ICAM1 initiates CTC cluster formation and trans-endothelial migration in lung metastasis of breast cancer
Open accessAbstract
Circulating tumor cell (CTC) clusters mediate metastasis at a higher efficiency and are associated with lower overall survival in breast cancer compared to single cells. Combining single-cell RNA sequencing and protein analyses, here we report the profiles of primary tumor cells and lung metastases of triple-negative breast cancer (TNBC). ICAM1 expression increases by 200-fold in the lung metastases of three TNBC patient-derived xenografts (PDXs). Depletion of ICAM1 abrogates lung colonization of TNBC cells by inhibiting homotypic tumor cell-tumor cell cluster formation. Machine learning-based algorithms and mutagenesis analyses identify ICAM1 regions responsible for homophilic ICAM1-ICAM1 interactions, thereby directing homotypic tumor cell clustering, as well as heterotypic tumor-endothelial adhesion for trans-endothelial migration. Moreover, ICAM1 promotes metastasis by activating cellular pathways related to cell cycle and stemness. Finally, blocking ICAM1 interactions significantly inhibits CTC cluster formation, tumor cell transendothelial migration, and lung metastasis. Therefore, ICAM1 can serve as a novel therapeutic target for metastasis initiation of TNBC.
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Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106 · see citing works
Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625 · see citing works
STAR: ultrafast universal RNA-seq aligner
Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709 · see citing works
HTSeq—a Python framework to work with high-throughput sequencing data
Anders, S., Pyl, P. T., & Huber, W. (2015) · Bioinformatics · doi:10.1093/bioinformatics/btu638 · Cited by 21,464 · see citing works
Siegel, R. L., Miller, K. D., & Jemal, A. (2018) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21442 · Cited by 16,632 · see citing works
Molecular portraits of human breast tumours
Perou, C., Sørlie, T., Eisen, M., van de Rijn, M., Jeffrey, S., Rees, C. A., Pollack, J., Ross, D., Johnsen, H., Akslen, L., et al. (2000) · Nature · doi:10.1038/35021093 · Cited by 16,551 · see citing works
Tissue-based map of the human proteome
Uhlén, M., Fagerberg, L., Hallström, B. M., Lindskog, C., Oksvold, P., Mardinoglu, A., Sivertsson, Å., Kampf, C., Sjöstedt, E., Asplund, A., et al. (2015) · Science · doi:10.1126/science.1260419 · Cited by 15,286 · see citing works
Nishimura, R., Osako, T., Nishiyama, Y., Tashima, R., Nakano, M., Fujisue, M., Toyozumi, Y., & Arima, N. (2013) · Oncology · doi:10.1159/000353099 · Cited by 13,239 · see citing works
Sørlie, T., Perou, C., Tibshirani, R., Aas, T., Geisler, S., Johnsen, H., Hastie, T., Eisen, M., van de Rijn, M., Jeffrey, S., et al. (2001) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.191367098 · Cited by 11,695 · see citing works
Prospective identification of tumorigenic breast cancer cells
Al‐Hajj, M., Wicha, M. S., Benito‐Hernández, A., Morrison, S. J., & Clarke, M. F. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0530291100 · Cited by 10,388 · see citing works
Mootha, V. K., Lindgren, C. M., Eriksson, K.-F., Subramanian, A., Sihag, S., Lehar, J., Puigserver, P., Carlsson, E., Ridderstråle, M., Laurila, E., et al. (2003) · Nature Genetics · doi:10.1038/ng1180 · Cited by 10,197 · see citing works
The cancer genome atlas pan-cancer analysis project
The Cancer Genome Atlas Research Network, Weinstein, J. N., Collisson, E. A., Mills, G. B., Shaw, K. R. M., Ozenberger, B. A., Ellrott, K., Shmulevich, I., Sander, C., & Stuart, J. M. (2013) · Nature Genetics · doi:10.1038/ng.2764 · Cited by 9,092 · see citing works
Triple-negative breast cancer: clinical features and patterns of recurrence
Dent, R., Trudeau, M., Pritchard, K. I., Hanna, W. M., Kahn, H. K., Sawka, C. A., Lickley, L. A., Rawlinson, E., Sun, P., & Narod, S. A. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-3045 · Cited by 5,091 · see citing works
Supervised Risk Predictor of Breast Cancer Based on Intrinsic Subtypes
Parker, J. S., Mullins, M., Cheang, M. C. U., Leung, S. C. Y., Voduc, D. K., Vickery, T. L., Davies, S. R., Fauron, C. M. ‐., He, X., Hu, Z., et al. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2008.18.1370 · Cited by 4,737 · see citing works
Foulkes, W. D., Smith, I. E., & Reis-Filho, J. S. (2010) · New England Journal of Medicine · doi:10.1056/nejmra1001389 · Cited by 4,719 · see citing works
Circulating Tumor Cells, Disease Progression, and Survival in Metastatic Breast Cancer
Cristofanilli, M., Budd, G. T., Ellis, M. J., Stopeck, A., Matera, J., Miller, M. C., Reuben, J. M., Doyle, G. V., Allard, W. J., Terstappen, L. W. M. M., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040766 · Cited by 4,602 · see citing works
Self-citationKi67 expression in breast cancer
Elkablawy, M. A., Albasri, A. M., Mohammed, R. A., Hussainy, A. S., Nouh, M. M., & Alhujaily, A. S. (2016) · Saudi Medical Journal · doi:10.15537/smj.2016.2.12285 · Cited by 4,382 · see citing works
Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1
Barbie, D. A., Tamayo, P., Boehm, J. S., Kim, S. Y., Moody, S. E., Dunn, I. F., Schinzel, A. C., Sandy, P., Meylan, E., Scholl, C., et al. (2009) · Nature · doi:10.1038/nature08460 · Cited by 3,869 · see citing works
The ClusPro web server for protein–protein docking
Kozakov, D., Hall, D. R., Xia, B., Porter, K. A., Padhorny, D., Yueh, C., Beglov, D., & Vajda, S. (2017) · Nature Protocols · doi:10.1038/nprot.2016.169 · Cited by 3,297 · see citing works
More powerful procedures for multiple significance testing
Hochberg, Y., & Benjamini, Y. (1990) · Statistics in Medicine · doi:10.1002/sim.4780090710 · Cited by 2,715 · see citing works
Association of reactive oxygen species levels and radioresistance in cancer stem cells
Diehn, M., Cho, R. W., Lobo, N. A., Kalisky, T., Dorie, M. J., Kulp, A. N., Qian, D., Lam, J. S., Ailles, L. E., Wong, M., et al. (2009) · Nature · doi:10.1038/nature07733 · Cited by 2,555 · see citing works
Circulating Tumor Cell Clusters Are Oligoclonal Precursors of Breast Cancer Metastasis
Aceto, N., Bardia, A., Miyamoto, D. T., Collier, M. D., Wittner, B. S., Spencer, J. A., Yu, M., Pely, A., Engstrom, A., Zhu, H., et al. (2014) · Cell · doi:10.1016/j.cell.2014.07.013 · Cited by 2,438 · see citing works
Metastatic colonization by circulating tumour cells
Massagué, J., & Obenauf, A. C. (2016) · Nature · doi:10.1038/nature17038 · Cited by 2,062 · see citing works
PID: the Pathway Interaction Database
Schaefer, C. F., Anthony, K., Krupa, S., Buchoff, J., Day, M., Hannay, T., & Buetow, K. H. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkn653 · Cited by 1,603 · see citing works
A framework for oligonucleotide microarray preprocessing
Carvalho, B. S., & Irizarry, R. A. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq431 · Cited by 1,554 · see citing works
Bayesian approach to single-cell differential expression analysis
Kharchenko, P. V., Silberstein, L., & Scadden, D. T. (2014) · Nature Methods · doi:10.1038/nmeth.2967 · Cited by 1,348 · see citing works
Prognostic markers in triple‐negative breast cancer
Rakha, E. A., El‐Sayed, M. E., Green, A. R., Lee, A. H. S., Robertson, J. F. R., & Ellis, I. O. (2006) · Cancer · doi:10.1002/cncr.22381 · Cited by 1,284 · see citing works
Neutrophils escort circulating tumour cells to enable cell cycle progression
Szczerba, B. M., Castro-Giner, F., Vetter, M. H. F., Krol, I., Gkountela, S., Landin, J., Scheidmann, M. C., Donato, C., Scherrer, R., Singer, J., et al. (2019) · Nature · doi:10.1038/s41586-019-0915-y · Cited by 1,225 · see citing works
survminer: Drawing Survival Curves using 'ggplot2'
Kassambara, A., Kosinski, M., & Biecek, P. (2016) · doi:10.32614/cran.package.survminer · Cited by 1,218 · see citing works
Haffty, B. G., Yang, Q., Reiß, M., Kearney, T. J., Higgins, S. A., Weidhaas, J. B., Harris, L. N., Hait, W., & Toppmeyer, D. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2006.06.5664 · Cited by 1,085 · see citing works
ICAM-1 (CD54): a counter-receptor for Mac-1 (CD11b/CD18).
Diamond, M., Staunton, D. E., de Fougerolles, A. R., Stacker, S. A., García‐Aguilar, J., Hibbs, M. L., & Springer, T. A. (1990) · The Journal of Cell Biology · doi:10.1083/jcb.111.6.3129 · Cited by 881 · see citing works
Meta- and Orthogonal Integration of Influenza “OMICs” Data Defines a Role for UBR4 in Virus Budding
Tripathi, S., Pohl, M. O., Zhou, Y., Rodríguez-Frandsen, A., Wang, G., Stein, D. A., Moulton, H. M., DeJesus, P., Che, J., Mulder, L. C. F., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.11.002 · Cited by 846 · see citing works
Yudi Pawitan, Y., Bjöhle, J., Amler, L. C., Borg, A.-L., Egyházi, S., Hall, P. N., Han, X., Holmberg, L., Huang, F., Klaar, S., et al. (2005) · Breast Cancer Research · doi:10.1186/bcr1325 · Cited by 832 · see citing works
Circulating Tumor Cell Clustering Shapes DNA Methylation to Enable Metastasis Seeding
Gkountela, S., Castro-Giner, F., Szczerba, B. M., Vetter, M. H. F., Landin, J., Scherrer, R., Krol, I., Scheidmann, M. C., Beisel, C., Stirnimann, C. U., et al. (2019) · Cell · doi:10.1016/j.cell.2018.11.046 · Cited by 801 · see citing works
Diamond, M., Staunton, D. E., Marlin, S. D., & Springer, T. A. (1991) · Cell · doi:10.1016/0092-8674(91)90548-d · Cited by 773 · see citing works
Yang, L., Froio, R. M., Sciuto, T. E., Dvořàk, A. M., Alon, R., & Luscinskas, F. W. (2005) · Blood · doi:10.1182/blood-2004-12-4942 · Cited by 720 · see citing works
Hatzis, C. (2011) · JAMA · doi:10.1001/jama.2011.593 · Cited by 699 · see citing works
Staunton, D. E., Dustin, M. L., Erickson, H., & Springer, T. A. (1990) · Cell · doi:10.1016/0092-8674(90)90805-o · Cited by 697 · see citing works
jPOSTrepo: an international standard data repository for proteomes
Okuda, S., Watanabe, Y., Moriya, Y., Kawano, S., Yamamoto, T., Matsumoto, M., Takami, T., Kobayashi, D., Araki, N., Yoshizawa, A. C., et al. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw1080 · Cited by 695 · see citing works
Mechanisms of Leukocyte Transendothelial Migration
Müller, W. A. (2011) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-011110-130224 · Cited by 627 · see citing works
Liu, H., Patel, M. R., Prescher, J. A., Patsialou, A., Qian, D., Lin, J., Wen, S., Chang, Y.-F., Bachmann, M. H., Shimono, Y., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006732107 · Cited by 465 · see citing works
Self-citationLiu, X., Taftaf, R., Kawaguchi, M., Chang, Y.-F., Chen, W., Entenberg, D. R., Zhang, Y., Gerratana, L., Huang, S., Patel, D. B., et al. (2018) · Cancer Discovery · doi:10.1158/2159-8290.cd-18-0065 · Cited by 386 · see citing works
Self-citationHuo, D., Hu, H., Rhie, S. K., Gamazon, E. R., Cherniack, A. D., Liu, J., Yoshimatsu, T. F., Pitt, J. J., Hoadley, K. A., Troester, M. A., et al. (2017) · JAMA Oncology · doi:10.1001/jamaoncol.2017.0595 · Cited by 282 · see citing works
En Route to Metastasis: Circulating Tumor Cell Clusters and Epithelial-to-Mesenchymal Transition
Aceto, N., Toner, M., Maheswaran, S., & Haber, D. A. (2015) · Trends in cancer · doi:10.1016/j.trecan.2015.07.006 · Cited by 275 · see citing works
Role of ICAM1 in invasion of human breast cancer cells
Rosette, C., Roth, R. B., Oeth, P. A., Braun, A. D., Kammerer, S., Ekblom, J., & Denissenko, M. F. (2005) · Carcinogenesis · doi:10.1093/carcin/bgi070 · Cited by 261 · see citing works
Cell Clustering Promotes a Metabolic Switch that Supports Metastatic Colonization
Labuschagne, C. F., Cheung, E. C., Blagih, J., Domart, M., & Vousden, K. H. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.07.014 · Cited by 223 · see citing works
Grillet, F., Bayet, E., Villeronce, O., Zappia, L., Lagerqvist, E. L., Lunke, S., Charafe‐Jauffret, E., Pham, K., Mølck, C., Rolland, N., et al. (2016) · Gut · doi:10.1136/gutjnl-2016-311447 · Cited by 217 · see citing works
Feng, W. W., Wilkins, O. M., Bang, S., Ung, M. H., Li, J., An, J., del Genio, C. L., Canfield, K., DiRenzo, J., Wells, W. A., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.11.008 · Cited by 214 · see citing works
Drawing Survival Curves using 'ggplot2' [R package survminer version 0.4.9]
Kassambara, A., Kosinski, M., & Biecek, P. (2021) · Cited by 198 · see citing works
ICAM-1 as a molecular target for triple negative breast cancer
Guo, P., Huang, J., Wang, L., Jia, D., Yang, J., Dillon, D. A. R., Zurakowski, D., Mao, H. Z., Moses, M. A., & Auguste, D. T. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1408556111 · Cited by 192 · see citing works
Chemokines: novel targets for breast cancer metastasis
Ali, S., & Lazennec, G. (2007) · Cancer and Metastasis Reviews · doi:10.1007/s10555-007-9073-z · Cited by 178 · see citing works
Reilly, P. L., Woska, J. R., Jeanfavre, D. D., McNally, E. J., Rothlein, R., & Bormann, B. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.2.529 · Cited by 171 · see citing works
LPS-induced IL-6, IL-8, VCAM-1, and ICAM-1 Expression in Human Lymphatic Endothelium
Sawa, Y., Ueki, T., Hata, M., Iwasawa, K., Tsuruga, E., Kojima, H., Ishikawa, H. T., & Yoshida, S. (2007) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.7a7299.2007 · Cited by 164 · see citing works
Role of LFA-1 and ICAM-1 in Cancer
Reina, M., & Espel, E. (2017) · Cancers · doi:10.3390/cancers9110153 · Cited by 146 · see citing works
Mu, Z., Wang, C., Ye, Z., Austin, L., Civan, J. M., Hyslop, T., Palazzo, J., Jaslow, R. J., Li, B., Myers, R. E., et al. (2015) · Breast Cancer Research and Treatment · doi:10.1007/s10549-015-3636-4 · Cited by 145 · see citing works
Self-citationSakurada, S., Kato, T., & Okamoto, T. (1996) · International Immunology · doi:10.1093/intimm/8.10.1483 · Cited by 122 · see citing works
Maruo, Y., Gochi, A., Kaihara, A., Shimamura, H., Yamada, T., Tanaka, N., & Orita, K. (2002) · International Journal of Cancer · doi:10.1002/ijc.10514 · Cited by 110 · see citing works
Prognostic value of intercellular adhesion molecule (ICAM)-1 expression in breast cancer
Schröder, C., Witzel, I., Müller, V., Krenkel, S., Wirtz, R. M., Jänicke, F., Schumacher, U., & Milde‐Langosch, K. (2011) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-011-0984-2 · Cited by 103 · see citing works
Kotteas, E. A., Boulas, P., Gkiozos, I., Tsagkouli, S., Tsoukalas, G. D., & Syrigos, K. N. (2014) · PubMed · Cited by 98 · see citing works
Expression of intercellular adhesion molecule-1 and prognosis in colorectal cancer
Maeda, K., Kang, S., Sawada, T., Nishiguchi, Y., Yashiro, M., Ogawa, Y., Ohira, M., Ishikawa, T., & Chung, K. H.-Y. (2002) · Oncology Reports · doi:10.3892/or.9.3.511 · Cited by 88 · see citing works
Kantara, C., O’Connell, M. R., Luthra, G. K., Gajjar, A. H., Sarkar, S., Ullrich, R. L., & Singh, P. (2014) · Laboratory Investigation · doi:10.1038/labinvest.2014.133 · Cited by 87 · see citing works
New Opportunities and Challenges to Defeat Cancer Stem Cells
Ramos, E. K., Hoffmann, A. D., Gerson, S. L., & Liu, H. (2017) · Trends in cancer · doi:10.1016/j.trecan.2017.08.007 · Cited by 82 · see citing works
Self-citationBorgan, Ø. (2001) · Statistics in Medicine · doi:10.1002/sim.956 · Cited by 80 · see citing works
Veitonmäki, N., Hansson, M., Zhan, F., Sundberg, A., Löfstedt, T., Ljungars, A., Li, Z., Niskanen, T. M., Zeng, M., Yang, Y., et al. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.02.026 · Cited by 72 · see citing works
ICAM1 Is a Potential Cancer Stem Cell Marker of Esophageal Squamous Cell Carcinoma
Tsai, S.-T., Wang, P.-J., Liou, N.-J., Lin, P.-S., Chen, C., & Chang, W. (2015) · PLoS ONE · doi:10.1371/journal.pone.0142834 · Cited by 58 · see citing works
Lai, C., Ou, Y., Chang, C., Pan, H., Chang, C., Liao, S., Su, H., & Chen, C. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2012.07889.x · Cited by 55 · see citing works
Wichert, S., Juliusson, G., Johansson, Å. C. M., Sonesson, E., Teige, I., Wickenberg, A. T., Frendéus, B., Korsgren, M., & Hansson, M. (2017) · PLoS ONE · doi:10.1371/journal.pone.0171205 · Cited by 50 · see citing works
Bockhorn, J., Prat, A., Chang, Y.-F., Liu, X., Huang, S., Shang, M., Nwachukwu, C., Gomez-Vega, M. J., Harrell, J. C., Olopade, O. I., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-1188 · Cited by 44 · see citing works
Self-citationEl-Shennawy, L., Dubrovskyi, O., Kastrati, I., Danes, J. M., Zhang, Y., Whiteley, H. E., Creighton, C. J., & Frasor, J. M. (2017) · Cancer Research · doi:10.1158/0008-5472.can-17-1686 · Cited by 38 · see citing works
Self-citationEZH2 knockdown suppresses the growth and invasion of human inflammatory breast cancer cells
Mu, Z., Li, H., Fernandez, S. V., Alpaugh, K. R., Zhang, R., & Cristofanilli, M. (2013) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/1756-9966-32-70 · Cited by 37 · see citing works
Self-citationStraetemans, T., Berrevoets, C., Coccoris, M., Treffers-Westerlaken, E., Wijers, R., Cole, D. K., Dardalhon, V., Sewell, A. K., Taylor, N. N., Verweij, J., et al. (2014) · Molecular Therapy · doi:10.1038/mt.2014.215 · Cited by 28 · see citing works
New Advances and Challenges of Targeting Cancer Stem Cells
Dashzeveg, N. K., Taftaf, R., Ramos, E. K., Torre-Healy, L. A., Chumakova, A. P., Silver, D. J., Alban, T. J., Sinyuk, M., Thiagarajan, P. S., Jarrar, A., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-17-0054 · Cited by 27 · see citing works
Self-citationDhawan, A., Friedrichs, J., Bonin, M. V., Bejestani, E. P., Werner, C., Wobus, M., Chavakis, T., & Bornhäuser, M. (2016) · Carcinogenesis · doi:10.1093/carcin/bgw057 · Cited by 25 · see citing works
Bayesian Active Learning for Optimization and Uncertainty Quantification in Protein Docking
Cao, Y., & Shen, Y. (2020) · Journal of Chemical Theory and Computation · doi:10.1021/acs.jctc.0c00476 · Cited by 21 · see citing works
Self-citationFaull, R., & Russ, G. R. (1990) · PubMed · Cited by 8 · see citing works
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ICAM-1 and VCAM-1: Gatekeepers in various inflammatory and cardiovascular disorders
Singh, V., Kaur, R., Kumari, P., Pasricha, C., & Singh, R. J. (2023) · Clinica Chimica Acta · doi:10.1016/j.cca.2023.117487 · Cited by 437 · see citing works
Biology, vulnerabilities and clinical applications of circulating tumour cells
Ring, A., Nguyen-Sträuli, B. D., WICKI, A. N., & Aceto, N. (2022) · Nature reviews. Cancer · doi:10.1038/s41568-022-00536-4 · Cited by 334 · see citing works
Better together: circulating tumor cell clustering in metastatic cancer
Schuster, E. J., Taftaf, R., Reduzzi, C., Albert, M. K., Romero‐Calvo, I., & Liu, H. (2021) · Trends in cancer · doi:10.1016/j.trecan.2021.07.001 · Cited by 262 · see citing works
Self-citationCirculating tumor cells: from new biological insights to clinical practice
Gu, X., Wei, S., & Lv, X. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01938-6 · Cited by 196 · see citing works
Targeting Breast Cancer Stem Cells
Zhang, L., Chen, W., Liu, S., & Chen, C. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.76187 · Cited by 190 · see citing works
Circulating tumor cell-blood cell crosstalk: Biology and clinical relevance
Pereira‐Veiga, T., Schneegans, S., Pantel, K., & Wikman, H. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111298 · Cited by 179 · see citing works
New insights into the correlations between circulating tumor cells and target organ metastasis
Zhan, Q., Liu, B., Situ, X., Luo, Y., Fu, T., Wang, Y., Xie, Z., Ren, L., Zhu, Y. J., He, W., et al. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01725-9 · Cited by 150 · see citing works
Khan, S. U., Fatima, K., & Malik, F. A. (2022) · Clinical & Experimental Metastasis · doi:10.1007/s10585-022-10172-9 · Cited by 142 · see citing works
Intercellular Adhesion Molecule 1: More than a Leukocyte Adhesion Molecule
Haydinger, C. D., Ashander, L. M., Tan, A. C. R., & Smith, J. R. (2023) · Biology · doi:10.3390/biology12050743 · Cited by 110 · see citing works
Circulating tumor cells: Blood-based detection, molecular biology, and clinical applications
Dai, C. S., Mishra, A., Edd, J., Toner, M., Maheswaran, S., & Haber, D. A. (2025) · Cancer Cell · doi:10.1016/j.ccell.2025.07.008 · Cited by 100 · see citing works
Liao, C., Li, G., Kang, F., Lin, C., Xie, C., Wu, Y., Hu, J., Lin, H., Zhu, S., Huang, X., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-50450-6 · Cited by 89 · see citing works
CPT1A promotes anoikis resistance in esophageal squamous cell carcinoma via redox homeostasis
Tian, T., Lu, Y., Lin, J., Chen, M., Qiu, H., Zhu, W., Sun, H., Huang, J., Yang, H., & Deng, W. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102544 · Cited by 75 · see citing works
Efficacy, Safety, and Challenges of CAR T-Cells in the Treatment of Solid Tumors
Chen, Q., Lu, L., & Ma, W. (2022) · Cancers · doi:10.3390/cancers14235983 · Cited by 72 · see citing works
Skin immunity in wound healing and cancer
Jakovija, A., & Chtanova, T. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1060258 · Cited by 66 · see citing works
Dashzeveg, N. K., Jia, Y., Zhang, Y., Gerratana, L., Patel, P. A., Shajahan, A., Dandar, T., Ramos, E. K., Almubarak, H. F., Adorno-Cruz, V., et al. (2023) · Cancer Discovery · doi:10.1158/2159-8290.cd-22-0644 · Cited by 62 · see citing works
Self-citationChen, M., Wu, C., Fu, Z., & Liu, S. (2022) · Cancer Science · doi:10.1111/cas.15532 · Cited by 59 · see citing works
Zheng, J., She, H., Han, R., Tang, J., Dou, Y., Lu, C., Huang, D., Lin, C., Wu, D., He, C., et al. (2025) · Developmental Cell · doi:10.1016/j.devcel.2025.07.014 · Cited by 59 · see citing works
Self-citationThe functional and clinical roles of liquid biopsy in patient-derived models
Zhu, Z., Hu, E., Shen, H., Tan, J., & Zeng, S. (2023) · Journal of Hematology & Oncology · doi:10.1186/s13045-023-01433-5 · Cited by 54 · see citing works
Zhang, R., Shen, Y., Zhang, Q., Feng, X., Liu, X., Huo, X., Sun, J., & Hao, J. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06383-x · Cited by 53 · see citing works
Self-citationKurma, K., & Alix‐Panabières, C. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1188499 · Cited by 50 · see citing works
Chen, Q., Zou, J., He, Y. Z., Pan, Y., Yang, G., Zhao, H., Huang, Y., Zhao, Y., Wang, A., Chen, W., et al. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.944487 · Cited by 49 · see citing works
Zhang, C., Zhang, L., Bao, B., Ouyang, W., Chen, W., Li, Q., & Li, D. (2022) · Advanced Materials Technologies · doi:10.1002/admt.202201138 · Cited by 42 · see citing works
Lung-specific metastasis: the coevolution of tumor cells and lung microenvironment
Xiao, G., Wang, X., Xu, Z., Liu, Y., & Jing, J. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02318-6 · Cited by 43 · see citing works
Circulating extracellular vesicles and tumor cells: sticky partners in metastasis
Jeřábková, K., Dupas, A., Osmani, N., Hyenne, V., & Goetz, J. G. (2022) · Trends in cancer · doi:10.1016/j.trecan.2022.05.002 · Cited by 41 · see citing works
Qian, W.-J., Yan, J., Gang, X., Xu, L., Shi, S., Li, X., Na, F., Cai, L.-T., Li, H., & Zhao, M. (2024) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2024.189187 · Cited by 42 · see citing works
Circulating tumor cells: Towards mechanical phenotyping of metastasis
Peralta, M., Osmani, N., & Goetz, J. G. (2022) · iScience · doi:10.1016/j.isci.2022.103969 · Cited by 39 · see citing works
Schepisi, G., Gianni, C., Palleschi, M., Bleve, S., Casadei, C., Lolli, C., Ridolfi, L., Martinelli, G., & Giorgi, U. D. (2023) · Cancers · doi:10.3390/cancers15051597 · Cited by 39 · see citing works
Shi, J., Zhang, Y., Wang, P., Nie, Y., & Ma, Q. (2021) · Talanta · doi:10.1016/j.talanta.2021.122969 · Cited by 39 · see citing works
Self-citationDeciphering the complexities of cancer cell immune evasion: Mechanisms and therapeutic implications
Gupta, I., Hussein, O., Sastry, K. S., Bougarn, S., Gopinath, N., Chin-Smith, E. C., Sinha, Y., Korashy, H. M., & Maccalli, C. (2023) · Advances in Cancer Biology - Metastasis · doi:10.1016/j.adcanc.2023.100107 · Cited by 37 · see citing works
Extracellular vesicle-cell adhesion molecules in tumours: biofunctions and clinical applications
Lin, W., Fang, J., Wei, S., He, G., Liu, J., Li, X., Peng, X., Dai, L., Yang, S., Li, X., et al. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-023-01236-8 · Cited by 37 · see citing works
Circulating tumor cells clusters and their role in Breast cancer metastasis; a review of literature
Sayed, Z. S., Khattap, M. G., Madkour, M. A., Yasen, N. S., Elbary, H. A., Elsayed, R. A., Abdelkawy, D. A., Wadan, A. S., Omar, I., & Nafady, M. H. (2024) · Discover Oncology · doi:10.1007/s12672-024-00949-7 · Cited by 39 · see citing works
Collective cell migration modes in development, tissue repair and cancer
Cheung, K. J., & Horne‐Badovinac, S. (2025) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-025-00858-9 · Cited by 34 · see citing works
Clinical and Biological Aspects of Disseminated Tumor Cells and Dormancy in Breast Cancer
Ring, A., Spataro, M., WICKI, A. N., & Aceto, N. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.929893 · Cited by 32 · see citing works
CTC-neutrophil interaction: A key driver and therapeutic target of cancer metastasis
Hu, C., Long, L., Lou, J., Leng, M., Yang, Q., Xu, X. M., & Zhou, X. W. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117474 · Cited by 32 · see citing works
Tackling Inflammatory Bowel Diseases: Targeting Proinflammatory Cytokines and Lymphocyte Homing
Song, Y., Yuan, M., Xu, Y., & Xu, H. (2022) · Pharmaceuticals · doi:10.3390/ph15091080 · Cited by 30 · see citing works
Furukawa, N., Stearns, V., Santa-Maria, C., & Popel, A. (2022) · Expert opinion on therapeutic targets · doi:10.1080/14728222.2022.2170779 · Cited by 30 · see citing works
Automatic detection of circulating tumor cells and cancer associated fibroblasts using deep learning
Shen, C., Rawal, S., Brown, R., Zhou, H., Agarwal, A., Watson, M. A., Côté, R. J., & Yang, C. (2023) · Scientific Reports · doi:10.1038/s41598-023-32955-0 · Cited by 31 · see citing works
Endorsement of TNBC Biomarkers in Precision Therapy by Nanotechnology
Chaudhuri, A., Kumar, D. N., Dehari, D., Patil, R., Singh, S. K., Kumar, D. K., & Agrawal, A. K. (2023) · Cancers · doi:10.3390/cancers15092661 · Cited by 31 · see citing works
Self-citationLiquid-based biomarkers in breast cancer: looking beyond the blood
Shuai, Y., Ma, Z., Ju, J., Wei, T., Gao, S., Kang, Y., Yang, Z., Wang, X., Yue, J., & Yuan, P. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04660-z · Cited by 30 · see citing works
Zhu, Z., Ren, H., Wu, D. Q., Ni, Z., & Xiang, N. (2024) · Microsystems & Nanoengineering · doi:10.1038/s41378-024-00661-0 · Cited by 29 · see citing works
Cell–Cell Interactions Drive Metastasis of Circulating Tumor Microemboli
Tao, J., Zhu, L., Yakoub, M., Reißfelder, C., Loges, S., & Schölch, S. (2022) · Cancer Research · doi:10.1158/0008-5472.can-22-0906 · Cited by 30 · see citing works
Jiang, C., Li, Y., Li, Y., Liu, L., Wang, X.-A., Wu, W., Bao, R., Weng, H., Li, M., Geng, Y., et al. (2022) · Medical Oncology · doi:10.1007/s12032-022-01874-x · Cited by 29 · see citing works
Extravasation of immune and tumor cells from an endothelial perspective
Dupas, A., Goetz, J. G., & Osmani, N. (2024) · Journal of Cell Science · doi:10.1242/jcs.262066 · Cited by 30 · see citing works
Su, Y. J., Leng, M., Yang, Q., Jiang, W., Xiang, G., Long, L., & Zhou, X. W. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03522-8 · Cited by 30 · see citing works
Farheen, J., Hosmane, N. S., Zhao, R., Zhao, Q. D., Iqbal, M. Z., & Kong, X. (2022) · Materials Today Bio · doi:10.1016/j.mtbio.2022.100450 · Cited by 28 · see citing works
Budden, K. F., Gellatly, S. L., Vaughan, A., Amorim, N. M. L., Horvat, J. C., Hansbro, N. G., Wood, D., Hugenholtz, P., Dennis, P. G., Wark, P. A. B., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010252 · Cited by 28 · see citing works
Integration of local and systemic immunity in ovarian cancer: Implications for immunotherapy
Rajtak, A., Ostrowska-Leśko, M., Żak, K., Tarkowski, R., Kotarski, J., & Okła, K. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1018256 · Cited by 27 · see citing works
Chen, M., Fu, Z., & Wu, C. (2024) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2024.106637 · Cited by 26 · see citing works
Zaarour, R. F., Ribeiro, M., Azzarone, B. G., Kapoor, S., & Chouaı̈b, S. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1222575 · Cited by 24 · see citing works
Diversity of Intercellular Communication Modes: A Cancer Biology Perspective
Ebrahim, T., Ebrahim, A. S., & Kandouz, M. (2024) · Cells · doi:10.3390/cells13060495 · Cited by 24 · see citing works
Applications of single-cell technologies in drug discovery for tumor treatment
Liu, B., Hu, S., & Wang, X. (2024) · iScience · doi:10.1016/j.isci.2024.110486 · Cited by 24 · see citing works
Zhao, M., Lin, Y., Zeng, Y., Lv, Z., Liang, J., Tang, P., Zhen, X., & Han, L. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.12.066 · Cited by 24 · see citing works
Fukushima, H., Kato, T., Furusawa, A., Okada, R., Wakiyama, H., Furumoto, H., Okuyama, S., Kondo, E., Choyke, P. L., & Kobayashi, H. (2022) · Cancer Science · doi:10.1111/cas.15466 · Cited by 24 · see citing works
Clinical applications of circulating tumor cells in metastasis and therapy
Yang, C., Liu, C., Xia, C., & Fu, L. (2025) · Journal of Hematology & Oncology · doi:10.1186/s13045-025-01733-y · Cited by 23 · see citing works
The paradox of cooperation among selfish cancer cells
Capp, J., Frédéric Thomas, A., Marusyk, A., Dujon, A. M., Tissot, S., Gatenby, R. A., Roche, B., Újvári, B., DeGregori, J. V., Brown, J. S., et al. (2023) · Evolutionary Applications · doi:10.1111/eva.13571 · Cited by 22 · see citing works
Circulating Tumour Cells (CTCs) in NSCLC: From Prognosis to Therapy Design
Kejík, Z., Kaplánek, R., Dytrych, P., Masařík, M., Veselá, K., Abramenko, N., Hoskovec, D., Vašáková, M., Králová, J., Pavel Martasek, E., et al. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13111879 · Cited by 23 · see citing works
Zheng, W., Shen, P., Yu, C., Tang, Y. R., Qian, C., Yang, C., Gao, M., Wu, Y., Yu, S., Tang, W., et al. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106986 · Cited by 24 · see citing works
Molecular dynamics at immune synapse lipid rafts influence the cytolytic behavior of CAR T cells
Gad, A. Z., Morris, J. S., Godret-Miertschin, L. M., Montalvo, M. J., Kerr, S. S., Berger, H. R., Lee, J. C. H., Saadeldin, A. M., Abu-Arja, M. H., Xu, S., et al. (2025) · Science Advances · doi:10.1126/sciadv.adq8114 · Cited by 22 · see citing works
Regev, O., Kizner, M., Roncato, F., Dadiani, M., Saini, M., Castro-Giner, F., Yajuk, O., Kozlovski, S., Levi, N., Addadi, Y., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.849701 · Cited by 22 · see citing works
Shanehband, N., & Naghib, S. M. (2024) · Biochimie · doi:10.1016/j.biochi.2024.01.001 · Cited by 21 · see citing works
Exploiting the metabolic vulnerability of circulating tumour cells
Merteroglu, M., & Santoro, M. M. (2024) · Trends in cancer · doi:10.1016/j.trecan.2024.03.004 · Cited by 21 · see citing works
4-1BB-encoding CAR causes cell death via sequestration of the ubiquitin-modifying enzyme A20
Dou, Z., Bonacci, T., Shou, P., Landoni, E., Woodcock, M. G., Sun, C., Savoldo, B., Herring, L. E., Emanuele, M. J., Song, F., et al. (2024) · Cellular and Molecular Immunology · doi:10.1038/s41423-024-01198-y · Cited by 20 · see citing works
Circulating tumour cell clusters: isolation, biological significance and therapeutic implications
Yang, Y., Huang, G., Lian, J., Long, C., Zhao, B., Liu, X., Zhang, B., Ye, W., Chen, J., Du, L., et al. (2024) · BMJ Oncology · doi:10.1136/bmjonc-2024-000437 · Cited by 20 · see citing works
Self-citationWang, S., Ye, G., Xu, X., Lin, Y., Li, X., Zhang, Z., Qi, M., Tan, L., Cheng, M.-J., Zhang, H., et al. (2025) · Gut · doi:10.1136/gutjnl-2024-334618 · Cited by 19 · see citing works
Self-citationHuang, X., Li, T., Li, T.-T., Zhang, J., Shi, X., Huang, X., Zhou, J., Tang, Z., & Huang, Z. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-01783-9 · Cited by 19 · see citing works
Adoptive cell immunotherapy for breast cancer: harnessing the power of immune cells
Li, X., Zhu, Y., Yi, J., Deng, Y., Lei, B., & Ren, H. (2023) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiad144 · Cited by 18 · see citing works
Srivastava, G., Mukherjee, E., Mittal, R., & Ganjewala, D. (2024) · Zeitschrift für Naturforschung C · doi:10.1515/znc-2023-0150 · Cited by 18 · see citing works
Wang, F., Zhang, F., Lin, B., Xiao, W., Wang, N., & Wang, N. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.156297 · Cited by 18 · see citing works
Wang, W., Fu, C., Lin, M., Lu, Y., Lian, S., Xie, X., Zhou, G., Li, W., Zhang, Y., Jia, L., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.960375 · Cited by 18 · see citing works
Self-citationRozenberg, J. M., Buzdin, A. A., Mohammad, T., Rakitina, O. A., Didych, D. A., Pleshkan, V. V., & Алексеенко, И. В. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1099921 · Cited by 17 · see citing works
Thomas, J. A., Moly, A. G. G., Xavier, H., Suboj, P., Ladha, A., Gupta, G., Singh, S. K., Palit, P., & Babykutty, S. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1063051 · Cited by 17 · see citing works
Self-citationWu, D., Sun, H., Yang, B. V., Song, E., Song, Y., & Tan, W. (2024) · ACS Nano · doi:10.1021/acsnano.3c09378 · Cited by 17 · see citing works
Unraveling the link between cardiorespiratory fitness and cancer: a state-of-the-art review
Kunutsor, S. K., Kaminsky, L. A., Lehoczki, A., & Laukkanen, J. A. (2024) · GeroScience · doi:10.1007/s11357-024-01222-z · Cited by 21 · see citing works
Platelet Membrane: An Outstanding Factor in Cancer Metastasis
Durán-Saenz, N. Z., Serrano-Puente, A., Gallegos-Flores, P. I., Mendoza-Almanza, B., Esparza-Ibarra, E. L., Godina-González, S., Gonzalez-Curiel, I. E., Ayala-Luján, J. L., Hernández-Barrales, M., Cueto-Villalobos, C. F., et al. (2022) · Membranes · doi:10.3390/membranes12020182 · Cited by 17 · see citing works
Numb exon 9 inclusion regulates Integrinβ5 surface expression and promotes breast cancer metastasis
Zhang, Y., Dho, S. E., Othman, K., Simpson, C. D., Lapierre, J., Bondoc, A., & McGlade, C. J. (2022) · Oncogene · doi:10.1038/s41388-022-02225-w · Cited by 17 · see citing works
Self-citationGuo, M., Yuan, Z., Jin, X. J., Li, X., Deng, Y., Zhou, S., Niu, R., Bae, J., Park, J. B., Shi, B., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-63796-2 · Cited by 16 · see citing works
Dotse, E., Lim, K. H., Wang, M., Wijanarko, K. J., & Chow, K. T. (2022) · Life · doi:10.3390/life12020323 · Cited by 16 · see citing works
Cancer cells spread aggressively during sleep
Ball, H. G., & Nagrath, S. (2022) · Nature · doi:10.1038/d41586-022-01639-6 · Cited by 16 · see citing works
Targeting circulating tumor cells to prevent metastases
Gostomczyk, K., Marsool, M. D. M., Tayyab, H., Pandey, A., Borowczak, J., Macome, F., Chacón, J. A., Dave, T., Maniewski, M., & Szylberg, Ł. (2023) · Human Cell · doi:10.1007/s13577-023-00992-6 · Cited by 16 · see citing works
McClellan, B., Wilson, C. N., Brenner, A. J., Jolly, C. A., & deGraffenried, L. A. (2024) · Oncogene · doi:10.1038/s41388-024-02946-0 · Cited by 16 · see citing works
Yang, C., Li, L., Ye, Z., Zhang, A., Bao, Y., Wu, X., Ren, G., Jiang, C., Wang, O., & Wang, Z. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01716-5 · Cited by 16 · see citing works
Scholten, D., El-Shennawy, L., Jia, Y., Zhang, Y., Hyun, E., Reduzzi, C., Hoffmann, A. D., Almubarak, H. F., Tong, F., Dashzeveg, N. K., et al. (2025) · Journal of Clinical Investigation · doi:10.1172/jci193521 · Cited by 15 · see citing works
Self-citationRoy, B., Ghosh, S., SenGupta, S., Chanda, S., Roy, S. S., Sen, S., Das, R., Acharya, M., & Mukherjee, A. (2025) · Journal of the American Chemical Society · doi:10.1021/jacs.5c15369 · Cited by 15 · see citing works
Circulating Tumor Cells: How Far Have We Come with Mining These Seeds of Metastasis?
Radhakrishnan, V., Kaifi, J. T., & Suvilesh, K. N. (2024) · Cancers · doi:10.3390/cancers16040816 · Cited by 15 · see citing works
Research progress on the multi-omics and survival status of circulating tumor cells
Xie, Q., Liu, S., Zhang, S., Liao, L., Xiao, Z., Wang, S., & Zhang, P. (2024) · Clinical and Experimental Medicine · doi:10.1007/s10238-024-01309-z · Cited by 15 · see citing works
Götze, J., Nitschke, C., Uzunoglu, F. G., Pantel, K., Sinn, M., & Wikman, H. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.918795 · Cited by 15 · see citing works
Lu, Y., Ma, Y., Liu, Q., & Luo, D. (2025) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2025.118291 · Cited by 14 · see citing works
From Discovery to Diagnosis: A Perspective for Circulating Tumor Cells in Personalized Oncology
Alix‐Panabières, C., & Pantel, K. (2025) · Cancer Discovery · doi:10.1158/2159-8290.cd-25-0164 · Cited by 14 · see citing works
Bait-trap chip for accurate and ultrasensitive capture of living circulating tumor cells
Jiang, W., Han, L., Li, G., Yang, Y., Shen, Q., Fan, B., Wang, Y., Yu, X., Sun, Y., He, S., et al. (2023) · Acta Biomaterialia · doi:10.1016/j.actbio.2023.03.019 · Cited by 14 · see citing works
Li, D., Park, Y.-H., Hemati, H., & Liu, X. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.105377 · Cited by 14 · see citing works
Self-citationClinical significance of genomic sequencing of circulating tumour cells (CTCs) in cancer
Auwal, A., Hossain, M. M., Pronoy, T. U. H., Rashel, K. M., Nurujjaman, M., Lam, A. K.-Y., & Islam, F. (2023) · The Journal of Liquid Biopsy · doi:10.1016/j.jlb.2023.100135 · Cited by 14 · see citing works
Cheng, X., Cao, Y., Liu, X., Li, Y., Li, Q., Gao, D., & Yu, Q. (2024) · Clinical and Translational Medicine · doi:10.1002/ctm2.70036 · Cited by 13 · see citing works
Self-citationHurtado, P., Martínez-Peña, I., Yepes-Rodríguez, S., Bascoy-Otero, M., Abuín, C., Fernández-Santiago, C., Sanchez, L. E., López‐López, R., & Piñeiro, R. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1076432 · Cited by 14 · see citing works
Xiao, X., Miao, X., Duan, S., Liu, S., Cao, Q., Wu, R., Tao, C., Zhao, J., Qu, Q., Markiewicz, A., et al. (2023) · Small Methods · doi:10.1002/smtd.202300096 · Cited by 13 · see citing works
Pan, J.-K., Lin, W.-D., Kuo, Y., Chen, Y., Loh, Z.-J., Lin, F., Cheng, H.-C., Hsiao, M., & Lu, P. (2023) · Oncogene · doi:10.1038/s41388-023-02769-5 · Cited by 13 · see citing works
Disturbed endothelial cell signaling in tumor progression and therapy resistance
Fischer, A., & Alsina‐Sanchís, E. (2023) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2023.102287 · Cited by 13 · see citing works
Schuster, E. J., Dashzeveg, N. K., Tong, F., Jia, Y., El-Shennawy, L., Zhang, T., Hoffman, A. D., Kitata, R. B., Kibria, G., Zhang, Y., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-62862-z · Cited by 13 · see citing works
Self-citationMicrofluidics for Cancer Biomarker Discovery, Research, and Clinical Application
Žvirblytė, J., & Mažutis, L. (2022) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-04039-9_20 · Cited by 13 · see citing works
The ubiquitin-specific peptidase 22 is a deubiquitinase of CD73 in breast cancer cells.
Gregory, S., Xu, Y., Xie, P., Fan, J., Gao, B., Mani, N. L., Iyer, R., Tang, A. Y., Wei, J., Chaudhuri, S. M., et al. (2022) · PubMed Central · Cited by 12 · see citing works
Self-citationKwok, H., Li, H., Yang, J., Deng, J., Lee, N. C., Au, T. W., Sit, A. K., Hsin, M. K. Y., Kwai‐Yee, S., Cheung, L. W., et al. (2023) · 癌症:英文版 · doi:10.1002/cac2.12449 · Cited by 12 · see citing works
- Authors
- Taftaf, R., Liu, X., Singh, S., Jia, Y., Dashzeveg, N. K., Hoffmann, A. D., El-Shennawy, L., Ramos, E. K., Adorno-Cruz, V., Schuster, E. J., Scholten, D., Patel, D., Zhang, Y., Davis, A. A., Reduzzi, C., Cao, Y., D’Amico, P., Shen, Y., Cristofanilli, M., Muller, W. A., Varadan, V., & Liu, H.
- Affiliations
- Northwestern University (US)
- Case Comprehensive Cancer Center (US)
- Texas A&M University System (US)
- Corresponding author
- Liu, Huiping
- ORCID
- Taftaf, Rokana
- Liu, Xia
- Singh, Salendra
- Jia, Yuzhi
- Dashzeveg, Nurmaa K.
- Hoffmann, Andrew D.
- El-Shennawy, Lamiaa
- Ramos, Erika K.
- Adorno-Cruz, Valery
- Schuster, Emma J.
- Scholten, David
- Patel, Dhwani
- Zhang, Youbin
- Davis, Andrew A.
- Reduzzi, Carolina
- D’Amico, Paolo
- Shen, Yang
- Cristofanilli, Massimo
- Muller, William A.
- Varadan, Vinay
- Liu, Huiping
- Venue
- Nature Communications
- Published
- 2021-08-11
- Volume
- 12
- Issue
- 1
- Pages
- 4867-4867
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC8358026
- OpenAlex
- W3189505974
- Cited by
- 261
- References
- 75
- Citations by year
- 2026: 42 · 2025: 54 · 2024: 57 · 2023: 67 · 2022: 38 · 2021: 3
- FWCI
- 15.10
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Digital Commons@Becker (Washington University School of Medicine) (submittedVersion, cc-by)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- U.S. Department of Health & Human Services | National Institutes of Health (CA080621-15, R35GM124952)
- Susan G. Komen (CCR18548501)
- U.S. Department of Health & Human Services | NIH | National Cancer Institute (R01CA245699)
- U.S. Department of Health & Human Services | NIH | NCI | Division of Cancer Epidemiology and Genetics, National Cancer Institute (R00CA160638)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
- Keywords
- ICAM-1, circulating tumor cell clusters, triple-negative breast cancer, lung metastasis, transendothelial migration, homotypic cell adhesion, metastasis initiation, therapeutic target, cell cycle, stemness, patient-derived xenografts
- MeSH terms
- Animals, Cell Aggregation, Cell Cycle, Cell Transformation, Neoplastic, Humans, Lung Neoplasms, Neoplastic Cells, Circulating, Biomarkers, Tumor, Signal Transduction, Intercellular Adhesion Molecule-1, Mice, Protein Interaction Domains and Motifs, Transendothelial and Transepithelial Migration, Triple Negative Breast Neoplasms
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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