Chen, Xiang

The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

Zhang, J., Ding, L., Holmfeldt, L., Wu, G., Heatley, S. L., Payne-Turner, D., Easton, J., Chen, X., Wang, J., Rusch, M., et al. (2012) · Nature

Acute Lymphoblastic Leukemia researchAcute Myeloid Leukemia Research

Cited by 1,596

Germline Mutations in Predisposition Genes in Pediatric Cancer

Zhang, J., Walsh, M. F., Wu, G., Edmonson, M. N., Gruber, T. A., Easton, J., Hedges, D., Ma, X., Zhou, X., Yergeau, D. A., et al. (2015) · New England Journal of Medicine

BRCA gene mutations in cancerCancer Genomics and Diagnostics

Cited by 1,345

Pan-cancer genome and transcriptome analyses of 1,699 paediatric leukaemias and solid tumours

Ma, X., Liu, Y., Liu, Y., Alexandrov, L. B., Edmonson, M. N., Gawad, C., Zhou, X., Li, Y., Rusch, M. C., Easton, J., et al. (2018) · Nature

Cancer Genomics and DiagnosticsChromatin Remodeling and Cancer

Cited by 901

Recurrent Somatic Structural Variations Contribute to Tumorigenesis in Pediatric Osteosarcoma

Chen, X., Bahrami, A., Pappo, A., Easton, J., Dalton, J., Hedlund, E., Ellison, D., Shurtleff, S., Wu, G., Wei, L., et al. (2014) · Cell Reports

Sarcoma Diagnosis and TreatmentCancer Genomics and Diagnostics

Cited by 752

Orthotopic patient-derived xenografts of paediatric solid tumours

Stewart, E., Federico, S. M., Chen, X., Shelat, A. A., Bradley, C., Gordon, B., Karlstrom, A., Twarog, N. R., Clay, M. R., Bahrami, A., et al. (2017) · Nature

Cancer Genomics and DiagnosticsCancer Cells and Metastasis

Cited by 286

Metabolic heterogeneity underlies reciprocal fates of TH17 cell stemness and plasticity

Karmaus, P. W. F., Chen, X., Lim, S. A., Herrada, A. A., Nguyen, T.-L. M., Xu, B., Dhungana, Y., Rankin, S., Chen, W., Rosencrance, C., et al. (2019) · Nature

T-cell and B-cell ImmunologyPsoriasis: Treatment and Pathogenesis

Cited by 215

Identification of Therapeutic Targets in Rhabdomyosarcoma through Integrated Genomic, Epigenomic, and Proteomic Analyses

Stewart, E., McEvoy, J., Wang, H., Chen, X., Honnell, V., Ocarz, M., Gordon, B., Dapper, J., Blankenship, K., Yang, Y., et al. (2018) · Cancer Cell

Sarcoma Diagnosis and TreatmentChromatin Remodeling and Cancer

Cited by 153

UMI-count modeling and differential expression analysis for single-cell RNA sequencing

Chen, W., Li, Y., Easton, J., Finkelstein, D., Wu, G., & Chen, X. (2018) · Genome Biology

Single-cell and spatial transcriptomicsGene expression and cancer classification

Cited by 113

Osteocyte-derived sclerostin impairs cognitive function during ageing and Alzheimer’s disease progression

Shi, T., Shen, S., Shi, Y., Wang, Q., Zhang, G., Lin, J., Chen, J., Bai, F., Zhang, L., Wang, Y., et al. (2024) · Nature Metabolism

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 87

A comparison of methods accounting for batch effects in differential expression analysis of UMI count based single cell RNA sequencing

Chen, W., Zhang, S., Williams, J., Ju, B., Shaner, B., Easton, J., Wu, G., & Chen, X. (2020) · Computational and Structural Biotechnology Journal

Single-cell and spatial transcriptomicsGene expression and cancer classification

Cited by 44

Combinatorial screening using orthotopic patient derived xenograft-expanded early phase cultures of osteosarcoma identify novel therapeutic drug combinations

Loh, A. H. P., Stewart, E., Bradley, C. L., Chen, X., Daryani, V., Stewart, C. F., Calabrese, C., Funk, A., Miller, G., Karlstrom, A., et al. (2019) · Cancer Letters

Sarcoma Diagnosis and TreatmentBone Tumor Diagnosis and Treatments

Cited by 36

A Meta-Analysis of Observational Studies on the Association of Chronic Urticaria With Symptoms of Depression and Anxiety

Huang, Y., Xiao, Y., Zhang, X., Li, J., Chen, X., & Shen, M. (2020) · Frontiers in Medicine

Urticaria and Related ConditionsPsychosomatic Disorders and Their Treatments

Cited by 36