Review: Astrocytes in Alzheimer's disease and other age‐associated dementias: a supporting player with a central role

The Hallmarks of Aging

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Astrocyte-endothelial interactions at the blood-brain barrier

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Astrocytes: Biology and pathology

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A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function

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Neurovascular pathways to neurodegeneration in Alzheimer’s disease and other disorders

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Tripartite synapses: glia, the unacknowledged partner

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Genomic analysis of reactive astrogliosis

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Brain energy metabolism: focus on Astrocyte-neuron metabolic cooperation

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Immune attack: the role of inflammation in Alzheimer disease

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Oxidative Damage Is the Earliest Event in Alzheimer Disease

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Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

Talbot, K., Wang, H.-Y., Kazi, H., Han, L.-Y., Bakshi, K. P., Stucky, A., Fuino, R. L., Kawaguchi, K. R., Samoyedny, A. J., Wilson, R. S., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59903 · Cited by 1,871 · see citing works

Tripartite synapses: astrocytes process and control synaptic information

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Astrocyte activation and reactive gliosis

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Protoplasmic Astrocytes in CA1 Stratum Radiatum Occupy Separate Anatomical Domains

Bushong, E. A., Martone, M. E., Jones, Y. Z., & Ellisman, M. H. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-01-00183.2002 · Cited by 1,578 · see citing works

Uniquely Hominid Features of Adult Human Astrocytes

Oberheim, N. A., Takano, T., Han, X., He, W., Lin, J. H. C., Wang, F., Xu, Q., Wyatt, J. D., Pilcher, W., Ojemann, J. G., et al. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.4707-08.2009 · Cited by 1,488 · see citing works

Control of Synapse Number by Glia

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Fine structural localization of glutamine synthetase in astrocytes of rat brain

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Neuropathology of older persons without cognitive impairment from two community-based studies

Bennett, D. A., Schneider, J. A., Arvanitakis, Z., Kelly, J. F., Aggarwal, N. T., Shah, R. C., & Wilson, R. S. (2006) · Neurology · doi:10.1212/01.wnl.0000219668.47116.e6 · Cited by 1,336 · see citing works

Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis

Yamanaka, K., Chun, S. J., Boillee, S., Fujimori-Tonou, N., Yamashita, H., Gutmann, D. H., Takahashi, R., Misawa, H., & Cleveland, D. W. (2008) · Nature Neuroscience · doi:10.1038/nn2047 · Cited by 1,140 · see citing works

Glial fibrillary acidic protein: From intermediate filament assembly and gliosis to neurobiomarker

Yang, Z., & Wang, K. K. W. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2015.04.003 · Cited by 1,050 · see citing works

GFAP-expressing progenitors are the principal source of constitutive neurogenesis in adult mouse forebrain

Garcia, A. D. R., Doan, N., Imura, T., Bush, T. G., & Sofroniew, M. V. (2004) · Nature Neuroscience · doi:10.1038/nn1340 · Cited by 990 · see citing works

Adult mouse astrocytes degrade amyloid-β in vitro and in situ

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Age, Neuropathology, and Dementia

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A Review: Inflammatory Process in Alzheimer's Disease, Role of Cytokines

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Astrocytes from familial and sporadic ALS patients are toxic to motor neurons

Haidet-Phillips, A. M., Hester, M. E., Miranda, C. J., Meyer, K., Braun, L., Frakes, A., Song, S., Likhite, S., Murtha, M. J., Foust, K. D., et al. (2011) · Nature Biotechnology · doi:10.1038/nbt.1957 · Cited by 782 · see citing works

Astroglial networks: a step further in neuroglial and gliovascular interactions

Giaume, C., Koulakoff, A., Roux, L., Holcman, D., & Rouach, N. (2010) · Nature reviews. Neuroscience · doi:10.1038/nrn2757 · Cited by 781 · see citing works

Astrocytic complexity distinguishes the human brain

Oberheim, N. A., Wang, X., Goldman, S., & Nedergaard, M. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.08.004 · Cited by 739 · see citing works

Astrocyte–neuron metabolic relationships: for better and for worse

Allaman, I., Bélanger, M., & Magistretti, P. J. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2010.12.001 · Cited by 639 · see citing works

Heterogeneity of astrocytic form and function.

Oberheim, N. A., Goldman, S. A., & Nedergaard, M. (2012) · Methods in Molecular Biology · doi:10.1007/978-1-61779-452-0_3 · Cited by 638 · see citing works

Astrocyte glycogen and brain energy metabolism

Brown, A. M., & Ransom, B. R. (2007) · Glia · doi:10.1002/glia.20557 · Cited by 626 · see citing works

Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer’s disease

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Amyloid beta oligomers induce impairment of neuronal insulin receptors

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Astrocyte Senescence as a Component of Alzheimer’s Disease

Bhat, R., Crowe, E. P., Bitto, A., Moh, M., Katsetos, C. D., Garcia, F. U., Johnson, F. B., Trojanowski, J. Q., Sell, C., & Torres, C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045069 · Cited by 586 · see citing works

Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-β peptides

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Glial cells in (patho)physiology

Parpura, V., Heneka, M. T., Montana, V., Oliet, S. H. R., Schousboe, A., Haydon, P. G., Stout, R. F., Spray, D. C., Reichenbach, A., Pannicke, T., et al. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2012.07664.x · Cited by 561 · see citing works

Aging-related tau astrogliopathy (ARTAG): Harmonized evaluation strategy

Kovacs, G. G., Ferrer, I., Grinberg, L. T., Alafuzoff, I., Attems, J., Budka, H., Cairns, N. J., Crary, J. F., Duyckaerts, C., Ghetti, B., et al. (2016) · Acta Neuropathologica · doi:10.1007/s00401-015-1509-x · Cited by 532 · see citing works

Local Ca2+ detection and modulation of synaptic release by astrocytes

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Cholesterol metabolism in neurons and astrocytes

Pfrieger, F. W., & Ungerer, N. (2011) · Progress in Lipid Research · doi:10.1016/j.plipres.2011.06.002 · Cited by 500 · see citing works

Concomitant astroglial atrophy and astrogliosis in a triple transgenic animal model of Alzheimer's disease

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Contribution of glial cells to the development of amyloid plaques in Alzheimer’s disease

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Invited review: Neuropathology of tauopathies: principles and practice

Kovacs, G. G. (2015) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12208 · Cited by 492 · see citing works

Reactive Glia not only Associates with Plaques but also Parallels Tangles in Alzheimer’s Disease

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Astrocytes in Alzheimer's Disease

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Neuroinflammatory processes in Alzheimer’s disease

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Suppression of neuroinflammation by astrocytic dopamine D2 receptors via αB-crystallin

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GFAP mRNA increases with age in rat and human brain

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Cooperative Astrocyte and Dendritic Spine Dynamics at Hippocampal Excitatory Synapses

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Astroglia in dementia and Alzheimer's disease

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Isolation of glia from Alzheimer’s mice reveals inflammation and dysfunction

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Do glia drive synaptic and cognitive impairment in disease?

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Astrocyte phenotype in relation to Alzheimer‐type pathology in the ageing brain

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Astrocytes are important mediators of Aβ-induced neurotoxicity and tau phosphorylation in primary culture

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How chronic inflammation can affect the brain and support the development of Alzheimer's disease in old age: the role of microglia and astrocytes

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Targeting p38 MAPK pathway for the treatment of Alzheimer's disease

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The contribution of activated astrocytes to Aβ production: Implications for Alzheimer's disease pathogenesis

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Direct conversion of patient fibroblasts demonstrates non-cell autonomous toxicity of astrocytes to motor neurons in familial and sporadic ALS

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Astrocytes in the aging brain express characteristics of senescence-associated secretory phenotype: Astrocyte senescence in aging brain

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Hippocampal Astrocytes In Situ Exhibit Calcium Oscillations That Occur Independent of Neuronal Activity

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Genetic insights in Alzheimer's disease

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Much of late life cognitive decline is not due to common neurodegenerative pathologies

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Targeting Astrocytes Ameliorates Neurologic Changes in a Mouse Model of Alzheimer's Disease

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GFAP Isoforms in Adult Mouse Brain with a Focus on Neurogenic Astrocytes and Reactive Astrogliosis in Mouse Models of Alzheimer Disease

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Changing perspectives regarding late-life dementia

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Possible Implications of Insulin Resistance and Glucose Metabolism in Alzheimer's Disease Pathogenesis

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Evidence for a wide extra-astrocytic distribution of S100B in human brain

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Epidemiological Pathology of Dementia: Attributable-Risks at Death in the Medical Research Council Cognitive Function and Ageing Study

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Overexpression of Low-Density Lipoprotein Receptor in the Brain Markedly Inhibits Amyloid Deposition and Increases Extracellular Aβ Clearance

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Acute isolation and transcriptome characterization of cortical astrocytes and microglia from young and aged mice

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Amyloid β‐Peptide(1‐42) Contributes to the Oxidative Stress and Neurodegeneration Found in Alzheimer Disease Brain

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Cooperation between independent hippocampal synapses is controlled by glutamate uptake

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Direct Astrocytic Contacts Regulate Local Maturation of Dendritic Spines

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Molecular comparison of GLT1 + and ALDH1L1 + astrocytes in vivo in astroglial reporter mice

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Alexander Disease

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Glial fibrillary acidic protein isoform expression in plaque related astrogliosis in Alzheimer's disease.

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Glial Cells and Neurotransmission

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Elevated Oxidative Stress and Decreased Antioxidant Function in the Human Hippocampus and Frontal Cortex with Increasing Age: Implications for Neurodegeneration in Alzheimer’s Disease

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Vascular β-amyloid and early astrocyte alterations impair cerebrovascular function and cerebral metabolism in transgenic arcAβ mice

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White matter lesions in an unselected cohort of the elderly: astrocytic, microglial and oligodendrocyte precursor cell responses

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Alterations of the blood-brain barrier and glial cells in white-matter lesions in cerebrovascular and Alzheimer’s disease patients

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Functions of Mature Mammalian Astrocytes: A Current View

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Glia as drivers of abnormal neuronal activity

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P53- and CD95-associated apoptosis in neurodegenerative diseases.

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Low-density Lipoprotein Receptor Represents an Apolipoprotein E-independent Pathway of Aβ Uptake and Degradation by Astrocytes

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Astrocyte loss of mutant SOD1 delays ALS disease onset and progression in G85R transgenic mice

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Microarray analysis of the astrocyte transcriptome in the aging brain: relationship to Alzheimer’s pathology and APOE genotype

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The contribution of astrocytes to the regulation of cerebral blood flow

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Astrocytic involvement in learning and memory consolidation

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Spatial and temporal expression of S100B in cells of oligodendrocyte lineage

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Glial influences on BBB functions and molecular players in immune cell trafficking

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Visualization of S100B‐positive neurons and glia in the central nervous system of EGFP transgenic mice

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