Akashi, Koichi

A clonogenic common myeloid progenitor that gives rise to all myeloid lineages

Akashi, K., Traver, D., Miyamoto, T., & Weissman, I. L. (2000) · Nature

Hematopoietic Stem Cell TransplantationAcute Myeloid Leukemia Research

Cited by 2,617

Identification of Clonogenic Common Lymphoid Progenitors in Mouse Bone Marrow

Kondo, M., Weissman, I. L., & Akashi, K. (1997) · Cell

Hematopoietic Stem Cell TransplantationT-cell and B-cell Immunology

Cited by 2,253

MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors

Huntly, B. J. P., Shigematsu, H., Deguchi, K., Lee, B. H., Mizuno, S., Duclos, N., Rowan, R., Amaral, S., Curley, D., Williams, I. R., et al. (2004) · Cancer Cell

Acute Myeloid Leukemia ResearchHematopoietic Stem Cell Transplantation

Cited by 697

Mouse development and cell proliferation in the absence of D-cyclins

Kozar, K., Ciemerych, M. A., Rebel, V. I., Shigematsu, H., Zagozdzon, A., Sicinska, E., Geng, Y., Yu, Q., Bhattacharya, S., Bronson, R. T., et al. (2004) · Cell

Cancer-related Molecular PathwaysDevelopmental Biology and Gene Regulation

Cited by 647

Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1.

Rosenbauer, F., Wagner, K., Kutok, J. L., Iwasaki, H., Le Beau, M. M., Okuno, Y., Akashi, K., Fiering, S., & Tenen, D. G. (2004) · Nature Genetics

Acute Myeloid Leukemia ResearchRetinoids in leukemia and cellular processes

Cited by 506

AML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation

Miyamoto, T., Weissman, I. L., & Akashi, K. (2000) · Proceedings of the National Academy of Sciences

Acute Myeloid Leukemia ResearchRetinoids in leukemia and cellular processes

Cited by 465

Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype

Growney, J. D., Shigematsu, H., Li, Z., Lee, B. H., Adelsperger, J., Rowan, R., Curley, D. P., Kutok, J. L., Akashi, K., Williams, I. R., et al. (2005) · Blood

Hematopoietic Stem Cell TransplantationAcute Myeloid Leukemia Research

Cited by 462

Distinctive and indispensable roles of PU.1 in maintenance of hematopoietic stem cells and their differentiation

Iwasaki, H., Somoza, C., Shigematsu, H., Duprez, E. A., Iwasaki-Arai, J., Mizuno, S.-I., Arinobu, Y., Geary, K., Zhang, P., Dayaram, T., et al. (2005) · Blood

Hematopoietic Stem Cell TransplantationAcute Myeloid Leukemia Research

Cited by 433

C/EBPβ is required for 'emergency' granulopoiesis

Hirai, H., Zhang, P., Dayaram, T., Hetherington, C. J., Mizuno, S.-I., Imanishi, J., Akashi, K., & Tenen, D. G. (2006) · Nature Immunology

Hematopoietic Stem Cell TransplantationBlood disorders and treatments

Cited by 425

Myeloid or Lymphoid Promiscuity as a Critical Step in Hematopoietic Lineage Commitment

Miyamoto, T., Iwasaki, H., Reizis, B., Ye, M., Graf, T., Weissman, I. L., & Akashi, K. (2002) · Developmental Cell

Hematopoietic Stem Cell TransplantationAcute Myeloid Leukemia Research

Cited by 415

Myeloid Lineage Commitment from the Hematopoietic Stem Cell

Iwasaki, H., & Akashi, K. (2007) · Immunity

Hematopoietic Stem Cell TransplantationAcute Myeloid Leukemia Research

Cited by 394

Reciprocal activation of GATA-1 and PU.1 marks initial specification of hematopoietic stem cells into myeloerythroid and myelolymphoid lineages

Arinobu, Y., Mizuno, S.-I., Chong, Y., Shigematsu, H., Iino, T., Iwasaki, H., Graf, T., Mayfield, R., Chan, S., Kastner, P., et al. (2007) · Cell Stem Cell

Hematopoietic Stem Cell TransplantationAcute Myeloid Leukemia Research

Cited by 309

Conditional expression of oncogenic K-ras from its endogenous promoter induces a myeloproliferative disease

Chan, I. T., Kutok, J. L., Williams, I. R., Cohen, S., Kelly, L., Shigematsu, H., Johnson, L., Akashi, K., Tuveson, D. A., Jacks, T., et al. (2004) · Journal of Clinical Investigation

Acute Myeloid Leukemia ResearchProtein Tyrosine Phosphatases

Cited by 270

Lymphoid cell growth and transformation are suppressed by a key regulatory element of the gene encoding PU.1

Rosenbauer, F., Owens, B. M., Yu, L., Tumang, J. R., Steidl, U., Kutok, J. L., Clayton, L. K., Wagner, K., Scheller, M., Iwasaki, H., et al. (2006) · Nature Genetics

Genomics and Chromatin DynamicsHematopoietic Stem Cell Transplantation

Cited by 237

Cyclin A Is Redundant in Fibroblasts but Essential in Hematopoietic and Embryonic Stem Cells

Kalaszczynska, I., Geng, Y., Iino, T., Mizuno, S.-I., Choi, Y., Kondratiuk, I., Silver, D. P., Wolgemuth, D. J., Akashi, K., & Sicinski, P. (2009) · Cell

Cancer-related Molecular PathwaysMicrotubule and mitosis dynamics

Cited by 215

Potential Autoregulation of Transcription Factor PU.1 by an Upstream Regulatory Element

Okuno, Y., Huang, G., Rosenbauer, F., Evans, E. K., Radomska, H. S., Iwasaki, H., Akashi, K., Moreau-Gachelin, F., Li, Y., Zhang, P., et al. (2005) · Molecular and Cellular Biology

Genomics and Chromatin DynamicsHematopoietic Stem Cell Transplantation

Cited by 174

Interaction between Toll-like receptors and natural killer cells in the destruction of bile ducts in primary biliary cirrhosis

Shimoda, S., Harada, K., Niiro, H., Shirabe, K., Taketomi, A., Maehara, Y., Tsuneyama, K., Nakanuma, Y., Leung, P., Ansari, A. A., et al. (2011) · Hepatology

Liver Diseases and ImmunityPediatric Hepatobiliary Diseases and Treatments

Cited by 126

Hematopoietic stem cell defects in mice with deficiency of Fancd2 or Usp1

Parmar, K., Kim, J., Sykes, S. M., Shimamura, A., Stuckert, P., Zhu, K., Hamilton, A., Deloach, M. K., Kutok, J. L., Akashi, K., et al. (2010) · Stem Cells

Hematopoietic Stem Cell TransplantationDNA Repair Mechanisms

Cited by 113

Regulation of the PU.1 gene by distal elements

Li, Y., Okuno, Y., Zhang, P., Radomska, H. S., Chen, H.-M., Iwasaki, H., Akashi, K., Klemsz, M. J., McKercher, S. R., Maki, R. A., et al. (2001) · Blood

Genomics and Chromatin DynamicsHematopoietic Stem Cell Transplantation

Cited by 110

Cx3cl1 (Fractalkine): A Signpost for Biliary Inflammation in Primary Biliary Cirrhosis

Shimoda, S., Harada, K., Niiro, H., Taketomi, A., Maehara, Y., Tsuneyama, K., Kikuchi, K., Nakanuma, Y., Mackay, I. R., Gershwin, E. M., et al. (2010) · Hepatology

Liver Diseases and ImmunityLiver physiology and pathology

Cited by 108

Natural killer cells regulate T cell immune responses in primary biliary cirrhosis

Shimoda, S., Hisamoto, S., Harada, K., Iwasaka, S., Chong, Y., Nakamura, M., Bekki, Y., Yoshizumi, T., Shirabe, K., Ikegami, T., et al. (2015) · Hepatology

Liver Diseases and ImmunityImmune Cell Function and Interaction

Cited by 82

Anti-GPRC5D/CD3 Bispecific T-Cell–Redirecting Antibody for the Treatment of Multiple Myeloma

Kodama, T., Kochi, Y., Nakai, W., Mizuno, H., Baba, T., Habu, K., Sawada, N., Tsunoda, H., Shima, T., Miyawaki, K., et al. (2019) · Molecular Cancer Therapeutics

Multiple Myeloma Research and TreatmentsMonoclonal and Polyclonal Antibodies Research

Cited by 80

Hydrophobic bile acids suppress expression of AE2 in biliary epithelial cells and induce bile duct inflammation in primary biliary cholangitis

Hisamoto, S., Shimoda, S., Harada, K., Iwasaka, S., Onohara, S., Chong, Y., Nakamura, M., Bekki, Y., Yoshizumi, T., Ikegami, T., et al. (2016) · Journal of Autoimmunity

Liver Diseases and ImmunityDrug Transport and Resistance Mechanisms

Cited by 57

JAK2 V617F uses distinct signalling pathways to induce cell proliferation and neutrophil activation

Oku, S., Takenaka, K., Kuriyama, T., Shide, K., Kumano, T., Kikushige, Y., Urata, S., Yamauchi, T., Iwamoto, C., Shimoda, H. K., et al. (2010) · British Journal of Haematology

Myeloproliferative Neoplasms: Diagnosis and TreatmentPlatelet Disorders and Treatments

Cited by 51