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PHF8-GLUL axis in lipid deposition and tumor growth of clear cell renal cell carcinoma

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β-Catenin Activation Reprograms Ammonia Metabolism to Promote Senescence Resistance in Hepatocellular Carcinoma

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Hepatic Zonation in MASLD: Old Question, New Challenge in the Era of Spatial Omics

Paolini, E., Longo, M., Meroni, M., & Dongiovanni, P. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262110701 · Cited by 16 · see citing works

Distinct mouse models of Stargardt disease display differences in pharmacological targeting of ceramides and inflammatory responses

Engfer, Z. J., Lewandowski, D., Dong, Z., Palczewska, G., Zhang, J., Kordecka, K., Płaczkiewicz, J., Panas, D., Foik, A. T., Tabaka, M., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2314698120 · Cited by 14 · see citing works

Novel roles of ammonia in physiology and cancer

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Tissue accumulation and hepatotoxicity of 8:2 chlorinated polyfluoroalkyl ether sulfonate: A multi-omics analysis deciphering hepatic amino acid metabolic dysregulation in mice

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Liver cancer wars: plant-derived polyphenols strike back

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The Spatial Transcriptional Activity of Hepatic TCF7L2 Regulates Zonated Metabolic Pathways that Contribute to Liver Fibrosis

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Ammonia scavenger and glutamine synthetase inhibitors cocktail in targeting mTOR/β-catenin and MMP-14 for nitrogen homeostasis and liver cancer

Elmetwalli, A., Nageh, A., Youssef, A. I., Youssef, M., Ahmed, M. A. E.-R., Noreldin, A. E., & El-Sewedy, T. (2023) · Medical Oncology · doi:10.1007/s12032-023-02250-z · Cited by 11 · see citing works

High-ammonia microenvironment promotes stemness and metastatic potential in hepatocellular carcinoma through metabolic reprogramming

Zou, R., Jiang, S., Mei, J., Chen, C., Yu, J. S., Fu, Y., & Chen, S. (2025) · Discover Oncology · doi:10.1007/s12672-025-01922-8 · Cited by 10 · see citing works

From the Inside Out: Exposing the Roles of Urea Cycle Enzymes in Tumors and Their Micro and Macro EnvironmentsPreprint

Hajaj, E., Pozzi, S., & Erez, A. (2023) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a041538 · Cited by 10 · see citing works

Impaired nitrogenous waste clearance promotes hepatocellular carcinoma

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Hepatic cell junctions: Pulling a double‐duty

Campenhout, R. V., & Vinken, M. (2024) · Liver International · doi:10.1111/liv.16045 · Cited by 6 · see citing works

The Possible Roles of Glucosamine-6-Phosphate Deaminases in Ammonium Metabolism in Cancer

Lara‐Lemus, R., Castillejos-López, M. D. J., & Aquino‐Gálvez, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252212054 · Cited by 6 · see citing works

Ammonia reduces glutamine synthetase expression in astrocytes via activation of Hippo-YAP signaling pathways

Nasu, Y., Kishikawa, S., Imai, M., Yokoyama, N., Iida, I., Tabeta, K., & Terunuma, M. (2025) · Communications Biology · doi:10.1038/s42003-025-09191-5 · Cited by 5 · see citing works

Genetic disruption of mitochondrial dynamics and stasis leads to liver injury and tumorigenesis

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Glutamine synthetase: a tumor suppressor in hepatocellular carcinoma?

Dai, W., & Zong, W. (2023) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjad007 · Cited by 5 · see citing works

Development and Validation of a Novel Prognosis Model Based on a Panel of Three Immunogenic Cell Death-Related Genes for Non-Cirrhotic Hepatocellular Carcinoma

Gong, J., Yu, R., Hu, X., Luo, H., Gao, Q., Li, Y., Tan, G., Luo, H., & Qin, B. (2023) · Journal of Hepatocellular Carcinoma · doi:10.2147/jhc.s424545 · Cited by 5 · see citing works

Covalent Modification of Protein by Chemical Probe in Living Cells for Structural and Interaction Studies

Zheng, Z., Cheng, Y., Li, P., & Tan, C. S. H. (2024) · ChemBioChem · doi:10.1002/cbic.202400715 · Cited by 4 · see citing works

Explainable machine learning reveals ribosome biogenesis biomarkers in preeclampsia risk prediction

Chen, J., Zhang, D., Zhu, C., Lin, L., Ye, K., Hua, Y., & Peng, M. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1595222 · Cited by 4 · see citing works

Glutamine synthetase loss in β-catenin–mutant hepatocellular carcinoma promotes tumor burden through macrophage metabolic reprogramming

Delgado, E. R., Patel, P., Tao, J., Krutsenko, Y., Liu, S., Green, D. M., Alzubali, R., Lehrich, B. M., Liu, J., Yasaka, T. M., et al. (2025) · Hepatology · doi:10.1097/hep.0000000000001591 · Cited by 4 · see citing works

Ammonium Hydroxide Enhancement of Dietary Protein in High-Fat Diets Modulates Liver Metabolism Signaling in a Sex- and Age-Dependent Manner in C3H/HeJ Mice

Barr, B., Subramaniyan, I., Li, L., Levitt, D. E., & Gollahon, L. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms27010403 · Cited by 3 · see citing works

RIPPLY1 suppresses cancer cell stemness via targeting TBX19 in CTNNB1-mutated hepatocellular carcinoma

Zhangyuan, G., Yu, W., Tian, W., Xie, J., Wang, J., Ying, X., Wang, F., Shao, Y., Tan, X., Qian, H., et al. (2025) · Hepatology · doi:10.1097/hep.0000000000001483 · Cited by 3 · see citing works

Hyper-methylation and DNMT3A mediated LTC4S downregulation promoted lung adenocarcinoma tumorigenesis via mTORC1 signaling pathway

Ren, Y., Zhang, P., Li, L., Wang, M., Hu, H., Shen, Y., Xu, P., Wu, Q., & Li, F. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e33203 · Cited by 3 · see citing works

Disruption of Mitochondrial Dynamics and Stasis Leads to Liver Injury and TumorigenesisPreprint

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Hepatitis viruses hijack cellular metabolic pathways to drive replication and disease: Implications for novel therapeutics

Peng, N., Lin, Q., Huang, X., & Yu, X. (2025) · Microbial Pathogenesis · doi:10.1016/j.micpath.2025.107837 · Cited by 2 · see citing works

Liver diseases, transaminases, and hepatobiliary–pancreatic cancer risk: a cohort and Mendelian randomisation study using data from UK Biobank

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Ammonia in cancer: dual roles and therapeutic strategies

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Glutamine reprogramming affects the tumor microenvironment and immune response in hepatocellular carcinoma

Sun, Y., Cui, Y., Luo, D., & Tian, C. (2025) · Molecular Biology Reports · doi:10.1007/s11033-025-11309-1 · Cited by 2 · see citing works

The evolving role of OMICS in gastrointestinal tumor biology and clinical practice

Li, Q., Zhang, J., Chen, J., Zhang, Q., Liu, R., Zhu, J., Qing, Y., Wei, X., & Sheng, J. (2026) · Molecular Cancer · doi:10.1186/s12943-026-02658-x · Cited by 2 · see citing works

A pan-cancer analysis of the oncogenic role of ATP binding cassette subfamily E member 1 (ABCE1) in human tumors: An observational study

Yu, J., Ma, H., Ji, H., Wang, M., Yu, B., Ge, S., & Dai, Z. (2022) · Medicine · doi:10.1097/md.0000000000031849 · Cited by 2 · see citing works

Genomic drivers in craniopharyngiomas: Analysis of the AACR project GENIE database

Lehrich, B. M., Tong, C. L. C., Hsu, P. K. F., & Kuan, C. E. (2024) · Child s Nervous System · doi:10.1007/s00381-024-06320-z · Cited by 2 · see citing works

Anxiety is a risk prognosis factor for hepatocellular carcinoma with portal vein tumor thrombus who underwent hepatic arterial infusion chemotherapy: a propensity score-matching cohort study

Tan, H.-Y., Liu, S., Liu, Y., Lü, L., Zheng, J.-L., & Feng, H.-G. (2025) · World Journal of Surgical Oncology · doi:10.1186/s12957-025-03845-8 · Cited by 2 · see citing works

The differential regulation of the urea cycle in tumors goes awry

Abou‐Shanab, A. M., Khedr, M. A., & Matosevic, S. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.117365 · Cited by 2 · see citing works

Letter to the editor on “GULP1 as a novel diagnostic and predictive biomarker in hepatocellular carcinoma”

Yang, J., Li, X., & Zheng, S. (2025) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2025.0216 · Cited by 2 · see citing works

Identification of amino acid metabolism‑related genes as diagnostic and prognostic biomarkers in sepsis through machine learning

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13N-Ammonia PET-CT for Evaluating Response to Antiangiogenic Therapy and Prognosis in Patients with Advanced Hepatocellular Carcinoma: A Pilot Study

Scolozzi, V., Nicoletti, A., Capotosti, A., Ponziani, F. R., Taralli, S., Genco, E., Leccisotti, L., Moretti, R., Indovina, L., Pompili, M., et al. (2025) · Cancers · doi:10.3390/cancers17040656 · Cited by 1 · see citing works

Ammonia signaling network: the intersection of tumor metabolism, epigenetics, and metastasis

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Associations between kidney function with all-cause and cause-specific mortality in type 2 diabetes mellitus patients: a prospective cohort study in China

He, J., Wan, Y., Fan, X., Yu, H., Qin, Y., Su, J., Lu, Y., Pan, E., Hang, D., Shen, C., et al. (2025) · Journal of Health Population and Nutrition · doi:10.1186/s41043-025-00809-2

Deletion of Nrf1α promotes glutamine addiction of HepG2 cells and thus enhances its apoptosis caused by glutamine deprivationPreprint

Deng, R., Zhang, Q., Liu, K., Hu, S., Wufuer, R., Cheng, X., Lv, D., & Zhang, Y. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.17.643732

Correspondence to letter to the editor on “GULP1 as a novel diagnostic and predictive biomarker in hepatocellular carcinoma”

Kim, H. S., Kim, S. S., Cheong, J. Y., & Eun, J. W. (2025) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2025.0287

Mesenchymal stromal cells ameliorate hyperammonemia in acute hepatic failure via inhibiting glutaminolysis

Cheng, H., Shi, Y., Li, X., Jin, N. Y., Liang, Y., Liu, Z., & Xie, J. (2025) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003573

Prognostic prediction of laryngeal cancer patients based on nitrogen metabolism-related genes

Wang, Y., Shen, T., & Wang, Y. (2025) · Computer Methods in Biomechanics & Biomedical Engineering · doi:10.1080/10255842.2025.2523309

Research advances on amino acid starvation interventions for hepatocellular carcinoma

Li, Y., Li, L., Hou, Y., Peng, X., & Li, H. (2025) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2025.189400

Metabolic reprogramming in macrophages: A glutamine rescue in β-catenin mutant hepatocellular carcinoma

Muliawan, G. K., & Lee, T. K. (2025) · Hepatology · doi:10.1097/hep.0000000000001619

Cancer Vaccines in Hepatocellular Carcinoma: Advances, Challenges, and Future Perspectives

Woo, H. Y., & Heo, J. (2025) · Convergence Hepatology · doi:10.65633/ch.2025.1.1.1

RHOJ derived peptide promotes chemosensitivity by inhibiting glutamine metabolism in gastric cancer

Li, J., Li, H., Ye, F., Wang, J., Li, F., Bei, S., Zhang, X., Jiang, J. H., & Li, F. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-07731-z

Dietary polyphenols and hepatocellular carcinoma: protective mechanisms, challenges, and future directions

Yang, T., Xu, W., Yuan, B., & Peng, F. (2026) · Discover Oncology · doi:10.1007/s12672-026-04525-z

Fascin-1 as a druggable target in Hepatoblastoma

Dif, L. (2024) · doi:10.70675/397187b4z98e4z4886zb816z1a59af68ea71

ABCC2 as a novel therapeutic target in lung adenocarcinoma: a machine learning-driven discovery linking ammonia metabolism to prognosis and drug resistance

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Impact of metabolic reprogramming on the immune response in hepatocellular carcinoma

Wang, Y., Lu, Y.-J., Zhou, J., & Yang, X.-R. (2026) · Hepatoma Research · doi:10.20517/2394-5079.2025.105

Targeting amino acid metabolism in hepatocellular carcinoma

Wu, Y., & Wong, C. C.-L. (2026) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2026.06.002

Diammonium phosphate supplementation in low-protein diets improves nitrogen utilization and feed efficiency without impairing carcass traits or meat quality in finishing pigs

Zeng, X., Tang, Y., Li, S., Wang, Q., & Yang, H. (2026) · Animal nutrition · doi:10.1016/j.aninu.2025.12.021

Alcohol reshapes liver zonal plasticity and immune-metabolic reprogramming in metabolic-syndrome associated hepatocellular carcinoma

Tian, T., Xue, Y., Sun, C., Yang, L., Wang, J., Jin-Smith, B., Barkin, J., Nzegwu, M., Jia, L., Zhou, H., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-77089-9

Glutamine metabolism in health and disease

Zhao, J., Lin, Y., Gao, R., Gao, H., & Li, L. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-026-02981-1

Ammonia scavenger and glutamine synthetase inhibitors cocktail in targeting mTOR/β-catenin and MMP-14 for nitrogen homeostasis and liver cancer

Elmetwalli, A., Nageh, A., Youssef, A. I., Youssef, M., Ahmed, M. A. E.-R., Noreldin, A. E., & El-Sewedy, T. (2023) · Medical Oncology · doi:10.1007/s12032-023-02250-z · Cited by 11 · see citing works

Inhibiting Glutamine-Dependent mTORC1 Activation Ameliorates Liver Cancers Driven by β-Catenin Mutations

Adebayo Michael, A. O., Ko, S., Tao, J., Moghe, A., Yang, H., Xu, M., Russell, J. O., Pradhan-Sundd, T., Liu, S., Singh, S., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.01.002 · Cited by 155 · see citing works

Glutamine synthetase loss in β-catenin–mutant hepatocellular carcinoma promotes tumor burden through macrophage metabolic reprogramming

Delgado, E. R., Patel, P., Tao, J., Krutsenko, Y., Liu, S., Green, D. M., Alzubali, R., Lehrich, B. M., Liu, J., Yasaka, T. M., et al. (2025) · Hepatology · doi:10.1097/hep.0000000000001591 · Cited by 4 · see citing works

L-Asparaginase and Inhibitors of Glutamine Synthetase Disclose Glutamine Addiction of β-Catenin-Mutated Human Hepatocellular Carcinoma Cells

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Drug‐induced glutamine depletion hinders the growth of β‐ catenin mutated human liver cancer xenografts

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