Goate, Alison M.

Genetic Heterogeneity in Alzheimer Disease and Implications for Treatment Strategies

Dominantly Inherited Alzheimer Network, Ringman, J. M., Goate, A., Masters, C. L., Cairns, N. J., Danek, A., Graff-Radford, N., Ghetti, B., & Morris, J. C. (2014) · Current Neurology and Neuroscience Reports

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Paired Immunoglobulin-like Type 2 Receptor Alpha G78R variant alters ligand binding and confers protection to Alzheimer's disease

Rathore, N., Ramani, S. R., Pantua, H., Payandeh, J., Bhangale, T., Wuster, A., Kapoor, M., Sun, Y., Kapadia, S. B., Gonzalez, L., et al. (2018) · PLOS Genetics

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

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Sex differences in the genetic predictors of Alzheimer’s pathology

Dumitrescu, L., Barnes, L. L., Thambisetty, M., Beecham, G., Kunkle, B., Bush, W. S., Gifford, K. A., Chibnik, L. B., Mukherjee, S., De Jager, P. L., et al. (2019) · Brain

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

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Analysis of whole genome-transcriptomic organization in brain to identify genes associated with alcoholism

Kapoor, M., Wang, J.-C., Farris, S. P., Liu, Y., McClintick, J., Gupta, I., Meyers, J. L., Bertelsen, S., Chao, M., Nurnberger, J., et al. (2019) · Translational Psychiatry

Substance Abuse Treatment and OutcomesAlcohol Consumption and Health Effects

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Polygenic Scores for Major Depressive Disorder and Risk of Alcohol Dependence

Andersen, A. M., Pietrzak, R. H., Kranzler, H. R., Ma, L., Zhou, H., Liu, X., Kramer, J., Kuperman, S., Edenberg, H. J., Nurnberger, J. I., et al. (2017) · JAMA Psychiatry

Genetic Associations and EpidemiologySubstance Abuse Treatment and Outcomes

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Association of childhood trauma exposure and GABRA2 polymorphisms with risk of posttraumatic stress disorder in adults

Nelson, E. C., Agrawal, A., Pergadia, M. L., Lynskey, M. T., Todorov, A. A., Wang, J. C., Todd, R. D., Martin, N. G., Heath, A. C., Goate, A. M., et al. (2009) · Molecular Psychiatry

Posttraumatic Stress Disorder ResearchChild Abuse and Trauma

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Extreme cerebrospinal fluid amyloid β levels identify family with late‐onset Alzheimer's disease presenilin 1 mutation

Kauwe, J. S. K., Jacquart, S., Chakraverty, S., Wang, J., Mayo, K., Fagan, A. M., Holtzman, D. M., Morris, J. C., & Goate, A. M. (2007) · Annals of Neurology

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

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Apolipoprotein E levels in cerebrospinal fluid and the effects of ABCA1polymorphisms

Wahrle, S. E., Shah, A. R., Fagan, A. M., Smemo, S., Kauwe, J. S., Grupe, A., Hinrichs, A., Mayo, K., Jiang, H., Thal, L. J., et al. (2007) · Molecular Neurodegeneration

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

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Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer’s disease resilience

Initiative, F. T. A. D. N., Ridge, P. G., Karch, C. M., Hsu, S., Arano, I., Teerlink, C. C., Ebbert, M. T. W., Gonzalez Murcia, J. D., Farnham, J. M., Damato, A. R., et al. (2017) · Genome Medicine

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

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Phosphorylated Tau-Aβ42 Ratio as a Continuous Trait for Biomarker Discovery for Early-Stage Alzheimer’s Disease in Multiplex Immunoassay Panels of Cerebrospinal Fluid

Harari, O., Cruchaga, C., Kauwe, J. S. K., Ainscough, B. J., Bales, K., Pickering, E. H., Bertelsen, S., Fagan, A. M., Holtzman, D. M., Morris, J. C., et al. (2014) · Biological Psychiatry

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

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Association between alcohol consumption and Alzheimer's disease: A Mendelian randomization study

Andrews, S. J., Goate, A., & Anstey, K. J. (2020) · Alzheimer's & Dementia

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Alzheimer’s disease risk variants show association with cerebrospinal fluid amyloid beta

Kauwe, J. S. K., Wang, J., Mayo, K., Morris, J. C., Fagan, A. M., Holtzman, D. M., & Goate, A. M. (2009) · neurogenetics

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

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BDNF Val66Met moderates memory impairment, hippocampal function and tau in preclinical autosomal dominant Alzheimer’s disease

Lim, Y. Y., Hassenstab, J., Cruchaga, C., Goate, A., Fagan, A. M., Benzinger, T. L. S., Maruff, P., Snyder, P. J., Masters, C. L., Allegri, R., et al. (2016) · Brain

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Genome-wide, high-content siRNA screening identifies the Alzheimer’s genetic risk factor FERMT2 as a major modulator of APP metabolism

ADGC, A. D. N. I., Chapuis, J., Flaig, A., Grenier-Boley, B., Eysert, F., Pottiez, V., Deloison, G., Vandeputte, A., Ayral, A.-M., Mendes, T., et al. (2017) · Acta Neuropathologica

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Astrocyte-secreted glypican-4 drives APOE4-dependent tau hyperphosphorylation

Saroja, S. R., Gorbachev, K., Julia, T., Goate, A. M., & Pereira, A. C. (2022) · Proceedings of the National Academy of Sciences

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APOE4 confers transcriptomic and functional alterations to primary mouse microglia

Machlovi, S. I., Neuner, S. M., Hemmer, B. M., Khan, R., Liu, Y., Huang, M., Zhu, J. D., Castellano, J. M., Cai, D., Marcora, E., et al. (2022) · Neurobiology of Disease

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Age-Specific Incidence Rates for Dementia and Alzheimer Disease in NIA-LOAD/NCRAD and EFIGA Families: National Institute on Aging Genetics Initiative for Late-Onset Alzheimer Disease/National Cell Repository for Alzheimer Disease (NIA-LOAD/NCRAD) and Estudio Familiar de Influencia Genetica en Alzheimer (EFIGA)

Vardarajan, B. N., Faber, K. M., Bird, T. D., Bennett, D. A., Rosenberg, R., Boeve, B. F., Graff-Radford, N. R., Goate, A. M., Farlow, M., Sweet, R. A., et al. (2014) · JAMA Neurology

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GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia

Shade, L. M. P., Katsumata, Y., Abner, E. L., Aung, K. Z., Claas, S. A., Qiao, Q., Heberle, B. A., Brandon, J. A., Page, M. L., Hohman, T. J., et al. (2024) · Nature Genetics

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Mutations in APP have independent effects on Aβ and CTFγ generation

Hecimovic, S., Wang, J., Dolios, G., Martinez, M., Wang, R., & Goate, A. M. (2004) · Neurobiology of Disease

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Autosomal dominant and sporadic late onset Alzheimer's disease share a common in vivo pathophysiology

Morris, J. C., Weiner, M., Xiong, C., Beckett, L., Coble, D., Saito, N., Aisen, P. S., Allegri, R., Benzinger, T. L. S., Berman, S. B., et al. (2022) · Brain

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MAOA‐uVNTR and early physical discipline interact to influence delinquent behavior

Edwards, A. C., Dodge, K. A., Latendresse, S. J., Lansford, J. E., Bates, J. E., Pettit, G. S., Budde, J. P., Goate, A. M., & Dick, D. M. (2010) · Journal of Child Psychology and Psychiatry

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A potential endophenotype for Alzheimer's disease: cerebrospinal fluid clusterin

Deming, Y., Xia, J., Cai, Y., Lord, J., Holmans, P., Bertelsen, S., Holtzman, D., Morris, J. C., Bales, K., Pickering, E. H., et al. (2016) · Neurobiology of Aging

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Genetic evaluation of dementia with Lewy bodies implicates distinct disease subgroups

Kaivola, K., Shah, Z., Chia, R., International LBD Genomics Consortium, Black, S. E., Gan-Or, Z., Keith, J., Masellis, M., Rogaeva, E., Brice, A., et al. (2022) · Brain

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Assessment of the Genetic Architecture of Alzheimer’s Disease Risk in Rate of Memory Decline

Del-Aguila, J. L., Fernández, M. V., Schindler, S., Ibanez, L., Deming, Y., Ma, S., Saef, B., Black, K., Budde, J., Norton, J., et al. (2018) · Journal of Alzheimer’s Disease

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