertoire of plasma cells

Reddy, S. T., Ge, X., Miklos, A. E., Hughes, R. A., Kang, S. H., Hoi, K. H., Chrysostomou, C., Hunicke-Smith, S. P., Iverson, B. L., Tucker, P. W., et al. (2010) · Nature Biotechnology

Monoclonal and Polyclonal Antibodies ResearchT-cell and B-cell Immunology

Cited by 292

Real-time detection of isothermal amplification reactions with thermostable catalytic hairpin assembly

Jiang, Y. (., Li, B., Milligan, J. N., Bhadra, S., & Ellington, A. D. (2013) · Journal of the American Chemical Society

Advanced biosensing and bioanalysis techniquesBiosensors and Analytical Detection

Cited by 292

Ribozyme Catalysis of Metabolism in the RNA World

Chen, X., Li, N., & Ellington, A. D. (2007) · Chemistry & Biodiversity

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 196

Recursive genomewide recombination and sequencing reveals a key refinement step in the evolution of a metabolic innovation in Escherichia coli

Quandt, E. M., Deatherage, D. E., Ellington, A. D., Georgiou, G., & Barrick, J. E. (2014) · Proceedings of the National Academy of Sciences

Evolution and Genetic DynamicsMicrobial Metabolic Engineering and Bioproduction

Cited by 78

Synthetic microbial sensing and biosynthesis of amaryllidaceae alkaloids

d’Oelsnitz, S., Diaz, D., Acosta, D., Schechter, M., Minus, M., Howard, J., Loy, J., Do, H., Alper, H. S., & Ellington, A. D. (2023) · Nature Communications

Enzyme Catalysis and ImmobilizationPlant biochemistry and biosynthesis

Cited by 58

Biosensor and machine learning-aided engineering of an amaryllidaceae enzyme

d’Oelsnitz, S., Diaz, D. J., Kim, W., Acosta, D. J., Dangerfield, T. L., Schechter, M. W., Minus, M. B., Howard, J. R., Do, H., Loy, J. M., et al. (2024) · Nature Communications

Enzyme Catalysis and ImmobilizationPlant biochemistry and biosynthesis

Cited by 58

Surprising fidelity of template-directed chemical ligation of oligonucleotides

James, K. D., & Ellington, A. D. (1997) · Chemistry & Biology

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 50

The search for missing links between self-replicating nucleic ACIDs and the RNA world

James, K. D., & Ellington, A. D. (1995) · Origins of life and evolution of the biosphere

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 39

Learning the local landscape of protein structures with convolutional neural networks

Kulikova, A. V., Diaz, D. J., Loy, J. M., Ellington, A. D., & Wilke, C. O. (2021) · Journal of Biological Physics

Protein Structure and DynamicsMachine Learning in Bioinformatics

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Two sequence- and two structure-based ML models have learned different aspects of protein biochemistry

Kulikova, A. V., Diaz, D. J., Chen, T., Cole, T. J., Ellington, A. D., & Wilke, C. O. (2023) · Scientific Reports

Machine Learning in BioinformaticsProtein Structure and Dynamics

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