Zhang, Jian

Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition

Shangary, S., Qin, D., McEachern, D., Liu, M., Miller, R. S., Qiu, S., Nikolovska-Coleska, Z., Ding, K., Wang, G., Chen, J., et al. (2008) · Proceedings of the National Academy of Sciences

Cancer-related Molecular PathwaysPI3K/AKT/mTOR signaling in cancer

Cited by 660

Ras Conformational Ensembles, Allostery, and Signaling

Lu, S., Jang, H., Muratcioglu, S., Gursoy, A., Keskin, O., Nussinov, R., & Zhang, J. (2016) · Chemical Reviews

Protein Kinase Regulation and GTPase SignalingReceptor Mechanisms and Signaling

Cited by 355

The Structural Basis of Oncogenic Mutations G12, G13 and Q61 in Small GTPase K-Ras4B

Lu, S., Jang, H., Nussinov, R., & Zhang, J. (2016) · Scientific Reports

Protein Kinase Regulation and GTPase SignalingProtein Structure and Dynamics

Cited by 219

Iduna protects the brain from glutamate excitotoxicity and stroke by interfering with poly(ADP-ribose) polymer-induced cell death

Andrabi, S. A., Kang, H. C., Haince, J.-F., Lee, Y.-I., Zhang, J., Chi, Z., West, A. B., Koehler, R. C., Poirier, G. G., Dawson, T. M., et al. (2011) · Nature Medicine

Cell death mechanisms and regulationPARP inhibition in cancer therapy

Cited by 216

Secondary Neurodegeneration in Remote Regions After Focal Cerebral Infarction: A New Target for Stroke Management?

Zhang, J., Zhang, Y., Xing, S., Liang, Z., & Zeng, J. (2012) · Stroke

Acute Ischemic Stroke ManagementNeuroinflammation and Neurodegeneration Mechanisms

Cited by 211

Drugging Ras GTPase: a comprehensive mechanistic and signaling structural view

Lu, S., Jang, H., Gu, S., Zhang, J., & Nussinov, R. (2016) · Chemical Society Reviews

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 188

Metformin Targets Multiple Signaling Pathways in Cancer

Lei, Y., Yi, Y., Liu, Y., Liu, X., Keller, E. T., Qian, C.-N., Zhang, J., & Lu, Y. (2017) · Chinese Journal of Cancer

Metabolism, Diabetes, and CancerCancer, Hypoxia, and Metabolism

Cited by 152

ASD v3.0: unraveling allosteric regulation with structural mechanisms and biological networks

Shen, Q., Wang, G., Li, S., Liu, X., Lu, S., Chen, Z., Song, K., Yan, J., Geng, L., Huang, Z., et al. (2016) · Nucleic Acids Research

Receptor Mechanisms and SignalingProtein Structure and Dynamics

Cited by 122

Emerging roles of allosteric modulators in the regulation of protein‐protein interactions (PPIs): A new paradigm for PPI drug discovery

Ni, D., Lu, S., & Zhang, J. (2019) · Medicinal Research Reviews

Chemical Synthesis and AnalysisComputational Drug Discovery Methods

Cited by 116

Small-molecule inhibitor targeting the Hsp90-Cdc37 protein-protein interaction in colorectal cancer

Wang, L., Zhang, L., Li, L., Jiang, J., Zheng, Z., Shang, J., Wang, C., Chen, W., Bao, Q., Xu, X., et al. (2019) · Science Advances

Heat shock proteins researchCancer-related Molecular Pathways

Cited by 110

Capsular and slime-polysaccharide production by Lactobacillus rhamnosus JAAS8 isolated from Chinese sauerkraut: Potential application in fermented milk products

Yang, Z., Li, S., Zhang, X., Zeng, X., Li, D., Zhao, Y., & Zhang, J. (2010) · Journal of Bioscience and Bioengineering

Probiotics and Fermented FoodsPolysaccharides Composition and Applications

Cited by 103

Recent computational advances in the identification of allosteric sites in proteins

Lu, S., Huang, W., & Zhang, J. (2014) · Drug Discovery Today

Computational Drug Discovery MethodsProtein Structure and Dynamics

Cited by 102

Growth inhibition of human hepatocellular carcinoma cells by blocking STAT3 activation with decoy-ODN

Sun, X., Zhang, J., Wang, L., & Tian, Z. (2008) · Cancer Letters

Cytokine Signaling Pathways and InteractionsHepatocellular Carcinoma Treatment and Prognosis

Cited by 80

Predicting risk for Alcohol Use Disorder using longitudinal data with multimodal biomarkers and family history: a machine learning study

Kinreich, S., Meyers, J. L., Maron-Katz, A., Kamarajan, C., Pandey, A. K., Chorlian, D. B., Zhang, J., Pandey, G., Subbie-Saenz de Viteri, S., Pitti, D., et al. (2021) · Molecular Psychiatry

Substance Abuse Treatment and OutcomesGenetic Associations and Epidemiology

Cited by 80

Drugging K-RasG12C through covalent inhibitors: Mission possible?

Ni, D., Li, X., He, X., Zhang, H., Zhang, J., & Lu, S. (2019) · Pharmacology & Therapeutics

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 73

Inhibitors of Ras–SOS Interactions

Lu, S., Jang, H., Zhang, J., & Nussinov, R. (2016) · ChemMedChem

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 72

Rufy3, a protein specifically expressed in neurons, interacts with actin‐bundling protein Fascin to control the growth of axons

Wei, Z., Sun, M., Liu, X., Zhang, J., & Jin, Y. (2014) · Journal of Neurochemistry

Axon Guidance and Neuronal SignalingNeurogenesis and neuroplasticity mechanisms

Cited by 39

Melatonin alleviates insulin resistance through the PI3K/AKT signaling pathway in ovary granulosa cells of polycystic ovary syndrome

Guo, R., Zheng, H., Li, Q., Qiu, X., Zhang, J., & Cheng, Z. (2022) · Reproductive Biology

Ovarian function and disordersReproductive Biology and Fertility

Cited by 37

Ginkgolide B inhibits NLRP3 inflammasome activation and promotes microglial M2 polarization in Aβ1-42-induced microglia cells

Zhang, Y., Zhao, Y., Zhang, J., Gao, Y., Li, S., Chang, C., Yu, D., & Yang, G. (2021) · Neuroscience Letters

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 36

Association Between Plasma Levels of BDNF and GDNF and the Diagnosis, Treatment Response in First-Episode MDD

Liu, X., Li, P., Ma, X., Zhang, J., Sun, X., Luo, X., & Zhang, Y. (2022) · Journal of Affective Disorders

Treatment of Major DepressionTryptophan and brain disorders

Cited by 34

Design and designability of protein-based assemblies

Zhang, J., Zheng, F., & Grigoryan, G. (2014) · Current Opinion in Structural Biology

Protein Structure and DynamicsSupramolecular Self-Assembly in Materials

Cited by 30

The effect of CX3CL1/ CX3CR1 signal axis on microglia in central nervous system diseases

Zhao, J., Li, Q., Ouyang, X., Wang, F., Li, Q., Xu, Z., Ji, D., Wu, Q., Zhang, J., Lu, C., et al. (2023) · Journal of Neurorestoratology

Neuroinflammation and Neurodegeneration MechanismsChemokine receptors and signaling

Cited by 29

Design, synthesis, and evaluation of peptidomimetics containing Freidinger lactams as STAT3 inhibitors

Gomez, C., Bai, L., Zhang, J., Nikolovska-Coleska, Z., Chen, J., Yi, H., & Wang, S. (2009) · Bioorganic & Medicinal Chemistry Letters

Cytokine Signaling Pathways and InteractionsHeterocyclic Compound Synthesis and Bioactivity

Cited by 26

Telemedicine-assisted structured self-monitoring of blood glucose in management of T2DM results of a randomized clinical trial

Han, C.-Y., Zhang, J., Ye, X.-M., Lu, J.-P., Jin, H.-Y., Xu, W.-W., Wang, P., & Zhang, M. (2023) · BMC Medical Informatics and Decision Making

Diabetes Management and EducationDiabetes Management and Research

Cited by 19