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Dual Regulation of Gluconeogenesis by Insulin and Glucose in the Proximal Tubules of the Kidney

Sasaki, M., Sasako, T., Kubota, N., Sakurai, Y., Takamoto, I., Kubota, T., Inagi, R., Seki, G., Goto, M., Ueki, K., et al. (2017) · Diabetes · doi:10.2337/db16-1602 · Cited by 80 · see citing works

Modulation of Insulin Sensitivity by Insulin-Degrading Enzyme

González-Casimiro, C. M., Merino, B., Casanueva-Álvarez, E., Postigo, T., Cámara-Torres, P., Fernández-Díaz, C. M., Leissring, M. A., Cózar‐Castellano, I., & Perdomo, G. (2021) · Biomedicines · doi:10.3390/biomedicines9010086 · Cited by 81 · see citing works

Dissecting the role of insulin resistance in the metabolic syndrome

Haas, J. T., & Biddinger, S. B. (2009) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e32832b2024 · Cited by 80 · see citing works

From chronic overfeeding to hepatic injury: Role of endoplasmic reticulum stress and inflammation

Mollica, M. P., Lionetti, L., Putti, R., Cavaliere, G., Gaita, M., & Barletta, A. (2011) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2010.10.012 · Cited by 80 · see citing works

Down-regulation of phosphatase and tensin homolog by hepatitis C virus core 3a in hepatocytes triggers the formation of large lipid droplets

Clément, S., Peyrou, M., Sanchez-Pareja, A., Bourgoin, L., Ramadori, P., Suter, D. M., Vinciguerra, M., Guilloux, K., Pascarella, S., Rubbia‐Brandt, L., et al. (2011) · Hepatology · doi:10.1002/hep.24340 · Cited by 78 · see citing works

Downregulation of macrophage Irs2 by hyperinsulinemia impairs IL-4-indeuced M2a-subtype macrophage activation in obesity

Kubota, T., Inoue, M., Kubota, N., Takamoto, I., Mineyama, T., Iwayama, K., Tokuyama, K., Moroi, M., Ueki, K., Yamauchi, T., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-07358-9 · Cited by 78 · see citing works

Role of protein tyrosine phosphatases in the modulation of insulin signaling and their implication in the pathogenesis of obesity-linked insulin resistance

Xu, E., Schwab, M. G., & Marette, A. (2013) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-013-9282-4 · Cited by 74 · see citing works

Positive selection of somatically mutated clones identifies adaptive pathways in metabolic liver disease

Wang, Z., Zhu, S., Jia, Y., Wang, Y., Kubota, N., Fujiwara, N., Gordillo, R., Lewis, C., Zhu, M., Sharma, T., et al. (2023) · Cell · doi:10.1016/j.cell.2023.03.014 · Cited by 72 · see citing works

Selective Regulation of Heme Oxygenase-1 Expression and Function by Insulin through IRS1/Phosphoinositide 3-Kinase/Akt-2 Pathway

Geraldes, P., Yagi, K., Ohshiro, Y., He, Z., Maeno, Y., Hiraoka‐Yamamoto, J., Rask‐Madsen, C., Chung, S. W., Perrella, M. A., & King, G. L. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m807036200 · Cited by 71 · see citing works

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Tetrahedral Framework Nucleic Acids Ameliorate Insulin Resistance in Type 2 Diabetes Mellitus via the PI3K/Akt Pathway

Li, Y., Tang, Y., Shi, S., Gao, S., Wang, Y., Xiao, D., Chen, T., He, Q. P., Zhang, J., & Lin, Y. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c11468 · Cited by 65 · see citing works

Intensive insulin treatment induces insulin resistance in diabetic rats by impairing glucose metabolism-related mechanisms in muscle and liver

Okamoto, M. M., Anhê, G. F., Silva, R. S., Marques, M. F. D. S. F., Freitas, H. S., Mori, R. C. T., Melo, K. F. S., & Machado, U. F. (2011) · Journal of Endocrinology · doi:10.1530/joe-11-0105 · Cited by 63 · see citing works

Loss of Pdk1-Foxo1 Signaling in Myeloid Cells Predisposes to Adipose Tissue Inflammation and Insulin Resistance

Kawano, Y., Nakae, J., Watanabe, N., Fujisaka, S., Iskandar, K., Sekioka, R., Hayashi, Y., Tobe, K., Kasuga, M., Noda, T., et al. (2012) · Diabetes · doi:10.2337/db11-0770 · Cited by 62 · see citing works

Distinct signalling properties of insulin receptor substrate (IRS)-1 and IRS-2 in mediating insulin/IGF-1 action

Rabiee, A., Krüger, M., Ardenkjær-Skinnerup, J., Kahn, C. R., & Emanuelli, B. (2018) · Cellular Signalling · doi:10.1016/j.cellsig.2018.03.003 · Cited by 62 · see citing works

Role of Insulin Signaling in the Interaction Between Alzheimer Disease and Diabetes Mellitus: A Missing Link to Therapeutic Potential

Sato, N., Takeda, S., Uchio‐Yamada, K., Ueda, H., Fujisawa, T., Rakugi, H., & Morishita, R. (2011) · Current Aging Science · doi:10.2174/1874609811104020118 · Cited by 61 · see citing works

Genetic Inactivation of Pyruvate Dehydrogenase Kinases Improves Hepatic Insulin Resistance Induced Diabetes

Tao, R., Xiong, X., Harris, R. A., White, M. F., & Dong, X. C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071997 · Cited by 60 · see citing works

Metformin prevents liver tumorigenesis induced by high-fat diet in C57Bl/6 mice

Tajima, K., Nakamura, A., Shirakawa, J., Togashi, Y., Orime, K., Sato, K., Inoue, H., Kaji, M., Sakamoto, E., Ito, Y., et al. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00133.2013 · Cited by 59 · see citing works

Adipokines and Redox Signaling: Impact on Fatty Liver Disease

Parola, M., & Marra, F. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3848 · Cited by 59 · see citing works

Blockade of class IB phosphoinositide-3 kinase ameliorates obesity-induced inflammation and insulin resistance

Kobayashi, N., Ueki, K., Okazaki, Y., Iwane, A., Kubota, N., Ohsugi, M., Awazawa, M., Kobayashi, M., Sasako, T., Kaneko, K., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016430108 · Cited by 57 · see citing works

Schisandrin B: A Double‐Edged Sword in Nonalcoholic Fatty Liver Disease

Leong, P. K., & Ko, K. M. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/6171658 · Cited by 56 · see citing works

IGF-1R signalling contributes to IL-6 production and T cell dependent inflammation in rheumatoid arthritis

Erlandsson, M. C., Silfverswärd, S. T., Nadali, M., Turkkila, M., Svensson, M. N. D., Jonsson, I., Andersson, K., & Bokarewa, M. I. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.06.002 · Cited by 56 · see citing works

Pu-erh tea extract ameliorates high-fat diet-induced nonalcoholic steatohepatitis and insulin resistance by modulating hepatic IL-6/STAT3 signaling in mice

Cai, X., Fang, C., Hayashi, S., Hao, S., Zhao, M., Tsutsui, H., Nishiguchi, S., & Sheng, J. (2016) · Journal of Gastroenterology · doi:10.1007/s00535-015-1154-0 · Cited by 55 · see citing works

Current perspectives of insulin resistance and polycystic ovary syndrome

Pauli, J. M., Raja-Khan, N. T., Wu, X., & Legro, R. S. (2011) · Diabetic Medicine · doi:10.1111/j.1464-5491.2011.03460.x · Cited by 55 · see citing works

The Double-stranded RNA–dependent Protein Kinase Differentially Regulates Insulin Receptor Substrates 1 and 2 in HepG2 Cells

Yang, X., Nath, A., Opperman, M. J., & Chan, C. (2010) · Molecular Biology of the Cell · doi:10.1091/mbc.e10-06-0481 · Cited by 53 · see citing works

Insulin Action Research and the Future of Diabetes Treatment: The 2017 Banting Medal for Scientific Achievement Lecture

Accili, D. (2018) · Diabetes · doi:10.2337/dbi18-0025 · Cited by 52 · see citing works

A Computational Model of Hepatic Energy Metabolism: Understanding Zonated Damage and Steatosis in NAFLD

Ashworth, W. B., Davies, N. A., & Bogle, I. D. L. (2016) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1005105 · Cited by 49 · see citing works

Role of insulin receptor substrates in the progression of hepatocellular carcinoma

Sakurai, Y., Kubota, N., Takamoto, I., Obata, A., Iwamoto, M., Hayashi, T., Aihara, M., Kubota, T., Nishihara, H., & Kadowaki, T. (2017) · Scientific Reports · doi:10.1038/s41598-017-03299-3 · Cited by 51 · see citing works

Liver and insulin resistance: New wine in old bottle!!!

Patel, B. M., & Goyal, R. K. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.172657 · Cited by 50 · see citing works

Protection from non-alcoholic steatohepatitis and liver tumourigenesis in high fat-fed insulin receptor substrate-1-knockout mice despite insulin resistance

Nakamura, A., Tajima, K., Zolzaya, K., Sato, K., Inoue, R., Yoneda, M., Fujita, K., Nozaki, Y., Kubota, K. C., Haga, H., et al. (2012) · Diabetologia · doi:10.1007/s00125-012-2703-1 · Cited by 48 · see citing works

Insulin Regulates Retinol Dehydrogenase Expression and All-trans-retinoic Acid Biosynthesis through FoxO1

Obrochta, K. M., Krois, C. R., Campos, B., & Napoli, J. L. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.609313 · Cited by 48 · see citing works

Palmitic acid-induced lipotoxicity promotes a novel interplay between Akt-mTOR, IRS-1, and FFAR1 signaling in pancreatic β-cells

Marafie, S. K., ALSHAWAF, E. M. M., Abubaker, J. A., & Arefanian, H. (2019) · Biological Research · doi:10.1186/s40659-019-0253-4 · Cited by 48 · see citing works

Chapter 12 Serine Kinases of Insulin Receptor Substrate Proteins

Boura‐Halfon, S., & Zick, Y. (2009) · Vitamins and hormones · doi:10.1016/s0083-6729(08)00612-2 · Cited by 46 · see citing works

Insulin regulates carboxypeptidase E by modulating translation initiation scaffolding protein eIF4G1 in pancreatic β cells

Liew, C. W., Aßmann, A., Templin, A. T., Raum, J. C., Lipson, K. L., Rajan, S., Qiang, G., Hu, J., Kawamori, D., Lindberg, I., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1323066111 · Cited by 45 · see citing works

Increased insulin receptor substrate 2 expression is associated with steatohepatitis and altered lipid metabolism in obese subjects

Rametta, R., Mozzi, E., Dongiovanni, P., Motta, B. M., Milano, M., Roviaro, G., Fargion, S. R., & Valenti, L. V. C. (2012) · International Journal of Obesity · doi:10.1038/ijo.2012.181 · Cited by 43 · see citing works

High-fructose corn syrup-induced hepatic dysfunction in rats: improving effect of resveratrol

Sadı, G., Ergin, V., Yılmaz, G., Pektaş, M. B., Yıldırım, O. G., Menevşe, A., & Akar, F. (2014) · European Journal of Nutrition · doi:10.1007/s00394-014-0765-1 · Cited by 43 · see citing works

Central insulin-mediated regulation of hepatic glucose production [Review]

Inoue, H. (2016) · Endocrine Journal · doi:10.1507/endocrj.ej15-0540 · Cited by 43 · see citing works

IL-6 deficiency in mice neither impairs induction of metabolic genes in the liver nor affects blood glucose levels during fasting and moderately intense exercise

Fritsche, L., Hoene, M., Lehmann, R., Ellingsgaard, H., Hennige, A. M., Pohl, A. K., Häring, H., Schleicher, E. D., & Weigert, C. (2010) · Diabetologia · doi:10.1007/s00125-010-1754-4 · Cited by 40 · see citing works

Insulin-induced serine phosphorylation of IRS-2 via ERK1/2 and mTOR: studies on the function of Ser675and Ser907

Fritsche, L., Neukamm, S. S., Lehmann, R., Kremmer, E., Hennige, A. M., Hunder-Gugel, A., Schenk, M., Häring, H., Schleicher, E. D., & Weigert, C. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00409.2010 · Cited by 40 · see citing works

Knockout mouse models of insulin signaling: Relevance past and future

Bunner, A. E., Chandrasekera, P. C., & Barnard, N. D. (2014) · World Journal of Diabetes · doi:10.4239/wjd.v5.i2.146 · Cited by 41 · see citing works

Potential mechanistic pathways underlying intestinal and hepatic effects of kefir in high-fructose-fed rats

Akar, F., Şumlu, E., Alçığır, M. E., Bostancı, A., & Sadı, G. (2021) · Food Research International · doi:10.1016/j.foodres.2021.110287 · Cited by 39 · see citing works

Impaired PRMT1 activity in the liver and pancreas of type 2 diabetic Goto–Kakizaki rats

Iwasaki, H. (2009) · Life Sciences · doi:10.1016/j.lfs.2009.05.007 · Cited by 39 · see citing works

Time-resolved gene expression profiling of human squamous cell carcinoma cells during the apoptosis process induced by photodynamic treatment with hypericin

Verwanger (2009) · International Journal of Oncology · doi:10.3892/ijo_00000407 · Cited by 38 · see citing works

Anti-diabetes effect of chronic intermittent hypobaric hypoxia through improving liver insulin resistance in diabetic rats

Tian, Y., Liu, Y., Wang, S., Dong, Y., Su, T., Ma, H., & Zhang, Y. (2016) · Life Sciences · doi:10.1016/j.lfs.2016.02.053 · Cited by 38 · see citing works

Glucose oxidation and nonoxidative glucose disposal during prolonged fasts of the northern elephant seal pup (Mirounga angustirostris)

Houser, D. S., Crocker, D. E., Tift, M. S., & Champagne, C. D. (2012) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00101.2012 · Cited by 37 · see citing works

Dietary protein deprivation upregulates insulin signaling and inhibits gluconeogenesis in rat liver

Toyoshima, Y., Tokita, R., Ohne, Y., Hakuno, F., Noguchi, T., Minami, S., Kato, H., & Takahashi, S. (2010) · Journal of Molecular Endocrinology · doi:10.1677/jme-10-0102 · Cited by 37 · see citing works

Truncation of Pik3r1 causes severe insulin resistance uncoupled from obesity and dyslipidaemia by increased energy expenditure

Kwok, A., Zvetkova, I., Virtue, S., Luijten, I. H. N., Huang‐Doran, I., Tomlinson, P. R., Bulger, D. A., West, J. A., Murfitt, S. A., Griffin, J. L., et al. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101020 · Cited by 36 · see citing works

Hepatic IRS1 and ß-catenin expression is associated with histological progression and overt diabetes emergence in NAFLD patients

Enooku, K., Kondo, M., Fujiwara, N., Sasako, T., Shibahara, J., Kado, A., Okushin, K., Fujinaga, H., Tsutsumi, T., Nakagomi, R., et al. (2018) · Journal of Gastroenterology · doi:10.1007/s00535-018-1472-0 · Cited by 35 · see citing works

The Association of Acute Phase Proteins in Stress and Inflammation-Induced T2D

Speelman, T., Dale, L., Louw, A., & Verhoog, N. J. D. (2022) · Cells · doi:10.3390/cells11142163 · Cited by 35 · see citing works

MiR-126 Suppresses the Glucose-Stimulated Proliferation via IRS-2 in INS-1 β Cells

Hong, T., Wang, M., Zhang, M., Zhang, S., Wang, C., Yuan, W., Sun, T., He, L., & Hu, Q. (2016) · PLoS ONE · doi:10.1371/journal.pone.0149954 · Cited by 35 · see citing works

Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growth

Dong, X. C., Park, S., Lin, X., Copps, K. D., Yi, X., & White, M. F. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25735 · Cited by 230 · see citing works

The Irs1 Branch of the Insulin Signaling Cascade Plays a Dominant Role in Hepatic Nutrient Homeostasis

Guo, S., Copps, K. D., Dong, X. C., Park, S., Cheng, Z., Pocai, A., Rossetti, L., Sajan, M. P., Farese, R. V., & White, M. F. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00138-09 · Cited by 150 · see citing works

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Dynamics of insulin signalling in liver during hyperinsulinemic euglycaemic clamp conditionsin vivoand the effects of high-fat feeding in male mice

Korsheninnikova, E., Voshol, P. J., Baan, B., van der Zon, G. C. M., Havekes, L. M., Romijn, J. A., Maassen, J. A., & Ouwens, D. M. (2007) · Archives of Physiology and Biochemistry · doi:10.1080/13813450701669084 · Cited by 5 · see citing works

How Insulin Receptor Substrate Proteins Regulate the Metabolic Capacity of the Liver - Implications for Health and Disease

Fritsche, L., Weigert, C., Häring, H., & Lehmann, R. (2008) · Current Medicinal Chemistry · doi:10.2174/092986708784534956 · Cited by 137 · see citing works