How ATP Inhibits the Open KATP Channel
Open accessAbstract
ATP-sensitive potassium (KATP) channels are composed of four pore-forming Kir6.2 subunits and four regulatory SUR1 subunits. Binding of ATP to Kir6.2 leads to inhibition of channel activity. Because there are four subunits and thus four ATP-binding sites, four binding events are possible. ATP binds to both the open and closed states of the channel and produces a decrease in the mean open time, a reduction in the mean burst duration, and an increase in the frequency and duration of the interburst closed states. Here, we investigate the mechanism of interaction of ATP with the open state of the channel by analyzing the single-channel kinetics of concatenated Kir6.2 tetramers containing from zero to four mutated Kir6.2 subunits that possess an impaired ATP-binding site. We show that the ATP-dependent decrease in the mean burst duration is well described by a Monod-Wyman-Changeux model in which channel closing is produced by all four subunits acting in a single concerted step. The data are inconsistent with a Hodgkin-Huxley model (four independent steps) or a dimer model (two independent dimers). When the channel is open, ATP binds to a single ATP-binding site with a dissociation constant of 300 μM.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
ATP closes KATP-channels by interacting with Kir6.2, whereas SUs inactivate by binding SUR1.
“In contrast to SUs inactivating the KATP-channels by binding to the SUR1 subunit, ATP closes them by interacting with Kir6.2.305”
From Pancreatic regulation of glucose homeostasis. (2016) · cites this paper as [305]
The Introduction states that ATP binding to Kir6.2 inhibits KATP-channel activity. It identifies SUR1 as the sulphonylurea receptor but does not say that sulphonylureas inactivate the channel by binding SUR1; the paper focuses on ATP inhibition. (LLM, conf=0.86)
Experimental — accuracy not yet measuredATP decreases the duration of KATP channel openings and increases the lifetimes of long closed states, whereas MgADP increases burst duration and reduces interburst intervals.
“ATP acts by decreasing the duration of the channel openings and increasing the lifetimes of the long closed states (132, 173, 691). Conversely, MgADP increases burst duration and reduces the interburst intervals (328).”
From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [132]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Hodgkin, A. L., & Huxley, A. F. (1952) · The Journal of Physiology · doi:10.1113/jphysiol.1952.sp004764 · Cited by 23,191 · see citing works
ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL.
Monod, J., Wyman, J., & Changeux, J. (1965) · Journal of Molecular Biology · doi:10.1016/s0022-2836(65)80285-6 · Cited by 7,681 · see citing works
Inagaki, N., Gonoi, T., Clement, J. P., Namba, N., Inazawa, J., Gonzalez, G., Aguilar-Bryan, L., Seino, S., & Bryan, J. (1995) · Science · doi:10.1126/science.270.5239.1166 · Cited by 1,709 · see citing works
Glucose induces closure of single potassium channels in isolated rat pancreatic β-cells
Ashcroft, F. M., Harrison, D. E., & Ashcroft, S. J. H. (1984) · Nature · doi:10.1038/312446a0 · Cited by 1,113 · see citing works
Self-citationColquhoun, D. M. (1998) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702164 · Cited by 893 · see citing works
Truncation of Kir6.2 produces ATP-sensitive K+ channels in the absence of the sulphonylurea receptor
Tucker, S. J., Gribble, F. M., Zhao, C., Trapp, S., & Ashcroft, F. M. (1997) · Nature · doi:10.1038/387179a0 · Cited by 753 · see citing works
Self-citationAssociation and Stoichiometry of KATP Channel Subunits
Clement, J. P., Kunjilwar, K., Gonzalez, G., Schwanstecher, M., Panten, U., Aguilar-Bryan, L., & Bryan, J. (1997) · Neuron · doi:10.1016/s0896-6273(00)80321-9 · Cited by 692 · see citing works
ATP-sensitive potassium channelopathies: focus on insulin secretion
Ashcroft, F. M. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25495 · Cited by 627 · see citing works
Self-citationOn the stochastic properties of bursts of single ion channel openings and of clusters of bursts
Colquhoun, D. M., & Hawkes, A. G. (1982) · Philosophical transactions of the Royal Society of London. Series B, Biological sciences · doi:10.1098/rstb.1982.0156 · Cited by 583 · see citing works
Miki, T., Liss, B., Minami, K., Shiuchi, T., Saraya, A., Kashima, Y., Horiuchi, M., Ashcroft, F., Minokoshi, Y., Roeper, J., et al. (2001) · Nature Neuroscience · doi:10.1038/87455 · Cited by 547 · see citing works
Self-citationAdenosine Diphosphate as an Intracellular Regulator of Insulin Secretion
Nichols, C. G., Shyng, S., Nestorowicz, A., Gläser, B., Clement, J. P., González, G., Aguilar‐Bryan, L., Permutt, M. A., & Bryan, J. (1996) · Science · doi:10.1126/science.272.5269.1785 · Cited by 525 · see citing works
Activating Mutations in Kir6.2 and Neonatal Diabetes
Hattersley, A. T., & Ashcroft, F. M. (2005) · Diabetes · doi:10.2337/diabetes.54.9.2503 · Cited by 413 · see citing works
Self-citation(1995) · FEBS Letters · doi:10.1016/0014-5793(95)01369-5 · Cited by 411 · see citing works
Self-citationMouse model of Prinzmetal angina by disruption of the inward rectifier Kir6.1
Miki, T., Suzuki, M., Shibasaki, T., Uemura, H., Sato, T., Yamaguchi, K., Koseki, H., Iwanaga, T., Nakaya, H., & Seino, S. (2002) · Nature Medicine · doi:10.1038/nm0502-466 · Cited by 347 · see citing works
Protective Role of ATP-Sensitive Potassium Channels in Hypoxia-Induced Generalized Seizure
Yamada, K., Ji, J., Yuan, H., Miki, T., Sato, S.-I., Horimoto, N., Shimizu, T., Seino, S., & Inagaki, N. (2001) · Science · doi:10.1126/science.1059829 · Cited by 339 · see citing works
Kir6.2 is required for adaptation to stress
Zingman, L. V., Hodgson, D. M., Bast, P., Kane, G. C., Pérez-Terzic, C. M., Gumina, R. J., Pucar, D., Bienengraeber, M., Dzeja, P. P., Miki, T., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.212315199 · Cited by 305 · see citing works
K-ATP channels promote the differential degeneration of dopaminergic midbrain neurons
Liss, B., Haeckel, O., Wildmann, J., Miki, T., Seino, S., & Roeper, J. (2005) · Nature Neuroscience · doi:10.1038/nn1570 · Cited by 300 · see citing works
Glucose-Sensing in Glucagon-Like Peptide-1-Secreting Cells
Reimann, F. M., & Gribble, F. M. (2002) · Diabetes · doi:10.2337/diabetes.51.9.2757 · Cited by 293 · see citing works
Liss, B., Bruns, R., & Roeper, J. (1999) · The EMBO Journal · doi:10.1093/emboj/18.4.833 · Cited by 254 · see citing works
MacDonald, P. E., Marinis, Y. Z. D., Ramracheya, R. D., Salehi, A. A., Ma, X., Johnson, P., Cox, R., Eliasson, L., & Rorsman, P. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050143 · Cited by 243 · see citing works
Molecular determinants of KATP channel inhibition by ATP
Tucker, S. J., Gribble, F. M., Proks, P., Trapp, S., Ryder, T. J., Haug, T. M., Reimann, F. M., & Ashcroft, F. M. (1998) · The EMBO Journal · doi:10.1093/emboj/17.12.3290 · Cited by 222 · see citing works
Self-citationDrain, P., Li, L., & Wang, J. (1998) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.95.23.13953 · Cited by 219 · see citing works
Cardiac K channels in health and disease
Kane, G. C., Liu, X., Yamada, S., Olson, T. M., & Terzic, A. (2005) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2005.02.026 · Cited by 196 · see citing works
Functional analysis of a structural model of the ATP‐binding site of the KATP channel Kir6.2 subunit
Antcliff, J. F., Haider, S. M., Proks, P., Sansom, M. S. P., & Ashcroft, F. M. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600487 · Cited by 185 · see citing works
Self-citationSignaling in Channel/Enzyme Multimers
Zingman, L. V., Alekseev, A. E., Bienengraeber, M., Hodgson, D. M., Karger, A. B., Dzeja, P. P., & Terzic, A. (2001) · Neuron · doi:10.1016/s0896-6273(01)00356-7 · Cited by 181 · see citing works
Burst kinetics of single calcium‐activated potassium channels in cultured rat muscle.
Magleby, K. L., & Pallotta, B. S. (1983) · The Journal of Physiology · doi:10.1113/jphysiol.1983.sp014958 · Cited by 178 · see citing works
The kinetic and physical basis of K(ATP) channel gating: toward a unified molecular understanding.
Enkvetchakul, D., Loussouarn, G., Makhina, E., Shyng, S., & Nichols, C. G. (2000) · Biophysical Journal · doi:10.1016/s0006-3495(00)76779-8 · Cited by 172 · see citing works
Molecular Analysis of ATP-sensitive K Channel Gating and Implications for Channel Inhibition by ATP
Trapp, S., Proks, P., Tucker, S. J., & Ashcroft, F. M. (1998) · The Journal of General Physiology · doi:10.1085/jgp.112.3.333 · Cited by 170 · cited 15× · see citing works
“Previous single-channel studies have characterized the ATP dependence of the mean open time and the mean burst duration ( Davies et al., 1992 ; Trapp et al., 1998 ; Fan and Makielski, 1999 ; Li et al., 2002 ).”
BackgroundMethodInfluentialSelf-citation3‐D structural and functional characterization of the purified KATP channel complex Kir6.2–SUR1
Mikhailov, M. V., Campbell, J. D., de Wet, H., Shimomura, K., Zadek, B., Collins, R. F., Sansom, M. S., Ford, R. C., & Ashcroft, F. M. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600877 · Cited by 168 · see citing works
Self-citationCoupling of Cell Energetics with Membrane Metabolic Sensing
Abraham, M. R., Selivanov, V. A., Hodgson, D. M., Pucar, D., Zingman, L. V., Wieringa, B., Dzeja, P. P., Alekseev, A. E., & Terzic, A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201777200 · Cited by 148 · see citing works
Mechanism of Cloned ATP-sensitive Potassium Channel Activation by Oleoyl-CoA
Gribble, F. M., Proks, P., Corkey, B. E., & Ashcroft, F. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.41.26383 · Cited by 133 · see citing works
Self-citationGillis, K. D., Gee, W. M., Hammoud, A. M., McDaniel, M. L., Falke, L. C., & Misler, S. (1989) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1989.257.6.c1119 · Cited by 123 · see citing works
The effect of intracellular anions on ATP‐dependent potassium channels of rat skeletal muscle.
McKillen, H. C., Davies, N. W., Stanfield, P. R., & Standen, N. B. (1994) · The Journal of Physiology · doi:10.1113/jphysiol.1994.sp020300 · Cited by 123 · see citing works
Hernández‐Sánchez, C., Basile, A. S., Fedorova, I., Arima, H., STANNARD, B. S., Fernandez, A. M., Ito, Y., & LeRoith, D. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051012898 · Cited by 95 · see citing works
Selivanov, V. A., Alekseev, A. E., Hodgson, D. M., Dzeja, P. P., & Terzic, A. (2003) · Molecular and Cellular Biochemistry · doi:10.1023/b:mcbi.0000009872.35940.7d · Cited by 93 · see citing works
Phosphoinositides Decrease Atp Sensitivity of the Cardiac Atp-Sensitive K+ Channel
Fan, Z., & Makielski, J. (1999) · The Journal of General Physiology · doi:10.1085/jgp.114.2.251 · Cited by 90 · see citing works
The effect of intracellular pH on ATP‐dependent potassium channels of frog skeletal muscle.
Davies, N. W., Standen, N., & Stanfield, P. (1992) · Journal of Physiology · doi:10.1113/jphysiol.1992.sp018939 · Cited by 90 · see citing works
Tandem linkage of Shaker K+ channel subunits does not ensure the stoichiometry of expressed channels
McCormack, K., Lin, L., Iverson, L. E., Tanouye, M. A., & Sigworth, F. J. (1992) · Biophysical Journal · doi:10.1016/s0006-3495(92)81703-4 · Cited by 83 · see citing works
Identification of residues contributing to the ATP binding site of Kir6.2
Trapp, S., Haider, S. M., Jones, P. C., Sansom, M. S. P., & Ashcroft, F. M. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg282 · Cited by 77 · see citing works
Self-citationMarkworth, E., Schwanstecher, C., & Schwanstecher, M. (2000) · Diabetes · doi:10.2337/diabetes.49.9.1413 · Cited by 76 · see citing works
Gong, B., Miki, T., Seino, S., & Renaud, J. (2000) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2000.279.5.c1351 · Cited by 74 · see citing works
Ligand-insensitive State of Cardiac ATP-sensitive K+ Channels
Alekseev, A. E., Brady, P. A., & Terzic, A. (1998) · The Journal of General Physiology · doi:10.1085/jgp.111.2.381 · Cited by 71 · see citing works
Liu, X., Yamada, S., Kane, G. C., Alekseev, A. E., Hodgson, D. M., O’Cochlain, F., Jahangir, A., Miki, T., Seino, S., & Terzic, A. (2004) · Diabetes · doi:10.2337/diabetes.53.suppl_3.s165 · Cited by 69 · see citing works
ATP dependence of KATP channel kinetics in isolated membrane patches from rat ventricle
Nichols, C. G., Lederer, W. J., & Cannell, M. (1991) · Biophysical Journal · doi:10.1016/s0006-3495(91)82152-x · Cited by 65 · see citing works
Focus on Kir6.2: a key component of the ATP-sensitive potassium channel
Haider, S. M., Antcliff, J. F., Proks, P., Sansom, M. S. P., & Ashcroft, F. M. (2005) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2005.01.007 · Cited by 64 · see citing works
Self-citationATP Interaction with the Open State of the KATP Channel
Enkvetchakul, D., Loussouarn, G., Makhina, E., & Nichols, C. G. (2001) · Biophysical Journal · doi:10.1016/s0006-3495(01)76051-1 · Cited by 56 · see citing works
Molecular Mechanism for ATP‐Dependent Closure of the K+ Channel Kir6.2
John, S., Weiss, J. N., Xie, L., & Ribalet, B. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.048843 · Cited by 55 · see citing works
Molecular basis for Kir6.2 channel inhibition by adenine nucleotides.
Ribalet, B., John, S., & Weiss, J. (2003) · Biophysical Journal · doi:10.1016/s0006-3495(03)74847-4 · Cited by 53 · see citing works
Reimann, F., Ryder, T., Tucker, S. J., & Ashcroft, F. M. (1999) · Journal of Physiology · doi:10.1111/j.1469-7793.1999.00661.x · Cited by 52 · see citing works
Self-citationHaider, S. M., Grottesi, A., Hall, B. A., Ashcroft, F. M., & Sansom, M. S. P. (2005) · Biophysical Journal · doi:10.1529/biophysj.104.052019 · Cited by 45 · see citing works
Self-citationDirect Photoaffinity Labeling of Kir6.2 by [γ-32P]ATP-[γ]4-Azidoanilide
Tanabe, K., Tucker, S. J., Ashcroft, F. M., Proks, P., Kioka, N., Amachi, T., & Ueda, K. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.2780 · Cited by 40 · see citing works
Self-citationFang, K., Csanády, L., & Chan, K. W. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.112748 · Cited by 37 · see citing works
Li, L., Geng, X.-H., & Drain, P. (2002) · The Journal of General Physiology · doi:10.1085/jgp.119.1.105 · Cited by 37 · see citing works
Concerted Gating Mechanism Underlying KATP Channel Inhibition by ATP
Drain, P. F., Geng, X., & Li, L. (2004) · Biophysical Journal · doi:10.1016/s0006-3495(04)74269-1 · Cited by 35 · see citing works
Shelley, C., & Colquhoun, D. M. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2004.081497 · Cited by 15 · see citing works
Subunit-Stoichiometric Evidence for Kir6.2 Channel Gating, ATP Binding, and Binding-Gating Coupling
Wang, R., Zhang, X., Cui, N., Wu, J., Piao, H., Wang, X., Su, J., & Jiang, C. L. (2007) · Molecular Pharmacology · doi:10.1124/mol.106.030528 · Cited by 11 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Inwardly Rectifying Potassium Channels: Their Structure, Function, and Physiological Roles
Hibino, H., Inanobe, A., Furutani, K., Murakami, S., Findlay, I., & Kurachi, Y. (2010) · Physiological Reviews · doi:10.1152/physrev.00021.2009 · Cited by 1,518 · see citing works
Pancreatic regulation of glucose homeostasis.
Röder, P. V., Wu, B., Liu, Y., & Han, W. (2016) · Experimental & Molecular Medicine · doi:10.1038/emm.2016.6 · Cited by 985 · see citing works
Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men
Rorsman, P., & Ashcroft, F. M. (2018) · Physiological Reviews · doi:10.1152/physrev.00008.2017 · Cited by 793 · see citing works
Self-citationSpégel, P., Sharoyko, V. V., Göhring, I., Danielsson, A. P. H., Malmgren, S., Nagorny, C. L. F., Andersson, L. E., Koeck, T., Sharp, G. W. G., Straub, S. G., et al. (2013) · Biochemical Journal · doi:10.1042/bj20121349 · Cited by 95 · see citing works
Pietak, A. M., & Levin, M. G. (2017) · Journal of The Royal Society Interface · doi:10.1098/rsif.2017.0425 · Cited by 96 · see citing works
S-sulfhydration as a cellular redox regulation
Iciek, M., Kowalczyk‐Pachel, D., Bilska‐Wilkosz, A., Kwiecień, I., Górny, M., & Włodek, L. B. (2015) · Bioscience Reports · doi:10.1042/bsr20150147 · Cited by 92 · see citing works
Srikanth, S., Jung, H.-J., Ribalet, B., & Gwack, Y. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.072736 · Cited by 80 · see citing works
Balistrieri, A., Makino, A., & Yuan, J. X. ‐. (2022) · Physiological Reviews · doi:10.1152/physrev.00030.2021 · Cited by 76 · see citing works
Hyperinsulinemic Hypoglycemia – The Molecular Mechanisms
Nessa, A., Rahman, S. A., & Hussain, K. (2016) · Frontiers in Endocrinology · doi:10.3389/fendo.2016.00029 · Cited by 66 · see citing works
Modeling KATP channel gating and its regulation
Proks, P., & Ashcroft, F. M. (2008) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2008.10.002 · Cited by 65 · see citing works
Self-citationHuman IAPP amyloidogenic properties and pancreatic β-cell death
Fernández, M. S. (2014) · Cell Calcium · doi:10.1016/j.ceca.2014.08.011 · Cited by 48 · see citing works
Proks, P., de Wet, H., & Ashcroft, F. M. (2013) · Diabetes · doi:10.2337/db13-0531 · Cited by 45 · see citing works
Self-citationChen, X., Feng, Y., Quinn, R. J., Pountney, D. L., Richardson, D. R., Mellick, G. D., & Ma, L. (2023) · Pharmacological Reviews · doi:10.1124/pharmrev.122.000743 · Cited by 44 · see citing works
Pathophysiological Insights of Methylglyoxal Induced Type-2 Diabetes
Dornadula, S., Bhakkiyalakshmi, E., Balashanmugam, P., Palanisamy, R., & Ramkumar, K. M. (2015) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.5b00171 · Cited by 42 · see citing works
Soty, M., Visa, M., Soriano, S., Carmona, M. C., Nadal, Á., & Novials, A. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.232801 · Cited by 41 · see citing works
Targeting Microglial K ATP Channels to Treat Neurodegenerative Diseases: A Mitochondrial Issue
Rodríguez, M. J., Martínez-Moreno, M., Ortega, F. J., & Mahy, N. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/194546 · Cited by 38 · see citing works
Niu, K., Saloman, J. L., Zhang, Y., & Ro, J. Y. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.01.045 · Cited by 37 · see citing works
Li, Z., Macaluso, K. R., Foil, L. D., & Swale, D. R. (2019) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0007153 · Cited by 36 · see citing works
Cui, Z. G., & Zhang, S. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.461715 · Cited by 34 · see citing works
The Nucleotide-Binding Sites of SUR1: A Mechanistic Model
Vedovato, N., Ashcroft, F. M., & Puljung, M. C. (2015) · Biophysical Journal · doi:10.1016/j.bpj.2015.10.026 · Cited by 32 · see citing works
Self-citationContribution of Mitochondria to Insulin Secretion by Various Secretagogues
Ježek, P., Holendová, B., Jabůrek, M., Dlasková, A., & Plecitá‐Hlavatá, L. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2021.0113 · Cited by 32 · see citing works
ATP-Sensitive Potassium Channels in Health and Disease
Clark, R. H., & Proks, P. (2010) · Advances in experimental medicine and biology · doi:10.1007/978-90-481-3271-3_8 · Cited by 29 · see citing works
Self-citationAre physiological oscillations physiological ?
Xiong, L., & Garfinkel, A. (2023) · The Journal of Physiology · doi:10.1113/jp285015 · Cited by 32 · see citing works
The now and then of gut-brain signaling
Kaelberer, M. M., & Bohórquez, D. V. (2018) · Brain Research · doi:10.1016/j.brainres.2018.03.027 · Cited by 31 · see citing works
Clara, R., Langhans, W., & Mansouri, A. (2015) · Metabolism · doi:10.1016/j.metabol.2015.10.003 · Cited by 30 · see citing works
Usher, S. G., Ashcroft, F. M., & Puljung, M. C. (2020) · eLife · doi:10.7554/elife.52775 · Cited by 27 · see citing works
Self-citationATP modulates Ca 2+ uptake by TRPV6 and is counteracted by isoform‐specific phosphorylation
Alansary, D., Bogeski, I., Disteldorf, B. M. J., Becherer, U., & Niemeyer, B. A. (2009) · The FASEB Journal · doi:10.1096/fj.09-141481 · Cited by 25 · see citing works
Metabolomics Analysis of Nutrient Metabolism in β-Cells
Spégel, P., & Mulder, H. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.07.020 · Cited by 24 · see citing works
Fardet, T., & Levina, A. (2020) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1008503 · Cited by 21 · see citing works
Lee, D. C., Vali, K., Baldwin, S. R., Divino, J. N., Feliciano, J. L., Fequiere, J. R., Fernandez, M. A., Frageau, J. C., Longo, F. K., Madhoun, S. S., et al. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01140 · Cited by 21 · see citing works
Stamenkovic, J., Andersson, L. E., Adriaenssens, A. E., Bagge, A., Sharoyko, V. V., Gribble, F. M., Reimann, F. M., Wollheim, C. B., Mulder, H., & Spégel, P. (2015) · Biochemical Journal · doi:10.1042/bj20140697 · Cited by 17 · see citing works
Driggers, C., & Shyng, S. (2021) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2021.02.008 · Cited by 14 · see citing works
de Wet, H., Shimomura, K., Aittoniemi, J., Ahmad, N., Lafond, M., Sansom, M., & Ashcroft, F. (2012) · Journal of Physiology · doi:10.1113/jphysiol.2012.236075 · Cited by 10 · see citing works
Self-citationProks, P., Puljung, M. C., Vedovato, N., Sachse, G., Mulvaney, R., & Ashcroft, F. M. (2016) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2015.0426 · Cited by 11 · see citing works
Self-citationKATP channels process nucleotide signals in muscle thermogenic response
Reyes, S., Park, S., Terzic, A., & Alekseev, A. (2010) · Critical reviews in biochemistry and molecular biology · doi:10.3109/10409238.2010.513374 · Cited by 11 · see citing works
Murovets, V. O., Lukina, E. A., Sozontov, E. A., Andreeva, J. V., Khropycheva, R. P., & Zolotarev, V. A. (2020) · PLoS ONE · doi:10.1371/journal.pone.0235913 · Cited by 10 · see citing works
Intractable hyperkalemia due to nicorandil induced potassium channel syndrome
Chowdhry, V., & Mohanty, B. (2015) · Annals of Cardiac Anaesthesia · doi:10.4103/0971-9784.148331 · Cited by 10 · see citing works
Liang, S., Tippens, N. D., Yaoda, Z., Mort, M. E., Stenson, P. D., Cooper, D. N., & Yu, H. (2017) · Genome biology · doi:10.1186/s13059-016-1138-2 · Cited by 9 · see citing works
Feige, K., Roth, S., M’Pembele, R., Galow, A., Koenig, S., Stroethoff, M., Raupach, A., Buse, G. L., Mathes, A., Hollmann, M. W., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232314557 · Cited by 8 · see citing works
Vedovato, N., Rorsman, O., Hennis, K., Ashcroft, F. M., & Proks, P. (2018) · The Journal of Physiology · doi:10.1113/jp276708 · Cited by 8 · see citing works
Self-citationCombination of Cyclosporine A and Levosimendan Induces Cardioprotection under Acute Hyperglycemia
Torregroza, C., Yueksel, B., Ruske, R., Stroethoff, M., Raupach, A., Heinen, A., Hollmann, M. W., Huhn, R., & Feige, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094517 · Cited by 8 · see citing works
Khurana, A., Shao, E., Kim, R. Y., Vilin, Y. Y., Huang, X., Yang, R. Y., & Kurata, H. T. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.249110 · Cited by 7 · see citing works
Possible involvement of monoamine neurons in the emotional abnormality in Kir6.2-deficient mice.
Saito, A., Miyagawa, K., Miyagishi, H., Kurokawa, K., Umeda, A., Okada, Y., Tsuji, M., & Takeda, H. (2018) · Physiology and Behavior · doi:10.1016/j.physbeh.2018.02.014 · Cited by 4 · see citing works
Razvickas, C. V., Borges, F. T., de Oliveira, A. S., Schor, N., & Boim, M. A. (2013) · Brazilian Journal of Nephrology · doi:10.5935/0101-2800.20130044 · Cited by 4 · see citing works
Perturbed Mitochondrial Metabolism in Islets from Donors with Type-2 DiabetesPreprint
Sun, J., Jain, R., Andersson, L. E., Medina, A., Storm, P., Spégel, P., & Mulder, H. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/212548 · Cited by 4 · see citing works
Doğanyiğit, Z., Akyüz, E., Yılmaz, S., Taheri, S., Okan, A., Başaran, K. E., Uçar, S., Güvenilir, E., Şükranlı, Z. Y., & Bor, T. B. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177288 · Cited by 3 · see citing works
Murovets, V. O., Sozontov, E. A., & Zolotarev, V. A. (2024) · Успехи физиологических наук · doi:10.31857/s0301179824040052 · Cited by 2 · see citing works
Sulfonylureas can Stimulate Insulin Release by Flip-Flop across Phospholipid Membranes
Alruwaili, J. (2016) · Journal of Biotechnology & Biomaterials · doi:10.4172/2155-952x.1000218 · Cited by 2 · see citing works
ATP-Sensitive Potassium Channels in Health and Disease
Proks, P., & Clark, R. H. (2014) · Springer eBooks · doi:10.1007/978-94-007-6686-0_6 · Cited by 2 · see citing works
Self-citationT1R taste receptors and the regulation of carbohydrate intake and metabolism in mammals
Murovets, V. O., & Lukina, E. A. (2022) · Integrative Physiology · doi:10.33910/2687-1270-2022-3-3-270-285 · Cited by 2 · see citing works
Expression of SUR1 isoforms in the brain and heart after ischemia/reperfusion
Alquisiras-Burgos, I., Peralta‐Arrieta, I., Espinoza-Rojo, M., Salazar-Salgado, A., Antonino-Olguín, I., Sánchez-Mendoza, A., Sánchez-Aguilar, M., Tachiquín, M. E. R., Valdez‐Salazar, H.-A., Ortíz-Plata, A., et al. (2025) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2025.1536409 · Cited by 1 · see citing works
Dongre, U. J., Meshram, V., & Bhoomi, D. (2014) · Cited by 1 · see citing works
Hypertension and Dyslipidemia in Patients with Pre-Diabetes
Tsimihodimos, V., & Florentin, M. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-800093-9.00013-2 · Cited by 1 · see citing works
Regulation of insulin secretion
Gupta, A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820234-0.00001-9 · Cited by 1 · see citing works
Regulatory mechanisms of the calcium selective ion channels TRPV6 and ORAI1
Alansary, D. (2009) · Publications of the UdS (Saarland University) · doi:10.22028/d291-21438
The Question of the End Effector of Ischemic Postconditioning of the Heart
Маслов, Л. Н., Naryzhnaya, N. V., Хануш, Л., Pei, J., Байков, А. Н., Zhang, I., Wang, H., & Халиулин, И. Г. (2015) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-015-0069-9
Maretty, L., Sibbesen, J. A., & Krogh, A. (2014)
Regulation of Myoplasmic Ca2+ During Fatigue in KATP Channel Deficient FDB Muscle Fibres
Selvin, D. (2013) · uO Research (University of Ottawa) · doi:10.20381/ruor-3254
Study of a glycine hinge in ATP-sensitive potassium channels
Bushman, J. D. (2012) · doi:10.6083/m44747v3
Coavoy-Sánchez, S. A. (2016) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.42.2016.tde-16082016-090906
Mechanisms Underlying the Pathogenesis of Atrial Arrhythmias in RGS4-deficient Mice
Mighiu, A. S. (2014) · TSpace (University of Toronto)
de Araujo, C. B., & Dominic, E. (2015)
ATP-Sensitive Potassium Channels in Health and Disease
Proks, P., & Clark, R. H. (2013) · Springer eBooks · doi:10.1007/978-94-007-6884-0_6-2
Self-citationATP-Sensitive Potassium Channels in Health and Disease
Proks, P., & Clark, R. H. (2014) · Springer eBooks · doi:10.1007/978-94-007-6884-0_6-3
Self-citationGhani, S. A., & Singh, L. (2026) · Molecular Biology Reports · doi:10.1007/s11033-026-12263-2
- Authors
- Craig, T. J., Ashcroft, F. M., & Proks, P.
- Affiliations
- University of Oxford (GB)
- Corresponding author
- Proks, Peter
- Venue
- The Journal of General Physiology
- Publisher
- Rockefeller University Press
- Published
- 2008-06-30
- Volume
- 132
- Issue
- 1
- Pages
- 131-144
- ISSN
- 0022-1295 (ISSN-L)
- 1540-7748
- PMC
- PMC2442177
- OpenAlex
- W2118417356
- Cited by
- 67
- References
- 56
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 3 · 2019: 4 · 2018: 3 · 2017: 4 · 2016: 5 · 2015: 8 · 2014: 7 · 2013: 7 · 2012: 2
- FWCI
- 1.51
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of General Physiology (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- UWE Research Repository (UWE Bristol) (submittedVersion, cc-by)
- Funders
- Brandeis University
- Wellcome Trust
- European Commission
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › ATP Synthase and ATPases Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
- Keywords
- ATP-sensitive potassium channels, Kir6.2, SUR1, ATP binding, channel gating, single-channel kinetics, burst duration, Monod-Wyman-Changeux model, ATP binding site, dissociation constant
- MeSH terms
- Kcnj11 Channel, Adenosine Triphosphate, Algorithms, Animals, Binding Sites, Electrophysiology, Female, Kinetics, Models, Molecular, Oocytes, Recombinant Fusion Proteins, Xenopus laevis, Ion Channel Gating, Amino Acid Substitution, Potassium Channels, Inwardly Rectifying, Mice, KATP Channels
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
