Han, Xianlin

Impaired mitochondrial fat oxidation induces adaptive remodeling of muscle metabolism

Wicks, S. E., Vandanmagsar, B., Haynie, K. R., Fuller, S. E., Warfel, J. D., Stephens, J. M., Wang, M., Han, X., Zhang, J., Noland, R. C., et al. (2015) · Proceedings of the National Academy of Sciences

Adipose Tissue and MetabolismMetabolism, Diabetes, and Cancer

Cited by 131

Phospholipids of APOE lipoproteins activate microglia in an isoform-specific manner in preclinical models of Alzheimer’s disease

Fitz, N. F., Nam, K. N., Wolfe, C. M., Letronne, F., Playso, B. E., Iordanova, B. E., Kozai, T. D. Y., Biedrzycki, R. J., Kagan, V. E., Tyurina, Y. Y., et al. (2021) · Nature Communications

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 129

Novel Role for Apolipoprotein E in the Central Nervous System

Han, X., Cheng, H., Fryer, J. D., Fagan, A. M., & Holtzman, D. M. (2003) · Journal of Biological Chemistry

Alzheimer's disease research and treatmentsCholesterol and Lipid Metabolism

Cited by 126

APOE2 eases cognitive decline during Aging: Clinical and preclinical evaluations

Shinohara, M., Kanekiyo, T., Yang, L., Linthicum, D., Shinohara, M., Fu, Y., Price, L., Frisch‐Daiello, J. L., Han, X., Fryer, J. D., et al. (2016) · Annals of Neurology

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 111

APOE3 -Jacksonville (V236E) variant reduces self-aggregation and risk of dementia

Liu, C.-C., Murray, M. E., Li, X., Zhao, N., Wang, N., Heckman, M. G., Shue, F., Martens, Y., Li, Y., Raulin, A.-C., et al. (2021) · Science Translational Medicine

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 108

Metabolomic and inflammatory signatures of symptom dimensions in major depression

Brydges, C. R., Bhattacharyya, S., Dehkordi, S. M., Milaneschi, Y., Penninx, B., Jansen, R., Kristal, B. S., Han, X., Arnold, M., Kastenmüller, G., et al. (2022) · Brain, Behavior, and Immunity

Tryptophan and brain disordersTreatment of Major Depression

Cited by 108

Potential mechanisms contributing to sulfatide depletion at the earliest clinically recognizable stage of Alzheimer’s disease: a tale of shotgun lipidomics

Han, X. (2007) · Journal of Neurochemistry

Alzheimer's disease research and treatmentsSphingolipid Metabolism and Signaling

Cited by 101

PNPLA3 is a triglyceride lipase that mobilizes polyunsaturated fatty acids to facilitate hepatic secretion of large-sized very low-density lipoprotein

Johnson, S. M., Bao, H., McMahon, C. E., Chen, Y., Burr, S. D., Anderson, A. M., Madeyski-Bengtson, K., Lindén, D., Han, X., & Liu, J. (2024) · Nature Communications

Lipid metabolism and disordersLiver Disease Diagnosis and Treatment

Cited by 100

APOE2 is associated with longevity independent of Alzheimer’s disease

Shinohara, M., Kanekiyo, T., Tachibana, M., Kurti, A., Shinohara, M., Fu, Y., Zhao, J., Han, X., Sullivan, P. M., Rebeck, G. W., et al. (2020) · eLife

Genetics, Aging, and Longevity in Model OrganismsAlzheimer's disease research and treatments

Cited by 82

Isotope Tracing Untargeted Metabolomics Reveals Macrophage Polarization-State-Specific Metabolic Coordination across Intracellular Compartments

Puchalska, P., Huang, X., Martin, S. E., Han, X., Patti, G. J., & Crawford, P. A. (2018) · iScience

Metabolomics and Mass Spectrometry StudiesImmune cells in cancer

Cited by 79

Apolipoprotein E mediates sulfatide depletion in animal models of Alzheimer’s disease

Cheng, H., Zhou, Y., Holtzman, D. M., & Han, X. (2010) · Neurobiology of Aging

Alzheimer's disease research and treatmentsSphingolipid Metabolism and Signaling

Cited by 79

APOE2 orchestrated differences in transcriptomic and lipidomic profiles of postmortem AD brain

Lefterov, I., Wolfe, C. M., Fitz, N. F., Nam, K. N., Letronne, F., Biedrzycki, R. J., Kofler, J., Han, X., Wang, J., Schug, J., et al. (2019) · Alzheimer's Research & Therapy

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 74

Regulation of astrocyte lipid metabolism and ApoE secretion by the microglial oxysterol, 25-hydroxycholesterol

Cashikar, A. G., Toral-Rios, D., Timm, D., Romero, J., Strickland, M., Long, J. M., Han, X., Holtzman, D. M., & Paul, S. M. (2023) · Journal of Lipid Research

Cholesterol and Lipid MetabolismNeuroinflammation and Neurodegeneration Mechanisms

Cited by 72

Lipidome disruption in Alzheimer’s disease brain: detection, pathological mechanisms, and therapeutic implications

He, S., Xu, Z., & Han, X. (2025) · Molecular Neurodegeneration

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 62

Absence of oligodendroglial glucosylceramide synthesis does not result in CNS myelin abnormalities or alter the dysmyelinating phenotype of CGT‐deficient mice

Saadat, L., Dupree, J. L., Kilkus, J., Han, X., Traka, M., Proia, R. L., Dawson, G., & Popko, B. (2010) · Glia

Lysosomal Storage Disorders ResearchSphingolipid Metabolism and Signaling

Cited by 61

Impaired Mitochondrial Energetics Characterize Poor Early Recovery of Muscle Mass Following Hind Limb Unloading in Old Mice

Zhang, X., Trevino, M. B., Wang, M., Gardell, S. J., Ayala, J. E., Han, X., Kelly, D. P., Goodpaster, B. H., Vega, R. B., & Coen, P. M. (2018) · The Journals of Gerontology: Series A

Muscle Physiology and DisordersNutrition and Health in Aging

Cited by 58

Cholesterol 25-hydroxylase mediates neuroinflammation and neurodegeneration in a mouse model of tauopathy

Toral-Rios, D., Long, J. M., Ulrich, J. D., Yu, J., Strickland, M. R., Han, X., Holtzman, D. M., Cashikar, A. G., & Paul, S. M. (2024) · Journal of Experimental Medicine

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 47

An RNAi therapeutic targeting hepatic DGAT2 in a genetically obese mouse model of nonalcoholic steatohepatitis

Yenilmez, B., Wetoska, N., Kelly, M., Echeverria, D., Min, K., Lifshitz, L., Alterman, J. F., Hassler, M. R., Hildebrand, S., DiMarzio, C., et al. (2022) · Molecular Therapy

Liver Disease Diagnosis and TreatmentRNA Interference and Gene Delivery

Cited by 46

Loss of transcriptional repression by BCL6 confers insulin sensitivity in the setting of obesity

Senagolage, M. D., Sommars, M. A., Ramachandran, K., Futtner, C. R., Omura, Y., Allred, A. L., Wang, J., Yang, C., Procissi, D., Evans, R. M., et al. (2018) · Cell Reports

Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Cited by 44

Microglial cGAS Deletion Preserves Intercellular Communication and Alleviates Amyloid‐β‐Induced Pathogenesis of Alzheimer's Disease

He, S., Li, X., Mittra, N., Bhattacharjee, A., Wang, H., Song, S., Zhao, S., Liu, F., & Han, X. (2025) · Advanced Science

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 34

Reconstitution of membrane fusion between pancreatic islet secretory granules and plasma membranes: Catalysis by a protein constituent recognized by monoclonal antibodies directed against glyceraldehyde-3-phosphate dehydrogenase

Han, X., Ramanadham, S., Turk, J., & Gross, R. W. (1998) · Biochimica et Biophysica Acta (BBA) - Biomembranes

Cellular transport and secretionPancreatic function and diabetes

Cited by 31

Ketogenesis supports hepatic polyunsaturated fatty acid homeostasis via fatty acid elongation

Queathem, E. D., Moazzami, Z., Stagg, D. B., Nelson, A. B., Fulghum, K., Hayir, A., Seay, A., Gillingham, J. R., d’Avignon, D. A., Han, X., et al. (2025) · Science Advances

Lipid metabolism and biosynthesisDiet and metabolism studies

Cited by 30

Circular-SWAT for deep learning based diagnostic classification of Alzheimer's disease: application to metabolome data

Jo, T., Kim, J., Bice, P., Huynh, K., Wang, T., Arnold, M., Meikle, P. J., Giles, C., Kaddurah-Daouk, R., Saykin, A. J., et al. (2023) · eBioMedicine

Dementia and Cognitive Impairment ResearchMetabolomics and Mass Spectrometry Studies

Cited by 15

Lipidomics Profiling of Myelin

Wang, C., Pablo Palavicini, J., & Han, X. (2018) · Methods in Molecular Biology

Metabolomics and Mass Spectrometry StudiesLipid metabolism and biosynthesis

Cited by 15