Loss of transcriptional repression by BCL6 confers insulin sensitivity in the setting of obesity
Open accessAbstract
Accumulation of visceral adiposity is directly linked to the morbidity of obesity, while subcutaneous body fat is considered more benign. We have identified an unexpected role for B cell lymphoma 6 (BCL6), a critical regulator of immunity, in the developmental expansion of subcutaneous adipose tissue. In adipocyte-specific knockout mice (Bcl6 AKO ), we found that Bcl6 deletion results in strikingly increased inguinal, but not perigonadal, adipocyte size and tissue mass in addition to marked insulin sensitivity. Genome-wide RNA expression and DNA binding analyses revealed that BCL6 controls gene networks involved in cell growth and fatty acid biosynthesis. Using deuterium label incorporation and comprehensive adipokine and lipid profiling, we discovered that ablation of adipocyte Bcl6 enhances subcutaneous adipocyte lipogenesis, increases levels of adiponectin and fatty acid esters of hydroxy fatty acids (FAHFAs), and prevents steatosis. Thus, our studies identify BCL6 as a negative regulator of subcutaneous adipose tissue expansion and metabolic health.
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Bcl6 is a transcriptional repressor that is enriched in the fed state and cooperates with PPARα to suppress the induction of fasting transcription, and Bcl6 loss has been shown to increase insulin sensitivity and repress NASH.
“Bcl6 is a transcriptional repressor that is enriched in the fed state and cooperates with PPARα to suppress the induction of fasting transcription, and Bcl6 loss has been shown to increase insulin sensitivity and repress NASH36-38.”
From Positive selection of somatically mutated clones identifies adaptive pathways in metabolic liver disease (2023) · cites this paper as [36]
The Introduction identifies BCL6 as a transcriptional repressor, and the Results section on adipocyte BCL6 deficiency reports improved liver insulin sensitivity and reduced hepatic steatosis and inflammatory markers in Bcl6AKO mice. The copy does not establish that BCL6 is enriched in the fed state or cooperates with PPARα to suppress fasting transcription. It also does not report that BCL6 loss represses NASH specifically; reduced steatosis and inflammatory markers do not establish that broader claim. (LLM, conf=0.88)
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Cites
The metabolic phenotype in obesity: Fat mass, body fat distribution, and adipose tissue function
Goossens, G. H. (2017) · Obesity Facts · doi:10.1159/000471488 · Cited by 8,481 · see citing works
What we talk about when we talk about fat
Rosen, E. D., & Spiegelman, B. M. (2014) · Cell · doi:10.1016/j.cell.2013.12.012 · Cited by 2,373 · see citing works
Adipose tissue remodeling and obesity
Sun, K., Kusminski, C. M., & Scherer, P. E. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45887 · Cited by 1,941 · see citing works
Hayashi, S., & McMahon, A. P. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0597 · Cited by 1,347 · see citing works
Obesity-associated improvements in metabolic profile through expansion of adipose tissue
Kim, J.-Y., van de Wall, E., Laplante, M., Azzara, A., Trujillo, M. E., Hofmann, S. M., Schraw, T., Durand, J. L., Li, H., Li, G., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31021 · Cited by 1,310 · see citing works
Tracking adipogenesis during white adipose tissue development, expansion and regeneration
Wang, Q. A., Tao, C., Gupta, R. K., & Scherer, P. E. (2013) · Nature Medicine · doi:10.1038/nm.3324 · Cited by 1,262 · see citing works
Adipose tissue browning and metabolic health
Bartelt, A., & Heeren, J. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.204 · Cited by 1,177 · see citing works
Identification of a Lipokine, a Lipid Hormone Linking Adipose Tissue to Systemic Metabolism
Cao, H.-M., Gerhold, K., Mayers, J. R., Wiest, M., Watkins, S., & Hotamışlıgil, G. S. (2008) · Cell · doi:10.1016/j.cell.2008.07.048 · Cited by 1,142 · see citing works
Metabolic Dysregulation and Adipose Tissue Fibrosis: Role of Collagen VI
Khan, T., Muise, E. S., Iyengar, P., Wang, Z. V., Chandalia, M., Abate, N., Zhang, B. B., Bonaldo, P., Chua, S., & Scherer, P. E. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01300-08 · Cited by 1,053 · see citing works
Control of Inflammation, Cytokine Expression, and Germinal Center Formation by BCL-6
Dent, A. L., Shaffer, A. L., Yu, X., Allman, D., & Staudt, L. M. (1997) · Science · doi:10.1126/science.276.5312.589 · Cited by 945 · see citing works
Inflammation and Lipid Signaling in the Etiology of Insulin Resistance
Glass, C. K., & Olefsky, J. M. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.001 · Cited by 942 · see citing works
The sexual dimorphism of obesity
Palmer, B. F., & Clegg, D. J. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.11.029 · Cited by 919 · see citing works
Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin
Holland, W. L., Miller, R. A., Wang, Z. V., Sun, K., Barth, B. M., Bui, H. H., Davis, K. E., Bikman, B. T., Halberg, N., Rutkowski, J. M., et al. (2011) · Nature Medicine · doi:10.1038/nm.2277 · Cited by 892 · see citing works
Neeland, I. J., Poirier, P., & Després, J.-P. (2018) · Circulation · doi:10.1161/circulationaha.117.029617 · Cited by 881 · see citing works
Insulin Degradation: Progress and Potential
Duckworth, W. C., Bennett, R. G., & Hamel, F. G. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.5.0349 · Cited by 875 · see citing works
Discovery of a Class of Endogenous Mammalian Lipids with Anti-Diabetic and Anti-inflammatory Effects
Yore, M. M., Syed, I., Moraes‐Vieira, P. M., Zhang, T., Herman, M. A., Homan, E. A., Patel, R. T., Lee, J., Chen, S., Peroni, O. D., et al. (2014) · Cell · doi:10.1016/j.cell.2014.09.035 · Cited by 845 · see citing works
Lee, M., Wu, Y., & Fried, S. K. (2012) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.10.001 · Cited by 804 · see citing works
Gavrilova, O., Haluzı́k, M., Matsusue, K., Cutson, J. J., Johnson, L. K., Dietz, K. R., Nicol, C. J. B., Vinson, C., Gonzalez, F. J., & Reitman, M. L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300043200 · Cited by 759 · see citing works
Epigenomic Signatures of Neuronal Diversity in the Mammalian Brain
Mo, A., Mukamel, E. A., Davis, F. P., Luo, C., Henry, G. L., Picard, S., Urich, M. A., Nery, J. R., Sejnowski, T. J., Lister, R., et al. (2015) · Neuron · doi:10.1016/j.neuron.2015.05.018 · Cited by 739 · see citing works
Mechanisms and Metabolic Implications of Regional Differences among Fat Depots
Tchkonia, T., Thomou, T., Zhu, Y. Z., Karagiannides, I., Pothoulakis, C., Jensen, M. D., & Kirkland, J. L. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.03.008 · Cited by 728 · see citing works
Beneficial Effects of Subcutaneous Fat Transplantation on Metabolism
Tran, T. T., Yamamoto, Y., Gesta, S., & Kahn, C. R. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.04.004 · Cited by 705 · see citing works
Adipocyte inflammation is essential for healthy adipose tissue expansion and remodeling
Wernstedt Asterholm, I., Tao, C., Morley, T. S., Wang, Q. A., Delgado-Lopez, F., Wang, Z. V., & Scherer, P. E. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.05.005 · Cited by 668 · see citing works
Transcriptional Control of Adipose Lipid Handling by IRF4
Eguchi, J., Wang, X., Yu, S., Kershaw, E. E., Chiu, P. C., Dushay, J. R., Estall, J. L., Klein, U., Maratos–Flier, E., & Rosen, E. D. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.02.005 · Cited by 607 · see citing works
Target analysis by integration of transcriptome and ChIP-seq data with BETA
Wang, S., Sun, H., Ma, J., Zang, C., Wang, C., Wang, J., Tang, Q., Meyer, C. A., Zhang, Y., & Liu, X. S. (2013) · Nature Protocols · doi:10.1038/nprot.2013.150 · Cited by 544 · see citing works
Self-citationThe cell biology of fat expansion
Rutkowski, J. M., Stern, J. H., & Scherer, P. E. (2015) · Journal of Cell Biology · doi:10.1083/jcb.201409063 · Cited by 541 · see citing works
Shepherd, P. R., Gnudi, L., Tozzo, E., Yang, H., Leach, F., & Kahn, B. B. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)41516-5 · Cited by 520 · see citing works
Thiazolidinediones and the promise of insulin sensitization in type 2 diabetes
Soccio, R. E., Chen, E. R., & Lazar, M. A. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.08.005 · Cited by 518 · see citing works
Leptin-specific patterns of gene expression in white adipose tissuePreprint
Soukas, A. A., Cohen, P., Socci, N. D., & Friedman, J. M. (2000) · Genes & Development · doi:10.1101/gad.14.8.963 · Cited by 516 · see citing works
McLaughlin, T., Lamendola, C., Liu, A., & Abbasi, F. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-0615 · Cited by 468 · see citing works
Kusminski, C. M., Holland, W. L., Sun, K., Park, J., Spurgin, S. B., Lin, Y., Askew, G. R., Simcox, J., McClain, D. A., Li, C., et al. (2012) · Nature Medicine · doi:10.1038/nm.2899 · Cited by 466 · see citing works
Roles of BCL6 in normal and transformed germinal center B cells
Basso, K., & Dalla‐Favera, R. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01112.x · Cited by 431 · see citing works
Rapid depot-specific activation of adipocyte precursor cells at the onset of obesity
Jeffery, E., Church, C. D., Holtrup, B., Colman, L., & Rodeheffer, M. S. (2015) · Nature Cell Biology · doi:10.1038/ncb3122 · Cited by 404 · see citing works
The expression of adipogenic genes is decreased in obesity and diabetes mellitus
Nadler, S. T., Stoehr, J. P., Schueler, K. L., Tanimoto, G., Yandell, B. S., & Attie, A. D. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.21.11371 · Cited by 386 · see citing works
The adipose tissue microenvironment regulates depot-specific adipogenesis in obesity
Jeffery, E., Wing, A., Holtrup, B., Sebo, Z., Kaplan, J. L., Saavedra-Peña, R., Church, C. D., Colman, L., Berry, R., & Rodeheffer, M. S. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.05.012 · Cited by 352 · see citing works
Xia, J. Y., Holland, W. L., Kusminski, C. M., Sun, K., Sharma, A. X., Pearson, M. J., Sifuentes, A. J., McDonald, J. G., Gordillo, R., & Scherer, P. E. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.06.007 · Cited by 348 · see citing works
Wang, M., Wang, C., & Han, X. (2016) · Mass Spectrometry Reviews · doi:10.1002/mas.21492 · Cited by 305 · see citing works
Self-citationIntrinsic Differences in Adipocyte Precursor Cells From Different White Fat Depots
Macotela, Y., Emanuelli, B., Mori, M. A., Gesta, S., Schulz, T. J., Tseng, Y., & Kahn, C. R. (2012) · Diabetes · doi:10.2337/db11-1753 · Cited by 300 · see citing works
Abdominal adiposity and insulin resistance in obese men
Ross, R., Aru, J., Freeman, J., HUDSON, R. W., & Janssen, I. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00469.2001 · Cited by 284 · see citing works
Titchenell, P. M., Quinn, W. J., Lu, M., Chu, Q., Lu, W., Li, C., Chen, H., Monks, B. R., Chen, J., Rabinowitz, J. D., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.04.022 · Cited by 281 · see citing works
Transcriptional networks and chromatin remodeling controlling adipogenesis
Siersbæk, R., Nielsen, R., & Mandrup, S. (2011) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2011.10.001 · Cited by 278 · see citing works
Signaling in Control of Cell Growth and MetabolismPreprint
Ward, P. S., & Thompson, C. B. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a006783 · Cited by 270 · see citing works
Glucose Metabolism In Vivo in Four Commonly Used Inbred Mouse Strains
Berglund, E. D., Li, C. Y., Poffenberger, G., Ayala, J. E., Fueger, P. T., Willis, S. E., Jewell, M. M., Powers, A. C., & Wasserman, D. H. (2008) · Diabetes · doi:10.2337/db07-1615 · Cited by 265 · see citing works
IL-4/STAT6 immune axis regulates peripheral nutrient metabolism and insulin sensitivity
Ricardo-González, R. R., Eagle, A. R., Odegaard, J. I., Jouihan, H. A., Morel, C. R., Heredia, J. E., Mukundan, L., Wu, D., Locksley, R. M., & Chawla, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1009152108 · Cited by 251 · see citing works
Shao, M., Ishibashi, J., Kusminski, C. M., Wang, Q. A., Hepler, C., Vishvanath, L., MacPherson, K. A., Spurgin, S. B., Sun, K., Holland, W. L., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.04.023 · Cited by 231 · see citing works
Diet-Induced Circadian Enhancer Remodeling Synchronizes Opposing Hepatic Lipid Metabolic Processes
Guan, D., Xiong, Y., Borck, P. C., Jang, C., Doulias, P., Papazyan, R., Fang, B., Jiang, C., Zhang, Y., Briggs, E. R., et al. (2018) · Cell · doi:10.1016/j.cell.2018.06.031 · Cited by 219 · see citing works
De novo lipogenesis in metabolic homeostasis: More friend than foe?
Solinas, G., Borén, J., & Dulloo, A. G. (2015) · Molecular Metabolism · doi:10.1016/j.molmet.2015.03.004 · Cited by 197 · see citing works
Syed, I., Lee, J., Moraes‐Vieira, P. M., Donaldson, C. J., Sontheimer-Phelps, A., Aryal, P., Wellenstein, K., Kolar, M. J., Nelson, A. T., Siegel, D. R., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.01.001 · Cited by 197 · see citing works
Han, X., Yang, K., & Gross, R. W. (2008) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.3595 · Cited by 190 · see citing works
Self-citationRationally designed BCL6 inhibitors target activated B cell diffuse large B cell lymphoma
Cardenas, M. G., Yu, W., Beguelin, W., Teater, M. R., Geng, H., Goldstein, R. L., Oswald, E., Hatzi, K., Yang, S.-N., Cohen, J., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci85795 · Cited by 176 · see citing works
Metabolically normal obese people are protected from adverse effects following weight gain
Fabbrini, E., Yoshino, J., Yoshino, M., Magkos, F., Tiemann Luecking, C., Samovski, D., Fraterrigo, G., Okunade, A. L., Patterson, B. W., & Klein, S. (2015) · Journal of Clinical Investigation · doi:10.1172/jci78425 · Cited by 172 · see citing works
Zhang, Y., Laz, E. V., & Waxman, D. J. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.06312-11 · Cited by 171 · see citing works
Baglioni, S., Cantini, G., Poli, G., Francalanci, M., Squecco, R., Franco, A. D., Borgogni, E., Frontera, S., Nesi, G., Liotta, F., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036569 · Cited by 165 · see citing works
Han, X., Yang, K., Cheng, H., Fikes, K. N., & Gross, R. W. (2005) · Journal of Lipid Research · doi:10.1194/jlr.d500007-jlr200 · Cited by 164 · see citing works
Self-citationWang, M., Han, R. H., & Han, X. (2013) · Analytical Chemistry · doi:10.1021/ac402078p · Cited by 162 · see citing works
Self-citationNajt, C. P., Subramanian, S., Aljazi, M. B., Fader, K. A., Olenic, S. D., Brock, J. R. L., Lydic, T. A., Jones, A. D., & Atshaves, B. P. (2016) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00436.2015 · Cited by 157 · see citing works
Measurement of Fatty Acid Oxidation Rates in Animal Tissues and Cell Lines
Huynh, F. K., Green, M. F., Koves, T. R., & Hirschey, M. D. (2014) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/b978-0-12-416618-9.00020-0 · Cited by 154 · see citing works
Direct control of hepatic glucose production by interleukin-13 in mice
Stanya, K. J., Jacobi, D., Liu, S., Bhargava, P., Dai, L., Gangl, M. R., Inouye, K., Barlow, J. L., Ji, Y., Mizgerd, J. P., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci64941 · Cited by 140 · see citing works
Distinct regulatory mechanisms governing embryonic versus adult adipocyte maturation
Wang, Q. A., Tao, C., Jiang, L., Shao, M., Ye, R., Zhu, Y., Gordillo, R., Ali, A., Lian, Y., Holland, W. L., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3217 · Cited by 134 · see citing works
Morley, T. S., Xia, J. Y., & Scherer, P. E. (2015) · Nature Communications · doi:10.1038/ncomms8906 · Cited by 109 · see citing works
Cidea improves the metabolic profile through expansion of adipose tissue
Abreu-Vieira, G., Fischer, A. W., Mattsson, C. L., de Jong, J. M. A., Shabalina, I. G., Rydén, M., Laurencikiene, J., Arner, P., Cannon, B., Nedergaard, J., et al. (2015) · Nature Communications · doi:10.1038/ncomms8433 · Cited by 104 · see citing works
Multidimensional Mass Spectrometry-Based Shotgun Lipidomics
Wang, M., & Han, X. (2014) · Methods in molecular biology · doi:10.1007/978-1-4939-1258-2_13 · Cited by 104 · see citing works
Self-citationMeyer, R., Laz, E. V., Su, T., & Waxman, D. J. (2009) · Molecular Endocrinology · doi:10.1210/me.2009-0242 · Cited by 89 · see citing works
Lipidomics: Comprehensive Mass Spectrometry of Lipids
Han, X. (2016) · Cited by 86 · see citing works
Self-citationHong, K. Y., Bae, H., Park, I., Park, D. Y., Kim, K. H., Kubota, Y., Cho, E., Kim, H., Adams, R. H., Yoo, O., et al. (2015) · Development · doi:10.1242/dev.125336 · Cited by 84 · see citing works
Adipocyte STAT5 deficiency promotes adiposity and impairs lipid mobilisation in mice
Kaltenecker, D., Mueller, K. M., Benedikt, P., Feiler, U., Themanns, M., Schlederer, M., Kenner, L., Schweiger, M., Haemmerle, G., & Moriggl, R. (2016) · Diabetologia · doi:10.1007/s00125-016-4152-8 · Cited by 62 · see citing works
Transcriptional targets in adipocyte biology
Rosen, E. D., Eguchi, J., & Xu, Z. (2009) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728220903039706 · Cited by 61 · see citing works
Pflimlin, E., Bielohuby, M., Korn, M., Breitschopf, K., Löhn, M., Wohlfart, P., Konkar, A. A., Podeschwa, M. A. L., Bärenz, F., Pfenninger, A., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.05.028 · Cited by 61 · see citing works
Dissociation between adipose tissue fluxes and lipogenic gene expression inob/obmice
Turner, S., Roy, S., Sul, H. S., Neese, R. A., Murphy, E. J., Samandi, W., Roohk, D. J., & Hellerstein, M. K. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00309.2005 · Cited by 50 · see citing works
Tao, C., Holland, W. L., Wang, Q. A., Shao, M., Jia, L., Sun, K., Lin, X., Kuo, Y.-C., Johnson, J. A., Gordillo, R., et al. (2017) · Endocrinology · doi:10.1210/en.2017-00024 · Cited by 41 · see citing works
Bederman, I. R., Dufner, D. A., Alexander, J. C., & Previs, S. F. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00340.2005 · Cited by 38 · see citing works
Self-citationLaPensee, C. R., Lin, G., Dent, A. L., & Schwartz, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097090 · Cited by 37 · see citing works
Chen, Y., Lin, G., Huo, J. S., Barney, D., Wang, Z., Livshiz, T., States, D. J., Qin, Z. S., & Schwartz, J. (2009) · Endocrinology · doi:10.1210/en.2009-0212 · Cited by 34 · see citing works
Identification of zinc finger protein Bcl6 as a novel regulator of early adipose commitment
Hu, X., Zhou, Y., Yang, Y., Peng, J., Song, T., Xu, T., Wei, H., Jiang, S., & Peng, J. (2016) · Open Biology · doi:10.1098/rsob.160065 · Cited by 22 · see citing works
Lin, G., LaPensee, C. R., Qin, Z. S., & Schwartz, J. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.07.020 · Cited by 20 · see citing works
Altered de novo lipogenesis contributes to low adipose stores in cystic fibrosis mice
Bederman, I. R., Perez, A., Henderson, L., Freedman, J. A., Poleman, J., Guentert, D., Ruhrkraut, N., & Drumm, M. L. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00451.2011 · Cited by 16 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Understanding FAHFAs: From structure to metabolic regulation
Brejchová, K., Balas, L., Paluchová, V., Březinová, M., Durand, T., & Kuda, O. (2020) · Progress in Lipid Research · doi:10.1016/j.plipres.2020.101053 · Cited by 132 · see citing works
Desoyé, G., & Herrera, E. (2020) · Progress in Lipid Research · doi:10.1016/j.plipres.2020.101082 · Cited by 126 · see citing works
Role of PAI-1 in hepatic steatosis and dyslipidemia
Levine, J. A., Oleaga, C., Eren, M., Amaral, A. P., Shang, M., Lux, E., Khan, S. S., Shah, S. J., Omura, Y., Pamir, N., et al. (2021) · Scientific Reports · doi:10.1038/s41598-020-79948-x · Cited by 102 · see citing works
Self-citationWang, Z., Zhu, S., Jia, Y., Wang, Y., Kubota, N., Fujiwara, N., Gordillo, R., Lewis, C., Zhu, M., Sharma, T., et al. (2023) · Cell · doi:10.1016/j.cell.2023.03.014 · Cited by 72 · see citing works
Li, X., Zhu, Q., Wang, W., Qi, J., He, Y., Wang, Y., Lu, Y., Wu, H., Ding, Y., & Sun, Y. W. (2018) · The FASEB Journal · doi:10.1096/fj.201802829r · Cited by 54 · see citing works
Song, T., Yang, Y., Jiang, S., & Peng, J. (2020) · Advanced Science · doi:10.1002/advs.202001563 · Cited by 51 · see citing works
Transcriptional regulation of N6-methyladenosine orchestrates sex-dimorphic metabolic traits
Salisbury, D. A., Casero, D., Zhang, Z., Wang, D., Kim, J., Wu, X., Vergnes, L., Mirza, A. H., León‐Mimila, P., Williams, K. J., et al. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00427-2 · Cited by 45 · see citing works
The Regulation of Lipokines by Environmental Factors
Hernández‐Saavedra, D., & Stanford, K. I. (2019) · Nutrients · doi:10.3390/nu11102422 · Cited by 34 · see citing works
B Cell Lymphoma 6 (BCL6): A Conserved Regulator of Immunity and Beyond
Liongue, C., Almohaisen, F. L. J., & Ward, A. C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252010968 · Cited by 30 · see citing works
Potential physio-pathological effects of branched fatty acid esters of hydroxy fatty acids
Benlebna, M., Balas, L., Gaillet, S., Durand, T., Coudray, C., Casas, F., & Feillet‐Coudray, C. (2021) · Biochimie · doi:10.1016/j.biochi.2020.12.020 · Cited by 28 · see citing works
BCL6 regulates brown adipocyte dormancy to maintain thermogenic reserve and fitness
Kutyavin, V. I., & Chawla, A. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1907308116 · Cited by 26 · see citing works
Zhang, H., Li, Y., Zhang, C., Huang, K., Zhao, J., Le, S., Jiang, L., Liu, H., Yang, P., Xiao, X., et al. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04812-x · Cited by 25 · see citing works
Epigenetic Regulators of White Adipocyte Browning
Nanduri, R. (2021) · Epigenomes · doi:10.3390/epigenomes5010003 · Cited by 23 · see citing works
The measurement, regulation and biological activity of FAHFAs
Tan, D., & Saghatelian, A. (2025) · Nature Chemical Biology · doi:10.1038/s41589-024-01827-7 · Cited by 22 · see citing works
Alur, V. C., Raju, V., Vastrad, B. M., Vastrad, C. M., Kavatagimath, S., & Kotrashetti, S. (2023) · Clinical Medicine Insights Endocrinology and Diabetes · doi:10.1177/11795514231155635 · Cited by 22 · see citing works
Transcriptional programming of translation by BCL6 controls skeletal muscle proteostasis
Ramachandran, K., Futtner, C. R., Sommars, M. A., Quattrocelli, M., Omura, Y., Fruzyna, E., Wang, J. C., Waldeck, N. J., Senagolage, M. D., Telles, C. G., et al. (2024) · Nature Metabolism · doi:10.1038/s42255-024-00983-3 · Cited by 20 · see citing works
Self-citationSinghal, N. S., Bai, M., Lee, E. M., Luo, S., Cook, K. R., & Dengke, K. (2020) · eLife · doi:10.7554/elife.55578 · Cited by 20 · see citing works
Chikada, H., Ida, K., Nishikawa, Y., Inagaki, Y., & Kamiya, A. (2020) · Scientific Reports · doi:10.1038/s41598-020-66539-z · Cited by 17 · see citing works
Metabolic Gatekeepers of Pathological B Cell Activation
Sadras, T., Chan, L. N., Xiao, G., & Müschen, M. (2020) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-061020-050135 · Cited by 14 · see citing works
Patel, S., Ganbold, K., Cho, C. H., Siddiqui, J., Yildiz, R., Sparman, N. Z. R., Sadeh, S., Nguyen, C. M., Wang, J., Whitelegge, J. P., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-52917-y · Cited by 12 · see citing works
Self-citationWolpe, A. G., Luse, M. A., Baryiames, C. P., Schug, W. J., Wolpe, J. B., Johnstone, S. R., Dunaway, L. S., Juśkiewicz, Z. J., Loeb, S. A., Page, H. R. A., et al. (2024) · Science Signaling · doi:10.1126/scisignal.adg2622 · Cited by 11 · see citing works
Xie, K., Ning, C., Yang, A., Zhang, Q., Wang, D., & Fan, X. (2024) · Genes · doi:10.3390/genes15040433 · Cited by 7 · see citing works
DIDO is necessary for the adipogenesis that promotes diet-induced obesity
García-López, M. Á., Mora, A., Corrales, P., Pons, T., de Diego, A. S., Gutiérrez, A., van Wely, K. H. M., Medina‐Gómez, G., Sabio, G., Martínez‐A, C., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2300096121 · Cited by 6 · see citing works
BCL6 coordinates muscle mass homeostasis with nutritional states
Wang, H. J., Fan, W., Liu, S., Kim, K., Matsushima, A., Ogawa, S., Kang, H. G., Zhu, J., Estepa, G., He, M., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2408896122 · Cited by 6 · see citing works
Self-citationAdipose tissue-derived microRNA-450a-5p induces type 2 diabetes mellitus by downregulating DUSP10
Zhu, J., Hou, Y., Yu, W., Wang, J., Chu, X., Zhang, X., Pang, H., Ma, D., Tang, Y., Li, M., et al. (2025) · Molecular Biomedicine · doi:10.1186/s43556-025-00247-w · Cited by 6 · see citing works
Self-citationIannone, V., Vaittinen, M., Gómez-Gallego, C., Mikkonen, S. J., Lok, J., D’Auria, G., Vazquez-Uribe, R., Tikkanen, I., Sommer, M. O. A., El-Nezami, H. S., et al. (2025) · International Journal of Obesity · doi:10.1038/s41366-025-01774-w · Cited by 6 · see citing works
Yang, J. D., Song, B., Zhang, F., Liu, B., Yan, J., Wang, Y., Sun, J. P., Zhao, C., Li, D., & Cao, H. (2025) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-025-01101-x · Cited by 6 · see citing works
Richard, A. J., Hang, H., Allerton, T. D., Zhao, P., Mendoza, T. M., Ghosh, S., Elks, C. M., & Stephens, J. M. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.812802 · Cited by 9 · see citing works
Targeting lipid metabolism overcomes BTK inhibitor resistance in diffuse large B-cell lymphoma
Liu, Z., Wu, C., Yao, Z., Wang, Y., Yu, Z., & Yu, J. (2024) · Medicine in Novel Technology and Devices · doi:10.1016/j.medntd.2024.100295 · Cited by 5 · see citing works
Analysis of key genes and pathways associated with the pathogenesis of Type 2 diabetes mellitusPreprint
Alur, V. C., Raju, V., Vastrad, B. M., Vastrad, C. M., & Kotrashetti, S. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.08.12.456106 · Cited by 3 · see citing works
Wohlfart, P., Chehtane, M., Luna, E., Mehta, R. S., Korn, M., Konkar, A. A., Schwahn, U., Petry, S., Tennagels, N., & Bielohuby, M. (2023) · Frontiers in Drug Discovery · doi:10.3389/fddsv.2023.1138461 · Cited by 2 · see citing works
Han, H., Li, Q., Wang, C., Liang, Z., Zhang, L., Zhang, S., Tian, M., Li, S., Liu, D., Yang, G., et al. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.07.028 · Cited by 1 · see citing works
Prevention of Cholestatic Liver Disease Through BCL6-FXR Enterohepatic Crosstalk
Fruzyna, E., Sommars, M. A., Omura, Y., Yarnoff, K. M., Wang, J. C., Futtner, C. R., Green, R. M., & Barish, G. D. (2025) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2025.101706 · Cited by 1 · see citing works
Self-citationAcevedo, A. F., Mack, J. J., & Valenzuela, N. M. (2024) · American Journal of Transplantation · doi:10.1016/j.ajt.2024.07.026 · Cited by 1 · see citing works
The DNA binding protein BCL6 regulates NFκB-controlled endothelial inflammatory gene expressionPreprint
Acevedo, A. F., Mack, J. J., & Valenzuela, N. M. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.11.03.514942 · Cited by 1 · see citing works
Vastrad, B. M., Pattanashetti, S., & Vastrad, C. M. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.13.618070 · Cited by 1 · see citing works
Cytoprotection by a naturally occurring variant of ATP5G1 in Arctic ground squirrelsPreprint
Singhal, N. S., Bai, M., Lee, E. M., Luo, S., Cook, K. R., & Dengke, K. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.01.31.929018
Najari, A., Aminiyanfar, M., Mobasheri, M., & Sobati, T. (2021) · Research Square · doi:10.21203/rs.3.rs-220326/v1
Transcriptional control of adipogenesis by PATZ1Preprint
Patel, S., Sparman, N. Z. R., Sadeh, S., Wang, J., Whitelegge, J. P., Fried, S. K., Waki, H., Villanueva, C. J., Seldin, M. M., Sakaguchi, S., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.05.24.493273
Self-citationBCL6 regulates the endothelial pro-immunogenic phenotype relevant to organ transplant rejectionPreprint
Acevedo, A. F., & Valenzuela, N. M. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.11.03.514941
Vastrad, B. M., & Vastrad, C. M. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.08.15.608116
BCL6 regulates skeletal muscle mass and mitochondrial bioenergetics
Usmani, S. E., Leduc‐Gaudet, J., Chau, S., Bellissimo, C. A., Vohra, S., Desjardins, K., Pollock‐Tahiri, E., Shi, I., Chun, F., Capobianco, A., et al. (2026) · Molecular Metabolism · doi:10.1016/j.molmet.2026.102367
Zhang, T., Yu, Y., Lin, C., Song, C., Liao, T., Sun, Y., & Tang, H. (2026) · PLoS ONE · doi:10.1371/journal.pone.0357970
- Authors
- Senagolage, M. D., Sommars, M. A., Ramachandran, K., Futtner, C. R., Omura, Y., Allred, A. L., Wang, J., Yang, C., Procissi, D., Evans, R. M., Han, X., Bederman, I. R., & Barish, G. D.
- Affiliations
- Northwestern University (US)
- The University of Texas at San Antonio Health Science Center (US)
- Salk Institute for Biological Studies (US)
- Case Western Reserve University (US)
- Corresponding author
- Barish, Grant D.
- ORCID
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2018-12
- Volume
- 25
- Issue
- 12
- Pages
- 3283-3298.e6
- ISSN
- 2211-1247 (ISSN-L)
- PMC
- PMC6377366
- OpenAlex
- W2904270746
- Cited by
- 44
- References
- 75
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 10 · 2023: 3 · 2022: 5 · 2021: 6 · 2020: 8 · 2019: 2 · 2018: 1
- FWCI
- 3.32
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cell Reports (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion, cc-by-nc-nd)
- PubMed Central (acceptedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- NCI (P30-CA060553)
- HHMI
- NIH (DK057978, HL105278, R01DK108987, P30DK020595, K08HL092298)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- BCL6, transcriptional repression, insulin sensitivity, obesity, subcutaneous adipose tissue, adipocyte size, fatty acid esters of hydroxy fatty acids, adiponectin, steatosis, fatty acid synthesis, adipose tissue expansion
- MeSH terms
- Animals, Adipose Tissue, Brown, Cell Differentiation, DNA, Fatty Liver, Fetus, Gene Expression Regulation, Humans, Inflammation, Insulin, Insulin Resistance, Lipids, Male, Obesity, Protein Binding, Transcription, Genetic, Signal Transduction, Adipocytes, Mice, Knockout, 3T3-L1 Cells, Subcutaneous Fat, Adiposity, Lipogenesis, Mice, Proto-Oncogene Proteins c-bcl-6, Adiponectin, Diet, High-Fat
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