A vascularized and perfused organ-on-a-chip platform for large-scale drug screening applications

Reconstituting organ-level lung functions on a chip

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Contributions of microbiome and mechanical deformation to intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip

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Human 3D vascularized organotypic microfluidic assays to study breast cancer cell extravasation

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Significance of blood vessel leakiness in cancer.

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Recreating blood-brain barrier physiology and structure on chip: A novel neurovascular microfluidic bioreactor

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Modular, pumpless body-on-a-chip platform for the co-culture of GI tract epithelium and 3D primary liver tissue

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Full range physiological mass transport control in 3D tissue cultures

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Plastic masters—rigid templates for soft lithography

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Synapse microarray identification of small molecules that enhance synaptogenesis

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Organs-on-chips (microphysiological systems): tools to expedite efficacy and toxicity testing in human tissue

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Instantaneous room temperature bonding of a wide range of non-silicon substrates with poly(dimethylsiloxane) (PDMS) elastomer mediated by a mercaptosilane

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An on-chip microfluidic pressure regulator that facilitates reproducible loading of cells and hydrogels into microphysiological system platforms

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Human organs-on-chips for disease modelling, drug development and personalized medicine

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Organs-on-chips: into the next decade

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Advances in organ-on-a-chip engineering

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Organs-on-a-Chip: A Fast Track for Engineered Human Tissues in Drug Development

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Consensus guidelines for the use and interpretation of angiogenesis assays

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Robotic fluidic coupling and interrogation of multiple vascularized organ chips

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Organ-on-a-chip devices advance to market

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A microfluidic platform integrating functional vascularized organoids-on-chip

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Multiorgan-on-a-Chip: A Systemic Approach To Model and Decipher Inter-Organ Communication

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Tumor-on-a-chip: from bioinspired design to biomedical application

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Colorectal tumor-on-a-chip system: a 3D tool for precision onco-nanomedicine

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Cardiovascular disease models: A game changing paradigm in drug discovery and screening

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Microfluidics for Drug Development: From Synthesis to Evaluation

Liu, Y., Sun, L., Zhang, H., Shang, L., & Zhao, Y. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c01289 · Cited by 209 · see citing works

Integrating organoids and organ-on-a-chip devices

Zhao, Y., Landau, S., Okhovatian, S., Liu, C., Lu, R. X. Z., Lai, B. F. L., Wu, Q., Kieda, J., Cheung, K., Rajasekar, S., et al. (2024) · Nature Reviews Bioengineering · doi:10.1038/s44222-024-00207-z · Cited by 206 · see citing works

Microsensor systems for cell metabolism – from 2D culture to organ-on-chip

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Engineering Vascularized Organoid-on-a-Chip Models

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3D bioprinting for cardiovascular regeneration and pharmacology

Cui, H., Miao, S., Esworthy, T. J., Zhou, X., Lee, S., Liu, C., Yu, Z., Fisher, J. P., Mohiuddin, M. M., & Zhang, L. G. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.07.014 · Cited by 195 · see citing works

Advances in predictive in vitro models of drug-induced nephrotoxicity

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High-Throughput Methods in the Discovery and Study of Biomaterials and Materiobiology

Yang, L., Pijuan‐Galito, S., Rho, H. S., Vasilevich, A. S., Eren, A. D., Ge, L., Habibović, P., Alexander, M. R., de Boer, J., Carlier, A., et al. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00752 · Cited by 187 · see citing works

Chemoresistance of Cancer Cells: Requirements of Tumor Microenvironment-mimicking In Vitro Models in Anti-Cancer Drug Development

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Organs-on-chips technologies – A guide from disease models to opportunities for drug development

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High-throughput organ-on-a-chip systems: Current status and remaining challenges

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Bioengineering methods for vascularizing organoids

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Vascularized microfluidic organ-chips for drug screening, disease models and tissue engineering

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Tissue chips – innovative tools for drug development and disease modeling

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Emerging trends in organ-on-a-chip systems for drug screening

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Applications of tumor chip technology

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Recent progress in translational engineered in vitro models of the central nervous system

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An <i>in vitro</i> vascularized micro-tumor model of human colorectal cancer recapitulates <i>in vivo</i> responses to standard-of-care therapy

Hachey, S. J., Movsesyan, S., Nguyen, Q. H., Burton-Sojo, G., Tankazyan, A., Wu, J., Hoang, T., Zhao, D., Wang, S., Hatch, M. M., et al. (2021) · Lab on a Chip · doi:10.1039/d0lc01216e · Cited by 124 · see citing works

Low levels of physiological interstitial flow eliminate morphogen gradients and guide angiogenesis

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Ex vivo Dynamics of Human Glioblastoma Cells in a Microvasculature‐on‐a‐Chip System Correlates with Tumor Heterogeneity and Subtypes

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In vitro grafting of hepatic spheroids and organoids on a microfluidic vascular bed

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Microphysiological systems for ADME-related applications: current status and recommendations for system development and characterization

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Microfluidic Tissue Engineering and Bio‐Actuation

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iPSC-Derived Brain Endothelium Exhibits Stable, Long-Term Barrier Function in Perfused Hydrogel Scaffolds

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Microfluidic-Based 3D Engineered Microvascular Networks and Their Applications in Vascularized Microtumor Models

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A 96-well format microvascularized human lung-on-a-chip platform for microphysiological modeling of fibrotic diseases

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A Multi-Niche Microvascularized Human Bone-Marrow-on-a-Chip

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Advances in microfluidic in vitro systems for neurological disease modeling

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A well plate–based multiplexed platform for incorporation of organoids into an organ-on-a-chip system with a perfusable vasculature

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Tomorrow today: organ-on-a-chip advances towards clinically relevant pharmaceutical and medical in vitro models

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Slug regulates the Dll4-Notch-VEGFR2 axis to control endothelial cell activation and angiogenesis

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Flat and microstructured polymeric membranes in organs-on-chips

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Organ-on-a-chip systems for vascular biology

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InVADE: integrated vasculature for assessing dynamic events

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Organs-on-a-chip: a union of tissue engineering and microfabrication

Zhao, Y., Wang, E. Y., Lai, F. B. L., Cheung, K., & Radisic, M. (2023) · Trends in Biotechnology · doi:10.1016/j.tibtech.2022.12.018 · Cited by 93 · see citing works

Microfluidic-based vascularized microphysiological systems

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Patient‐Specific Organoid and Organ‐on‐a‐Chip: 3D Cell‐Culture Meets 3D Printing and Numerical Simulation

Zheng, F., Xiao, Y., Liu, H., Fan, Y., & Dao, M. (2021) · Advanced Biology · doi:10.1002/adbi.202000024 · Cited by 92 · see citing works

Acoustofluidics for simultaneous nanoparticle-based drug loading and exosome encapsulation

Wang, Z., Rich, J. T., Hao, N., Gu, Y., Chen, C., Yang, S., Zhang, P., & Huang, T. J. (2022) · Microsystems & Nanoengineering · doi:10.1038/s41378-022-00374-2 · Cited by 92 · see citing works

Organotypic microfluidic breast cancer model reveals starvation-induced spatial-temporal metabolic adaptations

Ayuso, J. M., Gillette, A. A., Lugo-Cintrón, K. M., Acevedo‐Acevedo, S., Gomez, I., Morgan, M. M., Heaster, T. M., Wisinski, K. B., Palecek, S. P., Skala, M. C., et al. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.10.046 · Cited by 90 · see citing works

Joint-on-chip platforms: entering a new era of in vitro models for arthritis

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Intestinal organ chips for disease modelling and personalized medicine

Özkan, A., LoGrande, N., Feitor, J. F., Goyal, G., & Ingber, D. E. (2024) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-024-00968-3 · Cited by 89 · see citing works

Microfluidic high-throughput 3D cell culture

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Engineering Tissue Barrier Models on Hydrogel Microfluidic Platforms

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Organotypic cancer tissue models for drug screening: 3D constructs, bioprinting and microfluidic chips

Radhakrishnan, J., Varadaraj, S., Dash, S. K., Sharma, A., & Verma, R. S. (2020) · Drug Discovery Today · doi:10.1016/j.drudis.2020.03.002 · Cited by 87 · see citing works

Engineering and monitoring cellular barrier models

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Intestinal Villi Model with Blood Capillaries Fabricated Using Collagen-Based Bioink and Dual-Cell-Printing Process

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Recent progress in lab-on-a-chip for pharmaceutical analysis and pharmacological/toxicological test

Ai, Y., Zhang, F., Wang, C., Xie, R., & Liang, Q. (2019) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2019.06.026 · Cited by 86 · see citing works

On-chip anticancer drug screening – Recent progress in microfluidic platforms to address challenges in chemotherapy

Dhiman, N., Kingshott, P., Sümer, H., Sharma, C. S., & Rath, S. N. (2019) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2019.02.070 · Cited by 85 · see citing works

Bioprinting Tissue Analogues with Decellularized Extracellular Matrix Bioink for Regeneration and Tissue Models of Cartilage and Intervertebral Discs

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Microphysiological Systems: Design, Fabrication, and Applications

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Microvascularized tumor organoids-on-chips: advancing preclinical drug screening with pathophysiological relevance

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Current Advances in 3D Dynamic Cell Culture Systems

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Human Induced Pluripotent Stem-Cardiac-Endothelial-Tumor-on-a-Chip to Assess Anticancer Efficacy and Cardiotoxicity

Weng, K., Kurokawa, Y. K., Hajek, B., Paladin, J. A., Shirure, V. S., & George, S. C. (2019) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2019.0248 · Cited by 82 · see citing works

Bone/cartilage organoid on-chip: Construction strategy and application

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Developing in vitro assays to transform gastrointestinal safety assessment: potential for microphysiological systems

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Synthetic extracellular matrices with tailored adhesiveness and degradability support lumen formation during angiogenic sprouting

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Organ on Chip Technology to Model Cancer Growth and Metastasis

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The impact of microfluidics in high-throughput drug-screening applications

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