Rottapel, Robert

Measuring error rates in genomic perturbation screens: gold standards for human functional genomics

Hart, T., Brown, K. R., Sircoulomb, F., Rottapel, R., & Moffat, J. (2014) · Molecular Systems Biology

CRISPR and Genetic EngineeringBioinformatics and Genomic Networks

Cited by 398

A point mutation in CD28 distinguishes proliferative signals from survival signals.

Okkenhaug, K., Wu, L., Garza, K. M., La Rose, J., Khoo, W., Odermatt, B., Mak, T. W., Ohashi, P. S., & Rottapel, R. (2001) · Nature Immunology

T-cell and B-cell ImmunologySignaling Pathways in Disease

Cited by 210

The RhoGEF GEF-H1 is required for oncogenic RAS signaling via KSR-1

Cullis, J., Meiri, D., Sandi, M. J., Radulovich, N., Kent, O. A., Medrano, M., Mokady, D., Normand, J., Larose, J., Marcotte, R., et al. (2014) · Cancer Cell

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 100

Mechanistic Insight into the Microtubule and Actin Cytoskeleton Coupling through Dynein-Dependent RhoGEF Inhibition

Meiri, D., Marshall, C. B., Greeve, M. A., Kim, B., Balan, M., Suarez, F., Bakal, C., Wu, C., LaRose, J., Fine, N., et al. (2012) · Molecular Cell

Microtubule and mitosis dynamicsProtein Kinase Regulation and GTPase Signaling

Cited by 98

Modulation of Rho Guanine Exchange Factor Lfc Activity by Protein Kinase A-Mediated Phosphorylation

Meiri, D., Greeve, M. A., Brunet, A., Finan, D., Wells, C. D., LaRose, J., & Rottapel, R. (2009) · Molecular and Cellular Biology

Protein Kinase Regulation and GTPase Signaling14-3-3 protein interactions

Cited by 71

Mechanistic insight into GPCR-mediated activation of the microtubule-associated RhoA exchange factor GEF-H1

Meiri, D., Marshall, C. B., Mokady, D., LaRose, J., Mullin, M., Gingras, A.-C., Ikura, M., & Rottapel, R. (2014) · Nature Communications

Protein Kinase Regulation and GTPase SignalingReceptor Mechanisms and Signaling

Cited by 70

Spatiotemporal dynamics of GEF-H1 activation controlled by microtubule- and Src-mediated pathways

Azoitei, M. L., Noh, J., Marston, D. J., Roudot, P., Marshall, C. B., Daugird, T. A., Lisanza, S. L., Sandí, M.-J., Ikura, M., Sondek, J., et al. (2019) · Journal of Cell Biology

Protein Kinase Regulation and GTPase SignalingCellular Mechanics and Interactions

Cited by 61

Probing the GTPase cycle with real-time NMR: GAP and GEF activities in cell extracts

Marshall, C. B., Meiri, D., Smith, M. J., Mazhab-Jafari, M. T., Gasmi-Seabrook, G. M. C., Rottapel, R., Stambolic, V., & Ikura, M. (2012) · Methods

Protein Kinase Regulation and GTPase SignalingAdvanced NMR Techniques and Applications

Cited by 46

Repurposing Itraconazole and Hydroxychloroquine to Target Lysosomal Homeostasis in Epithelial Ovarian Cancer

Marastoni, S., Madariaga, A., Pesic, A., Nair, S. N., Li, Z. J., Shalev, Z., Ketela, T., Colombo, I., Mandilaras, V., Cabanero, M., et al. (2022) · Cancer Research Communications

Ovarian cancer diagnosis and treatmentAutophagy in Disease and Therapy

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