Simpson, Julie E.

White Matter Lesions in an Unselected Cohort of the Elderly: Molecular Pathology Suggests Origin From Chronic Hypoperfusion Injury

Fernando, M. S., Simpson, J. E., Matthews, F., Brayne, C., Lewis, C. E., Barber, R., Kalaria, R. N., Forster, G., Esteves, F., Wharton, S. B., et al. (2006) · Stroke

Cerebrovascular and genetic disordersNeurological Disease Mechanisms and Treatments

Cited by 587

Astrocyte phenotype in relation to Alzheimer‐type pathology in the ageing brain

Simpson, J. E., Ince, P. G., Lace, G., Forster, G., Shaw, P. J., Matthews, F., Savva, G., Brayne, C., & Wharton, S. B. (2010) · Neurobiology of Aging

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 381

Review: Astrocytes in Alzheimer's disease and other age‐associated dementias: a supporting player with a central role

Garwood, C. J., Ratcliffe, L. E., Simpson, J. E., Heath, P. R., Ince, P. G., & Wharton, S. B. (2017) · Neuropathology and Applied Neurobiology

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 233

Insulin and IGF1 signalling pathways in human astrocytes in vitro and in vivo; characterisation, subcellular localisation and modulation of the receptors

Garwood, C. J., Ratcliffe, L. E., Morgan, S. V., Simpson, J. E., Owens, H., Vazquez-Villaseñor, I., Heath, P. R., Romero, I. A., Ince, P. G., & Wharton, S. B. (2015) · Molecular Brain

Growth Hormone and Insulin-like Growth FactorsAlzheimer's disease research and treatments

Cited by 101

Oxidative Glial Cell Damage Associated with White Matter Lesions in the Aging Human Brain

Al‐Mashhadi, S., Simpson, J. E., Heath, P. R., Dickman, M., Forster, G., Matthews, F. E., Brayne, C., Ince, P. G., Wharton, S. B., & Medical Research Council Cognitive Function and Ageing Study (2015) · Brain Pathology

Cerebrovascular and genetic disordersNeurological Disease Mechanisms and Treatments

Cited by 85

Alterations of the blood-brain barrier in cerebral white matter lesions in the ageing brain

Simpson, J. E., Wharton, S. B., Cooper, J., Gelsthorpe, C., Baxter, L., Forster, G., Shaw, P. J., Savva, G., Matthews, F. E., Brayne, C., et al. (2010) · Neuroscience Letters

Barrier Structure and Function StudiesCerebrovascular and genetic disorders

Cited by 77

The nuclear retention of transcription factor FOXO3a correlates with a DNA damage response and increased glutamine synthetase expression by astrocytes suggesting a neuroprotective role in the ageing brain

Fluteau, A., Ince, P. G., Minett, T., Matthews, F. E., Brayne, C., Garwood, C. J., Ratcliffe, L. E., Morgan, S., Heath, P. R., Shaw, P. J., et al. (2015) · Neuroscience Letters

FOXO transcription factor regulationAlzheimer's disease research and treatments

Cited by 66

A neuronal DNA damage response is detected at the earliest stages of Alzheimer's neuropathology and correlates with cognitive impairment in the Medical Research Council's Cognitive Function and Ageing Study ageing brain cohort

Simpson, J. E., Ince, P. G., Matthews, F. E., Shaw, P. J., Heath, P. R., Brayne, C., Garwood, C., Higginbottom, A., Wharton, S. B., & MRC Cognitive Function and Ageing Neuropathology Study Group (2015) · Neuropathology and Applied Neurobiology

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 56

Mesial Temporal Astrocyte Tau Pathology in the MRC-CFAS Ageing Brain Cohort

Lace, G., Ince, P. G., Brayne, C., Savva, G. M., Matthews, F. E., de Silva, R., Simpson, J. E., & Wharton, S. B. (2012) · Dementia and Geriatric Cognitive Disorders

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 52

A Reduced Astrocyte Response to β-Amyloid Plaques in the Ageing Brain Associates with Cognitive Impairment

Mathur, R., Ince, P. G., Minett, T., Garwood, C. J., Shaw, P. J., Matthews, F. E., Brayne, C., Simpson, J. E., Wharton, S. B., & on behalf of the MRC Cognitive Function and Ageing Neuropathology Study Group (2015) · PLOS ONE

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 52

Calcium dysregulation in relation to Alzheimer‐type pathology in the ageing brain

Garwood, C., Faizullabhoy, A., Wharton, S. B., Ince, P. G., Heath, P. R., Shaw, P. J., Baxter, L., Gelsthorpe, C., Forster, G., Matthews, F. E., et al. (2013) · Neuropathology and Applied Neurobiology

Alzheimer's disease research and treatmentsCalpain Protease Function and Regulation

Cited by 47