The search for missing links between self-replicating nucleic ACIDs and the RNA world
Abstract
The notion that modern metabolism was derived from a complex 'RNA world' in which most reactions were catalyzed by ribozymes has received wide acceptance. However, the evolutionary links between the first self-replicating systems and ribozymes as complex as, say, the Group I self-splicing intron or the HDV ribozyme, have remained elusive. While prebiotic chemists have succeeded in synthesizing short oligonucleotides, it is not immediately obvious how these could have replicated and evolved to the point where they could assume complex shapes and catalytic functions. Nonetheless, recent experiments from a variety of disciplines suggest a plausible pathway from prebiotic chemistry to complex metabolism, and this review is intended as a hypothetical roadmap for the origin and subsequent evolution of life.
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The notion of an extended RNA World in which RNAs catalyze many biochemical reactions as well as cell division remains controversial.
“Despite these observations, the notion of an extended RNA World in which RNAs catalyze many biochemical reactions as well as cell division remains controversial”
From The Emergence of Life (2019) · cites this paper as James and Ellington 1995
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- Authors
- James, K. D., & Ellington, A. D.
- Affiliations
- Indiana University Bloomington (US)
- ORCID
- Ellington, Andrew D.
- Venue
- Origins of life and evolution of the biosphere
- Published
- 1995-12
- Volume
- 25
- Issue
- 6
- Pages
- 515-530
- ISSN
- 0169-6149 (ISSN-L)
- 1573-0875
- OpenAlex
- W2034100594
- Cited by
- 39
- References
- 76
- Citations by year
- 2025: 1 · 2021: 1 · 2019: 1 · 2017: 1 · 2012: 1
- FWCI
- 3.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Origins of Life and Evolution of Biospheres (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Francis Crick Institute
- Topics
- Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Keywords
- RNA world, ribozymes, origin of life, prebiotic chemistry, HDV ribozyme, metabolic evolution
- MeSH terms
- Biological Evolution, Molecular Biology, Nucleotides, RNA
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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