Kubota, Naoto

The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y., Kubota, N., Hara, K., Mori, Y., Ide, T., Murakami, K., Tsuboyama-Kasaoka, N., et al. (2001) · Nature Medicine

Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Cited by 4,915

Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions

Yamauchi, T., Nio, Y., Maki, T., Kobayashi, M., Takazawa, T., Iwabu, M., Okada-Iwabu, M., Kawamoto, S., Kubota, N., Kubota, T., et al. (2007) · Nature Medicine

Adipokines, Inflammation, and Metabolic DiseasesPeroxisome Proliferator-Activated Receptors

Cited by 1,396

Adiponectin and AdipoR1 Regulate PGC-1α and Mitochondria by Ca2+ and AMPK/SIRT1

Iwabu, M., Yamauchi, T., Okada-Iwabu, M., Sato, K., Nakagawa, T., Funata, M., Yamaguchi, M., Namiki, S., Nakayama, R., Tabata, M., et al. (2010) · Nature

Adipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic Diseases

Cited by 971

Adiponectin Stimulates AMP-Activated Protein Kinase in the Hypothalamus and Increases Food Intake

Kubota, N., Yano, W., Kubota, T., Yamauchi, T., Itoh, S., Kumagai, H., Kozono, H., Takamoto, I., Okamoto, S., Shiuchi, T., et al. (2007) · Cell Metabolism

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 844

A liver-derived secretory protein, selenoprotein P, causes insulin resistance

Misu, H., Takamura, T., Takayama, H., Hayashi, H., Matsuzawa-Nagata, N., Kurita, S., Ishikura, K., Ando, H., Takeshita, Y., Ota, T., et al. (2010) · Cell Metabolism

Adipokines, Inflammation, and Metabolic DiseasesSelenium in Biological Systems

Cited by 583

Role of Insulin Resistance in MAFLD

Sakurai, Y., Kubota, N., Yamauchi, T., & Kadowaki, T. (2021) · International Journal of Molecular Sciences

Liver Disease Diagnosis and TreatmentDiet, Metabolism, and Disease

Cited by 448

Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle

Kubota, T., Kubota, N., Kumagai, H., Yamaguchi, S., Kozono, H., Takahashi, T., Inoue, M., Itoh, S., Takamoto, I., Sasako, T., et al. (2011) · Cell Metabolism

Metabolism, Diabetes, and CancerAdipokines, Inflammation, and Metabolic Diseases

Cited by 435

Adiponectin Enhances Insulin Sensitivity by Increasing Hepatic IRS-2 Expression via a Macrophage-Derived IL-6-Dependent Pathway

Awazawa, M., Ueki, K., Inabe, K., Yamauchi, T., Kubota, N., Kaneko, K., Kobayashi, M., Iwane, A., Sasako, T., Okazaki, Y., et al. (2011) · Cell Metabolism

Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Cited by 277

Dynamic Functional Relay between Insulin Receptor Substrate 1 and 2 in Hepatic Insulin Signaling during Fasting and Feeding

Kubota, N., Kubota, T., Itoh, S., Kumagai, H., Kozono, H., Takamoto, I., Mineyama, T., Ogata, H., Tokuyama, K., Ohsugi, M., et al. (2008) · Cell Metabolism

Metabolism, Diabetes, and CancerPancreatic function and diabetes

Cited by 244

Insulin receptor substrate 2 plays a crucial role in β cells and the hypothalamus

Kubota, N., Terauchi, Y., Tobe, K., Yano, W., Suzuki, R., Ueki, K., Takamoto, I., Satoh, H., Maki, T., Kubota, T., et al. (2004) · Journal of Clinical Investigation

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 239

Neuronal IGF‐1 resistance reduces Aβ accumulation and protects against premature death in a model of Alzheimer's disease

Freude, S., Hettich, M. M., Schumann, C., Stöhr, O., Koch, L., Köhler, C., Udelhoven, M., Leeser, U., Müller, M., Kubota, N., et al. (2009) · The FASEB Journal

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 218

Differential hepatic distribution of insulin receptor substrates causes selective insulin resistance in diabetes and obesity

Kubota, N., Kubota, T., Kajiwara, E., Iwamura, T., Kumagai, H., Watanabe, T., Inoue, M., Takamoto, I., Sasako, T., Kumagai, K., et al. (2016) · Nature Communications

Metabolism, Diabetes, and CancerPancreatic function and diabetes

Cited by 143

Rimonabant ameliorates insulin resistance via both adiponectin-dependent and adiponectin-independent pathways

Watanabe, T., Kubota, N., Ohsugi, M., Kubota, T., Takamoto, I., Iwabu, M., Awazawa, M., Katsuyama, H., Hasegawa, C., Tokuyama, K., et al. (2009) · Journal of Biological Chemistry

Adipokines, Inflammation, and Metabolic DiseasesPharmacology and Obesity Treatment

Cited by 53

Anagliptin increases insulin-induced skeletal muscle glucose uptake via an NO-dependent mechanism in mice

Sato, H., Kubota, N., Kubota, T., Takamoto, I., Iwayama, K., Tokuyama, K., Moroi, M., Sugi, K., Nakaya, K., Goto, M., et al. (2016) · Diabetologia

Diabetes Treatment and ManagementMetabolism, Diabetes, and Cancer

Cited by 19

Physiological and pathophysiological actions of insulin in the liver

Kubota, N., Kubota, T., & Kadowaki, T. (2025) · Endocrine Journal

Metabolism, Diabetes, and CancerLiver Disease Diagnosis and Treatment

Cited by 19