MAOA‐uVNTR and early physical discipline interact to influence delinquent behavior

Edwards, Alexis C.; Dodge, Kenneth A.; Latendresse, Shawn J.; Lansford, Jennifer E.; Bates, John E.; Pettit, Gregory S.; Budde, John P.; Goate, Alison M.; Dick, Danielle M.

doi:10.1111/j.1469-7610.2009.02196.x

Cited by 67Child and Adolescent Psychosocial and Emotional DevelopmentChild Abuse and TraumaNeurotransmitter Receptor Influence on Behavior

MAOA‐uVNTR and early physical discipline interact to influence delinquent behavior

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Edwards, Alexis C., Dodge, Kenneth A., Latendresse, Shawn J., Lansford, Jennifer E., Bates, John E., Pettit, Gregory S., Budde, John P., Goate, Alison M. +1 more·2010·Journal of Child Psychology and Psychiatry

DOI 10.1111/j.1469-7610.2009.02196.xPMC PMC3035042

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Abstract

Background: A functional polymorphism in the promoter region of the monoamine oxidizing gene monoamine oxidase A ( MAOA ) has been associated with behavioral sensitivity to adverse environmental conditions in multiple studies (e.g., ; ). The present study investigates the effects of genotype and early physical discipline on externalizing behavior. We expand on the current literature in our assessment of externalizing, incorporating information across multiple reporters and over a broad developmental time period, and in our understanding of environmental risk. Method: This study uses data from the Child Development Project, an ongoing longitudinal study following a community sample of children beginning at age 5. Physical discipline before age 6 was quantified using a subset of questions from the Conflict Tactics Scale (). Externalizing behavior was assessed in the male, European‐American sub‐sample ( N = 250) by parent, teacher, and self‐report using Achenbach’s Child Behavior Checklist, Teacher Report Form, and Youth Self‐Report (), at 17 time points from ages 6 to 22. Regression analyses tested the influence of genotype, physical discipline, and their interaction on externalizing behavior, and its subscales, delinquency and aggression. Results: We found a significant interaction effect between genotype and physical discipline on levels of delinquent behavior. Similar trends were observed for aggression and overall externalizing behavior, although these did not reach statistical significance. Main effects of physical discipline held for all outcome variables, and no main effects held for genotype. Conclusion: The adverse consequences of physical discipline on forms of externalizing behavior are exacerbated by an underlying biological risk conferred by MAOA genotype.

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Untitled work
(1991) · Medical Entomology and Zoology · Cited by 8,071 · see citing works
Measuring Intrafamily Conflict and Violence: The Conflict Tactics (CT) Scales
Straus, M. A. (1979) · Journal of Marriage and the Family · doi:10.2307/351733 · Cited by 6,187 · see citing works
Role of genotype in the cycle of violence in maltreated children
Caspi, A., McClay, J., Moffitt, T. E., Mill, J., Martin, J., Craig, I. W., Taylor, A., & Poulton, R. (2002) · Science · doi:10.1126/science.1072290 · Cited by 4,842 · see citing works
Species Richness of Parasite Assemblages: Evolution and Patterns
Poulin, R. (1997) · Annual Review of Ecology and Systematics · doi:10.1146/annurev.ecolsys.28.1.341 · Cited by 3,500 · see citing works
The Cycle of Violence
Widom, C. S. (1989) · Science · doi:10.1126/science.2704995 · Cited by 1,976 · see citing works
Mechanisms in the Cycle of Violence
Dodge, K. A., Bates, J. E., & Pettit, G. S. (1990) · Science · doi:10.1126/science.2270481 · Cited by 1,803 · see citing works
Self-citation
Genetic and environmental influences on antisocial behavior: A meta-analysis of twin and adoption studies
Rhee, S. H., & Waldman, I. D. (2002) · Psychological Bulletin · doi:10.1037/0033-2909.128.3.490 · Cited by 1,266 · see citing works
Aggressive Behavior and Altered Amounts of Brain Serotonin and Norepinephrine in Mice Lacking MAOA
Cases, O., Seif, I., Grimsby, J. S., Gaspar, P., Chen, K., Vandormael‐Pournin, S., Müller, U., Aguet, M., Babinet, C., Shih, J. C., et al. (1995) · Science · doi:10.1126/science.7792602 · Cited by 1,225 · see citing works
MAOA, maltreatment, and gene–environment interaction predicting children’s mental health: new evidence and a meta-analysis
Kim-Cohen, J., Caspi, A., Taylor, A., Williams, B., Newcombe, R., Craig, I. W., & Moffitt, T. E. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001851 · Cited by 1,158 · see citing works
A functional polymorphism in the monoamine oxidase A gene promoter
Sabol, S. Z., Hu, S., & Hamer, D. (1998) · Human Genetics · doi:10.1007/s004390050816 · Cited by 1,079 · see citing works
A 12-year prospective study of the long-term effects of early child physical maltreatment on psychological, behavioral, and academic problems in adolescence
Lansford, J. E., Dodge, K. A., Pettit, G. S., Bates, J. E., Crozier, J., & Kaplow, J. (2002) · Archives of Pediatrics & Adolescent Medicine · doi:10.1001/archpedi.156.8.824 · Cited by 838 · see citing works
Self-citation
Early Physical Abuse and Later Violent Delinquency: A Prospective Longitudinal Study
Lansford, J. E., Miller-Johnson, S., Berlin, L. J., Dodge, K. A., Bates, J. E., & Pettit, G. S. (2007) · Child Maltreatment · doi:10.1177/1077559507301841 · Cited by 523 · see citing works
Self-citation
X-linked borderline mental retardation with prominent behavioral disturbance: phenotype, genetic localization, and evidence for disturbed monoamine metabolism.
Brunner, H. G., Nelen, M. R., van Zandvoort, P., Abeling, N. G. G. M., Gennip, A. H., Wolters, E. C., Kuiper, M. A., Ropers, H., & van Oost, B. A. (1993) · PubMed · Cited by 369 · see citing works
Ethnic differences in the link between physical discipline and later adolescent externalizing behaviors
Lansford, J. E., Deater-Deckard, K. D., Dodge, K. A., Bates, J. E., & Pettit, G. S. (2004) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2004.00273.x · Cited by 364 · see citing works
Self-citation
MAOA and the “Cycle of Violence:” Childhood Abuse and Neglect, MAOA Genotype, and Risk for Violent and Antisocial Behavior
Widom, C. S., & Brzustowicz, L. M. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.039 · Cited by 349 · see citing works
The timing of child physical maltreatment: A cross-domain growth analysis of impact on adolescent externalizing and internalizing problems
KEILEY, M. K., HOWE, T. R., DODGE, K. A., BATES, J. E., & PETTIT, G. S. (2001) · Development and Psychopathology · doi:10.1017/s0954579401004084 · Cited by 323 · see citing works
Self-citation
Escalated aggressive behavior: Dopamine, serotonin and GABA
de Almeida, R. M. M., Ferrari, P. F., Parmigiani, S., & Miczek, K. A. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.10.004 · Cited by 303 · see citing works
Nature and nurture predispose to violent behavior: serotonergic genes and adverse childhood environment
Reif, A., Rösler, M., Freitag, C. M., Schneider, M., Eujen, A., Kissling, C., Wenzler, D., Jacob, C. P., Retz-Junginger, P., Thome, J., et al. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301359 · Cited by 277 · see citing works
An Association between a Functional Polymorphism in the Monoamine Oxidase A Gene Promoter, Impulsive Traits and Early Abuse Experiences
Huang, Y., Cate, S. P., Battistuzzi, C., Oquendo, M. A., Brent, D. A., & Mann, J. J. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300455 · Cited by 267 · see citing works
Role of Monoamine Oxidase A Genotype and Psychosocial Factors in Male Adolescent Criminal Activity
Nilsson, K. W., Sjöberg, R. L., Damberg, M., Leppert, J., Öhrvik, J., Alm, P. O., Lindström, L., & Oreland, L. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.06.024 · Cited by 223 · see citing works
Environmental Adversity Increases Genetic Risk for Externalizing Disorders
Hicks, B. M., South, S., Dirago, A. C., Iacono, W., & McGue, M. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2008.554 · Cited by 209 · see citing works
Total Estimated Cost of Child Abuse and Neglect in the United States
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Early Trauma and Increased Risk for Physical Aggression during Adulthood: The Moderating Role of MAOA Genotype
Frazzetto, G., Lorenzo, G. D., Carola, V., Proietti, L., Sokolowska, E., Siracusano, A., Gross, C. T., & Troisi, A. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000486 · Cited by 195 · see citing works
MAOA Genotype, Maltreatment, and Aggressive Behavior: The Changing Impact of Genotype at Varying Levels of Trauma
Weder, N., Yang, B. Z., Douglas-Palumberi, H., Massey, J., Krystal, J. H., Gelernter, J., & Kaufman, J. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.09.013 · Cited by 190 · see citing works
Childhood Maltreatment, Subsequent Antisocial Behavior, and the Role of Monoamine Oxidase A Genotype
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Genotype × Environment Interaction in Psychopathology: Fact or Artifact?
Eaves, L. J. (2006) · Twin Research and Human Genetics · doi:10.1375/183242706776403073 · Cited by 183 · see citing works
Genotype × Environment Interaction in Psychopathology: Fact or Artifact?
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Young, S. E., Smolen, A., Hewitt, J. K., Haberstick, B. C., Stallings, M. C., Corley, R. P., & Crowley, T. J. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.6.1019 · Cited by 170 · see citing works
Catecholamines and Aggression: The Role of COMT and MAO Polymorphisms
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Catecholaminergic involvement in the control of aggression: hormones, the peripheral sympathetic, and central noradrenergic systems
Haller, J., Makara, G. B., & Kruk, M. R. (1997) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(97)00023-7 · Cited by 152 · see citing works
Association of autism severity with a monoamine oxidase A functional polymorphism
Cohen, I., Liu, X., Schutz, C. K., White, B., Jenkins, E., Brown, W., & Holden, J. (2003) · Clinical Genetics · doi:10.1034/j.1399-0004.2003.00115.x · Cited by 152 · see citing works
Interaction of prenatal exposure to cigarettes and MAOA genotype in pathways to youth antisocial behavior
Wakschlag, L. S., Kistner, E. O., Pine, D. S., Biesecker, G., Pickett, K. E., Skol, A. D., Dukić, V., Blair, J., LEVENTHAL, B. L., Cox, N. J., et al. (2009) · Molecular Psychiatry · doi:10.1038/mp.2009.22 · Cited by 135 · see citing works
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Rose, R. J., Dick, D. M., Viken, R. J., Pulkkinen, L., & Kaprio, J. A. (2004) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000141822.36776.55 · Cited by 88 · see citing works
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The MAO-A gene, platelet MAO-B activity and psychosocial environment in adolescent female alcohol-related problem behaviour
Nilsson, K. W., Wargelius, H., Sjöberg, R. L., Leppert, J., & Oreland, L. (2007) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2007.08.022 · Cited by 76 · see citing works
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Prichard, Z. M., Mackinnon, A. J., Jorm, A. F., & Easteal, S. (2007) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30581 · Cited by 55 · see citing works

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Fekhretdinova, D. I., Sukhodolskaya, E. M., Shibalev, D. V., Lazebnyy, O. E., Butovskaya, M., Рысков, А. П., & Vasilyev, V. A. (2018) · Molecular Genetics Microbiology and Virology · doi:10.3103/s0891416818030035 · Cited by 4 · see citing works
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Wissow, L. S. (2014) · Springer eBooks · doi:10.1007/978-94-017-8999-8_6 · Cited by 3 · see citing works
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Weisfeld, G. E., & Shattuck, K. S. (2017) · Springer eBooks · doi:10.1007/978-3-319-32132-5_6-2 · Cited by 2 · see citing works
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Joyner, B., & Beaver, K. M. (2020) · American Journal of Criminal Justice · doi:10.1007/s12103-020-09542-4 · Cited by 2 · see citing works
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Byrd, I. L., & Manuck, S. B. (2014) · Cited by 2 · see citing works
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Ojuope, A. V. (2021) · Journal of psychiatry · Cited by 1 · see citing works
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Abeykoon, M. R., Jayasinghe, C. D., Illeperuma, R. J., & Abeysinghe, T. (2024) · Asian Journal of Biochemistry Genetics and Molecular Biology · doi:10.9734/ajbgmb/2024/v16i9402 · Cited by 1 · see citing works
Association of Monoamine Oxidase A Gene Promoter Region (30 bp μVNTR) Polymorphism with Serum Levels in Multiple Psychiatric Disorders
Hashmi, A. N., Taj, R., Agha, Z., Qamar, R., Williams, J. B., & Azam, M. (2025) · Biomedicines · doi:10.3390/biomedicines13030698 · Cited by 1 · see citing works
Developmental Mechanisms in Gene-by-Intervention (GxI) Effects in the Fast Track Trial
Dodge, K. A. (2017) · Springer eBooks · doi:10.1007/978-3-319-49227-8_12 · Cited by 1 · see citing works
Self-citation
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Castillo-López, G., Ostrosky-Shejet, F., Camarena, B., & Vélez‐García, A. (2015) · Revista Médica Del Hospital General De México · doi:10.1016/j.hgmx.2015.03.002 · Cited by 1 · see citing works
Resilience and Vulnerability in Adolescents at Risk for Delinquency: A Behavioral Genetic Study of Differential Response to Risk
Newsome, J. (2013) · OhioLink ETD Center (Ohio Library and Information Network) · Cited by 1 · see citing works
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Jewkes, R. K. (2021) · doi:10.1093/med/9780198816805.003.0082 · Cited by 1 · see citing works
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Adeusi, S. O. (2013) · Covenant University Repository (Covenant University) · Cited by 1 · see citing works
Evolutionary Perspectives on Adolescence
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Interpersonal violence: a recent public health mandate
Jewkes, R. K. (2015) · doi:10.1093/med/9780199661756.003.0223
Polymorphism of two dopamine degradation enzyme genes (COMT and MAOA) in hadza and datoga populations
Fekhretdinova, D. I., Sukhodolskaya, E. M., Shibalev, D. V., Lazebnyy, O. E., Butovskaya, M., Рысков, А. П., & Vasilyev, V. A. (2018) · Molecular Genetics Microbiology and Virology (Russian) · doi:10.17116/molgen20183603138
The Effect of MAOA Gene × Gender on the Relationship between Negative Network News Browsing Preference and Aggression among College StudentsPreprint
Gao, F., Guo, Z., Zhan, X., Jun, W., Shi, H., Yan, Y., Sun, Y., & Wang, P. (2021) · Research Square · doi:10.21203/rs.3.rs-206982/v1
Gene-Environment Interactions
Abubucker, S., & Potash, J. B. (2023) · Springer eBooks · doi:10.1007/978-3-030-42825-9_54-1
Gene-Environment Interactions
Abubucker, S., & Potash, J. B. (2024) · Springer eBooks · doi:10.1007/978-3-030-51366-5_54 · Cited by 1 · see citing works
A systematic review and a meta-analysis of genetic studies linking dopaminergic alleles to aggression: Where are we now?
Palumbo, S., Grassi, G., Mariotti, V., & Pellegrini, S. (2025) · Aggression and Violent Behavior · doi:10.1016/j.avb.2025.102096

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Choe, D. E., Shaw, D. S., Hyde, L. W., & Forbes, E. E. (2014) · Clinical Psychological Science · doi:10.1177/2167702613518046 · Cited by 14 · see citing works
Harsh discipline, childhood sexual assault, and MAOA genotype: An investigation of main and interactive effects on diverse clinical externalizing outcomes
Derringer, J., Krueger, R., Irons, D., & Iacono, W. (2010) · Behavior Genetics · doi:10.1007/s10519-010-9358-9 · Cited by 57 · see citing works
The moderating effect of monoamine oxidase A gene polymorphism in relationship between childhood abuse of male adolescents and externalizing behaviors
Ming, Q., Yao, S., & Zhang, Y. (2012) · Zhonghua xingwei yixue yu naokexue zazhi · doi:10.3760/cma.j.issn.1674-6554.2012.08.003
High activity of Monoamine oxidase A is associated with externalizing behaviour in maltreated and nonmaltreated adoptees
van der Vegt, E. J. M., Oostra, B. A., Vásquez, A. A., van der Ende, J., Verhulst, F. C., & Tiemeier, H. W. (2009) · Psychiatric Genetics · doi:10.1097/ypg.0b013e32832a5084 · Cited by 29 · see citing works
Maltreatment, MAOA, and Delinquency: Sex Differences in Gene–Environment Interaction in a Large Population-Based Cohort of Adolescents
Åslund, C., Nordquist, N., Comasco, E., Leppert, J., Oreland, L., & Nilsson, K. W. (2010) · Behavior Genetics · doi:10.1007/s10519-010-9356-y · Cited by 126 · see citing works

Authors: Edwards, A. C., Dodge, K. A., Latendresse, S. J., Lansford, J. E., Bates, J. E., Pettit, G. S., Budde, J. P., Goate, A. M., & Dick, D. M.
Affiliations: Virginia Commonwealth University (US)
Duke University (US)
Indiana University Bloomington (US)
Auburn University (US)
Washington University in St. Louis (US)
ORCID: Edwards, Alexis C.
Dodge, Kenneth A.
Latendresse, Shawn J.
Lansford, Jennifer E.
Budde, John P.
Goate, Alison M.
Dick, Danielle M.
Venue: Journal of Child Psychology and Psychiatry
Publisher: Wiley
Published: 2010-05-10
Volume: 51
Issue: 6
Pages: 679-687
ISSN: 0021-9630 (ISSN-L)
1469-7610
DOI: 10.1111/j.1469-7610.2009.02196.x
PMC: PMC3035042
OpenAlex: W1895563932
Cited by: 67
References: 37
Citations by year: 2025: 2 · 2024: 3 · 2023: 1 · 2021: 4 · 2020: 5 · 2019: 3 · 2018: 5 · 2017: 4 · 2016: 6 · 2015: 8 · 2014: 7 · 2013: 8 · 2012: 2
FWCI: 3.85
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Child Psychology and Psychiatry (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (5p20da017589-05)
National Institute on Alcohol Abuse and Alcoholism (K02AA018755, AA 15416, R01AA015416)
National Institute of Mental Health (MH57024, R01MH057024, MH56961, R01MH057095, R01MH056961, MH57095, R01MH042498)
National Institute on Drug Abuse (DA016903, R01DA016903, P20- DA017589, K05DA015226, DA017589, DA015226)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD030572)
Topics: Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: monoamine oxidase A, promoter polymorphism, corporal punishment, delinquency, externalizing problems, aggression, gene-environment interaction, behavioral sensitivity, European American children
MeSH terms: Adolescent, Aggression, Child, Child, Preschool, Female, Genotype, Humans, Juvenile Delinquency, Longitudinal Studies, Male, Monoamine Oxidase, Punishment, Regression Analysis, Young Adult

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MAOA‐uVNTR and early physical discipline interact to influence delinquent behavior

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