Hughes, Christopher C. W.

Of Mice and Not Men: Differences between Mouse and Human Immunology

Mestas, J., & Hughes, C. C. W. (2004) · The Journal of Immunology

T-cell and B-cell ImmunologyImmune Response and Inflammation

Cited by 3,822

3D microtumors in vitro supported by perfused vascular networks

Sobrino, A., Phan, D. T. T., Datta, R., Wang, X., Hachey, S. J., Romero-López, M., Gratton, E., Lee, A. P., George, S. C., & Hughes, C. C. W. (2016) · Scientific Reports

3D Printing in Biomedical ResearchCancer Cells and Metastasis

Cited by 387

In Vitro Perfused Human Capillary Networks

Moya, M. L., Hsu, Y.-H., Lee, A. P., Hughes, C. C. W., & George, S. C. (2013) · Tissue Engineering Part C: Methods

3D Printing in Biomedical ResearchTissue Engineering and Regenerative Medicine

Cited by 387

A vascularized and perfused organ-on-a-chip platform for large-scale drug screening applications

Phan, D. T. T., Wang, X., Craver, B. M., Sobrino, A., Zhao, D., Chen, J. C., Lee, L. Y. N., George, S. C., Lee, A. P., & Hughes, C. C. W. (2017) · Lab on a Chip

3D Printing in Biomedical ResearchMicrofluidic and Capillary Electrophoresis Applications

Cited by 325

A three-dimensional in vitro model of tumor cell intravasation

Ehsan, S. M., Welch-Reardon, K. M., Waterman, M. L., Hughes, C. C. W., & George, S. C. (2014) · Integrative Biology

Cancer Cells and MetastasisAngiogenesis and VEGF in Cancer

Cited by 196

Applications of tumor chip technology

Hachey, S. J., & Hughes, C. C. W. (2018) · Lab on a Chip

3D Printing in Biomedical ResearchMicrofluidic and Capillary Electrophoresis Applications

Cited by 128

Recapitulating the human tumor microenvironment: Colon tumor-derived extracellular matrix promotes angiogenesis and tumor cell growth

Romero-López, M., Trinh, A. L., Sobrino, A., Hatch, M. M. S., Keating, M. T., Fimbres, C., Lewis, D. E., Gershon, P. D., Botvinick, E. L., Digman, M., et al. (2017) · Biomaterials

Cellular Mechanics and InteractionsHydrogels: synthesis, properties, applications

Cited by 125

Induction of Mesoderm and Neural Crest-Derived Pericytes from Human Pluripotent Stem Cells to Study Blood-Brain Barrier Interactions

Faal, T., Phan, D. T. T., Davtyan, H., Scarfone, V. M., Varady, E., Blurton-Jones, M., Hughes, C. C. W., & Inlay, M. A. (2019) · Stem Cell Reports

Barrier Structure and Function StudiesPluripotent Stem Cells Research

Cited by 124

An in vitro vascularized micro-tumor model of human colorectal cancer recapitulates in vivo responses to standard-of-care therapy

Hachey, S. J., Movsesyan, S., Nguyen, Q. H., Burton-Sojo, G., Tankazyan, A., Wu, J., Hoang, T., Zhao, D., Wang, S., Hatch, M. M., et al. (2021) · Lab on a Chip

3D Printing in Biomedical ResearchCancer Cells and Metastasis

Cited by 124

A strategy for integrating essential three-dimensional microphysiological systems of human organs for realistic anticancer drug screening

Heylman, C., Sobrino, A., Shirure, V. S., Hughes, C. C., & George, S. C. (2014) · Experimental Biology and Medicine

3D Printing in Biomedical ResearchTissue Engineering and Regenerative Medicine

Cited by 53

Targeting tumor–stromal interactions in triple-negative breast cancer using a human vascularized micro-tumor model

Hachey, S. J., Hatch, C. J., Gaebler, D., Mocherla, A., Nee, K., Kessenbrock, K., & Hughes, C. C. W. (2024) · Breast Cancer Research

Cancer Cells and MetastasisBreast Cancer Treatment Studies

Cited by 24

Structure-based design of CDC42 effector interaction inhibitors for the treatment of cancer

Jahid, S., Ortega, J. A., Vuong, L. M., Acquistapace, I. M., Hachey, S. J., Flesher, J. L., La Serra, M. A., Brindani, N., La Sala, G., Manigrasso, J., et al. (2022) · Cell Reports

Protein Kinase Regulation and GTPase SignalingComputational Drug Discovery Methods

Cited by 21

Microphysiological systems as models for immunologically ‘cold’ tumors

Gaebler, D., Hachey, S. J., & Hughes, C. C. W. (2024) · Frontiers in Cell and Developmental Biology

3D Printing in Biomedical ResearchCancer Cells and Metastasis

Cited by 14