Whitworth, Alexander J.
University of Cambridge · MRC Mitochondrial Biology Unit
12 papers on CoChatORCID 0000-0002-1154-6629
Most cited papers
- Verified
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Acevedo Arozena, A., Adachi, H., Adams, C. M., Adams, P. D., Adeli, K., et al. (2016) · Autophagy
Autophagy in Disease and TherapyCalcium signaling and nucleotide metabolism
Cited by 5,894
- Verified
Guidelines for the use and interpretation of assays for monitoring autophagy
Klionsky, D. J., Abdalla, F. C., Abeliovich, H., Abraham, R. T., Acevedo-Arozena, A., Adeli, K., Agholme, L., Agnello, M., Agostinis, P., Aguirre-Ghiso, J. A., et al. (2012) · Autophagy
Autophagy in Disease and TherapyCalcium signaling and nucleotide metabolism
Cited by 3,996
- Verified
Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants
Greene, J. C., Whitworth, A. J., Kuo, I., Andrews, L. A., Feany, M. B., & Pallanck, L. J. (2003) · Proceedings of the National Academy of Sciences
Parkinson's Disease Mechanisms and TreatmentsMitochondrial Function and Pathology
Cited by 1,203
- Verified
The PINK1/Parkin pathway regulates mitochondrial morphology
Poole, A. C., Thomas, R. E., Andrews, L. A., McBride, H. M., Whitworth, A. J., & Pallanck, L. J. (2008) · Proceedings of the National Academy of Sciences
Parkinson's Disease Mechanisms and TreatmentsMitochondrial Function and Pathology
Cited by 885
- Verified
Drosophila Parkin requires PINK1 for mitochondrial translocation and ubiquitinates Mitofusin
Ziviani, E., Tao, R. N., & Whitworth, A. J. (2010) · Proceedings of the National Academy of Sciences
Parkinson's Disease Mechanisms and TreatmentsAutophagy in Disease and Therapy
Cited by 735
- Verified
The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy
Webster, C. P., Smith, E. F., Bauer, C. S., Moller, A., Hautbergue, G. M., Ferraiuolo, L., Myszczynska, M. A., Higginbottom, A., Walsh, M. J., Whitworth, A. J., et al. (2016) · The EMBO Journal
Amyotrophic Lateral Sclerosis ResearchAutophagy in Disease and Therapy
Cited by 404
- Verified
The NAD+ precursor nicotinamide riboside rescues mitochondrial defects and neuronal loss in iPSC and fly models of Parkinson's disease
Schöndorf, D. C., Ivanyuk, D., Baden, P., Sanchez-Martinez, A., De Cicco, S., Yu, C., Giunta, I., Schwarz, L. K., Di Napoli, G., Panagiotakopoulou, V., et al. (2018) · Cell Reports
Parkinson's Disease Mechanisms and TreatmentsSirtuins and Resveratrol in Medicine
Cited by 337
- Verified
Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss
Tain, L. S., Mortiboys, H., Tao, R. N., Ziviani, E., Bandmann, O., & Whitworth, A. J. (2009) · Nature Neuroscience
Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and Signaling
Cited by 323
- Verified
Mitochondrial impairment activates the Wallerian pathway through depletion of NMNAT2 leading to SARM1-dependent axon degeneration
Loreto, A., Hill, C. S., Hewitt, V. L., Orsomando, G., Angeletti, C., Gilley, J., Lucci, C., Sanchez-Martinez, A., Whitworth, A. J., Conforti, L., et al. (2020) · Neurobiology of Disease
Nerve injury and regenerationHereditary Neurological Disorders
Cited by 131
- Verified
Genome-wide RNAi screen identifies the Parkinson disease GWAS risk locus SREBF1 as a regulator of mitophagy
Ivatt, R. M., Sanchez-Martinez, A., Godena, V. K., Brown, S., Ziviani, E., & Whitworth, A. J. (2014) · Proceedings of the National Academy of Sciences
Parkinson's Disease Mechanisms and TreatmentsAutophagy in Disease and Therapy
Cited by 130
- Verified
Modeling pathogenic mutations of human twinkle in Drosophila suggests an apoptosis role in response to mitochondrial defects
Sanchez-Martinez, A., Calleja, M., Peralta, S., Matsushima, Y., Hernandez-Sierra, R., Whitworth, A. J., Kaguni, L. S., & Garesse, R. (2012) · PLoS ONE
Mitochondrial Function and PathologyCell death mechanisms and regulation
Cited by 25
- Verified
USP8 Down-Regulation Promotes Parkin-Independent Mitophagy in the Drosophila Brain and in Human Neurons
Mauri, S., Bernardo, G., Martinez, A., Favaro, M., Trevisan, M., Cobraiville, G., Fillet, M., Caicci, F., Whitworth, A. J., & Ziviani, E. (2023) · Cells
Autophagy in Disease and TherapyParkinson's Disease Mechanisms and Treatments
Cited by 19
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