Chen, Xin

Cholangiocarcinomas can originate from hepatocytes in mice

Fan, B., Malato, Y., Calvisi, D. F., Naqvi, S., Razumilava, N., Ribback, S., Gores, G. J., Dombrowski, F., Evert, M., Chen, X., et al. (2012) · Journal of Clinical Investigation

Cholangiocarcinoma and Gallbladder Cancer StudiesPediatric Hepatobiliary Diseases and Treatments

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Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations

Affo, S., Nair, A., Brundu, F., Ravichandra, A., Bhattacharjee, S., Matsuda, M., Chin, L., Filliol, A., Wen, W., Song, X., et al. (2021) · Cancer Cell

Cholangiocarcinoma and Gallbladder Cancer StudiesLiver physiology and pathology

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Yes-Associated Protein Up-regulates Jagged-1 and Activates the NOTCH Pathway in Human Hepatocellular Carcinoma

Tschaharganeh, D. F., Chen, X., Latzko, P., Malz, M., Gaida, M. M., Felix, K., Ladu, S., Singer, S., Pinna, F., Gretz, N., et al. (2013) · Gastroenterology

Hippo pathway signaling and YAP/TAZCancer-related molecular mechanisms research

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Inhibiting Glutamine-Dependent mTORC1 Activation Ameliorates Liver Cancers Driven by β-Catenin Mutations

Adebayo Michael, A. O., Ko, S., Tao, J., Moghe, A., Yang, H., Xu, M., Russell, J. O., Pradhan-Sundd, T., Liu, S., Singh, S., et al. (2019) · Cell Metabolism

PI3K/AKT/mTOR signaling in cancerWnt/β-catenin signaling in development and cancer

Cited by 155

Harnessing big ‘omics’ data and AI for drug discovery in hepatocellular carcinoma

Chen, B., Garmire, L., Calvisi, D. F., Chua, M.-S., Kelley, R. K., & Chen, X. (2020) · Nature Reviews Gastroenterology & Hepatology

Hepatocellular Carcinoma Treatment and PrognosisComputational Drug Discovery Methods

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Loss of Fbxw7 synergizes with activated Akt signaling to promote c-Myc dependent cholangiocarcinogenesis

Wang, J., Wang, H., Peters, M., Ding, N., Ribback, S., Utpatel, K., Cigliano, A., Dombrowski, F., Xu, M., Chen, X., et al. (2019) · Journal of Hepatology

Cholangiocarcinoma and Gallbladder Cancer StudiesPediatric Hepatobiliary Diseases and Treatments

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Correlation of exon 3 β-catenin mutations with glutamine synthetase staining patterns in hepatocellular adenoma and hepatocellular carcinoma

Hale, G., Liu, X., Hu, J., Xu, Z., Che, L., Solomon, D., Tsokos, C., Shafizadeh, N., Chen, X., Gill, R., et al. (2016) · Modern Pathology

Hepatocellular Carcinoma Treatment and PrognosisWnt/β-catenin signaling in development and cancer

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Glutamine synthetase limits β-catenin–mutated liver cancer growth by maintaining nitrogen homeostasis and suppressing mTORC1

Dai, W., Shen, J., Yan, J., Bott, A. J., Maimouni, S., Daguplo, H. Q., Wang, Y., Khayati, K., Guo, J. Y., Zhang, L., et al. (2022) · Journal of Clinical Investigation

Amino Acid Enzymes and MetabolismCancer, Hypoxia, and Metabolism

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Nuclear factor erythroid 2–related factor 2 and β‐Catenin Coactivation in Hepatocellular Cancer: Biological and Therapeutic Implications

Tao, J., Krutsenko, Y., Moghe, A., Singh, S., Poddar, M., Bell, A., Oertel, M., Singhi, A. D., Geller, D., Chen, X., et al. (2021) · Hepatology

Genomics, phytochemicals, and oxidative stressWnt/β-catenin signaling in development and cancer

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Analysis of Tumor-Associated AXIN1 Missense Mutations Identifies Variants That Activate β-Catenin Signaling

Zhang, R., Li, S., Schippers, K., Li, Y., Eimers, B., Lavrijsen, M., Wang, L., Cui, G., Chen, X., Peppelenbosch, M. P., et al. (2024) · Cancer Research

Wnt/β-catenin signaling in development and cancerGenetic factors in colorectal cancer

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Overexpression of TBX3 suppresses tumorigenesis in experimental and human cholangiocarcinoma

Deng, S., Lu, X., Wang, X., Liang, B., Xu, H., Yang, D., Cui, G., Yonemura, A., Paine, H., Zhou, Y., et al. (2024) · Cell Death & Disease

Cholangiocarcinoma and Gallbladder Cancer StudiesPediatric Hepatobiliary Diseases and Treatments

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