Mesial Temporal Astrocyte Tau Pathology in the MRC-CFAS Ageing Brain Cohort
Open accessAbstract
BACKGROUND: Glial tau pathology is seen in certain tauopathies and in ageing. We determined its frequency in ageing mesial temporal lobe and its relationship to other tau pathologies in the MRC-CFAS population-representative neuropathology cohort. METHODS: Mesial temporal lobe, including hippocampus, amygdala, entorhinal cortex and white matter, was examined using immunohistochemistry with the AT8 antibody to phospho-tau and RD3 and RD4 antibodies to 3R and 4R tau isoforms. Gallyas silver stain was used to detect fibrillar aggregates. RESULTS: Thorn-shaped astrocytes (TSA), positive with AT8, RD4 and Gallyas, were present in 49% of cases. They were particularly prevalent in subpial, periventricular and white matter perivascular locations and were less frequent in grey matter. Coiled bodies were seen in 18.8%. TSA were not related to Braak neurofibrillary tangle or hippocampal tangle pathology stages. TSA in grey matter were associated with coiled bodies (p = 0.011) and argyrophilic grains (p = 0.048), which were identified in 11.5% of cases. They did not correlate with dementia. CONCLUSIONS: Astrocyte tau pathology is common in the ageing mesial temporal lobe. Its formation is independent of Alzheimer-type pathology. It is a 4R tauopathy, which may form part of a mesial temporal age-related 4R tauopathy that includes oligodendroglial tau and argyrophilic grains.
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Astrocytic PHF-tau pathology in CTE is predominantly 4R tau immunopositive and more widely distributed than that reported in the medial temporal lobe in aging and AD.
“Astrocytic PHF-tau pathology in CTE is predominantly 4R tau immunopositive, but more widely distributed than that reported in the medial temporal lobe in aging and AD [103, 114].”
From The neuropathology of sport (2014) · cites this paper as [103]
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- Authors
- Lace, G., Ince, P. G., Brayne, C., Savva, G. M., Matthews, F. E., de Silva, R., Simpson, J. E., & Wharton, S. B.
- Affiliations
- University of Sheffield (GB)
- Trinity College Dublin (IE)
- University of Cambridge (GB)
- Venue
- Dementia and Geriatric Cognitive Disorders
- Publisher
- S. Karger AG
- Published
- 2012
- Volume
- 34
- Issue
- 1
- Pages
- 15-24
- ISSN
- 1420-8008 (ISSN-L)
- 1421-9824
- OpenAlex
- W2055070038
- Cited by
- 52
- References
- 25
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 1 · 2023: 6 · 2022: 2 · 2021: 7 · 2020: 5 · 2019: 5 · 2018: 6 · 2017: 4 · 2016: 2 · 2015: 1 · 2014: 3 · 2013: 2 · 2012: 1
- FWCI
- 1.50
- Type
- journal article
- Language
- en
- Open access
- Licence
- cc-by
- Locations
- Dementia and Geriatric Cognitive Disorders (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Repository@Hull (Worktribe) (University of Hull) (submittedVersion, cc-by)
- UEA Digital Repository (University of East Anglia) (submittedVersion)
- Funders
- National Institute for Health and Care Research (NF-SI-0611-10084)
- Medical Research Council (MR/J004308/1)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- medial temporal lobe, brain aging, 4R tau, coiled bodies, argyrophilic grains, neurofibrillary tangles, hippocampus, amygdala, entorhinal cortex, white matter, tauopathy
- MeSH terms
- Aged, Aged, 80 and over, Aging, Apolipoproteins E, Astrocytes, Brain, Brain Chemistry, Cadaver, Female, Genotype, Hippocampus, Humans, Immunohistochemistry, Male, Neuroglia, Oligodendroglia, Cohort Studies, Silver Staining, tau Proteins, Disease Progression, Cell Shape
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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