Proks, Peter

Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes

Gloyn, A. L., Pearson, E. R., Antcliff, J. F., Proks, P., Bruining, G. J., Slingerland, A. S., Howard, N., Srinivasan, S., Silva, J. M. C. L., Molnes, J., et al. (2004) · New England Journal of Medicine

Pancreatic function and diabetesIon channel regulation and function

Cited by 1,137

Sulfonylurea Stimulation of Insulin Secretion

Proks, P., Reimann, F., Green, N., Gribble, F., & Ashcroft, F. (2002) · Diabetes

Ion channel regulation and functionPancreatic function and diabetes

Cited by 510

Reversible changes in pancreatic islet structure and function produced by elevated blood glucose

Brereton, M. F., Iberl, M., Shimomura, K., Zhang, Q., Adriaenssens, A. E., Proks, P., Spiliotis, I. I., Dace, W., Mattis, K. K., Ramracheya, R., et al. (2014) · Nature Communications

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 259

Stimulus-secretion coupling in pancreatic β cells

Ashcroft, F. M., Proks, P., Smith, P. A., Ämmälä, C., Bokvist, K., & Rorsman, P. (1994) · Journal of Cellular Biochemistry

Pancreatic function and diabetesIon channel regulation and function

Cited by 255

Rapid ATP‐Dependent Priming of Secretory Granules Precedes Ca 2+ ‐Induced Exocytosis in Mouse Pancreatic B‐Cells

Eliasson, L., Renström, E., Ding, W., Proks, P., & Rorsman, P. (1997) · The Journal of Physiology

Cellular transport and secretionPancreatic function and diabetes

Cited by 223

Permanent neonatal diabetes caused by dominant, recessive, or compound heterozygous SUR1 mutations with opposite functional effects

Ellard, S., Flanagan, S. E., Girard, C. A., Patch, A.-M., Harries, L. W., Parrish, A., Edghill, E. L., Mackay, D. J. G., Proks, P., Shimomura, K., et al. (2007) · The American Journal of Human Genetics

Pancreatic function and diabetesIon channel regulation and function

Cited by 215

Molecular Analysis of ATP-sensitive K Channel Gating and Implications for Channel Inhibition by ATP

Trapp, S., Proks, P., Tucker, S. J., & Ashcroft, F. M. (1998) · The Journal of General Physiology

Ion channel regulation and functionPancreatic function and diabetes

Cited by 170

Electrogenic arginine transport mediates stimulus‐secretion coupling in mouse pancreatic beta‐cells.

Smith, P. A., Sakura, H., Coles, B., Gummerson, N., Proks, P., & Ashcroft, F. M. (1997) · The Journal of Physiology

Pancreatic function and diabetesAmino Acid Enzymes and Metabolism

Cited by 142

Mechanism of Cloned ATP-sensitive Potassium Channel Activation by Oleoyl-CoA

Gribble, F. M., Proks, P., Corkey, B. E., & Ashcroft, F. M. (1998) · Journal of Biological Chemistry

Ion channel regulation and functionPancreatic function and diabetes

Cited by 133

Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic β cells recapitulates neonatal diabetes

Girard, C. A., Wunderlich, F. T., Shimomura, K., Collins, S., Kaizik, S., Proks, P., Abdulkader, F., Clark, A., Ball, V., Zubcevic, L., et al. (2008) · Journal of Clinical Investigation

Pancreatic function and diabetesIon channel regulation and function

Cited by 105

How ATP Inhibits the Open KATP Channel

Craig, T. J., Ashcroft, F. M., & Proks, P. (2008) · The Journal of General Physiology

Ion channel regulation and functionATP Synthase and ATPases Research

Cited by 67

Activation of the KATP channel by Mg-nucleotide interaction with SUR1

Proks, P., de Wet, H., & Ashcroft, F. M. (2010) · Journal of General Physiology

Ion channel regulation and functionAdenosine and Purinergic Signaling

Cited by 51

Sulfonylureas suppress the stimulatory action of Mg-nucleotides on Kir6.2/SUR1 but not Kir6.2/SUR2A KATP channels: A mechanistic study

Proks, P., de Wet, H., & Ashcroft, F. M. (2014) · Journal of General Physiology

Ion channel regulation and functionPancreatic function and diabetes

Cited by 22

Running out of time: the decline of channel activity and nucleotide activation in adenosine triphosphate-sensitive K-channels

Proks, P., Puljung, M. C., Vedovato, N., Sachse, G., Mulvaney, R., & Ashcroft, F. M. (2016) · Philosophical Transactions of the Royal Society B: Biological Sciences

Ion channel regulation and functionAdenosine and Purinergic Signaling

Cited by 11