Targeting tumor–stromal interactions in triple-negative breast cancer using a human vascularized micro-tumor model

Hachey, Stephanie J.; Hatch, Christopher J.; Gaebler, Daniela; Mocherla, Aneela; Nee, Kevin; Kessenbrock, Kai; Hughes, Christopher C. W.

doi:10.1186/s13058-023-01760-y

Targeting tumor–stromal interactions in triple-negative breast cancer using a human vascularized micro-tumor model

Triple-negative breast cancer (TNBC) is highly aggressive with limited available treatments. Stromal cells in the tumor microenvironment (TME) are crucial in TNBC progression; however, understanding the molecular basis of stromal cell activation and tumor–stromal crosstalk in TNBC is limited. To …