Jäkel, Sarah

Altered human oligodendrocyte heterogeneity in multiple sclerosis

Jäkel, S., Agirre, E., Mendanha Falcão, A., van Bruggen, D., Lee, K. W., Knuesel, I., Malhotra, D., ffrench-Constant, C., Williams, A., & Castelo-Branco, G. (2019) · Nature

Multiple Sclerosis Research StudiesSingle-cell and spatial transcriptomics

Cited by 854

Disease-specific oligodendrocyte lineage cells arise in multiple sclerosis

Falcão, A. M., van Bruggen, D., Marques, S., Meijer, M., Jäkel, S., Agirre, E., Samudyata, Floriddia, E. M., Vanichkina, D. P., ffrench-Constant, C., et al. (2018) · Nature Medicine

Multiple Sclerosis Research StudiesNeurogenesis and neuroplasticity mechanisms

Cited by 579

BCAS1 expression defines a population of early myelinating oligodendrocytes in multiple sclerosis lesions

Fard, M. K., van der Meer, F., Sánchez, P., Cantuti-Castelvetri, L., Mandad, S., Jäkel, S., Fornasiero, E. F., Schmitt, S., Ehrlich, M., Starost, L., et al. (2017) · Science Translational Medicine

Multiple Sclerosis Research StudiesNeurogenesis and neuroplasticity mechanisms

Cited by 249

Oligodendrocytes produce amyloid-β and contribute to plaque formation alongside neurons in Alzheimer’s disease model mice

Sasmita, A. O., Depp, C., Nazarenko, T., Sun, T., Siems, S. B., Ong, E. C., Nkeh, Y. B., Böhler, C., Yu, X., Bues, B., et al. (2024) · Nature Neuroscience

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 125

Apolipoprotein E aggregation in microglia initiates Alzheimer’s disease pathology by seeding β-amyloidosis

Kaji, S., Berghoff, S. A., Spieth, L., Schlaphoff, L., Sasmita, A. O., Vitale, S., Büschgens, L., Kedia, S., Zirngibl, M., Nazarenko, T., et al. (2024) · Immunity

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 104

snRNA-seq stratifies multiple sclerosis patients into distinct white matter glial responses

Macnair, W., Calini, D., Agirre, E., Bryois, J., Jäkel, S., Smith, R. S., Kukanja, P., Stokar-Regenscheit, N., Ott, V., Foo, L. C., et al. (2025) · Neuron

Multiple Sclerosis Research StudiesSingle-cell and spatial transcriptomics

Cited by 88

Apolipoprotein E aggregation in microglia initiates Alzheimer’s disease pathology by seeding β-amyloidosis

Kaji, S., Berghoff, S. A., Spieth, L., Schlaphoff, L., Sasmita, A. O., Vitale, S., Büschgens, L., Kedia, S., Zirngibl, M., Nazarenko, T., et al. (2025) · Immunity

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 7