Dobson, Christopher M.

Protein folding and misfolding

Dobson, C. M. (2003) · Nature

Protein Structure and DynamicsHeat shock proteins research

Cited by 4,791

Protein Misfolding, Amyloid Formation, and Human Disease: A Summary of Progress Over the Last Decade

Chiti, F., & Dobson, C. M. (2017) · Annual Review of Biochemistry

Prion Diseases and Protein MisfoldingAlzheimer's disease research and treatments

Cited by 2,629

Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases

Bucciantini, M., Giannoni, E., Chiti, F., Baroni, F., Formigli, L., Zurdo, J., Taddei, N., Ramponi, G., Dobson, C. M., & Stefani, M. (2002) · Nature

Prion Diseases and Protein MisfoldingAlzheimer's disease research and treatments

Cited by 2,434

The amyloid state and its association with protein misfolding diseases.

Knowles, T. P. J., Vendruscolo, M., & Dobson, C. M. (2014) · Nature Reviews Molecular Cell Biology

Alzheimer's disease research and treatmentsPrion Diseases and Protein Misfolding

Cited by 2,382

Rationalization of the effects of mutations on peptide andprotein aggregation rates

Chiti, F., Stefani, M., Taddei, N., Ramponi, G., & Dobson, C. M. (2003) · Nature

Alzheimer's disease research and treatmentsPrion Diseases and Protein Misfolding

Cited by 1,072

Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation

Galvagnion, C., Buell, A. K., Meisl, G., Michaels, T. C. T., Vendruscolo, M., Knowles, T. P. J., & Dobson, C. M. (2015) · Nature Chemical Biology

Parkinson's Disease Mechanisms and TreatmentsAlzheimer's disease research and treatments

Cited by 661

Widespread Proteome Remodeling and Aggregation in Aging C. elegans

Walther, D. M., Kasturi, P., Zheng, M., Pinkert, S., Vecchi, G., Ciryam, P., Morimoto, R. I., Dobson, C. M., Vendruscolo, M., Mann, M., et al. (2015) · Cell

Genetics, Aging, and Longevity in Model OrganismsHeat shock proteins research

Cited by 569

Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms

De, S., Wirthensohn, D. C., Flagmeier, P., Hughes, C., Aprile, F. A., Ruggeri, F. S., Whiten, D. R., Emin, D., Xia, Z., Varela, J. A., et al. (2019) · Nature Communications

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 448

Stabilization of neurotoxic Alzheimer amyloid-β oligomers by protein engineering

Sandberg, A., Luheshi, L. M., Söllvander, S., Pereira de Barros, T., Macao, B., Knowles, T. P. J., Biverstål, H., Lendel, C., Ekholm-Petterson, F., Dubnovitsky, A., et al. (2010) · Proceedings of the National Academy of Sciences

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 358

Understanding how proteins fold: the lysozyme story so far

Dobson, C. M., Evans, P. A., & Radford, S. E. (1994) · Trends in Biochemical Sciences

Protein Structure and DynamicsProtein purification and stability

Cited by 340

Widespread aggregation and neurodegenerative diseases are associated with supersaturated proteins

Ciryam, P., Tartaglia, G. G., Morimoto, R. I., Dobson, C. M., & Vendruscolo, M. (2013) · Cell Reports

Heat shock proteins researchProtein purification and stability

Cited by 270

Atmospheric aerosols as prebiotic chemical reactors

Dobson, C. M., Ellison, G. B., Tuck, A. F., & Vaida, V. (2000) · Proceedings of the National Academy of Sciences

Origins and Evolution of LifeAtmospheric chemistry and aerosols

Cited by 270

Macromolecular crowding perturbs protein refolding kinetics: implications for folding inside the cell

van den Berg, B., Wain, R., Dobson, C. M., & Ellis, R. J. (2000) · The EMBO Journal

Protein Structure and DynamicsProtein purification and stability

Cited by 269

Progressive Changes in the Structure of Hardened C 3 S Cement Pastes due to Carbonation

Groves, G. W., Brough, A., Richardson, I. G., & Dobson, C. M. (1991) · Journal of the American Ceramic Society

Concrete and Cement Materials ResearchCalcium Carbonate Crystallization and Inhibition

Cited by 257

Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein by Small Molecules as a Potential Therapeutic Strategy for Parkinson’s Disease

Tóth, G., Gardai, S. J., Zago, W., Bertoncini, C. W., Cremades, N., Roy, S. L., Tambe, M. A., Rochet, J.-C., Galvagnion, C., Skibinski, G., et al. (2014) · PLoS ONE

Parkinson's Disease Mechanisms and TreatmentsAlzheimer's disease research and treatments

Cited by 151

Clusterin facilitates in vivo clearance of extracellular misfolded proteins

Wyatt, A. R., Yerbury, J. J., Berghofer, P., Greguric, I., Katsifis, A., Dobson, C. M., & Wilson, M. R. (2011) · Cellular and Molecular Life Sciences

Clusterin in disease pathologyHeat shock proteins research

Cited by 145

Defining α-synuclein species responsible for Parkinson’s disease phenotypes in mice

Froula, J. M., Castellana-Cruz, M., Anabtawi, N. M., Camino, J. D., Chen, S. W., Thrasher, D. R., Freire, J., Yazdi, A. A., Fleming, S., Dobson, C. M., et al. (2019) · Journal of Biological Chemistry

Parkinson's Disease Mechanisms and TreatmentsAlzheimer's disease research and treatments

Cited by 129

Quantitative analysis of co-oligomer formation by amyloid-beta peptide isoforms.

Iljina, M., Garcia, G. A., Dear, A. J., Flint, J., Narayan, P., Michaels, T. C. T., Dobson, C. M., Frenkel, D., Knowles, T. P. J., & Klenerman, D. (2016) · Scientific Reports

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 68

A relationship between mRNA expression levels and protein solubility in E. coli

Tartaglia, G. G., Pechmann, S., Dobson, C. M., & Vendruscolo, M. (2009) · Journal of Molecular Biology

Protein purification and stabilityRNA and protein synthesis mechanisms

Cited by 63

Cavity hydration as a gateway to unfolding: An NMR study of hen lysozyme at high pressure and low temperature

Kamatari, Y. O., Smith, L. J., Dobson, C. M., & Akasaka, K. (2011) · Biophysical Chemistry

Protein Structure and DynamicsAdvanced NMR Techniques and Applications

Cited by 46

Neuronal Cx3cr1 Deficiency Protects against Amyloid β-Induced Neurotoxicity

Dworzak, J., Renvoisé, B., Habchi, J., Yates, E. V., Combadière, C., Knowles, T. P., Dobson, C. M., Blackstone, C., Paulsen, O., & Murphy, P. M. (2015) · PLOS ONE

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 30