Shen, Yang

Overcoming mutation-based resistance to antiandrogens with rational drug design

Balbas, M. D., Evans, M. J., Hosfield, D. J., Wongvipat, J., Arora, V. K., Watson, P. A., Chen, Y., Greene, G. L., Shen, Y., & Sawyers, C. L. (2013) · eLife

Prostate Cancer Treatment and ResearchDrug Transport and Resistance Mechanisms

Cited by 397

ICAM1 initiates CTC cluster formation and trans-endothelial migration in lung metastasis of breast cancer

Taftaf, R., Liu, X., Singh, S., Jia, Y., Dashzeveg, N. K., Hoffmann, A. D., El-Shennawy, L., Ramos, E. K., Adorno-Cruz, V., Schuster, E. J., et al. (2021) · Nature Communications

Cancer Cells and MetastasisCell Adhesion Molecules Research

Cited by 261

Blind prediction of homo- and hetero-protein complexes: the CASP13-CAPRI experiment

Lensink, M. F., Brysbaert, G., Nadzirin, N., Velankar, S., Chaleil, R. A. G., Gerguri, T., Bates, P. A., Laine, E., Carbone, A., Grudinin, S., et al. (2019) · Proteins Structure Function and Bioinformatics

Protein Structure and DynamicsEnzyme Structure and Function

Cited by 122

Explainable Deep Relational Networks for Predicting Compound-Protein Affinities and Contacts

Karimi, M., Wu, D., Wang, Z., & Shen, Y. (2019) · Journal of Chemical Information and Modeling

Computational Drug Discovery MethodsMachine Learning in Bioinformatics

Cited by 64

Explainable Deep Relational Networks for Predicting Compound–Protein Affinities and Contacts

Karimi, M., Wu, D., Wang, Z., & Shen, Y. (2021) · Journal of Chemical Information and Modeling

Computational Drug Discovery MethodsMachine Learning in Bioinformatics

Cited by 64

Structure-Informed Protein Language Models are Robust Predictors for Variant Effects

Sun, Y., & Shen, Y. (2023) · Human Genetics

Genomics and Rare DiseasesProtein Structure and Dynamics

Cited by 30

Cross-modality and self-supervised protein embedding for compound–protein affinity and contact prediction

You, Y., & Shen, Y. (2022) · Bioinformatics

Computational Drug Discovery MethodsMachine Learning in Bioinformatics

Cited by 21

Cross-Modality and Self-Supervised Protein Embedding for Compound–Protein Affinity and Contact Prediction

You, Y., & Shen, Y. (2022) · Bioinformatics

Computational Drug Discovery MethodsMachine Learning in Bioinformatics

Cited by 20