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Cited by 36Urticaria and Related ConditionsPsychosomatic Disorders and Their TreatmentsDermatology and Skin Diseases

A Meta-Analysis of Observational Studies on the Association of Chronic Urticaria With Symptoms of Depression and Anxiety

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Huang, Yuzhou, Xiao, Yi, Zhang, Xingyu, Li, Jie, Chen, Xiang, Shen, Minxue·2020·Frontiers in Medicine
DOI 10.3389/fmed.2020.00039PMC PMC7056669
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Abstract

Background: Chronic urticaria (CU) is a frequently occurring skin condition associated with many psychological factors, but the effect size of associations varied in literature. Objectives: To perform a systematic review and meta-analysis on the associations of CU with symptoms of depression and anxiety. Methods：Using a prespecified protocol, we systematically searched articles published in PubMed, Web of Science, CNKI and CQVIP databases between January 2000 and January 2019. Pooled estimates in terms of odds ratios (ORs) and standardized mean differences (SMDs) were calculated according to outcome measures. Subgroup analysis by disease subtypes and tool of measurement, and sensitivity analysis were performed. Risk of bias and quality of studies were evaluated. Results: Twelve studies were selected for systematic review. The ORs were 3.99 (95%CI: 3.24 to 4.91, P<0.001) for anxiety and 2.94 (95%CI: 2.42–3.58, P<0.001) for depression. The SMDs of severity were 0.98 for anxiety (95%CI: 0.76–1.200, P<0.001), and 0.84 for depression (95%CI: 0.59–1.10, P<0.001). Subgroup assessment by disease subtypes and tool of measurement showed variations in effect size, where chronic spontaneous urticaria showed greater effects on anxiety (OR=6.62, 95%CI: 3.67–11.95, P<0.001), and depression (OR=6.13, 95%CI: 2.31–16.31, P<0.001). Sensitivity analysis demonstrated consistent results. Conclusion: CU is associated with two- to three-fold risks of anxiety and depression.

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  • Psychotropic drugs could have a positive effect on CSU treatment.

    “Psychotropic drugs (e.g., antidepressants and benzodiazepines) could have a positive effect on CSU treatment 11,31 .”

    From Could distress tolerance levels be associated with the severity of chronic spontaneous urticaria? (2022) · cites this paper as [11]

    The Introduction and Discussion (page numbers unavailable) address psychiatric comorbidity and the association of CSU with anxiety and depression, but do not address whether psychotropic drugs improve CSU treatment. Searches for antidepressants, benzodiazepines, psychotropic drugs, and treatment found no passage supporting that effect. (LLM, conf=0.75)

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Cited by

Sorted by citations

Authors
Huang, Y., Xiao, Y., Zhang, X., Li, J., Chen, X., & Shen, M.
Affiliations
Central South University (CN)
Corresponding author
  • Li, Jie
  • Chen, Xiang
  • Shen, Minxue
ORCID
Venue
Frontiers in Medicine
Publisher
Frontiers Media SA
Published
2020-02-27
Volume
7
Pages
39-39
ISSN
2296-858X (ISSN-L)
DOI
10.3389/fmed.2020.00039
PMC
PMC7056669
OpenAlex
W3007904794
Cited by
36
References
4
Citations by year
2026: 6 · 2025: 6 · 2024: 9 · 2023: 7 · 2022: 3 · 2021: 3 · 2020: 2
FWCI
0.58
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Medicine (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
National Natural Science Foundation of China (81974476, 81673065)
Topics
  • Health Sciences › Medicine › Rheumatology › Urticaria and Related Conditions
  • Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
  • Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
Keywords
chronic urticaria, depression, anxiety, psychological comorbidity, chronic spontaneous urticaria, disease severity, mental health

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